2.3 Some proteins require small-molecule cofactors

Cofactors are non-protein substances that complex with particular proteins and are essential for their activity. They include prosthetic groups and coenzymes.

Coenzymes are organic molecules that bind only temporarily to an enzyme. They are often derivatives of a mono- or dinucleotide, e.g. nicotinamide adenine dinucleotide (NAD), and may serve as a vehicle for a chemical group generated or required in an enzyme-catalysed reaction. In contrast to coenzymes, prosthetic groups
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9.5 What went wrong with MMR?

Bellaby, P. (2003) ‘Communication and miscommunication of risk: understanding UK parents' attitudes to combined MMR vaccination’, British Medical Journal, 327, 27 September 2003, pp. 725–28. Reproduced by permission from the BMJ Publishing Group; Mary Evans Picture Library Ltd; P A Photos.

The extent of people's willingness to conform to public health programmes in Britain was and remains considerable. From the Introduction of the MMR vaccination in 1988 until the sc
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4th Grade Lesson 4.6 Use the Distributive Property
Using the distributive property to solve 69 divided by 3 and others. (09:29)
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21W.747 Rhetoric (MIT)
This course is an examination of the theory, the practice, and the implications of rhetoric & rhetorical criticism. This semester, you will have the opportunity to deepen many of your skills: Analysis, persuasion, oral presentation, and critical thinking. In this course you will act as both a rhetor (a person who uses rhetoric to persuade) and as a rhetorical critic (one who analyzes the rhetoric of others). Both the rhetor and the rhetorical critic write to persuade; both ask and answer imp
Author(s): Strang, Steven

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Color
Long ago, only the rich could afford colorful textiles. The search for new colors in the mid 1800s boosted the development of modern chemistry. Color is explained in terms of light and pigment. Join with experts to observe chemistry in action. Synthetic dyes were first discovered by an 18 year old chemist, and the video demonstrates how the first one was accidentally discovered.
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Resumo da Aula 03 de Algoritmos e Programação - Parte 02

Video link (see supported sites below). Please use the original link, not the shortcut, e.g. www.youtube.com/watch?v=abcde

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2 Animals at the extremes

The desert environment

Animal life has adapted to survive in the most unlikely and inhospitable habitats. This course looks at the surprisingly diverse desert climates throughout the world and mammals, birds, lizards and amphibians that survive there.
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3.5 Natural selection

Darwin summarised his theory of natural selection in the introduction to The Origin of Species as follows:

As many more individuals of each species are born than can possibly survive; and as, consequently, there is a frequently recurring struggle for existence, it follows that any being, if it vary however slightly in any manner profitable to itself, under the complex and sometimes varying conditions of life
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3.2 Shrews

Activity 2

4.5 Torture

The question of torture is also raised in the play. Herrenvolk claims that he does not do the torture; it is some Uzbekistan outfit that does it. He actually gives them a justification by saying, in a rather glib way, that it is a lot easier to open a human being than an encrypted laptop. Of course, the question is, is it ever ‘right’ to exploit this as a means of finding things out? I suspect most of us would say ‘no’.


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Summary of Section 3

  1. Watson–Crick base pairing arises due to hydrogen bonding between A and T and G and C and spatial limitations within the hydrophobic core of the helix.

  2. DNA commonly folds into the B-form helix; other forms such as Z-DNA form in vitro. A-form helices are formed primarily by duplex RNA.

  3. The twisting of DNA around its helical axis results in torsional stresses that promote the formation of high-energy alternative confo
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Lesson 05 - One Minute Romanian
In lesson 5 of One Minute Romanian you will learn to say that you're learning Romanian. Remember - even a few phrases of a language can help you make friends and enjoy travel more. Find out more about One Minute Romanian at our website - http://www.oneminutelanguages.com. One Minute Romanian is brought to you by the Radio Lingua Network and is ©Copyright 2008.Author(s): No creator set

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The Civil War in Four Minutes
One second per week, casualty counter in the lower right. (04:23)

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Multimedia e gravi disabilita

Gruppo Ricerca e Sviluppo Multimedia e GRavi Disabilita’ - Scuola Media Pertini - OVada- DSchola

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3.4 Specialisation within language areas: brain scanning

Is there any evidence from the undamaged brain that the view derived from aphasia is indeed correct? The most useful methodologies here use either PET or functional MRI (fMRI) scanning to establish which parts of the brain are active in particular tasks. The difficulty is that a standard linguistic task, such as understanding a sentence's meaning, involves phonology and syntax and semantics, and thus is not helpful when trying to tease out which of these subtasks happens in which areas.


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2.4 The covalent modification of proteins

Many proteins are modified by the covalent linking of groups that can affect their function and/or localisation in the cell. Such covalent modifications occur after synthesis and folding of the polypeptide component. The main types of covalent modification and their functions are listed below.

  1. Methylation/acetylation of amino acids at the N-terminal tails of histone proteins in eukaryotes can affect the structure of chromatin and ultimately gene
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3 The Silurian Period and the invasion of the land

Before going any further, click on 'View document' below and read pages 72-75 from Douglas Palmer's Atlas of the Prehistoric World.

View document

SAQ 7


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1.6 Fibrous proteins

Most of the proteins described so far have been globular proteins. There are, however, some distinctive features that characterise fibrous proteins and we present here a general overview of these. Elongated fibrous proteins frequently play a structural role in the cell. They do not readily crystallise but tend to aggregate along their long axis to form fibres. X-ray diffraction studies of these fibres, in contrast to analysis of protein crystals, provides only very limited information on the
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Digital Construction: Automated Design and Construction Experiments Using Customised On-Site Digital
This paper presents a currently on-going research trajectory, investigating integrated design and build work-fl ows using generative design strategies and custom built fabrication devices. The aim of the research, which is being developed through a series of experiments and workshops, is to explore scenarios in which these work-flows can produce emergent architectural structures which are highly adapted towards the intended performance within their specifi c context and site. The research has pr
Author(s): Ameijde, Jeroen van; Carlin, Brendon

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2.7 The 'salt' in seawater

The difficulty with having so much of the Earth's water locked up in the oceans is summed up poetically by Coleridge's 'Ancient Mariner', becalmed on board ship in the doldrums, beneath a blazing Sun.

Water, water, everywhere,

And all the boards did shrink;

Water, water, everywhere,

Nor any drop to drink.

(Samuel Taylor Coleridge, The Rime of the Ancient Mariner, 1797-8)
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