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Image of Paul Greenhaff

Paul Greenhaff

Professor of Muscle Metabolism, Faculty of Medicine & Health Sciences

Contact

  • workRoom D44 The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30133
  • fax0115 82 30103

Research Summary

Interests

  • Skeletal muscle metabolism, growth and atrophy.
  • Skeletal muscle fatigue in health and disease.
  • Nutritional, physiological and pharmacological strategies to alter skeletal muscle function.

Techniques

  • Determination of skeletal muscle function in vivo and ex vivo using a variety of approaches.Biochemical characterisation of skeletal muscle intermediary metabolism (spectrophotometry, fluorimetry and luminesence).
  • mRNA and protein determination in anabolic and catabolic skeletal muscle (Taqman, Microarray, Western blotting).

Projects

  • The influence of exercise and nutritional interventions on muscle growth and metabolism in humans. Funding provided by MuscleTech, Canada.
  • Functional and molecular changes in human skeletal muscle during acute wasting and rehabilitation. Funding provided by Pfizer Pharmaceuticals, USA.
  • Overcoming the blunted response to food to maximize muscle maintenance in the elderly (with Professor MJ Rennie (PI), Dr K Smith, Dr H Wakerhage and Professor IA Macdonald). Funding provided by BBSRC.
  • Identification of in vivo substrates of muscle atrophy-related ubiquitin ligases, MAFbx and MuRF-1 (with Dr R Layfield (PI) and Professsor S Gardiner). Funding provided by the MRC.
  • Statin induced muscle toxicity (with Professor T Bennett, Dr T Constantin-Teodosiu, Professor S Gardiner and Dr R Layfield). Funding provided by AstraZeneca Pharmaceuticals.
  • Molecular approaches to reversing muscle wasting in COPD (with Dr M Steiner (PI), Glenfield Hospital, Leicester). Funding provided by the MRC.
  • The central role of FOXO in muscle protein loss and insulin resistance (with Professor S Gardiner). PhD Studentship awarded by the BBSRC.
  • Strategies for improving performance during prolonged physical exercise: increasing the availability of carnitine and co-enzyme A in skeletal muscle (with Dr D Constantin-Teodosiu and professor IA Macdonald). PhD Studentship awarded by Qinetiq.

Centre Collaborators

  • Prof. Terence Bennett
  • Dr. Tim Constantin-Teodosiu
  • Prof. Sheila Gardiner
  • Prof. Ian Macdonald
  • Dr. Chris McIntyre
  • Dr. Kostas Tsintzas
  • Prof. Michael Rennie

Local Collaborators

  • Dr Rob Layfield (University of Nottingham)

Selected Publications

Future Research

regulation of skeletal muscle energy metabolism invivo and the significance that this has on muscle growth and function during exercise in health and disease utilising animal models and human volunteers.

School of Biomedical Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 823 0141
email: enquiries