TURYANSKA, L, BRADSHAW, TD, LI, M, BARDELANG, P, DREWE, WC, FAY, MW, MANN, S, PATANE, A and THOMAS, NR, 2012. The Differential Effect Of Apoferritin-Pbs Nanocomposites On Cell Cycle Progression In Normal And Cancerous Cells Journal Of Materials Chemistry. 22(2), 660-665 TING, KN, OTHMAN, M, TELFORD, G, CLARKE, G, BRADSHAW, TD, KHOO, TJ, LOH, HS, WIART, C, PRITCHARD, D and FRY, JR, 2011. Antioxidant, Cytoprotective, Growth Inhibitory And Immunomodulatory Activities Of Extracts Of Dysoxylum Cauliflorum Hiern., A Malaysian Meliaceae Journal Of Medicinal Plants Research. 5(24), 5867-5872
CHEW, EH, NAGLE, AA, ZHANG, YC, SCARMAGNANI, S, PALANIAPPAN, P, BRADSHAW, TD, HOLMGREN, A and WESTWELL, AD, 2010. Cinnamaldehydes Inhibit Thioredoxin Reductase And Induce Nrf2: Potential Candidates For Cancer Therapy And Chemoprevention Free Radical Biology And Medicine. 48(1), 98-111 TURYANSKA, L, BRADSHAW, TD, SHARPE, J, LI, M, MANN, S, THOMAS, NR and PATANE, A, 2009. The Biocompatibility Of Apoferritin-Encapsulated Pbs Quantum Dots Small. 5(15), 1738-1741 BRADSHAW, TRACEY D, STONE, ERICA L, TRAPANI, VALENTINA, LEONG, CHEE-ONN, MATTHEWS, CHARLES S, TE POELE, ROBERT and STEVENS, MALCOLM F G, 2008. Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl)benzothiazole in breast cancer cell lines. Breast Cancer Research and Treatment. 110(1), 57-68 AIELLO S, WELLS G, STONE EL, KADRI H, BAZZI R, BELL DR, STEVENS MFG, MATTHEWS CS, BRADSHAW TD and WESTWELL AD, 2008. Synthesis And Biological Properties Of Benzothiazole, Benzoxazole, And Chromen-4-One Analogues Of The Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (Pmx 610, Nsc 721648). Journal Of Medicinal Chemistry. 51(16), 5135-9 ATHANASIOU, ANDRIANI, CLARKE, ANNA B, TURNER, AMY E, KUMARAN, NETHIA M, VAKILPOUR, SARA, SMITH, PAUL A, BAGIOKOU, DIMITRA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, FANG, LIN, LOBO, DILEEP N and CONSTANTIN, 2007. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and biophysical research communications. 364(1), 131-7
MCCARROLL, ANDREW J, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, MATTHEWS, CHARLES S and STEVENS, MALCOLM F G, 2007. Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions. Journal of Medicinal Chemistry. 50(7), 1707-10 MORTIMER, CATRIONA G, WELLS, GEOFFREY, CROCHARD, JEAN-PHILIPPE, STONE, ERICA L, BRADSHAW, TRACEY D, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2006. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry. 49(1), 179-85 SHAH, M., WELLS, G., BRADSHAW, T. D., LAUGHTON, C. A., STEVENS, M. F. G. and WESTWELL, A. D., 2006. Antitubercular Properties of Substituted Hydroxycyclohexadienones LETTERS IN DRUG DESIGN AND DISCOVERY. VOL 3(NUMB 6), 419-423 LION, CEDRIC J, MATTHEWS, CHARLES S, WELLS, GEOFFREY, BRADSHAW, TRACEY D, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2006. Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols'). Bioorganic and Medicinal Chemistry Letters. 16(19), 5005-8 BRADSHAW, T.D., MATTHEWS, C.S., COOKSON, J., CHEW, E.-H., SHAH, M., BAILEY, K., MONKS, A., HARRIS, E., WESTWELL, A.D., WELLS, G., LAUGHTON, C.A. and STEVENS, M.FG., 2005. Elucidation of thioredoxin as a molecular target for antitumor quinols Cancer Research. 65(9), 3911-3919 MUKHERJEE, A., WESTWELL, A.D., BRADSHAW, T.D., STEVENS, M.F.G., CARMICHAEL, J. and MARTIN, S.G., 2005. Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study British Journal of Cancer. 92, 350-358 BERRY, J.M., BRADSHAW, T.D., FICHTNER, I., REN, R., SCHWALBE, C.H., WELLS, G., CHEW, E.-H., STEVENS, M.F.G. and WESTWELL, A.D., 2005. Quinols as novel therapeutic agents. 2. 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents Journal of Medicinal Chemistry. 48(2), 639-644 BRADSHAW,T.D., MORTIMER,C.G. and WESTWELL,A.D., 2005. Update to: the aryl hydrocarbon receptor in anticancer drug discovery: friend or foe? Medicinal Chemistry Reviews - Online. 2(2), 153-161 LEONG, C.O., SUGGITT, M., SWAINE, D.J., BIBBY, M.C., STEVENS, M.F.G. and BRADSHAW, T.D., 2004. <i>In vitro</i>, <i>in vivo</i>, and <i>in silico</i> analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Molecular Cancer Therapeutics. 3(12), 1565-1575 FICHTNER, I., MONKS, A., HOSE, C., STEVENS, M.F.G. and BRADSHAW, T.D., 2004. The experimental antitumor agents Phortress and Doxorubicin are equiactive against human-derived breast carcinoma xenograft models Breast Cancer Research and Treatment. 87(1), 97-107 BRANTLEY, E., TRAPANI, V., ALLEY, M.C., HOSE, C.D., BRADSHAW, T.D., STEVENS, M.F.G., SAUSVILLE, E.A. and STINSON, S.F., 2004. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells Drug Metabolism and Disposition. 32(12), 1392-1401 HIORNS, L R, BRADSHAW, T D, SKELTON, L A, YU, Q, KELLAND, L R and LEYLAND-JONES, B, 2004. Variation in RNA expression and genomic DNA content acquired during cell culture. British Journal of Cancer. 90(2), 476-82 PALLIS, MONICA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, GRUNDY, MARTIN, STEVENS, MALCOLM F G and RUSSELL, NIGEL, 2003. Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochemical Pharmacology. 66(9), 1695-705 O'BRIEN, S.E., BROWNE, H.L., BRADSHAW, T.D., WESTWELL, A.D., STEVENS, M.F.G. and LAUGHTON, C.A., 2003. Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1 Organic & Biomolecular Chemistry. 1(3), 493-497 WELLS, G., BERRY, J.M., BRADSHAW, T.D., BURGER, A.M., SEATON, A., WANG, B., WESTWELL, A.D. and STEVENS, M.F.G., 2003. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines Journal of Medicinal Chemistry. 46(4), 532-541 HUTCHINSON, IAN, BRADSHAW, TRACEY D, MATTHEWS, CHARLES S, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2003. Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. Bioorganic and Medicinal Chemistry Letters. 13(3), 471-4 PALLIS, M., BRADSHAW, T.D., WESTWELL, A.D., GRUNDY, M., STEVENS, M.F. and RUSSELL, N.H., 2003. The thioredoxin inhibitor AW464 and the dithiol oxidant diamide induce apoptosis without accumulation of reactive oxygen species Leukemia. 17, P25
LEONG, C-O, GASKELL, M, MARTIN, E A, HEYDON, R T, FARMER, P B, BIBBY, M C, COOPER, P A, DOUBLE, J A, BRADSHAW, T D and STEVENS, M F G, 2003. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. British Journal of Cancer. 88(3), 470-7 WELLS, G., BERRY, J.M., BRADSHAW, T.D., MATTHEWS, C.S., STEVENS, M.F., WESTWELL, A.D. and VASSELIN, D., 2002. Novel lead antitumour structures from oxygenated and hydroxylated bicyclic heterocycles British Journal of Cancer. 86(1), S117
WESTWELL, A.D., WELLS, G., BERRY, J.M., BRADSHAW, T.D., BURGER, A.M., MATTHEWS, C.S. and STEVENS, M.F., 2002. Synthesis of heteroaromatic quinols, novel agents with selective activity clustered in colon and renal cell lines Proceedings of the American Association for Cancer Research. 43, 1034
STEVENS, M.F., WELLS, G., BRADSHAW, T.D., WESTWELL, A.D. and HOLBECK, S.L., 2002. The use of the COMPARE algorithm to guide mechanistic studies on novel antitumour agents Proceedings of the American Association for Cancer Research. 43, 4731
MUKHERJEE, A., MARTIN, S., BRADSHAW, T.D., WESTWELL, A.D. and CARMICHAEL, J., 2002. <em>In vitro</em> antitumour and antiangiogenic activity of AW 464 (NSC 706704), a novel quinol British Journal of Cancer. 86(1), S108-S109
BRADSHAW, T D, CHUA, M-S, BROWNE, H L, TRAPANI, V, SAUSVILLE, E A and STEVENS, M F G, 2002. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. British Journal of Cancer. 86(8), 1348-54 BRADSHAW, T D, TRAPANI, V, VASSELIN, D A and WESTWELL, A D, 2002. The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe? Current Pharmaceutical Design. 8(27), 2475-90 BRADSHAW, TRACEY D, BIBBY, MICHAEL C, DOUBLE, JOHN A, FICHTNER, IDUNA, COOPER, PATRICIA A, ALLEY, MICHAEL C, DONOHUE, SUSAN, STINSON, SHERMAN F, TOMASZEWJSKI, JOSEPH E, SAUSVILLE, EDWARD A and STEVENS, MALCOLM F G, 2002. Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles. Molecular Cancer Therapeutics. 1(4), 239-46
LOAIZA-PÉREZ, ANDREA I, TRAPANI, VALENTINA, HOSE, CURTIS, SINGH, SHEO S, TREPEL, JANE B, STEVENS, MALCOLM F G, BRADSHAW, TRACEY D and SAUSVILLE, EDWARD A, 2002. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Molecular Pharmacology. 61(1), 13-9
BRADSHAW, T.D., BROWNE, H.L., HUTCHINSON, I., LAUGHTON, C.A., LEONG, C.O., OBRIEN, S., STEVENS, M.F., TRAPANI, V. and WESTWELL, A.D., 2001. Mechanistic studies and evaluation of clinical markers for phortress, a new agent for clinical trials British Journal of Cancer. 85, 272
HUTCHINSON, I., CHUA, M., BROWNE, H.L., TRAPANI, V., BRADSHAW, T.D., WESTWELL, A.D. and STEVENS, M.F., 2001. Antitumour benzothiazoles 14. Synthesis and <em>in vitro</em> biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles Journal of Medicinal Chemistry. 44, 1446-1455 BRADSHAW, T.D., STEVENS, M.F. and WESTWELL, A.D., 2001. The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203) and related compounds Current Medicinal Chemistry. 8, 203-210
SHI, D F, BRADSHAW, T D, CHUA, M S, WESTWELL, A D and STEVENS, M F, 2001. Antitumour benzothiazoles. Part 15: The synthesis and physico-chemical properties of 2-(4-aminophenyl)benzothiazole sulfamate salt derivatives. Bioorganic and Medicinal Chemistry Letters. 11(8), 1093-5