Ulvi Bayraktutan

Contact

• workRoom B76 Clinical Sciences Building
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 82 31764
• fax0115 8231767
• ulvi.bayraktutan@nottingham.ac.uk

Biography

Ulvi Bayraktutan is an Associate Professor at the Academic Unit of Mental Health and Clinical Neurosciences at the University of Nottingham. His research aims to develop clinical biomarkers and novel therapeutics for (physio)pathological conditions associated with neurodegeneration and/or endothelial dysfunction, notably stroke, hypertension, diabetes and ageing. He performs preclinical, translational and clinical research to achieve these goals.

He acts as a reviewer for many high profile international journals and is an editorial board member of five different journals. He provides expert opinion or advice to a number of national and international research councils, charities, healthcare companies, societies and institutions.

He has been a Fellow of Higher Education Academy (FHEA) since 2007 and supervised many postgraduate studies for the degrees of MSc, MD and PhD.

Dr Bayraktutan is the Chief investigator of the Dunhill Medical Trust EPC study investigating the specific effect of ageing on the circulatory level and functional aspects of endothelial progenitor cells as well as the diagnostic and prognostic value of endothelial progenitor cells in elderly patients with lacunar or cortical stroke.

Find out more:

• https://scholar.google.co.uk/citations?user=AbsSLM8AAAAJ&hl=en
• https://www.researchgate.net/profile/Ulvi_Bayraktutan
• https://clinicaltrials.gov/ct2/show/NCT02980354

Expertise Summary

Keywords:

Stroke, blood-brain barrier, stem cells, endothelial progenitor cells, regenerative medicine, cell-based and cell-free therapeutic approaches, novel therapeutics, neurodegeneration, neurovascular protection, ageing, age-related diseases, clinical biomarkers, senescence, cell biology, hypothermia, endothelial (dys)function, cytoskeleton, apoptosis, oxidative stress, experimental models of human disease and molecular biology.

Teaching Summary

Molecular Basis of Disease,

Atrial Fibrillation and Stroke,

Blood-Brain Barrier in Stroke Medicine and Research,

BMedSci projects (lab-based or literature review-based)

Postgraduate student teaching,

Tutorials.

Research Summary

· Molecular mechanisms of neurodegenerative diseases - stroke and multiple sclerosis

· Role of endothelial cell senescence in ageing and neurodegenerative diseases

· Regenerative medicine

· Identification and application of novel therapeutics for neurovascular conditions

· Clinical biomarkers

· Pioneering in vitro models of human cerebral disease

Selected Publications

• ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (In Press.)

• View all publications

• ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PM and BAYRAKTUTAN, U, 2023. Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. 19, 503-515
• RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PM and BAYRAKTUTAN, U., 2023. Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke Stem Cell Reviews and Reports.
• GAO, XIN and BAYRAKTUTAN, ULVI, 2023. Substance P reversibly compromises the integrity and function of blood-brain barrier Peptides. 167, 171048
• GAO, X and BAYRAKTUTAN, U, 2023. TNF-a evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor Immunobiology. 228, 152706
• YA, J and BAYRAKTUTAN, U, 2023. Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies International Journal of Molecular Sciences. 24, 11538
• KRISHNAN, K, CAMPOS, PB, NGUYEN, TN, TAN, W, CHAN, SL, APPLETON, JP, LAW, ZK, HOLLINGWORTH, M, KIRKMAN, M, ENGLAND, TJ, ROFFE, C, MACLEOD, MJ, DAWSON, J, BAYRAKTUTAN, U, WERRING, DJ, SPRIGG, N and BATH, PM, 2023. Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history and potential treatments from translation to clinical trials Frontiers in Stroke. 2,
• ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. MicroRNA: an emerging predictive, diagnostic, prognostic and therapeutic strategy in ischaemic stroke Cellular and Molecular Neurobiology. 42, 1301-1319
• BAYRAKTUTAN, U, 2022. Prognostic, Diagnostic and Therapeutic Potential of Endothelial Progenitor Cells for Patients with Ischaemic Stroke: hype or hope BIOCELL. 46(7), 1593-1598
• ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Treatment with Outgrowth Endothelial Cells Protects Cerebral Barrier against Ischaemic Injury Cytotherapy. 24, 489-499
• ALWJWAJ, M, ABDULKADIR, RR and BAYRAKTUTAN, U, 2022. Outgrowth Endothelial Progenitor Cells Restore Cerebral Barrier Function Following Ischaemic Damage: the impact of nox2 inhibition European Journal of Neuroscience. 55, 1658-1670
• ABDULKADIR, RR, ALWJWAJ, M, OTHMAN, AO, RAKKAR, K, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2022. Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells Brain Research. 1787, 147925
• GAO, X, FRAKICH, N, FILIPPINI, P, EDWARDS, LJ, VINKEMEIER, U, GRAN, B, BAYRAKTUTAN, U, COLOMBO, S and CONSTANTINESCU, CS, 2022. Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK1 receptor and depend on cell confluence Neuropeptides. 95, 102265
• ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Establishment of an in vitro model of human blood-brain barrier to study the impact of ischeamic injury. In: The Blood-Brain Barrier: Methods and Protocols 1st. Springer, Berlin. 357
• ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Protein Kinase C-β Distinctly Regulates Blood-Brain Barrier-Forming Capacity of Brain Microvascular Endothelial Cells and Outgrowth Endothelial Cells Metabolic Brain Disease Metabolic Brain Disease.
• MATHUR, M and BAYRAKTUTAN, U, 2022. Hypothermia as a Treatment Option for Intra and Post Ischemic Stroke Journal of Neurology and Neuroscience. 13(2), 411
• YA, J, ABDULKADIR, RR and BAYRAKTUTAN, U, 2022. Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction Tissue Barriers.
• MATHUR, M, GRAN, B, TANASESCU, R, CONSTANTINESCU, C and BAYRAKTUTAN, U, 2022. Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study SVOA Neurology. 3(5), 168- 173
• ALWJWAJ, M, ABDULKADIR, RR and BAYRAKTUTAN, U, 2021. The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke Neural Regeneration Research. 16(8), 1483-1489
• ABDULKADIR, RR, ALWJWAJ, M, MCCARTHY, Z and BAYRAKTUTAN, U, 2021. Therapeutic Hypothermia Augments the Restorative Effects of PKC-β and Nox2 Inhibition on an in vitro Model of Human Blood-Brain Barrier Metabolic Brain Disease. 36(7), 1817-1832
• ABDULKADIR, RR and BAYRAKTUTAN, U, 2020. Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke Cellular and Molecular Neurobiology. 40, 347-355
• ABDULKADIR, RR, ALWJWAJ, M, OTHMAN, OA, RAKKAR, K and BAYRAKTUTAN, U, 2020. Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage Neural Regeneration Research. 15(6), 1071-1078
• RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2020. Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischaemic stroke: Protocol for an observational case control study Neural Regeneration Research. 15(7), 1300-1307
• LAW ZK, DESBOROUGH, M, RAKKAR, K, BATH, PMW, BAYRAKTUTAN, U and SPRIGG, N, 2020. Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage Hemorrhagic Stroke. 1, 75-79
• BAYRAKTUTAN, U, 2019. Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke Pharmacological Research. 144, 181-191
• BAYRAKTUTAN , U, 2018. Endothelium, endothelial progenitor cells and stroke Journal of Neurology and Clinical Neuroscience. 2, 2-3
• SRIVASTAVA, K and BAYRAKTUTAN, U, 2017. Suppression of Protein Kinase C-α Ameliorates Hyperglycaemia-Evoked In Vitro Cerebral Barrier Dysfunction Stroke Research & Therapy. 2(1), 2
• LOACH, B and BAYRAKTUTAN, U, 2017. Hypothermia: a Therapeutic Option in Management of Stroke? Stroke Research & Therapy. 2(1), 3
• MATHUR, M and BAYRAKTUTAN, U, 2017. Therapeutic hypothermia protects in vitro brain barrier from ischaemic damage through attenuation of inflammatory cytokine release and apoptosis Stroke Research & Therapy. 2(1), 4
• RAKKAR, K and BAYRAKTUTAN U, 2016. Increases in intracellular calcium perturb blood-brain barrier via protein kinase C-alpha and apoptosis BBA - Molecular Basis of Disease. 1862, 56-71
• ABDULLAH, Z and BAYRAKTUTAN, U, 2016. Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system BBA - Molecular Basis of Disease. 1862, 1354-1362
• MATHUR, M and BAYRAKTUTAN, U, 2016. Therapeutic Hypothermia Protects In Vitro Brain Barrier from Ischaemic Damage: Roles of Oxidative Stress, Rho-Kinase and PKC-β Journal of Neurology and Experimental Neural Science. 2016(03), 114
• LOACH, B and BAYRAKTUTAN, U, 2016. Evaluation of Molecular Mechanisms Involved in Therapeutic Hypothermia- Mediated Neurovascular Protection Journal of Neurology and Experimental Neural Science. 2016(03), 115
• ABDULLAH, Z, RAKKAR, K, BATH, PMW and BAYRAKTUTAN, U, 2015. Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage Molecular and Cellular Neuroscience. 69, 65-79
• GIBSON, C,, SRIVASTAVA, K, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2014. Inhibition of Rho-kinase protects cerebral barrier from ischemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions Journal of Neurochemistry. 129, 816-826
• RAKKAR, K,, SRIVASTAVA, K, and BAYRAKTUTAN, U, 2014. Attenuation of urokinase activity during experimental ischemia protects cerebral barrier from damage through regulations of MMP-2 and NAD(P)H oxidase European Journal of Neuroscience. 39, 2119-2128
• SHAO, B and BAYRAKTUTAN, U, 2014. Hyperglycaemia promotes endothelial cell apoptosis via induction of protein kinase C-beta1 and prooxidant enzyme NADPH oxidase Redox Biology. 2, 694-701
• ABDULLAH, Z and BAYRAKTUTAN, U., 2014. NADPH oxidase mediates TNF-alpha-evoked in vitro brain barrier dysfunction: roles of apoptosis and time Molecular and Cellular Neuroscience. 61, 72-84
• SHAO, B. and BAYRAKTUTAN, U., 2013. Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β Diabetes, Obesity and Metabolism. n/a(n/a), n/a
• SRIVASTAVA, K, SHAO., B and BAYRAKTUTAN., U., 2013. PKC-beta exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA/Rho-kinase/MLC2 pathway Journal of Cerebral Blood Flow and Metabolism. 33, 1928-1936
• HISHAM, N.F and BAYRAKTUTAN, U., 2013. Epidemiology, pathophysiology and treatment of hypertension in ischaemic stroke patients Journal of Stroke and Cerebrovascular Diseases. 22, e4-e14
• SRIVASTAVA K, BATH PMW and BAYRAKTUTAN U, 2012. Current Therapeutic Strategies to Mitigate the eNOS Dysfunction in Ischaemic Stroke Cell Mol Neurobiol. 32, 319-336
• ALLEN, C., SRIVASTAVA, K. and BAYRAKTUTAN, U., 2010. Small GTPase RhoA and its effector Rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction Stroke. 41(9), 2056-2063
• MUIR, A.D., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2010. Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting Oxidative Medicine and Cellular Longevity. 3(3), 199-205
• MUIR, A.D., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2010. The Role of Oxidative Stress in Modulation of the Relaxant Responses of Saphenous Vein and Internal Mammary Artery The Open Circulation and Vascular Journal. 3, 59-66
• ALLEN, C.L. and BAYRAKTUTAN, U., 2009. Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability Diabetes, Obesity and Metabolism. 11(5), 480-490
• SHARIF, M.A., BAYRAKTUTAN, U., ARYA, N., O'DONNELL, M.E., BADGER, S.A., YOUNG, I.S. and SOONG, C.V., 2009. Smoking impairs the endothelial function in human saphenous vein in an ex vivo model Annals of Vascular Surgery. 23(1), 116-121
• SHARIF, M.A., BAYRAKTUTAN, U., ARYA, N., BADGER, S.A,, O’DONNELL, M.E., YOUNG, I.S. and SOONG, C.V., 2009. Effects of antioxidants on endothelial function in human saphenous vein in an ex vivo model Angiology. 60, 448-454
• ALLEN, C.L. and BAYRAKTUTAN, U., 2009. Oxidative stress and its role in the pathogenesis of cerebrovascular disease International Journal of Stroke. 4, 461-470
• ALLEN, C.L. and BAYRAKTUTAN, U., 2008. Risk factors for ischaemic stroke. International journal of stroke. 3(2), 105-16
• ALLEN, C.L. and BAYRAKTUTAN, U., 2008. Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells Journal of Molecular and Cellular Cardiology. 45(2), 198-208
• DEMIRCI, B, MCKEOWN, P.P and BAYRAKTUTAN, U, 2008. The bimodal regulation of vascular function by superoxide anion: role of endothelium BMB Reports. 31(3), 223-9
• SHARIF, M.A., BAYRAKTUTAN, U., YOUNG, I.S. and SOONG, C.V., 2007. N-acetylcysteine does not improve the endothelial and smooth muscle in human saphenous vein Vascular and Endovascular Surgery. 41, 239-45
• MAHADEVAN, V.S, CAMPBELL, M., MCKEOWN, P.P and BAYRAKTUTAN, U., 2006. Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular Research. 72(1), 60-8
• BAYRAKTUTAN, U., 2005. Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox. Free Radical Biology and Medicine. 39(10), 1342-52
• DEMIRCI, B., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2005. Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects. Journal of Hypertension. 23(12), 2219-27
• BAYRAKTUTAN, U., 2005. Enhanced antioxidant capacity and decreased migratory response to ox-LDL render human internal mammary arteries immune to atherosclerosis European Heart Journal. 26(abstract supplement), 543-44
• BAYRAKTUTAN, U., 2005. Reactive oxygen species, nitric oxide and hypertensive endothelial dysfunction Current Hypertension Reviews. 1(3), 201-215
• BAYRAKTUTAN, U., 2004. Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth Journal of Molecular and Cellular Cardiology. 36(2), 277-286
• SPENCE, M. S., MCGLINCHEY, P. G., PATTERSON, C. C., ALLEN, A. R., MURPHY, G., BAYRAKTUTAN, U., FOGARTY, D. G., EVANS, A. E. and MCKEOWN, P. P., 2004. Endothelial nitric oxide synthase gene polymorphism and ischemic heart disease American Heart Journal. VOL 148(NUMBER 5), 847-851
• WEIDIG, P., MCMASTER, D. and BAYRAKTUTAN, U., 2004. High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells Diabetes, Obesity and Metabolism. VOL 6(NUMBER 6), 432-441
• ULKER, S., MCMASTER, D., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2004. Antioxidant vitamins C and E ameliorate hyperglycaemia-induced oxidative stress in coronary endothelial cells Diabetes, Obesity and Metabolism. VOL 6(NUMBER 6), 442-451
• ULKER, S., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2003. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities Hypertension. 41(3), 534-539
• BAYRAKTUTAN, U., 2003. Effects of Ang II on nitric oxide generation in growing and resting rat aortic endothelial cells Journal of Hypertension. VOL 21(PART 11), 2093-2102
• ULKER, S., MCMASTER, D., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2003. Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation Cardiovascular Research. VOL 59(NUMBER 2), 488-500
• SPENCE, M. S., MCGLINCHEY, P. G., PATTERSON, C. C., ALLEN, A. R., MURPHY, G., BAYRAKTUTAN, U., FOGARTY, D. G., EVANS, A. E. and MCKEOWN, P. P., 2003. Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods Clinical Science. VOL 105(PART 6), 677-682
• BAYRAKTUTAN, U. and ULKER, S., 2003. Effects of Angiotensin II on Nitric Oxide Generation in Proliferating and Quiescent Rat Coronary Microvascular Endothelial Cells Hypertension Research. VOL 26(PART 9), 749-758
• ULKER, S., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2002. Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells Cardiovascular Research. VOL 55(NUMBER 4), 830-837
• BAYRAKTUTAN, U., 2002. Free radicals, diabetes and endothelial dysfunction Diabetes, Obesity and Metabolism. VOL 4(PART 4), 224-238
• ULKER, S., CINAR, M. G., BAYRAKTUTAN, U. and EVINC, A., 2001. Aprotinin impairs endothelium-dependent relaxation in rat aorta and inhibits nitric oxide release from rat coronary endothelial cells Cardiovascular Research. VOL 50(NUMBER 3), 589-596
• BAYRAKTUTAN, U, BALYNEY, L and SHAH, AM, 2000. Molecular characterisation and localisation of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology. 20, 1903-1911
• LANG, D, SMALL, GR, BAYRAKTUTAN, U, BELL, JP, SHAH, AM and LEWIS, MJ., 1999. Phenotypic changes in rat and guinea pig coronary microvascular endothelium after culture: loss of NO synthase activity. Cardiovascular Research. 42, 794-804
• BAYRAKTUTAN, U, DRAPER, N, LANG, D and SHAH, AM., 1998. Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells. Cardiovascular Research. 38, 256-262
• BAYRAKTUTAN, U, YANG, ZK and SHAH, AM, 1998. Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat Cardiovascular Research. 38, 719-726
• BAYRAKTUTAN, U and JONES, P., 1995. Expression of the human gene encoding urokinase plasminogen activator receptor is activated by disruption of the cytoskeleton. Experimental Cell Research. 486-495
• BAYRAKTUTAN, U and JONES, P., 1993. A novel urokinase receptor on monocyte-like macrophage cell line. Biochemical Society Transactions. 21, 395