Professor Robin Spiller and a team of experts from the Neurogastroenterology & Motility Section of the British Society of Gastroenterology who are based in 12 major research centres in the UK have been awarded a £2.1M grant from the National Institute of Health Research Efficacy and Mechanism Evaluation (NIHR EME) Programme to perform a clinical trial entitled "Treatment of IBS with diarrhoea with Titrated Ondansetron (TRITON)”. The trial will be coordinated from the Leeds Clinical Trials Research Unit and the mechanistic studies will involve specialist centres in Leeds, University College London and Barts and the London Hospital. Recruitment is expected to start in autumn 2017.
The trial offers a great opportunity for two specialist registrars to obtain a higher degree in the rapidly expanding field of neurogastroenterology. The trial will include studies of how ondansetron affects bowel motility and sensitivity. Understanding how ondansetron works will improve our ability to predict who will respond and will inform the development of new treatments for this common and distressing condition.
One registrar will be based at QMC, Nottingham and the other at QMUL, London; both are expected to start their fully supported OOP work in September 2017. The posts will be advertised soon with full information on how to apply.
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