Associate Professor, Faculty of Medicine & Health Sciences
I'm the Director of the Biochemistry Courses ad so have overall responsibility for programme design and delivery. Specifically I convene a module in year 2 that aim to showcase how experimental… read more
My research interests are the mechanisms and structures of proteins involved in transmembrane flux.
In particular, the group works on ATP binding cassette (ABC) transporters which are involved in multidrug efflux from cancer cells, and which are involved in the clinical drug resistance of many tumour types. We have a BBSRC funded project to investigate the pharmacology of ABCG2 in collaboration with Nicholas Holliday and Steve Briddon. We have strong collaborations with the group of Beth Coyle to understand the role played by ABC transporters in pediatric brain tumour drug drug resistance, and with the group of Richard Callaghan to understand the mechanism of human ABC proteins.
More broadly I am interested in all types of transporter proteins and have previously worked on plant auxin transporters and bacterial multidrug pumps. Some very related proteins are involved in ribosomal control (too long a story for here) and I've had a long-standing interest in those.
Methods for studying membrane proteins continue to improve and I've worked with several groups to help improve protein purification for functional activity.
I'm the Director of the Biochemistry Courses ad so have overall responsibility for programme design and delivery. Specifically I convene a module in year 2 that aim to showcase how experimental design and analysis can determine correlations and causation between genotype and phenotype. I also make significant contributions to a year 2 proteins module, to a year 3 diabetes and obesity module and run a 3rd year research project for 10-12 students invesitgating bacterial drug pump proteins
School of Life SciencesUniversity of NottinghamMedical School
Queen's Medical CentreNottingham NG7 2UH
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