Matthew Brook

Contact

• workRoom D74 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158230439
• Matthew.Brook@nottingham.ac.uk

Biography

Matthew Brook is a member of the Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences at the University of Nottingham (UoN), a member of the Medical Research Council (MRC) Arthritis Research UK (ARUK) Centre for Musculoskeletal Ageing Research (CMAR) as well as the National institute for Health Research and Biomedical Research Centres (NIHR BRC).

Matthew's recent research has centred on the development of strategies that utilise novel stable isotope tracers in combination with mass spectrometry as a minimally invasive method for measuring metabolism in humans. Matthew has played a key role in the development of novel stable isotopic methods using deuterium oxide to make multi-substrate measurements (i.e. Protein, RNA, DNA) across multiple tissues in vitro, animal models and humans. Applying these techniques to study the mechanisms of muscle adaptation in response to exercise and the regulation of age-related muscle loss, his work has produced highly cited papers and presenting at international conferences he has won various prestigious early carer awards e.g. ECSS young investigator award 1^stprize.Matthew is now implementing these methods to unravel the intricacies of the musculoskeletal system and muscle mass regulation during health, ageing and chronic disease.

Expertise Summary

Skeletal muscle mass regulation, Stable isotope tracers in metabolic Research

Teaching Summary

Muscle Adaptations to Resistance Exercise

Muscle Adaptation to Endurance Exercise

Biology of Ageing

Recent Publications

• BELL KE, BROOK MS, SNIJDERS T, KUMBHARE D, PARISE G, SMITH K, ATHERTON PJ and PHILLIPS SM, 2019. Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men. Frontiers in nutrition. 6, 40
• BROOK MS, WILKINSON DJ, SMITH K and ATHERTON PJ, 2019. It's not just about protein turnover: the role of ribosomal biogenesis and satellite cells in the regulation of skeletal muscle hypertrophy. European journal of sport science. 19(7), 952-963
• O, GNIMASSOU, R, FERN'ANDEZ-VERDEJO, M, BROOK, D, NASLAIN, E, BALAN, M, SAYDA, J, CEGIELSKI, H, NIELENS, A, DECOTTIGNIES, JB, DEMOULIN, K, SMITH, PJ, ATHERTON and L, DELDICQUE, 2018. Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
• USU, DIN, MS, BROOK, A, SELBY, J, QUINLAN, C, BOEREBOOM, H, ABDULLAH, M, FRANCHI, MV, NARICI, BE, PHILLIPS, JW, WILLIAMS, JA, RATHMACHER, DJ, WILKINSON, PJ, ATHERTON and K, SMITH, 2018. A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical nutrition (Edinburgh, Scotland).

• View all publications

• BELL KE, BROOK MS, SNIJDERS T, KUMBHARE D, PARISE G, SMITH K, ATHERTON PJ and PHILLIPS SM, 2019. Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men. Frontiers in nutrition. 6, 40
• BROOK MS, WILKINSON DJ, SMITH K and ATHERTON PJ, 2019. It's not just about protein turnover: the role of ribosomal biogenesis and satellite cells in the regulation of skeletal muscle hypertrophy. European journal of sport science. 19(7), 952-963
• O, GNIMASSOU, R, FERN'ANDEZ-VERDEJO, M, BROOK, D, NASLAIN, E, BALAN, M, SAYDA, J, CEGIELSKI, H, NIELENS, A, DECOTTIGNIES, JB, DEMOULIN, K, SMITH, PJ, ATHERTON and L, DELDICQUE, 2018. Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
• USU, DIN, MS, BROOK, A, SELBY, J, QUINLAN, C, BOEREBOOM, H, ABDULLAH, M, FRANCHI, MV, NARICI, BE, PHILLIPS, JW, WILLIAMS, JA, RATHMACHER, DJ, WILKINSON, PJ, ATHERTON and K, SMITH, 2018. A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical nutrition (Edinburgh, Scotland).
• SR, JACKMAN, MS, BROOK, RM, PULSFORD, EJ, COCKCROFT, MI, CAMPBELL, D, RANKIN, P, ATHERTON, K, SMITH and JL, BOWTELL, 2018. Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men. Experimental gerontology.
• JP, AHTIAINEN, S, LENSU, I, RUOTSALAINEN, M, SCHUMANN, JK, IHALAINEN, V, FACHADA, CL, MENDIAS, MS, BROOK, K, SMITH, PJ, ATHERTON, LG, KOCH, SL, BRITTON and H, KAINULAINEN, 2018. Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental physiology.
• MS, BROOK, DJ, WILKINSON, WK, MITCHELL, JL, LUND, BE, PHILLIPS, NJ, SZEWCZYK, H, KAINULAINEN, S, LENSU, LG, KOCH, SL, BRITTON, PL, GREENHAFF, K, SMITH and PJ, ATHERTON, 2017. A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle. American journal of physiology. Endocrinology and metabolism.
• MS, BROOK, DJ, WILKINSON, PJ, ATHERTON and K, SMITH, 2017. Recent developments in deuterium oxide tracer approaches to measure rates of substrate turnover: implications for protein, lipid, and nucleic acid research. Current opinion in clinical nutrition and metabolic care.
• DJ, WILKINSON, MS, BROOK, K, SMITH and PJ, ATHERTON, 2017. Stable isotope tracers and exercise physiology: past, present and future. The Journal of physiology.
• DJ, WILKINSON, SSI, BUKHARI, BE, PHILLIPS, MC, LIMB, J, CEGIELSKI, MS, BROOK, D, RANKIN, WK, MITCHELL, H, KOBAYASHI, JP, WILLIAMS, J, LUND, PL, GREENHAFF and PJ, ATHERTON, 2017. Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women. Clinical nutrition (Edinburgh, Scotland).
• DJ, WILKINSON, T, HOSSAIN, MC, LIMB, BE, PHILLIPS, J, LUND, JP, WILLIAMS, MS, BROOK, J, CEGIELSKI, A, PHILP, S, ASHCROFT, JA, RATHMACHER, NJ, SZEWCZYK, K, SMITH and PJ, ATHERTON, 2017. Impact of the calcium form of $beta$-hydroxy-$beta$-methylbutyrate upon human skeletal muscle protein metabolism. Clinical nutrition (Edinburgh, Scotland).
• MS, BROOK, DJ, WILKINSON and PJ, ATHERTON, 2017. Nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies. Current opinion in clinical nutrition and metabolic care.
• MS, BROOK, DJ, WILKINSON, K, SMITH and PJ, ATHERTON, 2016. The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise. European journal of sport science.
• MS, BROOK, DJ, WILKINSON, BE, PHILLIPS, J, PEREZ-SCHINDLER, A, PHILP, K, SMITH and PJ, ATHERTON, 2016. Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise. Acta physiologica (Oxford, England).
• MS, BROOK, DJ, WILKINSON, WK, MITCHELL, JN, LUND, BE, PHILLIPS, NJ, SZEWCZYK, PL, GREENHAFF, K, SMITH and PJ, ATHERTON, 2016. Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. The Journal of physiology.
• MS, BROOK, DJ, WILKINSON, WK, MITCHELL, JN, LUND, NJ, SZEWCZYK, PL, GREENHAFF, K, SMITH and PJ, ATHERTON, 2015. Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling. The FASEB Journal.
• WILKINSON, DANIEL J., FRANCHI, MARTINO V., BROOK, MATTHEW S., NARICI, MARCO V., WILLIAMS, JOHN P., MITCHELL, WILLIAM K., SZEWCZYK, NATHANIEL J., GREENHAFF, PAUL L., ATHERTON, PHILIP J. and SMITH, KENNETH, 2014. A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 306(5), E571-E579
• DJ, WILKINSON, MV, FRANCHI, MS, BROOK, MV, NARICI, JP, WILLIAMS, WK, MITCHELL, NJ, SZEWCZYK, PL, GREENHAFF, PJ, ATHERTON and K, SMITH, 2014. A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans. American journal of physiology. Endocrinology and metabolism.
• J, CEGIELSKI, MS, BROOK, JI, QUINLAN, DJ, WILKINSON, K, SMITH, PJ, ATHERTON and BE, PHILLIPS, A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study