3.6.2 The JAK–STAT pathway

Another important protein kinase pathway is the JAK–STAT pathway. Cytokines (Section 2.2), are frequently used for signalling between cells of the immune system. Cytokine-induced signal transduction cascades are often direct pathways to the nucleus for switching on sets of genes. Janus kinases (JAKs, named after the two-faced Roman god) are a particular
Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University

TALAT Lecture 3207: Solidification Defects in Castings
This lecture provides an introduction to the causes and remedies of the main solidification defects in castings. The students should be able to diagnose the major defects in castings and propose methods of preventing them. Basic knowledge of physics and foundry practice is assumed.
Author(s): TALAT,Richard A Harding, Interdisciplinary Researc

License information
Related content

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

2.1 Introduction

Polypeptides are synthesised by translation of messenger RNA (mRNA) on the ribosome, either in the cytosol or in association with the endoplasmic reticulum (rough ER). The polypeptide starts to adopt elements of secondary structure and to fold even as it is being synthesised, and certain covalent modifications of the polypeptide can also occur while translation is ongoing. Initial folding is rapid (of the order of a few seconds). Some proteins require cofactors, which are non-pr
Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University

Academic research on student engagement - lost formulae to inspiring students
This paper shows academic tutors take on a multitude of roles in their current positions at university and while teaching is expected, from most, it is often assumed that the tutor will apply appropriate pedagogical tools to convey knowledge to the students. This view is now being challenged as many students are being actively encouraged to voice their views of the teaching and learning experience this paper shows
Author(s): Creator not set

License information
Related content

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

16.522 Space Propulsion (MIT)
Space Propulsion begins with a review of rocket propulsion fundamentals. The course then proceeds into advanced propulsion concepts, ranging from chemical to electrical engines. Propulsion system selection criteria and mission analysis are introduced. The bulk of the semester is devoted to the physics and engineering of various engine classes, including electrothermal, electrostatic and electro-magnetic. Specific topics include arcjets, ion engines, Hall thrusters and colloid thrusters.
Author(s): Martinez-Sanchez, Manuel

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Basketball Stretching Tips
Basketball Stretching Tips. Part of the series: How to Play Basketball. This video shows how to stretch before working out. Make sure that those engaging in these activities are capable because they can cause injury if done without careful instruction.

Author(s): No creator set

License information
Related content

Greetings - basic Amharic
Greetings - basic Amharic.
Author(s): No creator set

License information
Related content

9.6 Changing parents' perceptions

Bellaby, P. (2003) ‘Communication and miscommunication of risk: understanding UK parents' attitudes to combined MMR vaccination’, British Medical Journal, 327, 27 September 2003, pp. 725–28. Reproduced by permission from the BMJ Publishing Group; Mary Evans Picture Library Ltd; P A Photos.

Vaccination has a heroic history in the control of communicable diseases. However, collective provision that is taken for granted today in Britain-not just vaccination, but also se
Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University

"How to Use "Word Magnets"
Word Magnets is a simple to use web tool that will take a piece of text and break it into individual magnets which can be moved around the screen, resized, removed, color coded, grouped, sorted and so on. New magnets can also be added at any point. This is a great tool to use with sequencing, language study, and can be molded to fit many areas of the curriculum. This is a great resource to help enhance technology instruction and use in the classroom. (2:34)
Author(s): No creator set

License information
Related content

3.063 Polymer Physics (MIT)
This course presents the mechanical, optical, and transport properties of polymers with respect to the underlying physics and physical chemistry of polymers in melt, solution, and solid state. Topics include conformation and molecular dimensions of polymer chains in solutions, melts, blends, and block copolymers; an examination of the structure of glassy, crystalline, and rubbery elastic states of polymers; thermodynamics of polymer solutions, blends, crystallization; liquid crystallinity, micro
Author(s): Thomas, Edwin (Ned)

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

8.05 Quantum Physics II (MIT)
Together, this course and 8.06: Quantum Physics III cover quantum physics with applications drawn from modern physics. Topics covered in this course include the general formalism of quantum mechanics, harmonic oscillator, quantum mechanics in three-dimensions, angular momentum, spin, and addition of angular momentum.
Author(s): Stewart, Iain

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Projectile Motion
Julia Liu

Some Rights Reserved

Author(s): No creator set

License information
Related content

2.1.1 Aims

The aims of these recordings, in which Sorley MacLean is interviewed by Iain Crichton-Smith, are to:

  • (a) help you to sense the power of MacLean's poetry in its original Gaelic;

  • (b) assist your understanding of the English texts of the poems, translated by MacLean himself.


Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University

21.09.2012 – Langsam gesprochene Nachrichten
Trainiere dein Hörverstehen mit den Nachrichten der Deutschen Welle von Freitag – als Text und als verständlich gesprochene Audio-Datei. *** Vor den Freitagsgebeten wächst die Sorge, dass es in der islamischen Welt erneut gewalttätige Ausschreitungen und Proteste gegen das Schmähvideo aus den USA und die Veröffentlichung von Mohammed-Karikaturen geben könnte. In Tunesien verbot das Innenministerium sämtliche Demonstrationen. In Pakistan, wo tausende Demonstranten erwartet werden, ve
Author(s): No creator set

License information
Related content

6.728 Applied Quantum and Statistical Physics (MIT)
6.728 is offered under the department's "Devices, Circuits, and Systems" concentration. The course covers concepts in elementary quantum mechanics and statistical physics, introduces applied quantum physics, and emphasizes an experimental basis for quantum mechanics. Concepts covered include: Schrodinger's equation applied to the free particle, tunneling, the harmonic oscillator, and hydrogen atom, variational methods, Fermi-Dirac, Bose-Einstein, and Boltzmann distribution functions, and simple
Author(s): Orlando, Terry

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

8.811 Particle Physics II (MIT)
8.811, Particle Physics II, describes essential research in High Energy Physics. We derive the Standard Model (SM) first using a bottom up method based on Unitarity, in addition to the usual top down method using SU3xSU2xU1. We describe and analyze several classical experiments, which established the SM, as examples on how to design experiments. Further topics include heavy flavor physics, high-precision tests of the Standard Model, neutrino oscillations, searches for new phenomena (compositenes
Author(s): Chen, Min

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

2.008 Design and Manufacturing II (MIT)
This course introduces you to modern manufacturing with four areas of emphasis: manufacturing processes, equipment/control, systems, and design for manufacturing. The course exposes you to integration of engineering and management disciplines for determining manufacturing rate, cost, quality and flexibility. Topics include process physics, equipment design and automation/control, quality, design for manufacturing, industrial management, and systems design and operation. Labs are integral parts o
Author(s): Chun, Jung-Hoon,Kim, Sang-Gook

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Budgetbeheer : Thema
Schermafbeelding_2014-12-01_om_12.21.05.png

Aan de hand van een krantenartikel, een beeldfragment of enkele stellingen wordt telkens een ander aspect van het omgaan met geld aangebracht. Zo is er aandacht voor het koopgedrag en de kracht van reclame hierbij, zakgeld en het eerste loon, …


Author(s): No creator set

License information
Related content

1.5 Defining dyslexia

The ongoing debate about dyslexia is reflected in the different approaches that have been taken to formally define it. Clearly this impacts on how dyslexia is defined in practice. The next three sections summarise how definitions of dyslexia have changed as our knowledge has increased. In short, there have been three main approaches to defining dyslexia: definition by exclusion, discrepancy definitions and the identification of positive indicators.


Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University

10.10 Conclusions

Hargreaves, I., Lewis, J. and Speers, T. ‘Towards a better map: Science, the public and the media’, Economic and Social Research Council.

We now return to three questions central to our inquiry. First, what do we, as a public, need to know about climate change, MMR and genetic media research? Second, what have most of us learnt from media coverage about these issues? And third, to what extent does our study suggest a model of media and public understanding which
Author(s): The Open University

License information
Related content

Copyright © 2016 The Open University