The Importance of Research in Cell Signalling
Molecular interactions between drugs and their cellular targets lie at the heart of both therapeutic and unwanted effects. Drugs bind receptors to change the physiological response to hormones or neurotransmitters, by altering downstream signalling pathways and, therefore, cell behaviour. Cell membrane transporters efficiently regulate drug concentration, and play a key role in determining resistance, for example to anti-cancer agents.
Our Research Interests in Cell Signalling
The goals of the CS group are to increase understanding of the fundamental mechanisms underlying drug-receptor interactions – receptor signalling and drug export – fields which continually provide advances for pharmacology and drug design. In addition to a full range of biochemical and pharmacological techniques, we have particularly strong expertise in the use of biophysical and high content imaging approaches to study drug and receptor behaviour at the single cell level. We also benefit from our existing academic and industrial collaborations, and welcome new opportunities in this regard.
For more information, please email Professor Steve Hill .
See research degree opportunities related to this group .
See confocal imaging and other services for details of our technical facilities.
- Traffic; Tarafder, A.K., Wasmeier, C., Figueiredo, A.C., Booth, A.E., Orihara, A., Ramalho, J.S., Hume, A.N., and Seabra, M.C.
- J Biol Chem; Sivertsen, B., Lang, M., Frimurer, T.M., Holliday, N.D., Bach, A., Els, S., Engelstoft, M.S., Petersen, P.S., Madsen, A.N., Schwartz, T.W., Beck-Sickinger, A.G., and Holst, B.
- Plant Physiol; De Smet, I., Voss, U., Lau, S., Wilson, M., Shao, N., Timme, R., Swarup, R., Kerr, I., Hodgman, C., Bock, R., Bennett, M., Jurgens, G., and Beeckman, T.
- Methods Mol Biol; Briddon, S.J., Kellam, B., and Hill, S.J.