logo
School of Biomedical Sciences
   
   
  
 

Image of Christophe Wiart

Christophe Wiart

Associate Professor, Faculty of Science

Contact

Biography

Wikipedia:

Dr. Christophe Wiart has been studying the medicinal plants of India, Southeast Asia and China for the last 16 years. He has collected, identified and classified several hundred species of medicinal plants and he is regarded as the most prominent authority in the field of Asian ethnopharmacology, chemotaxonomy and ethnobotany. Based in the School of Biomedical Sciences of the University of Nottingham (Malaysia Campus)], he currently supervises several PhD students working on the discovery of novel antibacterial, anticancer, and antioxidant principles from rare plants from the rainforest of Southeast Asia.

Dr. Christophe Wiart has authored several books of which:

1.Wiart C., (2000), Medicinal Plants of Southeast Asia, Pelanduk Publisher, Kuala Lumpur.100pp.[3] 2.Wiart C. and Kumar A., (2000), Practical Handbook of Pharmacognosy, Prentice Hall, Kuala Lumpur.100pp 3.Wiart C., (2002), Medicinal Plants of Southeast Asia, second edition, Prentice Hall, Kuala Lumpur. Preface of Professor Guy Mazars, (University Louis Pasteur, Strasbourg, President of The European Society of Ethnopharmacology) and reviewed by Professor Waterman (South Cross University, Australia).300pp. 4.Wiart C (2005), "Antibacterial activity of medicinal plants used for traditional medicine in the State of Perak, Malaysia". In Ethnomedicine, Der Grosse Leibeiker, Germany. 5.Wiart C., (2006), Medicinal Plants of the Asia-Pacific: Drugs from the Future? WorldScientific, Singapore. Preface of Professor Norman Farnsworth (University of Illinois, USA), Professor Nina Etkin (University of Hawaii) and Professor Elizabeth Williamson (London, UK). 800pp.[4]

Expertise Summary

I am specialized in the discovery of novel antibiotics, antioxidants and anticancer agents from tropical rainforest plants. We can locate in the rainforest of Malaysia rare samples which shall be extracted to afford some extracts from which we isolate active principles

I have published several books in the US, UK, and Singapore on the medicinal plants of Asia.

I am the current world authority in Asian medicinal plants

Research Summary

Ethnopharmacology of medicinal plants in Asia Pacific; bioprospection, collection and identification of medicinal botanical samples and phytochemical and pharmacological study for the identification… read more

Recent Publications

  • AMINIMOGHADAMFAROUJ N., NEMATOLLAHI A., WIART C, 2012. Reviews On 1,4-naphthoquinones from Diospyros L. Journal of Asian Natural Products Research. (In Press.)
  • TING KN, OTHMAN M, TELFORD G, CLARKE G, BRADSHAW T, KHOO TJ, LOH S, and WIART C, PRITCHARD D AND FRY JR, 2012. Antioxidant, cytoprotective, growth inhibitory andimmunomodulatory activities of extracts of Dysoxylum Journal of Medicinal Plants Research. (In Press.)
  • LIM SW, TING KN, BRADSHAW TD, ZEENATHUL NA, WIART C, KHOO TJ, LIM KH, H.S. LOH S, 2012. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks Journal of Ethnopharmacology. (In Press.)
  • 2011. Medicinal Fruit Trees of Southeast Asia. In: RAM SINGH, ed., Genetic Resources, chromosome engineering, and crop improvement CRC Press USA. 1056

Current Research

Ethnopharmacology of medicinal plants in Asia Pacific; bioprospection, collection and identification of medicinal botanical samples and phytochemical and pharmacological study for the identification of lead com-pounds .

The knowledge acquired allow to direct and to guide the different steps necessary to the development of vegetal substances and/or extracts from tropical plants into commercial products for pharmacy and/or cosmetology. That expertise is based on a deep knowledge of the pharmacochemistry, and botany of medicinal plants: -Botany: Field collection, identification, taxonomy. Choice of strategic plants according to the pharmacological activities or principles desired. -Phytochemistry: Extraction and purification of plant extracts using TLC, GC-MS, HPLC, and NMR. -Pharmacy: Choice of the best galenical forms as well as ingredients for a maximal pharmacological activity. -Pharmacology: The knowledge acquired allows the guidance and direction of in vitro or in vivo pharmacological activities of natural products and/or extracts in the following fields: oncology (cancer cells), virology (proliferation of HIV in cells), bacteriology (culture of bacteria), neurology, cardiovascular system and others. -Toxicology: The knowledge acquired allows the guidance and direction of in vitro or in vivo toxicity of natural products and/or extracts. -Others Lecturing pharmacognosy, publications and oral presentation in international symposia. Member and co-editor of the European Journal of Ethnopharmacology, editor of dePharmacog.net. Supervision of Masters and PhD. Consultation and patenting. Relations with an array of researchers in France, USA, Australia and Japan. In addition, the techniqu

Past Research

Screening of several plant species for antimicrobial, antioxidant and anticancer activity.

Isolation of antibacterial, cytotoxic and antioxidant principles from selected rainforest plants for drug development.

Future Research

Patenting of a topical antiseptic oinment from a tropical plant

Writting a new book on the medicinal plants of China

Supervision of PhD students in the field of drug discovery from plants.

Isolation of antibacterial, cytotoxic and antioxidant principles from selected rainforest plants for drug development.

  • AMINIMOGHADAMFAROUJ N., NEMATOLLAHI A., WIART C, 2012. Reviews On 1,4-naphthoquinones from Diospyros L. Journal of Asian Natural Products Research. (In Press.)
  • TING KN, OTHMAN M, TELFORD G, CLARKE G, BRADSHAW T, KHOO TJ, LOH S, and WIART C, PRITCHARD D AND FRY JR, 2012. Antioxidant, cytoprotective, growth inhibitory andimmunomodulatory activities of extracts of Dysoxylum Journal of Medicinal Plants Research. (In Press.)
  • LIM SW, TING KN, BRADSHAW TD, ZEENATHUL NA, WIART C, KHOO TJ, LIM KH, H.S. LOH S, 2012. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks Journal of Ethnopharmacology. (In Press.)
  • 2011. Medicinal Fruit Trees of Southeast Asia. In: RAM SINGH, ed., Genetic Resources, chromosome engineering, and crop improvement CRC Press USA. 1056
  • AMINIMOGHADAMFAROUJ N., NEMATOLLAHI A., WIART C,, 2011. Annonaceae: Bio-resource for tomorrow's drug discovery. Journal of Asian Natural Products. 13(5), 465-476
  • WIJAYA S, NEE TK, JIN KT, HON LK, SAN LH, WIART C., 2011. Antibacterial and antioxidant activities of synedrella nodiflora(L.) Gaertn. (Asteraceae). Journal of Complementary and Integrative Medicine. 8(1),
  • NEMATOLLAHI A, AMINIMOGHADAMFAROUJ N, WIART C, 2011. , Design and modeling studies on liriodenine derivatives as novel topoisomerase II inhibitors Journal of ChemTech Research. 3(3), 1622-1627
  • NEMATOLLAHI A, AMINIMOGHADAMFAROUJ N, WIART C., 2011. Anti-bacterial, antioxidant activity and phytochemical study of diospyros wallichii - an interesting malaysia's endemic species of ebenaceae. International Journal of PharmTech. 3(3), 1732-1736
  • MOGANA R, BRADSHAW TD, JIN KT, WIART C, 2011. In vitro antitumor potential of Canarium patentinervium Miq Academic Journal of Cancer Research. 4(1), 1-4
  • OTHMAN M, LOH HS, WIART C, KHOO TJ, LIM KH, TING KN, 2011. Optimal methods for evaluating antimicrobial activities from plant extracts. J Microbiol Methods. 84(2), 161-166
  • OTHMAN M, GENAPATHYA S, LIEW PS, CH’NG QT., LOH HS, KHOO TJ., WIART C AND TING, KN, 2011. Search for antibacterial agents from Malaysian rainforest and tropical plants Natural Product Research.
  • WIART C., 2009. Medicinal Plants from the East University of Nottingham Press, UK.
  • C WIART, 2006. Medicinal Plants of the Asia-Pacific: Drugs from the Future? WorldScientific, Singapore. (In Press.)
  • C WIART, 2006. Medicinal Plants of Asia and the Pacific CRC Press, USA. (In Press.)
  • C WIART, 2006. Ethnopharmacology of Medicinal Plants: Asia and the Pacific. Humana Press, USA. (In Press.)
  • HIROTO KAMBARA, TAKESHI YAMADA, MAKIKO TSUJIOKA, SHUNYO MATSUNAGA, REIKO TANAKA, HAMED I. ALI, C. WIART, MOHD YUSOF, HAMINA HASSAN, ABU HANIFAH, ZEESHARINA MOHD FAUZI, NOR HANA MAZLAN, MICHAEL JAY, MU, 2006. A Study on Medicinal Plants from Malaysia Focused on Acalypha siamensis Oliv ex Gage. Isolation and Structure of a New Tetraterpene, Acalyphaser A. Chemistry & Biodi-versity. 3(12), 1301-1306 (In Press.)
  • WIART C, HANNAH A, YUSOF M, HAMIMAH H, SULAIMAN M, 2005. Growth inhibition of foodborne and nosocomial pathogens by aqueous fraction of bearded Argostemma (Argostemma involucratum Hemsl., Rubiaceae) J Herb Pharmacother. 5(3), 97-102 (In Press.)
  • WIART C and AKAHO E, HANNAH M, YASSIM M, HAMIMAH H, AU TS, SULAIMAN M, 2005. The rainforest of South-east Asia, particularly Malaysia, is endowed with several medicinal plants species Am J Chin Med. 33(4), 683-685 (In Press.)
  • C WIART, 2005. Antibacterial activity of medicinal plants used for traditional medicine in the State of Perak, Malaysia in Ethnomedicine, Der Grosse Leibeiker, Germany. (In Press.)
  • WIART C, HANNAH A, YASSIM M, HAMIMAH H, SULAIMAN M, 2004. Antimicrobial activity of Acalypha siamensis Oliv. ex Gage. J Ethnopharmacol. 95(2-3), 285-286 (In Press.)
  • WIART C, 2004. 16-alpha-(-)-kauran-19-oic acid: An Antibacterial Diterpene from Sweet Apple (Annona squamosa L. Annonaceae) Int J Pharmacol. 1(3), 296-298 (In Press.)
  • WIART C, S. MOGANA, S. KHALIFAH, M. MAHAN, S, ISMAIL, M and M. SULAIMAN, 2004. Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia Fitoterapia. 75, 68-73 (In Press.)
  • WIART C, 2002. Medicinal Plants of Southeast Asia, second edition, Prentice Hall, Kuala Lumpur Preface of Professor Guy Mazars, (University Louis Pasteur, Strasbourg, President of The European Society of Eth-nopharmacology) and reviewed by Professor Waterman (South Cross University, Australia). 300 (In Press.)
  • WIART C, MARTIN MT, AWANG K, HUE N, SERANI L, LAPREVOTE O, 2001. Pais Sesquiterpenes and alkaloids from Scorodocarpus borneensis Phytochemistry. 58(4), 653-656 (In Press.)
  • WIART C., 2001. Medicinal Leguminosae of Southeast Asia In: 4th International Legume Conference, National Australian University, Canberra, 2-7 July, Australia.. (In Press.)
  • WIART C., 2000. Medicinal Plants of Southeast Asia Pelanduk Publisher, Kuala Lumpur. (In Press.)
  • WIART C. AND KUMAR A., 2000. Practical Handbook of Pharmacognosy Prentice Hall, Kuala Lumpur. (In Press.)
  • D. GUILET, C. MOREL, N. NOYER, M. CORNEC, D. SERAPHIN, C. WIART, P. RICHOMME ET J. BRUNETON, 1999. Four New 4-Phenylcoumarins from Calophyllum dispar Isolation and Hemisynthesis, Heterocycles. 51, 67-76 (In Press.)
  • C. MOREL, D. GUILET, J.M. OGER, D. SERAPHIN, C. WIART, A. HAMID A. HADI, P. RICHOMME ET J. BRUNETON, 1999. New 6-Acylcoumarins from Mesua racemosa Phytochemistry. 50(7), 1243-1247 (In Press.)
  • SHASYA U, ALI M, WIART C and GAILLARD J.F. & M. PAIS, 1997. Terengganensine A and B, Dihydroeburnane Alkaloids from Kopsia terengganensis Tetrahedron Letters. 38(9), 1571-1574 (In Press.)
  • ALLORGE L and WIART C. AND L.E. TOE, 1995. Kopsia terengganensis L. Allorge & C. Wiart (Apocynaceae), A New Malaysian Species. Acta Botanica Gallica. 42(5), 433-437 (In Press.)
  • MOGANA R, TENG-JIN K, WIART C, In Vitro Antimicrobial, Antioxidant Activities and Phytochemical Analysis of Canarium patentinervium Miq. from Malaysia Biotechnology Research International. (In Press.)
  • MOGANA R., WIART C., Canarium L.: a phytochemical and pharmacological review Journal of Pharmaceutical research. 4(8), 2482-2489
  • AMINIMOGHADAMFAROUJ N., NEMATOLLAHI A., WIART C, Antibacterial, antioxidant activity and phytochemical study of Uvaria grandiflora: a rare species of Annonaceae Journal of Pharmacy Research. 4(4), 954-955
  • THLIAMPLAM UM, KUPPUSAMY UR, KANTHIMATHI MS & WIART C, Comparison between the effects of Syzygium jambolanum leaf and fruit extracts on estrogen positive and estrogen negative breast cancer cell lines International Journal of Molecular Medicine and Advance Sciences. 2(2), 236-238

School of Biomedical Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 823 0141
email: enquiries