Centre for Cancer Sciences
 

Neil Oldham

Professor of Biomolecular Mass Spectrometry, Faculty of Science

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Research Summary

My research focuses on the application of mass spectrometry in solving biological problems. Of particular interest is the study of non-covalent protein-ligand and protein-protein interactions by… read more

Selected Publications

  • MANZI, LUCIO, BARROW, ANDREW S., SCOTT, DANIEL, LAYFIELD, ROBERT, WRIGHT, TIMOTHY G., MOSES, JOHN E. and OLDHAM, NEIL J., 2016. Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions NATURE COMMUNICATIONS. 7,
  • MANZI, LUCIO, BARROW, ANDREW S., HOPPER, JONATHAN T. S., KAMINSKA, RENATA, KLEANTHOUS, COLIN, ROBINSON, CAROL V., MOSES, JOHN E. and OLDHAM, NEIL J., 2017. Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 56(47), 14873-14877
  • JENNER, MATTHEW, KOSOL, SIMONE, GRIFFITHS, DANIEL, PRASONGPHOLCHAI, PANWARD, MANZI, LUCIO, BARROW, ANDREW S., MOSES, JOHN E., OLDHAM, NEIL J., LEWANDOWSKI, JOZEF R. and CHALLIS, GREGORY L., 2018. Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases NATURE CHEMICAL BIOLOGY. 14(3), 270-+
  • KOSOL, SIMONE, GALLO, ANGELO, GRIFFITHS, DANIEL, VALENTIC, TIMOTHY R., MASSCHELEIN, JOLEEN, JENNER, MATTHEW, DE LOS SANTOS, EMMANUEL L. C., MANZI, LUCIO, SYDORL, PAULINA K., REA, DEAN, ZHOU, SHANSHAN, FULOP, VILMOS, OLDHAM, NEIL J., TSAI, SHIOU-CHUAN, CHALLIS, GREGORY L. and LEWANDOWSKI, JOZEF R., 2019. Structural basis for chain release from the enacyloxin polyketide synthase NATURE CHEMISTRY. 11(10), 913-923

Current Research

My research focuses on the application of mass spectrometry in solving biological problems. Of particular interest is the study of non-covalent protein-ligand and protein-protein interactions by electrospray-mass spectrometry, ion mobility spectroscopy, cross linking, and hydrogen-deuterium exchange.

Centre for Cancer Sciences

The University of Nottingham
Centre for Biomolecular Sciences
Nottingham, NG7 2RD


telephone: +44 (0) 115 823 1546
email: MS-CCS@nottingham.ac.uk