Peter Wigmore

Contact

• workRoom E2 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30172
• fax0115 82 30142
• peter.wigmore@nottingham.ac.uk

Teaching Summary

Neuroanatomy and neurodevelopment. Neural stem cells. Medical human anatomy

Research Summary

My research interests are in the control of adult neurogenis. In particular the action of drugs which increase or decrease the formation of new neurons in the hippocampus. We are currently looking at… read more

Recent Publications

• LYONS L, ELBELTAGY M, BENNETT G and WIGMORE P, 2012. Fluoxetine Counteracts The Cognitive And Cellular Effects Of 5-Fluorouracil In The Rat Hippocampus By A Mechanism Of Prevention Rather Than Recovery. Plos One. 7(1), e30010
• MACHUCA-TZILI, L.E., BUXTON, S., THORPE, A., TIMSON, C.A., WIGMORE, P., LUTHER, P.K. and BROOK, P.K., 2011. Muscleblind-like 2 deficient Zebrafish exhibit features of Myotonic Dystrophy Disease Models and Mechanisms. 4, 381-392
• LYONS, L., ELBELTAGY, M., UMKA, J., MARKWICK, R., STARTIN, C., BENNETT, G. and WIGMORE, P., 2011. Fluoxetine reverses the deficits in memory, hippocampal cell proliferation and survival caused by methotrexate chemotherapy Psychopharmacology. 215, 105-115
• TARHONI MH, VIGNESWARA V, SMITH M, ANDERSON S, WIGMORE P, LEES JE, RAY DE and CARTER WG, 2011. Detection, Quantification, And Microlocalisation Of Targets Of Pesticides Using Microchannel Plate Autoradiographic Imagers. Molecules (Basel, Switzerland). 16(10), 8535-51

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Current Research

My research interests are in the control of adult neurogenis. In particular the action of drugs which increase or decrease the formation of new neurons in the hippocampus. We are currently looking at the effects of chemotherapy and antidpressants and how these drugs influence spatial memory.

• LYONS L, ELBELTAGY M, BENNETT G and WIGMORE P, 2012. Fluoxetine Counteracts The Cognitive And Cellular Effects Of 5-Fluorouracil In The Rat Hippocampus By A Mechanism Of Prevention Rather Than Recovery. Plos One. 7(1), e30010
• MACHUCA-TZILI, L.E., BUXTON, S., THORPE, A., TIMSON, C.A., WIGMORE, P., LUTHER, P.K. and BROOK, P.K., 2011. Muscleblind-like 2 deficient Zebrafish exhibit features of Myotonic Dystrophy Disease Models and Mechanisms. 4, 381-392
• LYONS, L., ELBELTAGY, M., UMKA, J., MARKWICK, R., STARTIN, C., BENNETT, G. and WIGMORE, P., 2011. Fluoxetine reverses the deficits in memory, hippocampal cell proliferation and survival caused by methotrexate chemotherapy Psychopharmacology. 215, 105-115
• TARHONI MH, VIGNESWARA V, SMITH M, ANDERSON S, WIGMORE P, LEES JE, RAY DE and CARTER WG, 2011. Detection, Quantification, And Microlocalisation Of Targets Of Pesticides Using Microchannel Plate Autoradiographic Imagers. Molecules (Basel, Switzerland). 16(10), 8535-51
• LYONS, L, ELBELTAGY, M, BENNETT, G and WIGMORE, P, 2011. The Effects Of Cyclophosphamide On Hippocampal Cell Proliferation And Spatial Working Memory In Rat Plos One. 6(6), -
• ELBELTAGY, M., MUSTAFA, S., UMKA, J., LYONS, L., SALMAN, A., CHUR-YOE, G.T., BHALLA, N., BENNETT, G. and WIGMORE, P., 2010. Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-Fluorouracil Behavioural Brain Research. 208(1), 112-117
• WIGMORE, P.M., MUSTAFA, S., ELBELTAGY, M., LYONS, L., UMKA, J. and BENNETT, G., 2010. Effects of 5-FU Advances in Experimental Medicine and Biology. 678, 157-164
• UMKA, J., MUSTAFA, S., ELBELTAGY, M., THORPE, A., LATIF, L., BENNETT, G. and WIGMORE, P.M., 2010. Valproic acid reduces the spatial working memory and cell proliferation in the hippocampus. Neuroscience. 166(1), 15-22
• MUSTAFA, S, WALKER, A, BENNETT, G and WIGMORE, PM, 2008. 5-Fluorouracil Chemotherapy Affects Spatial Working Memory And Newborn Neurons In The Adult Rat Hippocampus European Journal Of Neuroscience. 28(2), 323-330
• GREEN, W., PATIL, P., MARSDEN, C.A., BENNETT, G.W. and WIGMORE, P.M, 2006. Treatment with olanzapine increases cell proliferation in the subventricular zone and prefrontal cortex. Brain Research. 1070(1), 242-245
• PINTO CARDOSO, S.M., MUTCH, P., SCOTTING, P.J. and WIGMORE, P.M, 2004. Gene transfer into intact fetal skeletal muscle grown in vitro. Muscle and Nerve. 30(1), 87-94
• YANG, Z-J., APPLEBY, V.J., COYLE, B., CHAN, W-I., TAHMASEB, M., WIGMORE, P.M. and SCOTTING, P.J, 2004. Novel strategy to study gene expression and function in developing cerebellar granule cells. Journal of Neuroscience Methods. 132(2), 149-160
• LE, ROUËDEC D, RAYNER, K, REX, M, WIGMORE, P M and SCOTTING, P J, 2002. The transcription factor cSox2 and Neuropeptide Y define a novel subgroup of amacrine cells in the retina. Journal of Anatomy. 200(1), 51-56
• WIGMORE, PM and EVANS, DJR, 2002. Molecular And Cellular Mechanisms Involved In The Generation Of Fiber Diversity During Myogenesis
• EVANS, D J, BRITLAND, S and WIGMORE, P M, 1999. Differential response of fetal and neonatal myoblasts to topographical guidance cues in vitro. Development, Genes and Evolution. 209(7), 438-42
• DUNGLISON, G F, SCOTTING, P J and WIGMORE, P M, 1999. Rat embryonic myoblasts are restricted to forming primary fibres while later myogenic populations are pluripotent. Mechanisms of Development. 87(1-2), 11-9
• WIGMORE,P., REX,M. and SCOTTING,P.J., 1997. The role of sox genes in the migration and differentiation of neurons in the developing central nervous system Journal of Anatomy. 191, 132
• REX, M, ORME, A, UWANOGHO, D, TOINTON, K, WIGMORE, P M, SHARPE, P T and SCOTTING, P J, 1997. Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Developmental Dynamics. 209(3), 323-32
• WIGMORE, P M, MALEKI, F, EVANS, D J and MCERLAIN, M, 1996. After embryonic day 17, distribution of cells on surface of primary muscle fibres in mouse is non-random. Developmental Dynamics. 207(2), 215-21