NCARE (Nottingham Centre for the Advancement of Research into Supportive, Palliative and End-of-life Care)

A Randomised Controlled Trial of Excisional Surgery Versus Imiquimod 5% Cream for Nodular and Superficial Basal Cell Carcinoma (The SINS Trial)

Project Duration

September 2002 - September 2007

Funder

Cancer Research UK (Imiquimod and funding for genetic markers addendum provided by 3M)

Project Staff

Main grant holder 

  • Dr Fiona Bath-Hextall 

Principal investigator

  • Prof Hywel Williams 

Steering committee

  • Dr William Perkins 2
  • Dr Lesley Millard 2
  • Dr Jan Bong 2
  • Dr Irshad Zaki 3
  • Dr Graham Colver 4
  • Dr Paul Miller 1
  • Dr Sarah Armstrong 1
  • Graeme Perks 2
  • Mara Ozolins 1

Clinical Research Nurses

  • Joanne Llewellyn 1
  • Beryl Cunningham 3
  • Gloria Kemeny
  • Sam Annasamy 4

Data monitoring committee

  • Dr Nick Telfer 5
  • Dr Stephen Walters 6
  • Prof Carol Jagger  7

Staff Institutions

  1. The University of Nottingham
  2. Department of Dermatology, Queen's Medical Centre, Nottingham, 
  3. Department of Dermatology, Solihull Hospital
  4. Department of Dermatology, Chesterfield Royal Hospital
  5. Hope Hospital, Manchester
  6. School of Health Related Research, Sheffield
  7. Leicester TIHSR
 

Aims

The study aims to assess cure rates for tumours at low risk sites, cost-effectiveness and cosmetic result. 

Recurrence at intervals up to five years will also be assessed, the primary assessment point being three years. Genetic markers will also be investigated.

Methods

This is a randomised controlled trial of excisional surgery vs Imiquimod 5% cream (Aldara) for nodular and superficial basal cell carcinoma.

Outcomes and Findings

This project is now complete.

Return to NCARE

Contact the team

 

 

NCARE (Nottingham Centre for the Advancement of Research into Supportive, Palliative and End-of-life Care)

University of Nottingham
School of Health Sciences
Queen's Medical Centre
Nottingham, NG7 2HA


email: kristian.pollock@nottingham.ac.uk