Brain Network Dysfunction in Multiple Sclerosis (BraNDy-MS)

Trial Overview

Investigators

Thomas Welton, Dr Rob Dineen, Radiological Sciences in the School of Medicine, University of Nottingham.

Background

Funded by the MS Society, this study aims to find out whether brain network changes are related to cognitive impairment or fatigue in individuals with multiple sclerosis (MS). It will also investigate the reliability of brain network measurements over time.

Purpose of the study

A 'marker' is something that can be measured (for example in the blood or urine, or on a scan) to monitor a biological process, disease or treatment response.

We are looking for better imaging markers that can be used in trials of new treatments for MS and MS symptoms. As new treatments are developed for treating problems with thought processes such as memory and concentration (referred to as cognitive processes) in MS, it is important to have a meaningful and easily-interpretable marker to show how organisation of brain networks alters in response to the new treatments.

Recruitment

We are now only seeking healthy participants without MS.

If you would like to participate in the study, or would like more information, please contact Tom Welton:

E: msxtw3@nottingham.ac.uk

T: 0115 748 4389

Details

Participation requires one attendance lasting approximately 2 hours. A researcher will contact you to arrange a time that is convenient.

You will be met at the entrance to the Queen’s Medical Centre and go to a private room where the researcher will explain the study to you and answer any questions you have. If you have decided you would like to take part, you will be asked to sign a consent form and the researcher will go through a set of questionnaires with you to test various cognitive processes. You will then go to University of Nottingham’s Medical Imaging Unit, where a researcher will check that it is safe for you to be scanned. You will then have an MRI scan of your brain, lasting approximately 40 minutes. Inside the scanner, you will simply have to lie down and relax without falling asleep.