Cynthia Bosquillon

Contact

• workRoom D10 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8466078
• cynthia.bosquillon@nottingham.ac.uk

Biography

I graduated as a pharmacist from the Université catholique de Louvain, Belgium in 1998 and then pursued post-graduate studies under the co-supervision of Profs. Rita Vanbever and Véronique Préat. I gained my PhD in September 2003 and in 2004, I moved to London to work on a post-doctoral project directed by Dr.Ben Forbes (King's College London) and Dr.Nicola Clear (Pfizer R&D). In 2005, I was awarded a University of London Maplethorpe fellowship, which gave me, in addition to a valuable teaching experience, the opportunity to develop my own research area and supervise both undergraduate and postgraduate research students at King's. I was appointed to a lectureship in Drug Delivery at Nottingham in 2007.

My research interests have so far focussed on drug inhalation, of which I've explored different aspects, from the formulation and characterisation of dry powders for systemic delivery of therapeutic proteins to the development and validation of in vitro and ex vivo models of the lungs as tools to predict pulmonary drug absorption in vivo.

Research Summary

My current research projects involve the use of respiratory epithelial cell cultures and an isolated and perfused rat lung system to evaluate the impact of transporters and lung pathological… read more

Recent Publications

• STEWART CE, TORR EE, MOHD JAMILI NH, BOSQUILLON C and SAYERS I, 2012. Evaluation Of Differentiated Human Bronchial Epithelial Cell Culture Systems For Asthma Research. Journal Of Allergy. 2012, 943982
• MUKHERJEE M, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation Of Air-Interfaced Calu-3 Cell Layers For Investigation Of Inhaled Drug Interactions With Organic Cation Transporters In Vitro. International Journal Of Pharmaceutics. (In Press.)
• REDHEAD M, MANTOVANI G, NAWAZ S, CARBONE P, GORECKI DC, ALEXANDER C and BOSQUILLON C, 2012. Relationship Between The Affinity Of Peo-Ppo-Peo Block Copolymers For Biological Membranes And Their Cellular Effects. Pharmaceutical Research. (In Press.)
• IEONG, N.S., REDHEAD, M., BOSQUILLON, C., ALEXANDER, C., KELLAND, M. and O REILLY, R.K., 2011. The Missing Lactam-Thermoresponsive and Biocompatible Poly(N-vinylpiperidone) Polymers by Xanthate-Mediated RAFT Polymerization MACROMOLECULES. VOL 44(NUMB 4), 886-893

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Current Research

My current research projects involve the use of respiratory epithelial cell cultures and an isolated and perfused rat lung system to evaluate the impact of transporters and lung pathological conditions on drug disposition from the lungs. Those in vitro and ex vivo models of the lungs are also used, for instance, to investigate the fate of inhaled materials in the lungs or highlight any toxic effect of formulations for inhalation.

Teaching

Drug inhalation on the B31C07 (Pharmaceutical Technology), B32D05 (Biopharmaceutics) and B33E01 (Advanced Drug Delivery) modules.

B31A09 (Practical Dispensing and the Science of Medicines Manufacture)

• STEWART CE, TORR EE, MOHD JAMILI NH, BOSQUILLON C and SAYERS I, 2012. Evaluation Of Differentiated Human Bronchial Epithelial Cell Culture Systems For Asthma Research. Journal Of Allergy. 2012, 943982
• MUKHERJEE M, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation Of Air-Interfaced Calu-3 Cell Layers For Investigation Of Inhaled Drug Interactions With Organic Cation Transporters In Vitro. International Journal Of Pharmaceutics. (In Press.)
• REDHEAD M, MANTOVANI G, NAWAZ S, CARBONE P, GORECKI DC, ALEXANDER C and BOSQUILLON C, 2012. Relationship Between The Affinity Of Peo-Ppo-Peo Block Copolymers For Biological Membranes And Their Cellular Effects. Pharmaceutical Research. (In Press.)
• IEONG, N.S., REDHEAD, M., BOSQUILLON, C., ALEXANDER, C., KELLAND, M. and O REILLY, R.K., 2011. The Missing Lactam-Thermoresponsive and Biocompatible Poly(N-vinylpiperidone) Polymers by Xanthate-Mediated RAFT Polymerization MACROMOLECULES. VOL 44(NUMB 4), 886-893
• RYMER, S.J., TENDLER, S.J.B., BOSQUILLON, C., WASHINGTON, C and ROBERTS, C.J.R., 2011. Self-assembling peptides and their potential applications in biomedicine Therapeutic Delivery. 2(8), 1043-1056
• MUKHERJEE, M, PRITCHARD, DI and BOSQUILLON, C, 2011. Variations in the expression of Organic Cation Transporters (OCT) in bronchial epithelial cells following exposure to house dust components In: Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI). 1832-1832
• AL GHANAMI,RC, SAUNDERS BR, BOSQUILLON, C, SHAKESHEFF, KM and ALEXANDER, C, 2010. Responsive particulate dispersions for reversible binding and deconstruction of 3D cell environments Soft Matter. 6(20), 5037-5044
• BOSQUILLON CYNTHIA, 2010. Assessing the Role of Transporters in the Disposition of Inhaled Drugs Using a Respiratory Epithelial Cell Culture Model Proceedings of the Respiratory Drug Delivery Conference. 1, 83-90
• BOSQUILLON, CYNTHIA, 2010. Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs? Journal of pharmaceutical sciences. 99(5), 2240-55
• DOS SANTOS, MA, BOSQUILLON, C, RUSSOMANO, T, SUNDARESAN, A, FALCAO, F, MARRIOTT, C and FORBES, B, 2010. Modelling The Effects Of Microgravity On The Permeability Of Air Interface Respiratory Epithelial Cell Layers Advances In Space Research. 46(6), 712-718
• MUKHERJEE, M, CALANDE, T, CHEUNG, J, PRITCHARD, DI and BOSQUILLON, C, 2010. Organic Cation Transporters are Functional in Layers of the Human Bronchial Epithelial Cell Line Calu-3 Journal of Pharmacy & Pharmacology. 62, 1289-1290
• HUTTER, V, HILGENDORF, C, BROWN, A, ZANN, V, COOPER, A, PRITCHARD, D and BOSQUILLON, C, 2010. Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture model Journal of Pharmacy & Pharmacology. 62, 1225-1226
• HUTTER, V, TANG, N, ZANN, V, COOPER, A, PRITCHARD, DI and BOSQUILLON, C, 2010. Evaluation of the rat airway epithelial RL65 cell line as a novel in-vitro model for screening inhaled drug candidates Journal of Pharmacy & Pharmacology. 62, 1230-1232
• BAYARD, F, CALANDE, T, PRITCHARD, DI, THIELEMANS, W, YOUNG, S, PAINE, S and BOSQUILLON, C, 2010. Esterase activity in the Human Bronchial Epithelial Calu-3 Cell Line Journal of Pharmacy & Pharmacology. 62, 1316-1317
• MADLOVA, MICHAELA, BOSQUILLON, CYNTHIA, ASKER, DAN, DOLEZAL, PAVEL and FORBES, BEN, 2009. In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity. Journal of Pharmacy and Pharmacology. 61(3), 293-301
• SALEM, L BELHADJ, BOSQUILLON, C, DAILEY, L A, DELATTRE, L, MARTIN, G P, EVRARD, B and FORBES, B, 2009. Sparing methylation of beta-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro. Journal of controlled release : official journal of the Controlled Release Society. 136(2), 110-6
• MADLOVA, M., BOSQUILLON, C. and FORBES, B., 2007. P-Glycoprotein inhibitor, GF120918A, does not affect substrate absorption in the isolated perfused rat lung AEROSOLS -CONFERENCE- AEROSOL SOCIETY-. Conf 18th, 274-277
• BOSQUILLON, C., MADLOVA, M., CLEAR, N. and FORBES, B., 2007. A Simple Ex-vivo Lung Model for Screening Inhaled Drug Products AEROSOLS -CONFERENCE- AEROSOL SOCIETY-. Conf 18th, 13-16
• PATEL, J., SALEM, L. B., MARTIN, G. P., DELATTRE, L., EVRARD, B., FORBES, B. and BOSQUILLON, C., 2006. Use of the MTT assay to evaluate the biocompatibility of beta-cyclodextrin derivatives with respiratory epithelial cells JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL 58(SUPP/1), 172
• BOSQUILLON, C., PRÉAT, V. and VANBEVER, R., 2004. Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats Journal of Controlled Release. 96(2), 233-244
• BOSQUILLON, C., ROUXHET, P.G., AHIMOU, F., SIMON, D., CULOT, C., PRÉAT, V. and VANBEVER, R., 2004. Aerosolization properties, surface composition and physical state of spray-dried protein powders Journal of Controlled Release. 99(3), 357-367
• LOMBRY, C., BOSQUILLON, C., PRÉAT, V. and VANBEVER, R., 2002. Confocal imaging of rat lungs following intratracheal delivery of dry powders or solutions of fluorescent probes Journal of Controlled Release. 83(3), 331-341
• BOSQUILLON, C., LOMBRY, C., PRÉAT, V. and VANBEVER, R., 2001. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance Journal of Controlled Release. 70(3), 329-339
• BOSQUILLON, C, LOMBRY, C, PREAT, V and VANBEVER, R, 2001. Comparison of particle sizing techniques in the case of inhalation dry powders. Journal of Pharmaceutical Sciences. 90(12), 2032-41