Evidence Based Child Health
  • Print

Landmark clinical trial

TORPEDO Chart: Kaplan-Meier plot

Kaplan-Meier plot

A landmark clinical trial carried out over 10 years by the Universities of Bristol and Nottingham has shown that oral antibiotics are just as effective as intravenous antibiotics for treating new infection with Pseudomonas aeruginosa in people with cystic fibrosis (CF). P aeruginosa is a common bacteria but causes a chronic destructive lung infection in people with CF. It cannot be eradicated unless it is caught in the early stages.

The TORPEDO trial was a multicentre, parallel group, open label, randomised controlled trial which included 286 patients with a first ever or new isolate of P aeruginosa. Patients were randomised to either intravenous antibiotic treatment or oral antibiotics. The primary outcome was eradication of P aerugoinosa at 3 months and the results showed that intravenous antibiotics did not achieve sustained eradication of P aeruginosa in a greater proportion of patients and was more expensive.


Read the full paper here


Posted on Friday 2nd October 2020

The Evidence Based Child Health Group

Division of Child Health, Obstetrics & Gynaecology
The University of Nottingham
E Floor, East Block, QMC
Nottingham, NG7 2UH

telephone: +44 (0) 115 82 30611