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Research Projects

 

Here you can explore current and recent research projects, search for vacancies and find out more about our influential academics.

Projects

  • Search for a project by entering a keyword (e.g., neuropeptides) in the 'Filter' box.
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Supervisor Project Theme(s) Keyword(s)
Dr Stephen Alexander Evaluation of a new rodent model of schizophrenia Neuroscience, Molecular Pharmacology animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Dr Stephen Alexander Acyl derivatives of co-enzyme A as novel endogenous antagonists of vascular P2Y1 purine receptors Physiology, Pharmacology Purines, P2 receptors, cannabinoids, sympathetic nerves, sensory nerves, autonomic nervous system, blood vessel contractility, endothelium
Dr Stephen Alexander Characterization of endocannabinoid signalling in human tissue Neuroscience, Molecular Pharmacology GPCR signalling, nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport
Dr Stephen Alexander Cannabinoids and neuropathic pain Neuroscience, Molecular Pharmacology GPCR signalling, nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport, feeding behaviour
Dr Stephen Alexander G-protein coupled receptors in human skeletal muscle Biochemistry, Molecular Pharmacology GPCR signalling, nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport, feeding behaviour
Dr Stephen Alexander Regulation of vascular tone by intracellular signal transduction pathways Biochemistry, Transcriptomics, Cancer, Diabetes GPCR signalling, nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport
Dr Lynn Bedford Investigation of Parkinson's Disease & Lewy Bodies in mouse model Neuroscience, Neurodegeneration, Neuropharmacology Neurodegeneration, Parkinson's Disease, Dementia with Lewy bodies, Lewy body, Ubiquitin Proteasome System, proteolytic dysfunction, alpha-synuclein
Dr Andrew Bennett Analysis of the molecular mechanisms involved in the pathogenesis of NASH/NAFLD Biochemistry, Molecular biology, Liver disease Molecular signalling pathways, pathogenesis
Dr Andrew Bennett Characterization of endocannabinoid signalling in human tissue Neuroscience, Molecular Pharmacology nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport
Dr Andrew Bennett G-protein coupled receptors in human skeletal muscle Biochemistry, Molecular Pharmacology nuclear receptors, metabolism, diabetes, cancer, inflammation, transcriptomics
Dr Andrew Bennett Endocannabinoid receptors and human skeletal muscle in the rat Biochemistry, Cell Biology, Cancer, Proteomics nuclear receptors, metabolism, diabetes, cancer, inflammation, transcriptomics
Dr Andrew Bennett Regulation of metabolic genes in human skeletal muscle Physiology, Human Physiology, Muscle Metabolism nuclear receptors, metabolism, diabetes, cancer, inflammation, transcriptomics
Dr Rudi Billeter-Clark The activation of satellite cells in skeletal muscle during adaptation to altered load Physiology, Human Anatomy skeletal muscle, cardiac muscle, satellite cells, sinoatrial node, exercise, exercise physiology, functional anatomy, RT-PCR, microarray, in situ hybridisation, immunocytochemistry
Dr Edward Bolt cas-CRISPR, genome plasticity and recombination: antibiotic resistance Molecular microbiology, Cell biology, Genetics, Biochemistry antibiotic resistance, homologous recombination, cas-CRISPR, proteins, microbiology
Dr Boyan Bonev Interaction of antibiotics with bacterial cell membranes using NMRi and bacteria Biochemistry cell membrane, bacteria, NMRi
Dr Stephen Briddon Fluorescent H1 ligand bindings Neuroscience, Cognition, Neuropharmacology, Neurodegeneration GPCR , adenosine, microdomain, fluorescence, single cell, pharmacology, confocal imaging, spectroscopy, adrenoceptors
Dr Angus Brown Evaluation of the contribution of astrocyte function to neurovascular coupling Physiology, Electrophysiology, Biochemistry, Neuroscience CNS white matter, axons, astrocytes, glycogen, lactate, brain energy metabolism
Dr Angus Brown The neuroprotective role of glycogen in the nervous system Physiology, Electrophysiology, Biochemistry, Neuroscience CNS white matter, axons, astrocytes, glycogen, lactate, brain energy metabolism
Dr Angus Brown Changes in glutamatergic neuronal function in a social isolation animal model of schizophrenia Neuroscience, Cognition, Neuropharmacology, Neurodegeneration CNS white matter, axons, astrocytes, glycogen, lactate, brain energy metabolism
Dr Ronald Chalmers The mechanism of DNA recombination and transposition in the genomes of higher eukaryotes and/or bacteria Biochemistry, Proteomics, Genetics DNA recombination, transposition, gene therapy, pathogen, infection, Neisseria meningitis, cancer, DNA replication
Dr Susan Chan Role of endogenous cannabinoids in regulation of insulin secretion Physiology, Diabetes insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling
Dr Susan Chan Exploration into the molecular mechanisms of insulin resistance Physiology, Diabetes insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling
Dr Susan Chan Molecular pharmacology and insulin signalling Physiology, Human Physiology, Muscle Metabolism insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling
Dr Susan Chan Fructose feeding, metabolism and hypertension in rats Physiology, Human Physiology, Muscle Metabolism insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling
Dr Susan Chan Roles of calcium in adipocyte cell function Physiology, Pharmacology insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling, hypertension, myography, cannabinoids
Professor Victoria Chapman Control of calcium signalling in sensory nerve in vitro Neuroscience, Pain Biology, Neuropharmacology pain mechanisms, analgesics, spinal cord, neuronal responses, behavioural studies, cannabinoid receptors
Professor Victoria Chapman Dissecting the complex roles of peripheral sensory afferent input and supraspinal influences in osteoarthritic pain Pain biology, Neuroscience pain, arthritis, behaviour, electrophysiology
Dr Laura Conforti The role of NAD synthesis in models of cerebral ischemia Neurodegeneration, Cell Biology, Biochemistry NAD synthetic pathways, compartmentalised cell death, axon degeneration, mechanisms of neuroprotection, animal models of neurodegenerative diseases, cerebral ischemia
Dr Laura Conforti Role of axon degeneration in mouse models of neurodegenerative diseases Neurodegeneration, Cell Biology, Biochemistry NAD synthetic pathways, compartmentalised cell death, axon degeneration, mechanisms of neuroprotection, animal models of neurodegenerative diseases, Huntington's disease, motor neuron disease
Dr Laura Conforti Mechanisms of compartmentalised neuronal cell death and strategies of neuroprotection Neurodegeneration, Cell Biology, Biochemistry NAD synthetic pathways, compartmentalised cell death, axon degeneration, mechanisms of neuroprotection, animal models of neurodegenerative diseases, Huntington's disease, motor neuron disease
Dr Dimitri Constantin-Teodosiu Involvement of pyruvate dehydrogenase complex in sepsis (mitochondria) and fatigue development Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Dr Dimitri Constantin-Teodosiu Studies into peripheral arterial disease, intervention and therapeutic manipulation Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth, energy substrate integration, muscle contraction
Dr Dimitri Constantin-Teodosiu Molecular basis of insulin action in health and type 2 diabetes Human Physiology, Diabetes Molecular signalling pathways, muscle atrophy, hypertrophy, insulin resistance, sepsis, energy substrate integration, muscle contraction
Dr Dimitri Constantin-Teodosiu The role of muscle carnitine availability in the regulation of fat and carbohydrate oxidation in skeletal muscle Human Physiology, Obesity, Diabetes, Human Nutrition, Cardiovascular Function Molecular signalling pathways, muscle atrophy, hypertrophy, insulin resistance, sepsis, energy substrate integration, muscle contraction
Dr Dimitri Constantin-Teodosiu Carnitine metabolism in muscle Neuroscience Molecular signalling pathways, muscle atrophy, hypertrophy, insulin resistance, sepsis, energy substrate integration, muscle contraction
Dr Dimitri Constantin-Teodosiu  The Role of Pyruvate Dehydrogenase Complex in Regulating Skeletal Muscle and Myocardian Fuel Metabolism During Sepsis Physiology, Pharmacology Molecular signalling pathways, muscle atrophy, hypertrophy, insulin resistance, sepsis, energy substrate integration, muscle contraction, hypertension, myography, cannabinoids
Dr Simon Dawson Role of a novel family of arrestin-like proteins in the intracellular trafficking and signalling of G protein-coupled receptors Biochemistry, Cell Biology, Proteomics GPCPR, proteasome, protein sorting and trafficking, arrestin, receptor-mediated endocytosis, gankyrin, hepatocellular carcinoma, NFkB, HECT-family ubiquitin ligases
Dr Simon Dawson Role of a novel family of arrestin-like proteins in the intracellular trafficking and signalling of G protein-coupled receptors Biochemistry, Cell Biology, Proteomics, Pharmacology ubiquitin, proteasome, protein sorting and trafficking, arrestin, receptor-mediated endocytosis, gankyrin, hepatocellular carcinoma, NFkB, HECT-family ubiquitin ligases
Dr William Dunn Anatomical and physiological characterisation of nerves in porcine blood vessels Human Physiology, Human Anatomy, Cell Biology, Diabetes vascular smooth muscle, sympathetic nerves, endothelium, nitric oxide, EDHF, hydrogen sulphide, noradrenaline, ATP, adrenoceptors, purinoceptors, myogenic tone
Dr William Dunn Cell signalling in small arteries in normal and diseased states Biochemistry, Cell Biology, Cancer vascular smooth muscle, sympathetic nerves, endothelium, nitric oxide, EDHF, hydrogen sulphide, noradrenaline, ATP, adrenoceptors, purinoceptors, myogenic tone
Dr William Dunn Sympatheitic neurotransmission in the rat mesenteric vascular bed vascular smooth muscle, sympathetic nerves, endothelium, nitric oxide, EDHF, hydrogen sulphide, noradrenaline, ATP, adrenoceptors, purinoceptors, myogenic tone
Dr William Dunn Vascular effects of hydrogen sulphide Physiology, Pharmacology vascular smooth muscle, sympathetic nerves, endothelium, nitric oxide, EDHF, hydrogen sulphide, noradrenaline, ATP, adrenoceptors, purinoceptors, myogenic tone
Dr William Dunn Endothelial function in veins Physiology, Pharmacology vascular smooth muscle, sympathetic nerves, endothelium, nitric oxide, EDHF, hydrogen sulphide, noradrenaline, ATP, adrenoceptors, purinoceptors, myogenic tone
Professor Francis Ebling The contribution of endocannabinoid hydrolyzing enzymes to endocannabinoid turnover and function Neuroscience, Molecular Pharmacology food intake, body weight, seasonal rhythms, hypothalamus, energy balance
Professor Francis Ebling The role of thyroid hormone in the control of appetite and body weight Neuroscience, Metabolism, Behaviour food intake, body weight, seasonal rhythms, hypothalamus, energy balance
Professor Francis Ebling The effects of FGF21 on food intake, energy emetabolism and body weight Neuroscience, Metabolism, Behaviour food intake, body weight, seasonal rhythms, hypothalamus, energy balance
Professor Kevin Fone Evaluation of a new rodent model of schizophrenia Neuroscience, Cognition, Neuropharmacology, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Evaluation of functional role of trace amines in the rat CNS Neuroscience, Cognition, Neuropharmacology, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Molecular basis of cognition in pharmacological, behavioural and proteomic changes Neuroscience, Cognition, Neuropharmacology, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Changes in glutamatergic neuronal function in a social isolation animal model of schizophrenia Neuroscience, Cognition, Neuropharmacology, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Effects of endocannabinoids and an evaluation of isolation rearing in rats Neuroscience, Cognition, Neuropharmacology, Neurodegeneration, Behaviour animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Methylazoxymethnol (MAM) in behavioural studies in vivo Neuroscience, Cognition, Neuropharmacology, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Effects of MDMA (Ecstasy) on novel object discrimination Neuroscience, Neuropharmacology, Pharmacology animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Identifying hippocampal protein expression accompanying learning and memory Neuroscience, Pain Biology, Neuropharmacology animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Stress and depression: involvement of the citoskeletal microtubular system Biochemistry, Proteomics, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone The impact of social isolation on rat behaviour Biochemistry, Proteomics, Neurodegeneration animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Professor Kevin Fone Phencyclidine animal models of schizophrenia Neuroscience, Neurodegeneration, Neuropharmacology animal models of CNS disorders, schizophrenia, depression, ADHD, cognitive disorders, in vivo neuropharmacology, serotonin
Dr Jeffery Fry Investigation of cytoprotective properties of extracts of some medicinal plants Toxicology antioxidants, cytoprotection, oxidative stress, drug metabolism, cytotoxicity
Dr Jeffery Fry Influence of heavy metal exposure on cellular expression of heat shock proteins Neuroscience, Pain Biology, Neuropharmacology antioxidants, cytoprotection, oxidative stress, drug metabolism, cytotoxicity
Dr Jeffery Fry Recombinant expression of the aryl hydrocarbon receptor Human Physiology, Obesity, Diabetes, Human Nutrition, Cardiovascular Function antioxidants, cytoprotection, oxidative stress, drug metabolism, cytotoxicity
Dr Marios Georgiou Understanding the genesis of cell shape during terminal differentiation in Drosophila Cell biology, Genetics Cell morphogenesis, Actin, Polarity, Protrusion dynamics, In vivo imaging, cell signalling, trafficking, differentiation, development, Drosophila, Genetics
Dr Marios Georgiou Development and function of neuronal morphologies in the Drosophila brain Cell biology, Neurobiology Cell morphogenesis, Actin, Neurons, CNS, Polarity, Connectivity, Neuronal function, Optic lobe, Drosophila, in vivo imaging
Dr Marios Georgiou A screen for lethal and conditional lethal mutations that perturb cell morphogenesis Cell biology, Genetics Cell morphogenesis, Mutagenesis, Genetics, Screen, temperature sensitive, Drosophila
Dr Marios Georgiou Defining the morphological events that accompany tumour progression and invasion Cell biology, Cancer, Genetics Cell morphogenesis, Invasion, Metastasis, tumour progression, EMT, tumour model system, epithelia, Drosophila, Genetics, in vivo imaging
Dr Marios Georgiou A candidate screen to identify genes that promote or inhibit tumour progression and invasion Cell biology, Cancer, Genetics Cell morphogenesis, Invasion, Metastasis, tumour progression, EMT, tumour model system, epithelia, Drosophila, Genetics, in vivo imaging, Screen
Professor Paul Greenhaff Characterization of an in vivo skeletal muscle function assay applied to longitundinal studies of muscle degeneration and recovery Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Involvement of pyruvate dehydrogenase complex in sepsis (mitochondria) and fatigue development Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff The central role of FOXO in muscle protein loss and insulin resistance Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Effects of high molecular weight glucose polymer on exercise metabolism in humans Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Studies into peripheral arterial disease, intervention and therapeutic manipulation Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Resistance training in geriatric subjects Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff The role of muscle carnitine availability in the regulation of fat and carbohydrate oxidation in skeletal muscle Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff The activation of satellite cells in skeletal muscle during adaptation to altered load Physiology, Human Physiology, Muscle Metabolism, Bioinformatics, Human Anatomy muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Molecular regulation of the skeletal muscle atrophy programme Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Carnitine metabolism in muscle Cognition, Neuroanatomy muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff The Role of Pyruvate Dehydrogenase Complex in Regulating Skeletal Muscle and Myocardian Fuel Metabolism During Sepsis Toxicology muscle metabolism, muscle function, muscle atrophy, muscle growth
Professor Paul Greenhaff Effects of nutrients and exercise on the molecular regulation of skeletal muscle protein synthesis and degradation in healthy humans Human Physiology, Human Anatomy, Cell Biology, Diabetes muscle metabolism, muscle function, muscle atrophy, muscle growth
Dr Gareth Hathway Dissecting the complex roles of peripheral sensory afferent input and supraspinal influences in osteoarthritic pain Pain biology, Neuroscience pain, arthritis, behaviour, electrophysiology
Dr Gareth Hathway The development of supraspinal pain control systems Pain biology, Neuroscience pain, brain, spinal cord, electrophysiology, immunohistochemistry, development, opiods, cannabinoids
Professor Stephen Hill Fluorescent H1 ligand bindings Pharmacology, Molecular Pharmacology GPCR , cell signalling
Professor Stephen Hill Design and synthesis of novel fluorescent Ligands for the A1-Adenosine Receptor Biochemistry, Cell Biology, Cancer GPCR , cell signalling
Professor Stephen Hill Exploring the function of neuropeptide Y receptor dimers by bimolecular fluorescence complementation. Molecular pharmacology G protein coupled receptors, obesity, neuropeptides, intracellular trafficking, cell signalling, molecular pharmacology, high content imaging, arrestin
Dr Nicholas Holliday Biophysical analysis of ligand-receptor interactions at free fatty acid receptors Molecular pharmacology ligand, receptor, cell signalling, molecular pharmacology
Dr Nick Holliday Role of a novel family of arrestin-like proteins in the intracellular trafficking and signalling of G protein-coupled receptors Biochemistry, Cell Biology, Proteomics, Pharmacology ubiquitin, proteasome, protein sorting and trafficking, arrestin, receptor-mediated endocytosis, gankyrin, hepatocellular carcinoma, NFkB, HECT-family ubiquitin ligases
Dr Nick Holliday Exploring the function of neuropeptide Y receptor dimers by bimolecular fluorescence complementation. Molecular pharmacology G protein coupled receptors, obesity, neuropeptides, intracellular trafficking, cell signalling, molecular pharmacology, high content imaging, arrestin
Dr Alistair Hume Regulation of organelle motility by molecular motors and small GTPases Cell biology Intracellular trafficking, Rab GTPases, kinesin, dynein, melanosome, live cell imaging and analysis, live cell imaging and analysis
Dr Alistair Hume Development of protein-based inhibitors of Rab GTPase regulated intracellular transport Cell biology, Molecular Medicine Intracellular trafficking, Rab27, inflammation, pigmentation
Dr Peter Jones Blood Brain barrier and drug delivery Biochemistry, Cell Biology signal transduction, transcription regulation, cell adhesion and migration
Dr Peter Jones Gene regulation and survival in cardiomyctes following hypoxia Biochemistry, Cell Biology, Proteomics, Cancer signal transduction, transcription regulation, cell adhesion and migration
Dr Peter Jones Tyrosine phosphorylation during osteoblast adhesion to biomaterial surfaces signal transduction, transcription regulation, cell adhesion and migration
Professor David Kendall Modelling depression in post-partum mice Neuroscience, Neuropharmacology, Pharmacology stress-related mental disorders, animal models, Alzheimer's disease, cognition
Professor David Kendall Effects of endocannabinoids on behaviour in normal and psychotic rats Neuroscience, Neuropharmacology, Pharmacology endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Corticosterone in reward and stress behaviour in mice Neuroscience, Neuropharmacology, Pharmacology endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Cannabinoids and neuropathic pain Neuroscience, Neuropharmacology, Pharmacology endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Neuropharmacology and degenerative disease Neuroscience, Neuropharmacology, Pharmacology endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Effects of endocannabinoids and an evaluation of isolation rearing in rats Neuroscience, Neuropharmacology, Pharmacology, Behaiour endocannabinoid, cannabinoid, antidepressant
Professor David Kendall The role of endocannabinoids in Alzheimer's Disease using a transgenic mouse model Neuroscience, Neuropharmacology, Pharmacology, Neurodegeneration endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Control of calcium signalling in sensory nerve in vitro Neuroscience, Pain Biology, Neuropharmacology pain mechanisms, analgesics, spinal cord, neuronal responses, behavioural studies, cannabinoid receptors
Professor David Kendall Studies of neurodegenerative diseases Physiology, Obesity, Diabetes endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Measurement of endocannabinoids in biological systems Pharmacology, Molecular Pharmacology endocannabinoid, cannabinoid, antidepressant
Professor David Kendall Behavioural and Cognitive Effect of 9-THG Biochemistry, Cell Biology, Proteomics endocannabinoid, cannabinoid, antidepressant
Professor David Kendall The role of the noradrenergic system in cognition and neuroinflammation Physiology, Human Physiology, Muscle Metabolism endocannabinoid, cannabinoid, antidepressant
Dr Ian Kerr Purification and functional studies of the plant auxin transporter AUX1 Biochemistry, Cell Biology membrane proteins, transport, ABC proteins, drug resistance, protein purification, cancer, auxin
Dr Ian Kerr ABC-proteins and antibiotic resistance: ribosome protection or transport Biochemistry, Cell Biology, Proteomics membrane proteins, transport, ABC proteins, drug resistance, protein purification, cancer, auxin
Dr Ian Kerr Structure and function of ABCG2 Biochemistry, Cell Biology, Proteomics membrane proteins, transport, ABC proteins, drug resistance, protein purification, cancer, auxin
Dr Robert Layfield Gene mutation and its effect in Paget's Bone Disease Biochemistry, Cell Biology, Genetics ubiquitin, proteasome, Paget's disease, bone, muscle atrophy, neurodegeneration
Dr Robert Layfield UBA domain mutations of P62 and Paget's disease of bone Biochemistry, Proteomics ubiquitin, proteasome, Paget's disease, bone, muscle atrophy, neurodegeneration
Dr Lopa Leach Vascular dysfunction in the human diabetic placenta Neuroscience, Neuropharmacology, Pharmacology angiogenesis, vascular permeability, junctional adhesion molecules, blood retinal barrier, human placenta, diabetes, gestational diabetes and pre-eclampsia
Dr Lopa Leach An investigation into mechanisms inhibiting human microvascular endothelial cell (HMEC-1) capillary cord formation on collagen type 1 Pharmacology, Molecular Pharmacology angiogenesis, vascular permeability, junctional adhesion molecules, blood retinal barrier, human placenta, diabetes, gestational diabetes and pre-eclampsia
Dr Lopa Leach Establishment and characterisation of an in-vitro model for the outer blood-retina barrier Physiology, Human Physiology, Muscle Metabolism angiogenesis, vascular permeability, junctional adhesion molecules, blood retinal barrier, human placenta, diabetes, gestational diabetes and pre-eclampsia
Dr Lopa Leach Regulation of angiogenesis by ß-catenin in normal and Type 1 diabetic placenta Physiology, Human Physiology, Muscle Metabolism angiogenesis, vascular permeability, junctional adhesion molecules, blood retinal barrier, human placenta, diabetes, gestational diabetes and pre-eclampsia
Dr Siobhan Loughna GATA, TVX gene expression in cardiac development Genetics, Cell Biology heart development, cardiovascular development, congenital heart defects, knockdown, gene expression, gene function, chick, structural proteins, transcription factors
Dr Siobhan Loughna Role of SRF cleavage in apoptosis following hypoxia in cardiomyctes Physiology, Pharmacology heart development, cardiovascular development, congenital heart defects, knockdown, gene expression, gene function, chick, structural proteins, transcription factors
Dr Siobhan Loughna Structural Proteins in Heart Development Cell Biology, Cardiovascular Function, Genetics heart development, cardiovascular development, congenital heart defects, knockdown, gene expression, gene function, chick, structural proteins, transcription factors
Dr Siobhan Loughna BNF knockdown in the chick heart - a model for cardiac fibrosis? Cell Biology, Cardiovascular Function, Genetics As above
Dr Siobhan Loughna The role of Sox genes in the developing cardiovascular system Cell Biology, Cardiovascular Function, Genetics As above
Professor Ian Macdonald Analysis of the molecular mechanisms involved in the pathogenesis of NASH/NAFLD Biochemistry, Molecular biology, Liver disease Molecular signalling pathways, pathogenesis
Professor Ian Macdonald Factors influencing the initiation and termination of eating Human Physiology, Obesity, Diabetes, Human Nutrition, Cardiovascular Function human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Effects of high molecular weight glucose polymer on exercise metabolism in humans Human Physiology, Obesity, Diabetes, Human Nutrition, Cardiovascular Function human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Liver fat metabolism and diabetes Human Physiology, Diabetes, Liver disease human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Biomarkers response to oral and enteral nutrition Human Physiology, Human Nutrition human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Hypertension/Diabetes/CVS Human Physiology, Diabetes, Hypertension, Cardiovascular function human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Resistance training in geriatric subjects Physiology, Human Physiology, Muscle Metabolism muscle metabolism, muscle function, muscle atrophy, muscle growth, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald The role of the autonomic nervous system in cardiovascular and metabolic health in adolescence Human Physiology, Metabolism human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity, diabetes, exercise, cardiovascular function
Professor Ian Macdonald Metabolic effects of flavanoids Physiology, Diabetes insulin resistance, body fat content, inflammatory markers, plasma lipids
Professor Ian Macdonald Dietary influences on thermogenesis Physiology, Diabetes energy expenditure, macronutrient metabolism, thermogenic agents
Dr Rob Mason Descending auditory system in the guinea pig Neuroscience, Electrophysiology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Rob Mason Neural correlates of sound detection Behaviour, Electrophysiology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Rob Mason Cannabinoid modulation of neuronal ensemble excitability in the rat brain Neuroscience, Electrophysiology, Neuropharmacology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Rob Mason Electrohysiological response characteristics of guinea pig auditory cortex to simple stimuli and conspecific communication calls Neuroscience, Electrophysiology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Rob Mason Sensory Gating in the Hippocampus and the medial Prefrontal Cortex Neuroscience, Electrophysiology, Neuropharmacology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Rob Mason Effects of Inactivating Auditory Cortex upon the Responses of MGB Neurons in the Guinea Pig Neuroscience, Electrophysiology neuronal networks, neuronal ensemble recording, computational neuroscience, schizophrenia, sensory gating, endocannabinoid, epilepsy
Dr Marie-Christine Pardon Modelling depression in post-partum mice Neuroscience, Neurodegeneration, Cognition stress-related mental disorders, animal models, Alzheimer's disease, cognition
Dr Marie-Christine Pardon Corticosterone in reward and stress behaviour in mice Neuroscience, Neurodegeneration, Cognition stress-related mental disorders, animal models, Alzheimer's disease, cognition
Dr Marie-Christine Pardon The role of endocannabinoids in Alzheimer's Disease using a transgenic mouse model Neuroscience, Neurodegeneration, Neuropharmacology, Neurodegeneration stress-related mental disorders, animal models, Alzheimer's disease, cognition
Dr Marie-Christine Pardon Studies of neurodegenerative diseases Neuroscience, Neuropharmacology, Pharmacology stress-related mental disorders, animal models, Alzheimer's disease, cognition
Dr Terry Parker Blood Brain barrier and drug delivery Biochemistry, Cell Biology signal transduction, transcription regulation, cell adhesion and migration
Dr Terry Parker Neural stem cell repair of the ataxic cerebellum: an in-vitro organotypic slice culture model Physiology, Pharmacology , stem cell, neurones, ataxia
Dr Margaret Pratten Teratogens and cardiomyocytes Human Anatomy Teratogens, cardiomyctes
Dr Margaret Pratten Chick micromass and D3 stem cell assays for embryotoxicity prediction: Development and Evaluation Neuroscience, Neuropharmacology, Pharmacology stem cell, embryotoxicity
Dr Margaret Pratten Structural Proteins in Heart Development Cell Biology, Cardiovascular Function, Genetics
Dr Vera Ralevic Acyl derivatives of co-enzyme A as novel endogenous antagonists of vascular P2Y1 purine receptors Physiology, Pharmacology Purines, P2 receptors, cannabinoids, sympathetic nerves, sensory nerves, autonomic nervous system, blood vessel contractility, endothelium
Dr Vera Ralevic Anatomical and physiological characterisation of nerves in porcine blood vessels Physiology, Pharmacology Purines, P2 receptors, cannabinoids, sympathetic nerves, sensory nerves, autonomic nervous system, blood vessel contractility, endothelium, hypertension, myography, cannabinoids
Dr Vera Ralevic Sympatheitic neurotransmission in the rat mesenteric vascular bed Purines, P2 receptors, cannabinoids, sympathetic nerves, sensory nerves, autonomic nervous system, blood vessel contractility, endothelium
Dr Michael Randall Role of endogenous cannabinoids in regulation of insulin secretion Physiology, Diabetes insulin secretion, insulin resistance, diabetes/obesity, islet of Langerhans, adipocyte, cell signalling
Dr Richard Roberts Regulation of vascular tone by intracellular signal transduction pathways Human Physiology, Obesity, Diabetes, Human Nutrition, Cardiovascular Function GPCR signalling, nuclear receptor activation, endocannabinoid turnover, endocannabinoid transport
Dr Tyson Sharp The role of the LIM domain protein LIMD1 as a novel and critical regulator of the hypoxic response: a mechanistic investigation Biochemistry, Cell Biology, Cancer LIMD1, cancer, tumor suppressor
Dr Tyson Sharp LIMD1 has a role in the hypoxic response Biochemistry, Cell Biology, Cancer LIMD1, cancer, tumor suppressor
Dr Tyson Sharp Control of LIMD1 and its involvement in human lung tumours Biochemistry, Cell Biology, Cancer LIMD1, cancer, tumor suppressor
Dr Tyson Sharp LIMD1 & lung cancer Neuroscience LIMD1, cancer, tumor suppressor
Dr Tyson Sharp Structure & function of novel tumour suppressor gene LIMD1 and its involvement in lung cancer development Biochemistry, Proteomics, Neurodegeneration LIMD1, cancer, tumor suppressor
Professor Peter Shaw Nucleocytoplasmic transport of STAT1 and STAT3 proteins and their molecular mechanism Biochemistry, Cell Biology, Cancer, Proteomics STAT 3, gene expression, reactive oxygen species, protein oxidation, cancer
Professor Peter Shaw Gene regulation and survival in cardiomyctes following hypoxia Biochemistry, Cell Biology, Cancer, Proteomics STAT 3, gene expression, reactive oxygen species, protein oxidation, cancer
Professor Peter Shaw Redox sensitivity of STAT3 and its role in the survival of cardiomycytes during hypoxia/oxidative stress Biochemistry, Cell Biology, Proteomics STAT 3, gene expression, reactive oxygen species, protein oxidation, cancer
Professor Peter Shaw Role of SRF cleavage in apoptosis following hypoxia in cardiomyctes Cell Biology, Cardiovascular Function, Genetics STAT 3, gene expression, reactive oxygen species, protein oxidation, cancer
Professor Peter Shaw The Regulation of STAT3 Transcriptional Activity by Reactive Oxygen Species Biochemistry, Proteomics STAT 3, gene expression, reactive oxygen species, protein oxidation, cancer
Dr Paul Smith Exploration into the molecular mechanisms of insulin resistance Physiology, Diabetes electrophysiology, patch clamp, fluorimetry, adipocyte, beta-cell, antidepressant, somatostatin, mitochondria, ion channels, diabetes, obesity
Dr Paul Smith Molecular pharmacology and insulin signalling Physiology, Diabetes electrophysiology, patch clamp, fluorimetry, adipocyte, beta-cell, antidepressant, somatostatin, mitochondria, ion channels, diabetes, obesity
Dr Paul Smith Cell signalling in small arteries in normal and diseased states Biochemistry, Cell Biology, Cancer, Proteomics electrophysiology, patch clamp, fluorimetry, adipocyte, beta-cell, antidepressant, somatostatin, mitochondria, ion channels, diabetes, obesity
Dr Paul Smith Roles of calcium in adipocyte cell function Physiology, Pharmacology electrophysiology, patch clamp, fluorimetry, adipocyte, beta-cell, antidepressant, somatostatin, mitochondria, ion channels, diabetes, obesity, hypertension, myography, cannabinoids
Dr Moira Taylor Comparison of the integrated cardiovascular effects of acute ingestion of apple derived flavanols and statins in healthy volunteers Physiology, Nutrition flavanols, cardiovascular
Dr Moira Taylor Flavinoids and vascular smooth muscle function Physiology, Pharmacology Flavinoids, smooth muscle, metabolism
Dr Moira Taylor Factors influencing the initiation and termination of eating Nutrition, Behaviour human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity
Dr Moira Taylor Biomarkers response to oral and enteral nutrition Nutrition, Human Physiology human metabolism, energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity
Dr Kostas Tsintzas Liver fat metabolism and diabetes Human Physiology, Diabetes, Liver disease energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity
Dr Kostas Tsintzas Effects of gene-environment interactions of diet-induced obesity and associated hypertension Human Physiology, Diabetes energy metabolism, fat metabolism, carbohydrate metabolism, insulin resistance, obesity
Dr Kostas Tsintzas Molecular basis of insulin action in health and type 2 diabetes Human Physiology, Diabetes Molecular signalling pathways, insulin resistance, diabetes
Professor Uwe Vinkemeier Nucleocytoplasmic transport of STAT1 and STAT3 proteins and their molecular mechanism Biochemistry, Cell Biology, Proteomics STATs, cellullar signal processing, transcription
Professor Uwe Vinkemeier Redox sensitivity of STAT3 and its role in the survival of cardiomycytes during hypoxia/oxidative stress Biochemistry, Cell Biology, Proteomics STATs, cellullar signal processing, transcription
Professor Uwe Vinkemeier The Regulation of STAT3 Transcriptional Activity by Reactive Oxygen Species Biochemistry, Proteomics STATs, cellullar signal processing, transcription
Dr Peter Wigmore Teratogens and cardiomyocytes Human Anatomy Teratogens, cardiomyctes, adult neurogenesis, notch signalling, action of chemotherapy on the brain, in vitro models of stem cell proliferation, skeletal muscle development
Dr Peter Wigmore Effects of anti-cancer drugs on memory and cognition in the rat brain Cognition, Neuroanatomy cognition, animal models of memory, adult neurogenesis, notch signalling, action of chemotherapy on the brain, in vitro models of stem cell proliferation, skeletal muscle development
Dr Peter Wigmore Chemotherapy on cognition in animal models Cognition, Neuroanatomy cognition, animal models of memory, adult neurogenesis, notch signalling, action of chemotherapy on the brain, in vitro models of stem cell proliferation, skeletal muscle development
Dr Peter Wigmore The control of adult neural stem cell proliferartion by valproic acid and notch signalling Neuroscience cognition, animal models of memory, adult neurogenesis, notch signalling, action of chemotherapy on the brain, in vitro models of stem cell proliferation, skeletal muscle development
Dr Peter Wigmore Modelling the cognitive and cellular effects of chemotherapy in the adult hippocampus Human Physiology, Human Anatomy, Cell Biology, Diabetes cognition, animal models of memory, adult neurogenesis, notch signalling, action of chemotherapy on the brain, in vitro models of stem cell proliferation, skeletal muscle development
Dr Vince Wilson Comparison of the integrated cardiovascular effects of acute ingestion of apple derived flavanols and statins in healthy volunteers Physiology, Nutrition flavanols, cardiovascular
Dr Vince Wilson Flavinoids and vascular smooth muscle function Physiology, Pharmacology Flavinoids, smooth muscle, metabolism
Dr Vince Wilson Manipulation of cellular cholesterol and cholesterol ester content by methyl-ß-cyclodextrin in the porcine isolated coronary artery: effects on contractile function and smooth muscle caveolae Physiology, Pharmacology cholesterol, cholesterol, nutrition

 

School of Biomedical Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham, NG7 2UH

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