Dr Conrad A. Nieduszynski
| Overview | Research | Publications | Opportunities |
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BBSRC David Phillips Fellow (Institute Member) Room: D116 (Medical School) Address: Institute of Genetics, The University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK Tel: 0115 8230352 (int 30352) |
These pages contain brief details of my research interests, but to find out more please visit my lab web pages »
Research Overview: Genome maintenance and the regulation of chromosome replication
Complete, accurate replication of the genome is essential for life. All chromosomes in eukaryotic cells must be duplicated and then segregated to daughter cells to ensure genetic integrity and produce the large number of cells that make up a multicellular organism. We are using genetic, genomic and computational methods to understand how chromosome replication is regulated to ensure genome stability. By focusing on the basic biology that underpins cell growth and division we aim to provide new insights that may help our understanding of diseases such as cancer and congenital disorders.
Education, appointments and honours
BA, University of Cambridge (1996); PhD, University of Cambridge (2000); Postdoctoral Fellow, University of Dundee (2000-2003); Postdoctoral Fellow, University of Aberdeen (2003-2006); Leverhulme Trust Early Career Fellow (2006-2007), BBSRC David Phillips Fellow (2008-).
Selected publications
F. Chang, J.F. Theis, F. Miller, C.A. Nieduszynski, C.S. Newlon, M. Weinreich (2008). Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved "WTW" sequence within the ORC binding site. Molecular and Cellular Biology, in press; doi:10.1128/MCB.00206-08. PubMed.
C.A. Nieduszynski, S. Hirage, P. Ak, C.J. Benham, A.D. Donaldson (2007). OriDB: a DNA Replication Origin Database. Nucleic Acids Research, 35: D40-D46; doi:10.1093/nar/gkl758. PubMed.
C.A. Nieduszynski, Y. Knox & A.D. Donaldson (2006). Comparative genomics identifies yeast DNA replication origin sequences genome-wide. Genes & Development 20: 1874. PubMed. F1000.
C.A. Nieduszynski, J.J. Blow & A.D. Donaldson (2005). Transcription affects the requirement of replication origins for pre-replication complex proteins. Nucleic Acids Research 33: 2410. PubMed. PubMedCentral.
A.J. Cosgrove, C.A. Nieduszynski, & A.D. Donaldson (2002). Ku complex controls the replication time of DNA in telomere regions. Genes & Development 16: 2485. PubMed.
C.A. Nieduszynski, J. Murray & M. Carrington (2002). Whole-genome analysis of animal A- and B-type cyclins. Genome Biology, 3: RESEARCH0070. PubMed. PubMedCentral.
C.A. Nieduszynski, A.D. Donaldson & J.J. Blow (2001). Eukaryotic DNA Replication: from ORC to fork. Genome Biology 2: REPORTS4030.
Group Members
| Michelle Hawkins | Research Fellow | +44 (0)115 823 1052 internal (QMC) 31052 |
D116 |
| Amy Upton | Research Fellow | +44(0)115 823 1052 internal (QMC) 31052 |
D116 |
| Renata Retkute | Research Fellow | +44(0)115 823 0374 internal (QMC) 30374 |
D116 |
| Carolin Müller | Postgraduate Student | +44(0) 115 8320277 internal (QMC) 30377 |
D119 |
