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School of Biomedical Sciences
   
   
  
 

Kostas Tsintzas

Associate Professor of Human Physiology, Faculty of Medicine & Health Sciences

Contact

  • workRoom D62a The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30127
  • fax0115 82 30103

Research Summary

Interests

  • Energy metabolism and fatigue in human skeletal muscle.
  • Nutrition and exercise in health and disease.
  • Nutrient-gene interactions in skeletal muscle.
  • Molecular basis of insulin resistance.

Techniques

  • Determination of skeletal muscle and cardiovascular function.
  • Measurements of insulin sensitivity, energy expenditure and body composition.
  • Determination of blood and muscle metabolites and enzyme activities (fluorescence, spectrophotometry and radioimmunoassays).
  • Microassays for single muscle fibre metabolites (fluorescence, radioisotopes, histochemistry).
  • Characterisation of RNA and protein in skeletal muscle (Real-Time PCR, SDS-PAGE, Western blotting).

Projects

  • The functional role of pyruvate dehydrogenase kinase in human skeletal muscle in various nutritional states (BBSRC).
  • Calpain-10 and insulin resistance in human skeletal muscle (BBSRC).
  • Factors affecting metabolism during, and recovery from, exercise in patients with type I diabetes mellitus (QMC Hospital Fund).

Centre Collaborators

  • Dr. Andy Bennett
  • Dr. Tim Constantin-Teodosiu
  • Prof. Paul Greenhaff
  • Prof. Ian Macdonald

UK Collaborators

  • Dr. Ron Bardsley and Dr, Tim Parr (School of Biosciences).
  • Dr. P Mansell (Department of Diabetes Endocrinology and Nutrition).
  • Prof. Clyde Williams (Loughborough University).

Selected Publications

Future Research

Research: regulation of substrate utilization in human skeletal muscle at rest and in exercise in various metabolic and nutritional states; metabolic basis of fatigue during exercise; nutrient-gene interactions in skeletal muscle in health and disease.

School of Biomedical Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 823 0141
email: enquiries