Ed Louis

Contact

• workRoom D115 Genetics
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 0375
• fax0115 823 1140
• ed.louis@nottingham.ac.uk
• www.nottingham.ac.uk/genetics/louis

Biography

BSc in Biology and Mathematics, Clarkson University 1981; PhD in Genetics, University of California at Berkeley 1986 (National Science Foundation Scholarship; American Cancer Society Postdoctoral Research Fellow, Brandeis University 1986-1991; Wellcome Trust Senior Research Fellow, Institute of Molecular Medicine, Oxford 1991-1998; Lecturer and Tutorial Fellow, Dept. of Biochemistry and Corpus Christi College, Oxford 1998-2000; Professor of Genetics, University of Leicester 2000-2005; Professor of Genome Dynamics, University of Nottingham 2005- current. Royal Society Wolfson Research Merit Award 2008. Fellow of the Society of Biology 2009.

Research Summary

​Work in progress

The overall research theme in the lab has been genome dynamics and evolution with a particular interest in telomeres and subtelomeres in Saccharomyces yeasts. This has led to the description of new yeast species, mechanisms of speciation, the genetic structure of yeast populations and species and the complex genetic architecture underlying complex traits through QTL analysis. The study of the rapid dynamics of telomere regions has led to the study of subtelomere dynamics and its control, telomere position effect in natural chromosome ends, and the mechanisms and control of telomeres without telomerase. Along the way various tools and resources have been developed to aid in the cloning and analysis of telomeres and subtelomeres and these have been applied to various parasites (Trypanosoma brucei and Plasmodium falciparum) in addition to budding yeasts. Specific programmes of research are as follows:

Population genomics and genome evolution: We have had a long-standing interest in genome evolution, speciation and natural variation in Saccharomyces yeasts. Previous research has determined that chromosomal rearrangements do not correlate with speciation events in Saccharomyces. Research by a former student, Duncan Greig rules out most possible major gene differences ala Dobzhansky-Muller incompatibilities. Our studies support a role for the accumulation of sequence divergence and the action of the mismatch repair system as a major component of postzygotic reproductive isolation in Saccharomyces sensu stricto yeast leading to speciation. Recent work has determined the population structure of S. cerevisiae, our oldest friend, and its closest relative S. paradoxus, the wild cousin rarely if ever used in human fermentation. The major observations are that there is greater genetic variation in S. paradoxus than S. cerevisiae yet more phenotypic variation in S. cerevisiae. S. paradoxus consists of several well defined populations separated on geographic boundaries while S. cerevisiae is composed of several clean populations/lineages and several mosaic strains that are recent outcrosses of the clean populations. Human activity appears to have provided the opportunity for outcrossing rather than imposed selection leading to domestication. This outcrossing may explain in part the greater phenotypic diversity.

Quantitative trait loci underlying phenotypic variation: The genetic analysis of yeast populations and the phenotypic characterization of all strains sequenced provided an unprecedented opportunity for advanced QTL analysis of complex traits in yeast.

Telomeres, genome dynamics and evolution: Telomeres and telomere associated sequences (subtelomeres) are dynamic and highly polymorphic in virtually all linear chromosomes. They are associated with genome stability over all as well as in ageing, cancer, pathogenicity and evolution. We study the structure, function and dynamics of these sequences in the yeast S. cerevisiae at several levels. In addition we study genome evolution and speciation in yeasts and telomeres in parasites.

The main theme of research has been genome stability with an emphasis on telomeres in the yeast Saccharomyces cerevisiae. Recent work on general genome organisation and evolution, general stability, telomere structure and dynamics and telomere biology can be found on the following pages.

• The subtelomeric regions in yeast are highly polymorphic and dynamic. See Louis and Haber 1990a and b; 1992; Louis et al. 1994; Pryde et al. 1995; Pryde and Louis
• 1997
• Telomere
• and subtelomeric region structure. Sibling species of S. cerevisiae and their Chromosome Evolution. See Naumov et al. 1992; Louis et al. 1994; Naumov et al. 1995 a and b; Naumov et al. 2000; Fischer et al. 2000; Delneri et al. 2003; Liti et al. 2005
• Population Genomics of Saccharomyces yeasts - 1-3X sequence coverage of S. paradoxus and S. cerevisiae isolates.
• Trypanosome Telomere Resource - Cloning telomeres from other organisms using Transformation Associated Recombination. See Becker et al. 2004
• Sibling species of S. cerevisiae and their Chromosome Evolution. See Naumov et al. 1992; Louis et al. 1994; Naumov et al. 1995 a and b; Naumov et al. 2000; Fischer et al. 2000; Delneri et al. 2003; Liti et al. 2005.

Selected Publications

• LITI, G, CARTER, DM, MOSES, AM, WARRINGER, J, PARTS, L, JAMES, SA, DAVEY, RP, ROBERTS, IN, BURT, A, KOUFOPANOU, V, TSAI, IJ, BERGMAN, CM, BENSASSON, D, O'KELLY, MJT, VAN OUDENAARDEN, A, BARTON, DBH, BAILES, E, BA, ANN, JONES, M, QUAIL, MA, GOODHEAD, I, SIMS, S, SMITH, F, BLOMBERG, A, DURBIN, R and LOUIS, EJ, 2009. Population Genomics Of Domestic And Wild Yeasts Nature. 458(7236), 337-341
• LITI, G, HARICHARAN, S, CUBILLOS, FA, TIERNEY, AL, SHARP, S, BERTUCH, AA, PARTS, L, BAILES, E and LOUIS, EJ, 2009. Segregating Yku80 And Tlc1 Alleles Underlying Natural Variation In Telomere Properties In Wild Yeast Plos Genetics. 5(9), -
• PARTS, L, CUBILLOS, FA, WARRINGER, J, JAIN, K, SALINAS, F, BUMPSTEAD, SJ, MOLIN, M, ZIA, A, SIMPSON, JT, QUAIL, MA, MOSES, A, LOUIS, EJ, DURBIN, R and LITI, G, 2011. Revealing The Genetic Structure Of A Trait By Sequencing A Population Under Selection Genome Research. 21(7), 1131-1138
• CUBILLOS, FRANCISCO A, BILLI, ELEONORA, ZÖRGÖ, ENIKÖ, PARTS, LEOPOLD, FARGIER, PATRICK, OMHOLT, STIG, BLOMBERG, ANDERS, WARRINGER, JONAS, LOUIS, EDWARD J and LITI, GIANNI, 2011. Assessing the complex architecture of polygenic traits in diverged yeast populations. Molecular ecology. 20, 1401–1413

• View all publications

Research Resources

There is a project page for the yeast resequencing project at The Sanger Institute. This lists the strains being sequenced. Half of them have already been sequenced, and there are links to the sequence reads, and the other half are planned to be sequenced in the next couple of months (we have DNA). The strains will be available from the NCYC as well as from the Ed Louis lab.

We also have draft sequences for each strain being sequenced, based on alignments to the reference sequence, and draft SNP calls based on these.The provisional versions of this data are available for download.

A more user friendly multiple alignment and browser is being developed for these sequences and a test version is available here.

I hope that suitable strains are available in the list being sequenced - we are keen for the data to be useful to the yeast community. Please note the data release policy on the web site, which states that we are planning to publish a global description of the project and its systematic analysis, which we hope you will respect.

Other Resources

Telomere and subtelomeric region structure

• WARRINGER, JONAS, ZÖRGÖ, ENIKÖ, CUBILLOS, FRANCISCO A, ZIA, AMIN, GJUVSLAND, ARNE, SIMPSON, JARED T, FORSMARK, ANNABELLE, DURBIN, RICHARD, OMHOLT, STIG W, LOUIS, EDWARD J and LITI, GIANNI, 2011. Trait variation in yeast is defined by population history. PLoS genetics. 7(6), e1002111
• CUBILLOS, FRANCISCO A, BILLI, ELEONORA, ZÖRGÖ, ENIKÖ, PARTS, LEOPOLD, FARGIER, PATRICK, OMHOLT, STIG, BLOMBERG, ANDERS, WARRINGER, JONAS, LOUIS, EDWARD J and LITI, GIANNI, 2011. Assessing the complex architecture of polygenic traits in diverged yeast populations. Molecular ecology. 20, 1401–1413
• GAIDA, ANNETTE, BECKER, MARION M, SCHMID, CHRISTOPH D, BÜHLMANN, TOBIAS, LOUIS, EDWARD J and BECK, HANS-PETER, 2011. Cloning of the Repertoire of Individual Plasmodium falciparum var Genes Using Transformation Associated Recombination (TAR). PloS one. 6(3), e17782
• DUNHAM, MAITREYA J and LOUIS, EDWARD J, 2011. Yeast evolution and ecology meet genomics. EMBO reports. 12(1), 8-10
• PARTS, L, CUBILLOS, FA, WARRINGER, J, JAIN, K, SALINAS, F, BUMPSTEAD, SJ, MOLIN, M, ZIA, A, SIMPSON, JT, QUAIL, MA, MOSES, A, LOUIS, EJ, DURBIN, R and LITI, G, 2011. Revealing The Genetic Structure Of A Trait By Sequencing A Population Under Selection Genome Research. 21(7), 1131-1138
• LOUIS, E. J, CASTRILLO J. I and OLIVER S. G, 2011. Saccharomyces cerevisiae: Gene annotation and Genome variability, state-of-the-art through comparative genomics. In: WALKER, JOHN M., ed., Yeast Systems Biology 31-40
• LOUIS, E. J, 2011. Population genomics and speciation in yeasts Fungal Biology Reviews. 25, 136-142
• IRIZAR, A, YU, Y, REED, SH, LOUIS, EJ and WATERS, R, 2010. Silenced Yeast Chromatin Is Maintained By Sir2 In Preference To Permitting Histone Acetylations For Efficient Ner Nucleic Acids Research. 38(14), 4675-4686
• LITI, G, CARTER, DM, MOSES, AM, WARRINGER, J, PARTS, L, JAMES, SA, DAVEY, RP, ROBERTS, IN, BURT, A, KOUFOPANOU, V, TSAI, IJ, BERGMAN, CM, BENSASSON, D, O'KELLY, MJT, VAN OUDENAARDEN, A, BARTON, DBH, BAILES, E, BA, ANN, JONES, M, QUAIL, MA, GOODHEAD, I, SIMS, S, SMITH, F, BLOMBERG, A, DURBIN, R and LOUIS, EJ, 2009. Population Genomics Of Domestic And Wild Yeasts Nature. 458(7236), 337-341
• LITI, G, HARICHARAN, S, CUBILLOS, FA, TIERNEY, AL, SHARP, S, BERTUCH, AA, PARTS, L, BAILES, E and LOUIS, EJ, 2009. Segregating Yku80 And Tlc1 Alleles Underlying Natural Variation In Telomere Properties In Wild Yeast Plos Genetics. 5(9), -
• CUBILLOS, FA, LOUIS, EJ and LITI, G, 2009. Generation Of A Large Set Of Genetically Tractable Haploid And Diploid Saccharomyces Strains Fems Yeast Research. 9(8), 1217-1225
• LONEY, ER, INGLIS, PW, SHARP, S, PRYDE, FE, KENT, NA, MELLOR, J and LOUIS, EJ, 2009. Repressive And Non-Repressive Chromatin At Native Telomeres In Saccharomyces Cerevisiae Epigenetics & Chromatin. 2, -
• MARVIN, ME, GRIFFIN, CD, EYRE, DE, BARTON, DBH and LOUIS, EJ, 2009. In Saccharomyces Cerevisiae, Yku And Subtelomeric Core X Sequences Repress Homologous Recombination Near Telomeres As Part Of The Same Pathway Genetics. 183(2), 441-451
• MARVIN, ME, BECKER, MM, NOEL, P, HARDY, S, BERTUCH, AA and LOUIS, EJ, 2009. The Association Of Yku With Subtelomeric Core X Sequences Prevents Recombination Involving Telomeric Sequences Genetics. 183(2), 453-467
• LOUIS, EJ, 2009. Evolutionary Genetics Origins Of Reproductive Isolation
• HERTZ-FOWLER, C, FIGUEIREDO, LM, QUAIL, MA, BECKER, M, JACKSON, A, BASON, N, BROOKS, K, CHURCHER, C, FAHKRO, S, GOODHEAD, I, HEATH, P, KARTVELISHVILI, M, MUNGALL, K, HARRIS, D, HAUSER, H, SANDERS, M, SAUNDERS, D, SEEGER, K, SHARP, S, TAYLOR, JE, WALKER, D, WHITE, B, YOUNG, R, CROSS, GAM, RUDENKO, G, BARRY, JD, LOUIS, EJ and BERRIMAN, M, 2008. Telomeric Expression Sites Are Highly Conserved In Trypanosoma Brucei Plos One. 3(10), -e3527
• YOUNG, R, TAYLOR, JE, KURIOKA, A, BECKER, M, LOUIS, EJ and RUDENKO, G, 2008. Isolation And Analysis Of The Genetic Diversity Of Repertoires Of Vsg Expression Site Containing Telomeres From Trypanosoma Brucei Gambiense, T. B. Brucei And T. Equiperdum Bmc Genomics. 9, -
• POPE, G.A and D.A. MACKENZIE, M. DEFERNEZ, M.A. AROSO, L.J. FULLER, F.A. MELLON, W.B. DUNN, M. BROWN, R. GOODACRE, D.B. KELL, M.E. MARVIN, E.J. LOUIS, AND I.N. ROBERTS, 2007. Metabolic footprinting as a tool for discriminating between brewing yeasts. Yeast. 24, 667-669
• CODD, VERYAN, DOLEZEL, DAVID, STEHLIK, JAN, PICCIN, ALBERTO, GARNER, KAREN J, RACEY, SETH N, STRAATMAN, KORNELIS R, LOUIS, EDWARD J, COSTA, RODOLFO, SAUMAN, IVO, KYRIACOU, CHARALAMBOS P and ROSATO, EZIO, 2007. Circadian Rhythm Gene Regulation in the Housefly Musca domestica. Genetics. 177(3), 1539-51
• STRAATMAN, KR and LOUIS, EJ, 2007. Localization Of Telomeres And Telomere-Associated Proteins In Telomerase-Negative Saccharomyces Cerevisiae Chromosome Research. 15(8), 1033-1050
• CODD, V, DOLEZEL, D, STEHLIK, J, PICCIN, A, GARNER, KJ, RACEY, SN, STRAATMAN, KR, LOUIS, EJ, COSTA, R, SAUMAN, I, KYRIACOU, CP and ROSATO, E, 2007. Circadian Rhythm Gene Regulation In The Housefly Musca Domestica Genetics. 177(3), 1539-1551
• LOUIS, EJ, 2007. Evolutionary Genetics - Making The Most Of Redundancy
• LITI, G., BARTON, D.B.H. and LOUIS, E.J., 2006. Sequence diversity, reproductive isolation and species concepts in Saccharomyces. Genetics. 174(2), 839-850
• VASA-NICOTERA, M., BROUILETTE, S., MANGINO, M., THOMPSON, J.R., BRAUND, P., CLEMITSON, J.-R., MASON, A., BODYCOTE, C.L., RALEIGH, S.M., LOUIS, E. and SAMANI, N.J., 2005. Mapping of a major locus that determines telomere length in humans American Journal of Human Genetics. 76(1), 147-151
• LITI, G. and LOUIS, E.J., 2005. Yeast evolution and comparative genomics Annual Review of Microbiology. 59, 135-154
• LOUIS, E.J. and VERSHININ, A.V., 2005. Chromosome ends: different sequences may provide conserved functions BioEssays. 27(7), 685-697
• LITI, G., PERUFFO, A., JAMES, S. A., ROBERTS, I. N. and LOUIS, E. J., 2005. Inferences of evolutionary relationships from a population survey of LTR-retrotransposons and telomeric-associated sequences in the Saccharomyces sensu stricto complex Yeast. VOL 22(NUMB 3), 177-192
• INGLIS, P. W., RIGDEN, D. J., MELLO, L. V., LOUIS, E. J. and VALADARES-INGLIS, M. C., 2005. Monomorphic subtelomeric DNA in the filamentous fungus, Metarhizium anisopliae,contains a RecQ helicase-like gene Molecular Genetics and Genomics. VOL 274(NUMB 1), 79-90
• BECKER, M., AITCHESON, N., BYLES, E., WICKSTEAD, B., LOUIS, E. and RUDENKO, G., 2004. Isolation of the repertoire of <i>VSG</i> expression site containing telomeres of <i>Trypanosoma brucei</i> 427 using transformation-associated recombination in yeast Genome Research. 14(11), 2319-2329
• MOORE, S. P., LITI, G., STEFANISKO, K. M., NYSWANER, K. M., CHANG, C., LOUIS, E. J. and GARFINKEL, D. J., 2004. Analysis of a Ty1-less variant of Saccharomyces paradoxus: the gain and loss of Ty1 elements Yeast. VOL 21(NUMB 8), 649-660
• TALAREK, N., LOUIS, E. J., CULLIN, C. and AIGLE, M., 2004. Developing methods and strains for genetic studies in the Saccharomyces bayanus var. uvarum species Yeast. VOL 21(NUMB 14), 1195-1204
• LITI, G. and LOUIS, E.J., 2003. <i>NEJ1</i> prevents NHEJ-dependent telomere fusions in yeast without telomerase Molecular Cell. 11(5), 1373-1378
• DELNERI, D., COLSON, I., GRAMMENOUDI, S., ROBERTS, I.N., LOUIS, E.J. and OLIVER, S.G., 2003. Engineering evolution to study speciation in yeasts Nature. 422(6927), 68-71
• GREIG, D., TRAVISANO, M., LOUIS, E.J. and BORTS, R.H., 2003. A role for the mismatch repair system during incipient speciation in Saccharomyces Journal of Evolutionary Biology. 16(3), 429-437
• LOUIS, E. J. and BORTS, R. H., 2003. Meiotic Recombination: Too Much of a Good Thing? Current Biology. VOL 13(NUMBER 24), R953-R955
• GREIG, D., LOUIS, E.J., BORTS, R.H. and TRAVISANO, M., 2002. Hybrid speciation in experimental populations of yeast Science. 298(5599), 1773-1775
• GREIG, D, BORTS, RH, LOUIS, EJ and TRAVISANO, M, 2002. Epistasis And Hybrid Sterility In Saccharomyces Proceedings Of The Royal Society B-Biological Sciences. 269(1496), 1167-1171
• LOUIS, EJ, 2002. Are Drosophila Telomeres An Exception Or The Rule?
• HUANG, P.-H., PRYDE, F.E., LESTER, D., MADDISON, R.L., BORTS, R.H., HICKSON, I.D. and LOUIS, E.J., 2001. <i>SGS1</i> is required for telomere elongation in the absence of telomerase Current Biology. 11(2), 125-129
• BISHOP, A J, LOUIS, E J and BORTS, R H, 2000. Minisatellite variants generated in yeast meiosis involve DNA removal during gene conversion. Genetics. 156(1), 7-20
• FISCHER, G, JAMES, S A, ROBERTS, I N, OLIVER, S G and LOUIS, E J, 2000. Chromosomal evolution in Saccharomyces. Nature. 405(6785), 451-4
• DELNERI, D, TOMLIN, G C, WIXON, J L, HUTTER, A, SEFTON, M, LOUIS, E J and OLIVER, S G, 2000. Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system. Gene. 252(1-2), 127-35
• NAUMOV, G I, JAMES, S A, NAUMOVA, E S, LOUIS, E J and ROBERTS, I N, 2000. Three new species in the Saccharomyces sensu stricto complex: Saccharomyces cariocanus, Saccharomyces kudriavzevii and Saccharomyces mikatae. International journal of systematic and evolutionary microbiology. 50 Pt 5, 1931-42
• PRYDE, F E and LOUIS, E J, 1999. Limitations of silencing at native yeast telomeres. EMBO Journal. 18(9), 2538-50
• WANG, X, WATT, P M, BORTS, R H, LOUIS, E J and HICKSON, I D, 1999. The topoisomerase II-associated protein, Pat1p, is required for maintenance of rDNA locus stability in Saccharomyces cerevisiae. Molecular and General Genetics. 261(4-5), 831-40
• GREIG, D, BORTS, R H and LOUIS, E J, 1998. The effect of sex on adaptation to high temperature in heterozygous and homozygous yeast. Proceedings of the Royal Society B: Biological Sciences. 265(1400), 1017-23
• LAROCHE, T, MARTIN, S G, GOTTA, M, GORHAM, H C, PRYDE, F E, LOUIS, E J and GASSER, S M, 1998. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Current Biology. 8(11), 653-6
• HABER, J E and LOUIS, E J, 1998. Minisatellite origins in yeast and humans. Genomics. 48(1), 132-5
• PRYDE, F E and LOUIS, E J, 1997. Saccharomyces cerevisiae telomeres. A review. Biochemistry. Biokhimii͡a. 62(11), 1232-41
• FLINT, J, BATES, G P, CLARK, K, DORMAN, A, WILLINGHAM, D, ROE, B A, MICKLEM, G, HIGGS, D R and LOUIS, E J, 1997. Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains. Human Molecular Genetics. 6(8), 1305-13
• PRYDE, F E, GORHAM, H C and LOUIS, E J, 1997. Chromosome ends: all the same under their caps. Current Opinion in Genetics & Development. 7(6), 822-8
• WANG, X, WATT, P M, LOUIS, E J, BORTS, R H and HICKSON, I D, 1996. Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae. Nucleic Acids Research. 24(23), 4791-7
• CHAMBERS, S R, HUNTER, N, LOUIS, E J and BORTS, R H, 1996. The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome loss. Molecular and Cellular Biology. 16(11), 6110-20
• UNDERWOOD, A P, LOUIS, E J, BORTS, R H, STRINGER, J R and WAKEFIELD, A E, 1996. Pneumocystis carinii telomere repeats are composed of TTAGGG and the subtelomeric sequence contains a gene encoding the major surface glycoprotein. Molecular Microbiology. 19(2), 273-81
• WATT, P M, HICKSON, I D, BORTS, R H and LOUIS, E J, 1996. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics. 144(3), 935-45
• GALIBERT, F, ALEXANDRAKI, D, BAUR, A, BOLES, E, CHALWATZIS, N, CHUAT, J C, COSTER, F, CZIEPLUCH, C, DE HAAN, M, DOMDEY, H, DURAND, P, ENTIAN, K D, GATIUS, M, GOFFEAU, A and GRIVELL,...LOUIS, E J,..., 1996. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO Journal. 15(9), 2031-49
• GOFFEAU, A, BARRELL, B G, BUSSEY, H, DAVIS, R W, DUJON, B, FELDMANN, H, GALIBERT, F, HOHEISEL, J D, JACQ, C, JOHNSTON, M, LOUIS, E J, MEWES, H W, MURAKAMI, Y, PHILIPPSEN, P, TETTELIN, H and OLIVER, S G, 1996. Life with 6000 genes. Science. 274(5287), 546, 563-7
• NAUMOV, G I, NAUMOVA, E S and LOUIS, E J, 1995. Genetic mapping of the alpha-galactosidase MEL gene family on right and left telomeres of Saccharomyces cerevisiae. Yeast. 11(5), 481-3
• WATT, P M, LOUIS, E J, BORTS, R H and HICKSON, I D, 1995. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell. 81(2), 253-60
• LOUIS, E J, 1995. The chromosome ends of Saccharomyces cerevisiae. Yeast. 11(16), 1553-73
• PRYDE, F E, HUCKLE, T C and LOUIS, E J, 1995. Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Yeast. 11(4), 371-82
• ROCQUES, P J, CLARK, J, BALL, S, CREW, J, GILL, S, CHRISTODOULOU, Z, BORTS, R H, LOUIS, E J, DAVIES, K E and COOPER, C S, 1995. The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes. Human Molecular Genetics. 4(2), 243-9
• JOHNSTON, M, ANDREWS, S, BRINKMAN, R, COOPER, J, DING, H, DOVER, J, DU, Z, FAVELLO, A and ...LOUIS, E J..., 1994. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Science. 265(5181), 2077-82
• FELDMANN, H, AIGLE, M, ALJINOVIC, G, ANDRÉ, B, BACLET, M C, BARTHE, C, BAUR, A, BÉCAM, A M and ...LOUIS, E J..., 1994. Complete DNA sequence of yeast chromosome II. EMBO Journal. 13(24), 5795-809
• UNDERWOOD, A P, LOUIS, E J, BORTS, R H and WAKEFIELD, A E, 1994. A technique for cloning the telomeres and subtelomeric regions from Pneumocystis carinii. The Journal of eukaryotic microbiology. 41(5), 113S
• DUJON, B, ALEXANDRAKI, D, ANDRÉ, B, ANSORGE, W, BALADRON, V, BALLESTA, J P, BANREVI, A, BOLLE, P A, BOLOTIN-FUKUHARA, M and ...LOUIS, E J..., 1994. Complete DNA sequence of yeast chromosome XI. Nature. 369(6479), 371-8
• LOUIS, E J, NAUMOVA, E S, LEE, A, NAUMOV, G and HABER, J E, 1994. The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics. 136(3), 789-802
• NAUMOV, G I, NAUMOVA, E S, LANTTO, R A, LOUIS, E J and KORHOLA, M, 1992. Genetic homology between Saccharomyces cerevisiae and its sibling species S. paradoxus and S. bayanus: electrophoretic karyotypes. Yeast. 8(8), 599-612
• LOUIS, E J and HABER, J E, 1992. The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics. 131(3), 559-74
• LOUIS, E J and HABER, J E, 1991. Evolutionarily recent transfer of a group I mitochondrial intron to telomere regions in Saccharomyces cerevisiae. Current Genetics. 20(5), 411-5
• LOUIS, E J and HABER, J E, 1990. The subtelomeric Y' repeat family in Saccharomyces cerevisiae: an experimental system for repeated sequence evolution. Genetics. 124(3), 533-45
• LOUIS, E J and HABER, J E, 1990. Mitotic recombination among subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics. 124(3), 547-59
• LOUIS, E J and HABER, J E, 1989. Nonrecombinant meiosis I nondisjunction in Saccharomyces cerevisiae induced by tRNA ochre suppressors. Genetics. 123(1), 81-95
• LOUIS, E J and DEMPSTER, E R, 1987. An exact test for Hardy-Weinberg and multiple alleles. Biometrics. 43(4), 805-11
• LOUIS, EJ, PAYAMI, H and THOMSON, G, 1987. The Affected Sib Method .5. Testing The Assumptions Annals Of Human Genetics. 51, 75-92
• THOMSON, G, KLITZ, W, LOUIS, E J, LO, S K, BERTRAMS, J, BAUR, M and NEUGEBAUER, M, 1986. HLA and IDDM predisposition: new aspects. Genetic epidemiology. Supplement. 1, 363-8
• LOUIS, E J, PAYAMI, H, KLITZ, W, LO, S K and THOMSON, G, 1986. A synergistic three allele model for the HLA-linked components of coeliac disease predisposition. Genetic epidemiology. Supplement. 1, 277-82
• PAYAMI, H, LOUIS, E J, KLITZ, W, LO, S K and THOMSON, G, 1986. Family and population analysis of multiple sclerosis. Genetic epidemiology. Supplement. 1, 381-6
• LOUIS, E J and THOMSON, G, 1986. Three-allele synergistic mixed model for insulin-dependent diabetes mellitus. Diabetes. 35(9), 958-63
• PAYAMI, H, THOMSON, G, MOTRO, U, LOUIS, EJ and HUDES, E, 1985. The Affected Sib Method .4. Sib Trios Annals Of Human Genetics. 49(OCT), 303-314
• PAYAMI, H, THOMSON, G and LOUIS, EJ, 1984. The Affected Sib Method .3. Selection And Recombination American Journal Of Human Genetics. 36(2), 352-362
• LOUIS, EJ, THOMSON, G and PAYAMI, H, 1983. The Affected Sib Method .2. The Intermediate Model Annals Of Human Genetics. 47(JUL), 225-243