Jan Bradley

Overview

Professor of Parasitology

Room: B135 (Biology Building)

Address: The School of Biology, Biology Building, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK

Tel: +44 (0)115 951 3207 (int 13207)
Fax: 0115 951 3251
Email: Jan.Bradley@nottingham.ac.uk

Research Overview: The host parasite relationship: worms and mammals do both benefit from the association?

The relationship between helminth infections and the human immune system has developed over evolutionary time and is likely to provide some beneficial elements for the host as well as the parasite. In vertebrate wildlife populations in general, helminth infection is near ubiquitous. The human immune response has evolved in a wormy environment and has probably been selected to operate under challenge from worms, as a matter of course. Thus, having helminth infections may affect the outcome of exposure to other pathogens such as viruses and protozoan parasites. We have a particular interest in evaluating if helminth infection can protect against the development of severe malaria. In developed countries helminth infections are rare and disorders of immune regulation: allergies and autoimmune diseases are becoming increasingly common. We are investigating the association between the two in developing countries to assess if treating against worms increases the risk of these diseases.

Education, appointments and honours

Hull University BSc Zoology 1977, London School of Hygiene and Tropical Medicine PhD 1984, Research fellow Scripps clinic and research Centre La Jolla California 1984-86

Research fellow Imperial college 1986-1995, Lecturer Reader and Professor –Salford university 1995-2000, The University of Nottingham 2000-Current.

Selected Publications

D'ELIA, RICCARDO, BEHNKE, JERZY M, BRADLEY, JANETTE E and ELSE, KATHRYN J, 2009. Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival. Journal of immunology (Baltimore, Md. : 1950), 182(4), 2340-8. JACKSON, JOSEPH A, FRIBERG, IDA M, LITTLE, SUSAN and BRADLEY, JANETTE E, 2009. Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?. Immunology, 126(1), 18-27. JACKSON, JOSEPH A, FRIBERG, IDA M, BOLCH, LUKE, LOWE, ANN, RALLI, CATRIONA, HARRIS, PHILIP D, BEHNKE, JERZY M and BRADLEY, JANETTE E, 2009. Immunomodulatory parasites and toll-like receptor-mediated tumour necrosis factor alpha responsiveness in wild mammals. BMC Biology, 7, 16. AL-RIYAMI, L, EGAN, C A, BRADLEY, J E, LUSTIGMAN, S and HARNETT, W, 2008. Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite immunology, 30(5), 304-8. ANDREWS, J A, BLIGH, W J, CHIODINI, P L, BRADLEY, J E, NDE, P N and LUCIUS, R, 2008. The role of a recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus. Journal of clinical pathology, 61(3), 347-51. BRADLEY, and JACKSON,, 2008. Measuring immune system variation to help understand host-pathogen community dynamics. Parasitology, 1-17. TURNER, JOSEPH D, JACKSON, JOSEPH A, FAULKNER, HELEN, BEHNKE, JERZY, ELSE, KATHRYN J, KAMGNO, JOSEPH, BOUSSINESQ, MICHEL and BRADLEY, JANETTE E, 2008. Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness. Journal of Infectious Diseases, 197(8), 1204-12. HEDELER, C., PATON, N. W., BEHNKE, J. M., BRADLEY, J. E., HAMSHERE, M. G. and ELSE, K. J., 2006. A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology (Cambridge), 132(2), 157-168. JACKSON, J.A., PLEASS, R.J., CABLE, J., BRADLEY, J.E. and TINSLEY, R.C., 2006. Heterogenous interspecific interactions in a host-parasite system. International Journal for Parasitology, 36(13), 1341-1349. JACKSON, J.A., TURNER, J.D., KAMAL, M., WRIGHT, V., BICKLE, Q., ELSE, K.J., RAMSAN, M. and BRADLEY, J.E., 2006. Gastrointestinal nematode infection is associated with variation in innate immune responsiveness. Microbes and Infection, 8(2), 487-492.

Group Members

Anne Lowe	Research Technician	+44 (0)115 951 3243 internal (UP) 13243	B133
Ida Friberg	Research Fellow	internal (QMC)
Miss Catriona Ralli	Research Techician	internal (UP)
Bibiana Alvarez Vazquez	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 18486	B145
Ida Friberg	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 12274	B42
Susan Little	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 12274	B42
Ivonne Siebeke	Postgraduate Student	+44 (0)115 823 0314 internal (UP) 12274	B42
Amy Hall	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 12274	B42
Yadong Zheng	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 12274	B42
Sarah Smith	Postgraduate Student
Fawzia Shawesh	Postgraduate Student	+44 (0)115 951 5151 internal (UP) 12274	B42