One Virology

Mechanisms of resistance to infection

A common feature of many novel viral infections affecting humans or animals is their emergence from another animal species, which acts as a reservoir for the virus.

The reservoir, or natural host, typically isn’t affected by the virus, probably due to co-evolution over thousands of years. In contrast, when the virus crosses species boundaries and infects either humans or other animals, it can cause particularly severe, life-threatening disease.

Understanding why some species – and individuals – are resistant to diseases, while others are devastated by them, gives us a powerful basis for developing new therapies. Our work in this field is paving the way for new treatments which will tackle the virus infections associated with severe disease.

Mechanisms of resistance to infection_210px

Research that’s making an impact

Differences in innate resistance to avian influenza infection

We’re studying the cellular mechanisms of resistance or susceptibility to devastating influenza viruses like H5N1 and H9N2, advancing the development of novel treatments. 


Malignant catarrhal fever

Collaborating with researchers worldwide, we’re deepening scientific understanding of malignant catarrhal fever (MCF) and developing a potential vaccine. 


Endogenous retroviruses and disease in koalas

We’re making major advances in understanding koala retrovirus and helping protect this iconic, threatened species from infection.

Meet our research team

Our research team

Discover our research team and their areas of specialism

Postgraduate research opportunities

Study with us

Find out about study opportunities aligning to our research



One Virology

University of Nottingham