Neuroscience at Nottingham
 

Image of Nikos Evangelou

Nikos Evangelou

Clinical Professor of Neurology, Faculty of Medicine & Health Sciences

Contact

Biography

I did my undergraduate studies in Greece and the UK and trained as a Neurologist in Oxford and Nottingham. I gained my DPhil in Oxford studying axonal damage in MS with MRI and histopathology.

Since 2003, I have been a Consultant Neurologist at Nottingham University Hospital. In 2012 I became clinical lead for the department of Neurology, at the Nottingham University Hospital.

In 2011, I joined the University as a Clinical Associate Professor in Neurology and was appointed as a Clinical Professor of Neurology in 2023.

Expertise Summary

I lead a translational group of clinicians and scientists aiming to better understand the pathophysiology of neurological diseases such as Multiple Sclerosis, Parkinson's, Dementia and traumatic brain injury. I have participated in most major clinical trials in MS. Clinically, I run regular general neurology clinics, but my clinical expertise lies in Multiple Sclerosis and headache management.

My team is interested in clinical trials in MS and I am the Co-Principle Investigator of a large study to compare in many sites in the UK and USA escalation vs. highly effective treatment in MS. https://www.pcori.org/research-results/2017/determining-effectiveness-early-intensive-versus-escalation-approaches

Our current MRI research focuses in facilitating the early recognition of demyelinating disorders and quick diagnosis of MS through the demonstration of the pathogenic central vein in demyelinating lesions. We work on 3T and 7T MRI scanners at the medical school and SPMMR centre. We are currently the DECISIVE study, an NIHR funded multicentre trial and found that the detection of central vein is as good for MS diagnosis as the invasive lumbar puncture detecting oligoclonal bands.

I work with the SPMIC and Prof Brookes on OPM- MEG and study how MEG in naturalistic condition involving patients standing, sitting and moving can help understand brain activation and connectivity.

In addition, we study remyelination and lesion activity in the grey and white matter in vivo using mainly high resolution MRI imaging.

Working with academic neuropsychologists and with the help of the NIHR, we also run a programme grant (NEUROMS) where we try to understand how best to screen for cognitive deficits in MS.

Teaching Summary

Current supervisor for 4 PhD students

2 Post doctoral students

4 academic clinical fellows in Neurology

BMedsci supervisor for Clinical Neuroscience and Psychiatry

Research Summary

Clinical trials

DELIVER MS : https://www.pcori.org/research-results/2017/determining-effectiveness-early-intensive-versus-escalation-approaches

I am also participating in a number of commercial and non-commercial trials as principle investigator in Nottingham.

Neuroimaging

Investigations trying to understand brain disorders (MS and brain injury) and symptoms (cognition impairment, fatigue) through MRI and clinical trials ​​including:

Central veins in MS diagnosis https://clinicaltrials.gov/ct2/show/NCT04024969

The Role of MEG in Assessment and Diagnosis In mTBI (MEGAbIT) https://clinicaltrials.gov/ct2/show/NCT03867513

Neuropsychology of MS

Member of the research team of NEUROMS, an NIHR programme grant for the neuropsychological evaluation and rehabilitation in Multiple sclerosis https://neuroms.org/

Selected Publications

Past Research

Neuropathology og Multiple Sclerosis

Neuroscience at Nottingham

The University of Nottingham
Address line two
Nottingham, postcode


telephone: +44 (0) 115 XXX XXXX
email: research-group-email@nottingham.ac.uk