One Virology

Mechanisms of resistance to infection

A common feature of many novel viral infections affecting humans or animals is their emergence from another animal species, which acts as a reservoir for the virus.

The first step in interspecies transmission of viruses is the availability of receptors recognised and bound by virus proteins to enter the host cells. Inside the cell, intrinsic factors can act as a further barrier to successful infection.

Understanding why some species – and individuals – are resistant to diseases, while others are devastated by them, gives us a powerful basis for developing new therapies.

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Research that’s making an impact

Differences in innate resistance to avian influenza infection

We’re studying the cellular mechanisms of resistance or susceptibility to devastating influenza viruses like H5N1 and H9N2, advancing the development of novel treatments. 


Endogenous retroviruses and disease in koalas

We’re making major advances in understanding koala retrovirus and helping protect this iconic, threatened species from infection.

Postgraduate research opportunities

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One Virology

University of Nottingham