Michael Jones obtained a BSc (Hons) in Microbiology from the University of Sheffield. He carried out postgraduate research at the University of East Anglia obtaining an MSc (1991) and PhD (1994). He then spent three and a half years as a research fellow at the University of Aberdeen, Institute for Medical Sciences, studying stretch activated channels. He then moved to work at the Institute for Animal Health, Compton Laboratory in 1997 where he worked on host pathogen interactions during bacterial gastrointestinal disease in farm animals , vaccine development and host genetics. His research links molecular biology, bacterial physiology and host immune responses to infection.
In 2006 Dr Jones moved to help establish the School of Veterinary Medicine and Science where he was a foundation lecturer. Dr Jones planned, implemented and convenes the microbiology components of the BVM BVS and BVMedSci course. During this time he has obtained his PGCHE and an MA in higher education from the University of Nottingham and has carried on his research on intestinal pathogens and host interactions. He also convenes the principles of Veterinary Sciences module which combines a number of areas of teaching on pharmacology, pathology, immunology, microbiology and parasitology.
His current research is focused on two main zoonotic pathogens Campylobacter and Salmonella. In addition he has supported the development of undergraduate research projects and placements resulting in projects in the following areas. Understanding the micro-flora of zoological species, antibiotic Resistance and molecular detection cells models of infection.
Dr Jones acknowledges and would like to thanks the following for their support: DEFRA, BBSRC, FSA, EU, Novartis and Intervet in his research.
Dr Jones is responsible for overseeing the implementation of the Microbiology within the BVMS course. His work focuses on foodbourne bacterial pathogens in particular Campylobacter and Salmonella. He has worked in public health since 1994 and has been actively researching animal health since 1997. He studies both bacterial and host factors involved in carriage and disease in food producing animals.
Dr Jones is School of Veterinary Sciences biological safety and safety officer.
He is also chair of the campus genetic modification scientific committee (GMSCd).
Dr Jones convenes the microbiology (hidden module) and principles of Veterinary Sciences module. He lectures in veterinary microbiology and molecular biology in years 1 - 4 of the BVMS course. The… read more
His current research is directed at understanding the host interactions of bacteria disease and routes to control these infections.
His research interests developed from the study of bacterial physiology through to the molecular and immunological mechanisms involved in colonization and disease.
The main focus of his work is on the following genera of bacteria, Campylobacter, Salmonella and Mycobacterium.
Research on Campylobacter includes investigations into phase variation, the physiology and immunology of colonization of the chicken and the development of vaccines. This work is being carried out in collaboration with Departments of Food Sciences and Bimolecular sciences and Mathematics at the University of Nottingham, the universities of Leicester and Cambridge.
The studies on Salmonella are investigating the molecular basis of host specificity and virulence of Salmonella serovars Gallinarum, Pullorum and Enteritidis. This work is in collaboration with Paul Barrow at the University of Nottingham, the Roslin and the Sanger Institutes.
Work on Mycobacterium has focused on understanding the interaction of Mycobacterium avium in poultry. With work focusing on immune responses and the physical interaction of these bacteria with the host cells.
The overall aim of the research program is to improve the understanding of the nature of infectious diseases to identify and improved routes for control of important animal and zoonotic diseases.
KARLYSHEV A.V., THACKER G., JONES M.A., CLEMENTS M.O. and WREN B.W., 2014. Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation. FEBS Open Bio. 4, 468-72 BAYLISS, C.D., BIDMOS, F.A., ANJUM, A., MANCHEV, V.T., RICHARDS, R.L., GROSSIER, J., WOOLDRIDGE, K.G., KETLEY, J.M., BARROW, P.A., JONES, M.A. and TRETYAKOV, M.V., 2012. Phase Variable Genes Of Campylobacter Jejuni Exhibit High Mutation Rates And Specific Mutational Patterns But Mutability Is Not The Major Determinant Of Population Structure During Host Colonization. Nucleic Acids Research. 40(13), 82152 SETTA, A., BARROW, P.A., KAISER, P. and JONES, M.A., 2012. Early immune dynamics following infection with Salmonella enterica serovars Enteritidis, Infantis, Pullorum and Gallinarum: cytokine and chemokine gene expression profile and cellular changes of chicken cecal tonsils Comparative Immunology, Microbiology and Infectious Diseases. 35(5), 397-410
SETTA, A., BARROW, P., KAISER, P. and JONES, M., 2012. Immune dynamics following infection of avian macrophages and epithelial cells with typhoidal and non-typhoidal Salmonella enterica serovars; bacterial invasion and persistence, nitric oxide and oxygen production, differential host gene expression, NF-κB signalling and cell cytotoxicity Veterinary Immunology and Immunopathology.
Dr Jones convenes the microbiology (hidden module) and principles of Veterinary Sciences module. He lectures in veterinary microbiology and molecular biology in years 1 - 4 of the BVMS course. The course has an innovative integrated delivery and is based around body systems, so delivery of specific pathogens is related to both anatomy and physiology of specific body systems.
The principles of veterinary sciences module which bring together other integrated modules in the course of pharmacology, pathology, immunology microbiology and parasitology.
Previously Dr Jones worked as a research fellow in the University of Aberdeen where he worked on stretch activated channels and was part of the team which identified double membrane spanning MscL channel in E. coli.
Dr Jones then moved to the Institute for Animal Health to work on Type-III secretion systems in Salmonella.
He then established the IAH Campylobacter research group. This group was the first to identify defined lines of poultry resistant to Campylobacter colonisation, in vivo gene transcripts from bacteria in the GI tract and to show a pro-inflammatory avian immune responses to the commensal Campylobacter.
The work has been carried on to evaluate infection models for Campylobacter and to investigate the potential for vaccines against this important foodborne pathogen.
Alongside the current research Dr Jones also has interests in Antimicrobial resistance and novel control of bacteria. He is also collaborating with Professor Jamie Leigh well established group in developing novel areas of streptococcal research.