Clinical Neurology

Clinical Neurology research

Aims and Expertise

Our research mainly focuses on multiple sclerosis, an inflammatory demyelinating disease of the central nervous system that affects about 100,000 people in the UK. We have a broad range of expertise in this field, covering disease pathogenesis, pathology, imaging by advanced techniques, experimental disease models, epidemiology, and clinical trials.

Additional areas of research include neuroimmunology and neurodegeneration.

Associate Professor Nikos Evangelou

Researcher with clinical trial volunteer


Research topics

Our research topics in the field of multiple sclerosis include immunopathogenesis (the immune mechanisms that lead to myelin and axonal damage), the study of the role of infections in the aetiology of the disease and its activation; the role of advanced imaging techniques in the study of tissue damage, in vivo detection of pathology, correlation with neuropathology, and differential diagnosis in the clinic; epidemiology, including the role and mechanisms of smoking in susceptibility and clinical progression of MS; the identification of new therapeutic approaches, including immunomodulation, neuroprotection, and remyelination by pharmacological, biological, and cell-based treatments. 


Group members have participated in pivotal trials that led to the introduction of most drugs currently used in MS, helped establish the principle of some treatments and the basis for combination therapy in multiple sclerosis.

MS Clinical Trials Unit

We have an active, internationally recognised clinical trials unit. We conduct a number of commercial and non-commercial trials, many of which are investigator-led, and collaborate closely with the Comprehensive Clinical Research Network (CLRN) for the National Institute for Health Research (NIHR) portfolio studies.


Worms For Immune Regulation in Multiple Sclerosis (WiRMS) trial


Clinical service

Our senior academics have clinical honorary contracts within the NHS, and there is fertile ground for bench-to-bedside and bedside-to-bench translational work. We deliver neurological care to a population of more than 3 million people. The MS clinic is possibly the largest in England.

Visit the NHS Neurology Services in Nottingham.

NeuRoi image analysis software

We have developed the NeuRoi image analysis software for processing MRI images. Its application can be found in leading peer-reviewed publications such as Brain and Journal of Magnetic Resonance Imaging.



Our research has been published in leading journals.

See other publications under the individual profiles of our group members.


Clinical Neurology

School of Medicine
The University of Nottingham
C Floor, South Block, Queen's Medical Centre Nottingham, NG7 2UH

telephone: +44 (0) 115 823 1441
email:Group Administrator