Felicity Rose

Contact

• workRoom B57 Centre for Biomolecular Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8467856
• fax0115 9515122
• felicity.rose@nottingham.ac.uk

Biography

I attained a BSc (HONS) degree in Applied Biochemistry from Liverpool John Moores University in 1993 following which I joined the Department of Gastroenterology at the University of Nottingham. I attained my PhD in 1999 under the supervision of Professor Yash Mahida. In 2000, I took the opportunity to join the Tissue Engineering Group within the School of Pharmacy and was rapidly promoted to Senior Research Fellow in 2002. In 2003, I was awarded a prestigious University of Nottingham sponsored Anne McLaren Research Fellowship, aimed at encouraging female scientists to pursue a career in academia. At the same time, I was appointed to a Lectureship in Tissue Engineering, a post which I took up in 2005. As part of a team of stem cell biologists, tissue engineers, and mathematical modellers, I am an academic member of the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM) based within the newly built state-of-the-art multidisciplinary research facilities, the Centre for Biomolecular Sciences (CBS).

In addition to my research, I am a Tissue and Cell Engineering Society (TCES) committee member and am co-editor of the TCES newsletter. I have also recently been accepted to the EPSRC Peer Review College 2006 and regularly review grant applications for BBSRC, NC3Rs and Action Medical Research. In addition, I review manuscripts for publication for journals such as Biomaterials, Journal of Biomedical Materials Research, and Tissue Engineering. I am the UK representative on the Biomedicine and Molecular Biosciences Domain Committee; BMBS DC) of the European Cooperation in the field of Scientific and Technical Research (COST) funding body. Communicating science to school children is a particular passion for which I won an 'Exceptional Winner' Staff Volunteering Award (2005) from the Higher Education Active Community Fund (HEACF) for establishing a departmental after-school science club for primary school children.

Teaching Summary

Master of Pharmacy (MPharm): Laboratory Skills in Pharmaceutical Sciences (microbiology component lead)

MPHARM 2012 - DMP Bacterial and Fungal Infections (module convenor)

Final Year Research Projects

Masters in Stem Cell Technology (MSc): Cellular and Molecular Biology

Tissue Engineering and Clinical Applications (practical component lead)

Research Skills & Stem Cell Technology Exploitation (module convener)

Research Projects

PhD training courses

Mammalian Cell Culture: theory to support the practice

Research Summary

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening… read more

Recent Publications

• LEMON, G., HOWARD, D., YANG, H., RATCHEV, S.M., SEGAL, J.I., ROSE, F.R.A.J., JENSEN, O.E., WATERS, S.L. and KING, J.R., 2011. Growth of the chorioallantoic membrane into a rapid-prototyped model pore system: experiments and mathematical model Biomechanics and Modeling in Mechanobiology. 10, 539-558
• HUYNH NT, HE D, HAYES-GILL BR, CROWE JA, WALKER JG, MATHER ML, ROSE FRAJ, PARKER NG, POVEY MJW, MORGAN SP, 2011. Application of a maximum likelihood algorithm to ultrasound modulated optical tomography In: Proc. Photons plus Ultrasound: Imaging and Sensing 2011, SPIE Vol. 7899.
• LEMON, G., HOWARD, D., ROSE, F. R. A. J. and KING, J. R., 2011. Individual-based modelling of angiogenesis inside three-dimensional porous biomaterials Biosystems. VOL 103(NUMBER 3), 372-383
• NELSON, M.R., HOWARD, D., JENSEN, O.E., KING, J.R., ROSE, F.R.A.J. and WATERS, S.L., 2011. Growth-induced buckling of an epithelial layer Biomechanics and Modelling in Mechanobiology. 10, 883-900

• View all publications

Current Research

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening applications, and ultimately tissues for transplantation. In particular, I have interests in epithelial tissue engineering with a focus on intestinal and corneal regeneration. In addition, I am involved in developing scaffolds that support tissue growth, by providing more efficient nutrient transport networks, and those that mimic the in vivo architecture of the native tissue. I also collaborate with optical engineers to develop sophisticated bioreactor systems that can be used for online monitoring of tissue growth.

The intestinal tissue engineering programme is currently supported with funding from the BBSRC (and in collaboration with Professors Chris Hawkey and Ilyas Mohammed, and Drs Lee Buttery, Virginie Sottile, Luisa Martinez Pomares, and Morgan Alexander, Nottingham) and is focussed on developing methods to derive and maintain intestinal progenitors for future tissue engineering programmes and the design of scaffolds to mimic the intestinal stem cell niche in vitro. This includes a collaboration with mathematical modellers (Dr Sarah Waters and Professor John King, Nottingham) to derive models of the dynamic environment of the intestinal crypts in order to recreate this in vitro. Corneal regeneration is funded by the EPSRC and MRC (in collaboration with Professors Kevin Shakesheff and Harminder Dua, and Dr Paddy Tighe, Nottingham) and involves developing a controlled release drug delivery device for wound healing and tissue engineering of the corneal stroma. Collaborations with Drs John Crowe and Steven Morgan from the Applied Optics Group (Nottingham) and Sarah Waters have focussed on developing imaging systems for monitoring tissue development within bioreactors and we are currently developing methods to include nutrient monitoring which will eventually lead to automated feedback systems.

Memberships of Committees and Professional Bodies

• Tissue and Cell Engineering Society (TCES) Committee Member.• EU COST (European Cooperation in the field of Scientific and Technical Research) Committee Member (Biomedicine and Molecular Biosciences Domain Committee).• Member, EPSRC Peer Review College.

• LEMON, G., HOWARD, D., YANG, H., RATCHEV, S.M., SEGAL, J.I., ROSE, F.R.A.J., JENSEN, O.E., WATERS, S.L. and KING, J.R., 2011. Growth of the chorioallantoic membrane into a rapid-prototyped model pore system: experiments and mathematical model Biomechanics and Modeling in Mechanobiology. 10, 539-558
• HUYNH NT, HE D, HAYES-GILL BR, CROWE JA, WALKER JG, MATHER ML, ROSE FRAJ, PARKER NG, POVEY MJW, MORGAN SP, 2011. Application of a maximum likelihood algorithm to ultrasound modulated optical tomography In: Proc. Photons plus Ultrasound: Imaging and Sensing 2011, SPIE Vol. 7899.
• LEMON, G., HOWARD, D., ROSE, F. R. A. J. and KING, J. R., 2011. Individual-based modelling of angiogenesis inside three-dimensional porous biomaterials Biosystems. VOL 103(NUMBER 3), 372-383
• NELSON, M.R., HOWARD, D., JENSEN, O.E., KING, J.R., ROSE, F.R.A.J. and WATERS, S.L., 2011. Growth-induced buckling of an epithelial layer Biomechanics and Modelling in Mechanobiology. 10, 883-900
• DEY, S, KELLAM, B, ALEXANDER, MR, ALEXANDER, C and ROSE, FRAJ, 2011. Enzyme-Passage Free Culture Of Mouse Embryonic Stem Cells On Thermo-Responsive Polymer Surfaces Journal Of Materials Chemistry. 21(19), 6883-6890
• MAHLSTEDT, M.M, ANDERSON, D., SHARP, J.S., MCGILVRAY, R., MUÑOZ, M.D., BUTTERY, L.D., ALEXANDER, M.R., ROSE, F.R.A.J. and DENNING, C., 2010. Maintenance of pluripotency in human embryonic stem cells cultured on a synthetic substrate in conditioned medium. Biotechnology and Bioengineering. 105(1), 130-140
• CHAU DYS, TINT NL, COLLIGHAN RJ, GRIFFIN M, DUA HS, SHAKESHEFF KM, ROSE FRAJ, 2010. The visualisation of vitreous using surface modified poly(DL-lactic-co-glycolic acid) microparticles British Journal of Ophthalmology. 94, 648-653 (In Press.)
• MAJANI, RUBY, ZELZER, MISCHA, GADEGAARD, NIKOLAJ, ROSE, FELICITY R and ALEXANDER, MORGAN R, 2010. Preparation of Caco-2 cell sheets using plasma polymerised acrylic acid as a weak boundary layer. Biomaterials. 31(26), 6764-71
• YANG, J., ROSE, F.R.A.J., GADEGAARD, N. and ALEXANDER, M.R., 2009. A high-throughput assay of cell-surface interactions using topographical and chemical gradients. Advanced Materials. 21(3), 300-304
• CUMMINGS, L.J, SAWYER. N.B.E, MORGAN, S.P, ROSE, F.R.A.J and WALTERS, S.L., 2009. Tracking large solid constructs suspended in a rotating bioreactor: a combined experimental and theoretical study Biotechnology and Bioengineering. 104(6), 1224-1234
• YANG, J., ROSE, F.R.A.J, GADEGAARD, N. and ALEXANDER, M.R., 2009. Effect of Sessile Drop Volume on the Wetting Anisotropy observed on grooved surfaces Langmuir. 25 (5), 2567-2571
• FRIEBOES, HERMANN B, EDGERTON, MARY E, FRUEHAUF, JOHN P, ROSE, FELICITY R A J, WORRALL, LISA K, GATENBY, ROBERT A, FERRARI, MAURO and CRISTINI, VITTORIO, 2009. Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer research. 69(10), 4484-92
• ZELZER M., MAJANI R., BRADLEY J.W., ROSE F.R.A.J., DAVIES M.C. and ALEXANDER M., 2008. Investigation of cell-surface interactions using chemical gradients formed from plasma polymers. Biomaterials. 29, 172-184
• HOU, Q, CHAU, DYS, PRATOOMSOOT, C, TIGHE, PJ, DUA, HS, SHAKESHEFF, KM and ROSE, FRAJ, 2008. In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine. Journal of Pharmaceutical Sciences. 97(9), 3972-3980
• PRATOOMSOOT, CHAYANIN, TANIOKA, HIDETOSHI, HORI, KUNIKO, KAWASAKI, SATOSHI, KINOSHITA, SHIGERU, TIGHE, PATRICK J, DUA, HARMINDER, SHAKESHEFF, KEVIN M and ROSE, FELICITY ROSAMARI A J, 2008. A thermoreversible hydrogel as a biosynthetic bandage for corneal wound repair. Biomaterials. 29(3), 272-81
• SAWYER, N.B.E., WORRAL, L.K., ROSE, F.R.A.J., CROWE, J.A., WATERS, S. and MORGAN, S.P., 2008. In situ monitoring of 3D in vitro cell aggregation using an optical imaging system Biotechnology and Bioengineering. 100(1), 159-167
• GINTY, P.J., HOWARD, D., UPTON, C.E., BARRY, JJ.A., ROSE, R.A.J., SHAKESHEFF, K.M. and HOWDLE, S.M., 2008. A supercritical CO2 injection system for the production of polymer/mammalian cell composites Journal of Supercritical Fluids. 43, 535-541 (In Press.)
• ZELZER, M., MAJANI, R., BRADLEY, J.W., ROSE, F.R.A.J., DAVIES, M.C. and ALEXANDER, M.R., 2008. Surface chemical gradients for guidance of cellular adhesion Biomaterials. 29, 172-184 (In Press.)
• HIDALGO-BASTIDA, L.A., BARRY, J.J.A., EVERITT, N.M., ROSE, F.R.A.J., BUTTERY, L.D., HALL, I.P., CLAYCOMB, W.C. and SHAKESHEFF, K.M., 2007. Mechanical properties of a Flexible Scaffold for Cardiac Tissue Engineering Acta Biomaterialia. 387(4), 457-462
• PRATOOMSOOT, C., TANIOKA, H., HORI, K., KAWASAKI, S., KINOSHITA, S., TIGHE, P.J., DUA, H., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2007. A thermoreversible hydrogel as a biosynthetic bandage for corneal wound repair Biomaterials. 29(3), 272-281
• LEMON, G., WATERS, S.L., ROSE, F.R.A.J. and KING, J.R., 2007. Mathematical modelling of human messenchymal stem cell proliferation and differentiation inside artificial porous scaffolds Journal of Theoretical Biology. 249, 543-553
• SAWYER, N.B.E., WORRALL, L.K., CROWE, J.A., WATERS, S.L., SHAKESHEFF, K.M., ROSE, F.R.A.J. and MORGAN, S.P., 2007. In situ monitoring of 3D in vitro cell aggregation using an optical imaging system Biotechnology and Bioengineering. (In Press.)
• GATENBY, R.A., SMALLBONE, K., MAINI, P., ROSE, F.R.A.J., AVERILL, J., NAGLE, R. and GILLIES, R., 2007. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer British Journal of Cancer. 97 (5), 646-653
• GINTY, P.J., HOWARD, D., ROSE, F.R.A.J., WHITAKER, M.J., BARRY, J.J.A., TIGHE, P., MUTCH, S.R., SERHATKULU, G., OREFFO, R.O.C., HOWDLE, S.M. and SHAKESHEFF, K.M., 2006. Mammalian cell survival and processing in supercritical CO₂ Proceedings of the National Academy of Sciences of the United States of America. 103(19), 7426-7431
• SILVA, M.M.C.G., CYSTER, L.A., BARRY, J.J.A., YANG, X.B., OREFFO, R.O.C., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials. 27(35), 5909-5917
• WATERS, S.L., CUMMINGS, L.J., SHAKESHEFF, K.M and ROSE, F.R.A.J., 2006. Tissue growth in a rotating bioreactor. Part I: mechanical stability Mathematical Medicine and Biology. 23(4), 311-337
• SUCIATI, T., HOWARD, D., BARRY, J., EVERITT, N.M., SHAKESHEFF, K.M. and ROSE, F.R., 2006. Zonal release of proteins within tissue engineering scaffolds Journal of Materials Science: Materials in Medicine. 17(11), 1049-1056
• WATERS, S.L., CUMMINGS, L.J., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. Tissue growth in a rotating bioreactor. Part 1: Mechanical stability. IMA Journal of Mathematics Applied in Medicine and Biology.
• SUCIATI, T., HOWARD, D., BARRY, J., EVERITT, N.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. Zonal Release of Proteins within Tissue Engineering Scaffolds Journal of Materials Science: Materials in Medicine. 17, 1049-1056
• SILVA, M.M.C.G., CYSTER, L.A., BARRY, J.J.A., YANG, X.B., OREFFO, R.O.C., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials. 27, 5909-5917
• GINTY, P.J., HOWARD, D., MUTCH, S., ROSE, F.R.A.J., WHITAKER, M.J., BARRY, J.J., SERHATKULU, G., OREFFO, R.O.C., HOWDLE, S.M. and SHAKESHEFF, K.M., 2006. Mammalian Cell survival and Processing in Supercritical CO2 PNAS. 103, 7426-7431
• CYSTER, L.A., GRANT, D.M., HOWDLE, S.M., ROSE, F.R.A.J., IRVINE, D.J., FREEMAN, D., SCOTCHFORD, C.A. and SHAKESHEFF, K.M., 2005. The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering Biomaterials. 26(7), 697-702
• BARRY, J.J.A., NAZHAT, S.N., ROSE, F.R.A.J., HAINSWORTH, A.H., SCOTCHFORD, C.A. and HOWDLE, S.M., 2005. Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering Journal of Materials Chemistry. 15(46), 4881-4888
• BARRY, J.J.A., NAZHAT, S.N., ROSE, F.R.A.J., HAINSWORTH, A.H., SCOTCHFORD, C.A. and HOWDLE, S.M., 2005. Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for soft tissue engineering J. Mater Chem. 15(46), 4881-4888
• CYSTER, L.A., GRANT, D.M., HOWDLE, S.M., ROSE, F.R.A.J., IRVINE, D., FREEMAN, D., SCOTCHFORD, C.A. and SHAKESHEFF, K.M., 2005. The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering Biomaterials. 26(7), 697-702
• ROSE, F.R., CYSTER, L.A., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M. and SHAKESHEFF, K.M., 2004. In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel. Biomaterials. 25(24), 5507-14
• ROSE, FELICITY R A J, HOU, QINGPU and OREFFO, RICHARD O C, 2004. Delivery systems for bone growth factors - the new players in skeletal regeneration. Journal of Pharmacy and Pharmacology. 56(4), 415-27
• ROSE, F.R.A.J., HOU, Q. and OREFFO, R.O.C., 2004. Delivery systems for bone growth factors - the new players in skeletal regeneration J. Pharm. Pharmacol. 56, 415-427
• ROSE, F.R.A.J., CYSTER, L.A., GRANT, C.M., SCOTCHFORD, C.A. and HOWDLE, S.M. SHAKESHEFF, K.M., 2004. In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel Biomaterials. 25(24), 5507-5514
• SALEM, A.K., ROSE, F.R.A.J., OREFFO, R.O.C., YANG, X., DAVIES, M.C., MITCHELL, J.R., ROBERTS, C.J., STOLNIK-TRENKIC, S., TENDLER, S.J.B., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2003. Porous polymer and cell composites that self-assemble <i>in situ</i> Advanced Materials. 15(3), 210-213
• UNSWORTH, J. M., ROSE, F. R. A. J., WRIGHT, E., SCOTCHFORD, C. A. and SHAKESHEFF, K. M., 2003. Seeding Cells into Needled Felt Scaffolds for Tissue Engineering Applications JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 66(PART 2), 425-431
• SALEM, A.M., ROSE, F.R.A.J., DAVIES, M.C., MITCHELL, J.R., ROBERTS, C.J., STOLNIK-TRENKIC, S., TENDLER, S.J.B., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2003. Porous polymer and cell composites that self-assemble in situ Adv. Mater. 15, 210
• UNSWORTH, J.M., ROSE, F.R.A.J., WRIGHT, E., SCOTCHFORD, C. and SHAKESHEFF, K.M., 2003. Seeding cells into needled felt scaffolds for tissue engineering applications J. Biomed Mat. Res. 66A, 425-431
• CUNLIFFE, R.N., KAMAL, M., ROSE, F.R.A.J., JAMES, P.D. and MAHIDA, Y.R., 2002. Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa Journal of Clinical Pathology. 55(4), 298-304
• SHAKESHEFF, K.M., SILVA, M., HOWDLE, S.M., SALEM, A.K., ROSE, F.R., WHITAKER, M.J., WOOD, I., DE BANK, P., KENDALL, D.A. and KELLAM, B., 2002. Delivering protein and cell therapeutics for tissue regeneration In: International Symposium on Recent Advances in Drug Delivery Systems.
• ROSE, F.R.A.J. and OREFFO, R.O.C., 2002. Bone tissue engineering: Hope vs Hype Biochem. Biophys. Res. Comm. 292, 1
• ROSE, FELICITY R A J and OREFFO, RICHARD O C, 2002. Bone tissue engineering: hope vs hype. Biochemical and Biophysical Research Communications. 292(1), 1-7
• CUNLIFFE, R.N., ROSE, F.R.A.J., KEYTE, J., ABBERLEY, L., CHAN, W.C. and MAHIDA, Y.R., 2001. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease Gut: Journal of the British Society of Gastroenterology. 48(2), 176-185
• ROSE, F.R., SHAKESHEFF, K.M. and QUIRK, R., 2001. Tissue Engineering - New Technologies at the Interface between Pharmaceutical and Cell Sciences
• ROSE, F.R.A.J., SHAKESHEFF, K. and QUIRK, R, 2001. Tissue Engineering-New Technologies at the Interface between Pharmaceutical and Cell Sciences Business Briefing: Pharmatech. 189 (In Press.)
• ROSE, F.R.A.J., BAILEY, K., KEYTE, J.W., CHAN, W.C., GREENWOOD, D and MAHIDA, Y.R., 1998. Potential role of epthelial cell-derived histone H1 proteins in innate antimicrobial defence in the human gastrointestinal tract Infect. Immun.. 66, 3255 (In Press.)
• MAHIDA, Y.R., ROSE, F.R.A.J. and CHAN, W.C., 1997. Antimicrobial peptides in the gastrointestinal tract Gut. 40, 161 (In Press.)