Institute of Genetics

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Alistair Chambers

Overview Research Publications Opportunities

Lecturer (Institute Member)

Room: B62 (Biology Building)

Address: Institute of Genetics, The University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK

Tel: +44 (0)115 823 0344 (int 30344)
Fax: 0115 951 3252
Email: Alistair.Chambers@nottingham.ac.uk

Research Overview: Telomeres and telomere proteins in fission yeast

Telomeres are the ends of eukaryotic chromosomes. They perform key roles in protecting the genome from degradation and preventing inappropriate DNA damage responses. In mammalian cells, processes involving the telomeres are central to cellular ageing and the development of cancer. We are using fission yeast as a model system to study the functions of telomeres, focusing particularly on the proteins that interact with the telomere DNA.

Education, appointments and honours

BSc University of Durham 1983; PhD University of Warwick 1987, Postdoctoral Researcher, University of Oxford 1986-90, Lecturer, University of Nottingham 1990.

Selected Publications

  • SPINK, K., HO, J.C.Y., TANAKA, K., WATTS, F.Z. and CHAMBERS, A., 2005. The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast. Biochemical Genetics, 43(3-4), 103-117.
  • MIZUNO, T., KISHIMOTO, T., SHINZATO, T., HAW, R., CHAMBERS, A., WOOD, J., SINCLAIR, D. and UEMURA, H., 2004. Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. Yeast, 21(10), 851-866.
  • YU, L., SABET, N., CHAMBERS, A. and MORSE, R.H., 2001. The N-terminal and C-terminal domains of RAP1 are dispensable for chromatin opening and GCN4-mediated HIS4 activation in budding yeast. Journal of Biological Chemistry, 276(35), 33257-33264.
  • SPINK, K. G., EVANS, R. J. and CHAMBERS, A., 2000. Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA. Nucleic Acids Research, 28(2), 527-533.
  • GRAHAM, L. R. and CHAMBERS, A., 1997. Constitutive Expression Vectors: PGK. Methods in Molecular Biology, 62, 159-172.
  • CHAMBERS,A., 1996. Highly conserved toxicity of Saccharomyces cerevisiae Rap1p. Molecular Microbiology, 22(3), 449-458.
  • DUFFY, M. and CHAMBERS, A., 1996. DNA-protein interactions at the telomeric repeats of Schizosaccharomyces pombe. Nucleic Acids Research, 24(8), 1412-1419.

Ivan Yuan MRes Student +44 (0)115 955 5151
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