Evidence Based Child Health
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The Evidence Based Child Health Group

The Evidence Based Child Health Group is focussed on ensuring that clinical decisions in the field of paediatrics are supported by the best available evidence.

We work together with patients, clinicians and other stakeholders to encourage an evidence based approach to child health, and an evidence based systematic approach to setting the future research agenda and establishing research priorities

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Research issues

Currently, we are targeting evidence synthesis in the field of Cystic Fibrosis (CF), but we will expand into other areas of Paediatrics as our group grows.

We work closely with the Cochrane CF and Genetic Disorders group of which Professor Alan Smyth is the co-ordiinating editor. Our priority setting work in CF helps to ensure that Cochrane review titles are those which are important to the CF community. Go to the website to see a list of priority titles.

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What are we doing about

1. Assessing the evidence base to inform decision making in clinical care

A systematic review attempts to identify, appraise and synthesise all the empirical evidence that meets pre-specified eligibility criteria to answer a given research question.

To do this we use explicit methods aimed at minimising bias, in order to produce more reliable findings that can be used to inform decision making. At present the following Cochrane systematic reviews are being undertaken within Evidence Based Child Health:

  • Antibiotic adjuvant therapy for pulmonary infection
  • Antibiotic strategies for eradicating Pseudomonas aeruginosa
  • Therapies for preventing recurrence of Pseudomonas aeruginosa in people with cystic fibrosis
  • Digital technology for monitoring adherence to inhaled therapies and for predicting and intervening early in exacerbations
  • Short-acting inhaled bronchodilators in CF
  • Dosing regimens for pancreatic enzyme replacement therapy (PERT) in CF

Members of the group are also authors on other reviews which are going through the routine update cycle, including percutaneous lines for intravenous antibiotics in cystic fibrosis, intravenous antibiotics in cystic fibrosis, and long-acting inhaled bronchodilators in cystic fibrosis.

Prof Alan Smyth is coordinating editor of the Cochrane Cystic Fibrosis and Genetic Disorders Group

 
2. Identifying evidence gaps in treatment decisions in CF

We do not always have the evidence to support treatment decisions. We have conducted a systematic review to identify the known evidence gaps in treatment decisions in CF. These evidence gaps will be used to guide both researchers and funding bodies to priority areas.

Rowbotham NJ, Smith S, Prayle AP, et al. Gaps in the evidence for treatment decisions in cystic fibrosis: A systematic review. Thorax. 2018;74:229-36. doi: http://dx.doi.org/10.1136/thoraxjnl-2017-210858.

 
3. Shaping the future research agenda in partnership with the CF community

We have carried out a programme of research, in partnership with the CF community, to try and identify priority areas for research and clinical trials that may address them. 

James Lind Alliance Priority Setting Partnership

In 2016-17 we undertook a James Lind Alliance Priority Setting Partnership (JLA PSP) in CF. This brought together patients, families, healthcare professionals and commissioners to agree shared priorities for research. 

Top 10 priorities for clinical research in CF

Here are our final top ten questions as agreed by the CF community:

  1. What are the effective ways of simplifying the treatment burden of people with CF?
  2. How can we relieve gastro-intestinal symptoms, such as stomach pain, bloating and nausea?
  3. What is the best treatment for non-tuberculous mycobacterium (including when to start and what medication)?
  4. Which therapies are effective in delaying or preventing progression of lung disease in early life?
  5. Is there a way of preventing CF related diabetes?
  6. What effective ways of motivation, support and technologies help people with CF improve and sustain adherence to treatment?
  7. Can exercise replace chest physiotherapy?
  8. Which antibiotic combinations and dosing plans should be used for CF exacerbations and should antibiotic combinations be rotated?
  9. Is there a way of reducing the negative effects of antibiotics e.g. resistance risk and adverse symptoms in people with CF?
  10. What is the best way of eradicating Pseudomonas aeruginosa?

James Lind CF 2

We then took this work further by looking at four of the top ten priorities, which were broad in their nature, in more depth. We wanted to find out what the CF community understood by the priorities and at the same time to try and identify more specific questions that could be answered by clinical research.

We reached out to the whole CF community via online surveys and focus groups. We also made use of videoconferencing so that we could include as many people as possible without cross-infection risks.

The four questions we focussed on are:

  • What are the effective ways of simplifying the treatment burden of people with CF?
  • How can we relieve gastro-intestinal symptoms, such as stomach pain, bloating and nausea?
  • What effective ways of motivation, support and technologies help people with CF improve and sustain adherence to treatment?
  • Can exercise replace chest physiotherapy?

PICO questions

We explored each of the four priority areas via online surveys and a focus group, and identified ideas for clinical trials based on the data from the surveys and input from the steering group / experts in the field.

IMPACT

The results of this programme of work has led to a number of outputs:

  • NIHR – HTA  put out a call for research proposals which was based on 7 of our top ten priorities
  • The top ten priorities fed into the Cochrane priority titles list
  • Primary research (GIFT-CF) looking at imaging of GI function.
  • Collaborations with other research teams
  • Publications relating to this programme of work
 
4. Understanding gut symptoms in CF

Gut investigations are currently invasive or expose patients to radiation and there is little objective evidence on the mechanisms of gut disease in CF. We aim to use Magnetic Resonance Imaging to assess the gut function and transit in CF. Currently we have completed recruitment for our observational study of people with CF and controls. We are currently open to recruitment for a CFTR modulator cross-over trial. 

Molly on scanner

 

  

Current projects

Key publications

Smyth AR, Smith SJ, Rowbotham NJ. Infection prevention and control in cystic fibrosis: One size fits all The argument against. Paediatric Respiratory Reviews 2020;36:94-96. doi: https://doi.org/10.1016/j.prrv.2019.08.001

Langton Hewer SC, Smyth AR, Brown M, et al. Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial. Lancet Respir Med 2020;8:975-86

Smith S, Rowbotham N, Davies G, et al. How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey. BMJ Open Respiratory Research 2020;7(1):e000614. doi: 10.1136/bmjresp-2020-000614

Calthorpe RJ, Smith SJ, Rowbotham NJ, et al. What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment? BMJ Open Respiratory Research 2020;7(1):e000601. doi: 10.1136/bmjresp-2020-000601

Ng C, Dellschaft NS, Hoad CL, et al. Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging [published online ahead of print, 2020 Jun 16]. J Cyst Fibros. 2020;S1569-1993(20)30733-5. doi:10.1016/j.jcf.2020.06.004

Smyth AR, Rawlinson C, Jenkins G Preprint servers: a ‘rush to publish’ or ‘just in time delivery’ for science?Thorax Published Online First: 20 April 2020. doi: 10.1136/thoraxjnl-2020-214937

Kalaitzis, I.S., N.J. Rowbotham, S.J. Smith, and A.R. Smyth, Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review. Journal of Cystic Fibrosis., 2019. 19(1): p. 26-33.

Ojha S, Szatkowski L, Sinha R, et al Rojiroti microfinance and child nutrition: a cluster randomised trialArchives of Disease in Childhood Published Online First: 10 October 2019. doi: 10.1136/archdischild-2018-316471

Rowbotham NJ, Smith SJ, Elliott ZC, Leighton PA, Rayner OC, Morley R, et al. Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement. 2019;5(1):24.

Gichuru W, Ojha S, Smith S, et al. Is microfinance associated with changes in women's well-being and children's nutrition? A systematic review and meta-analysis. BMJ Open 2019;9:e023658

Rowbotham NJ,Smith S, Prayle AP, et al. Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review. Thorax 2019;74(3):229-36 doi:10.1136/thoraxjnl-2017-210858

Cochrane library

Cochrane CF and Genetic Disorders webpage

 

 

 

The Evidence Based Child Health Group

Division of Child Health, Obstetrics & Gynaecology
The University of Nottingham
E Floor, East Block, QMC
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 30611
email:childhealth@nottingham.ac.uk