School of Life Sciences
  • Print
   
   
 

Andrew Bennett

Associate Professor of Molecular Biology/Biochemistry, Faculty of Medicine & Health Sciences

Contact

  • workRoom E131 The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30113
  • fax0115 82 30142

Research Summary

Interests

  • Nutrient regulation of carbohydrate and lipid metabolism.
  • Regulation of gene expression by lipids and carbohydrate.
  • Role of steroid hormone transcription factors in health and disease.

Techniques

  • Primary and transformed cell line tissue culture.
  • General molecular biology - PCR, mutagenesis, cloning etc.
  • Transfection/reporter gene approaches for analysis of promoter function.
  • Gene expression analysis - RNAse protection, Real Time Q RTPCR, Gene array, western blotting 2D gel electrophoresis and Mass spec. analysis of protein expression patterns.

Projects

  • Effects of dietary fatty acids on the intestinal mucosal barrier (BBSRC).
  • Macronutrient control of uncoupling protein (UCP-2 and UCP-3) expression in man: effects on energy balance regulation (BBSRC).
  • Uncoupling protein -3 expression in inflammation and malignancy (MRC).
  • Engineering functional liver tissue in vitro: exploiting the link between cell communication and gene expression (BBSRC).
  • Effect of specific isomers of conjugated linoleic acid upon lipid metabolism: a proteomics approach, (BBSRC).
  • Regulation of SREBP1c gene expression by dietary lipid and carbohydrate (BBSRC).
  • Effect of dietary flavonoids on hepatic lipid metabolism and gene expression (Saudi Government).

Centre Collaborators

  • Prof. Ian Macdonald

UK Collaborators

  • Dr Andy Salter, Prof Chris Hawkey, Prof Kevin Shakesheff (University of Nottingham).
  • Prof Joan Higgins (University of Sheffield).

International Collaborators

  • Prof Walter Wahli, Dr Liliane Michalik (University of Lausanne, Switzerland).
  • Prof Patrick Collins, Prof Gerald Tomkin, Dr Daphne Owens (Royal College of Surgeons in Ireland).

Recent Publications

Future Research

Control of gene expression by lipids and carbohydrate - specifically the role of transcription factors including: peroxisome proliferator activated receptors, sterol regulatory element binding proteins and hepatic nuclear factors in nutrient gene interactions in the liver, small intestine and adipose tissue.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

Contact us