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Claire Seedhouse

Associate Professor, Faculty of Medicine & Health Sciences

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Biography

Dr Claire Seedhouse is an Associate Professor within the Division of Cancer and Stem Cells, in the School of Medicine, at the University of Nottingham

Claire studied for a BSc (Hons) at Bath University which included two industrial placements (1995). She did her PhD at the Paterson Institute for Cancer Research, Manchester where she developed an interest in DNA damage and repair (1999). After completing several post-doctoral research positions and a fellowship at the University of Nottingham she was appointed as the Skillington Haematology Lecturer in 2009. She has published more than 40 papers (h index 22) and receives external, and local, peer-reviewed funding for her research.

Teaching Summary

Course Director MSc Oncology

Theme lead for MSc in Clinical Sciences (Blood Sciences)

Research Summary

Claire's area of research is mechanisms of drug resistance in acute myeloid leukaemia (AML), with a particular focus on the DNA damage and repair response. Her work has demonstrated that aberrant DNA… read more

Selected Publications

Current Research

Claire's area of research is mechanisms of drug resistance in acute myeloid leukaemia (AML), with a particular focus on the DNA damage and repair response. Her work has demonstrated that aberrant DNA repair pathways may contribute to both the pathogenesis of AML and the resistance of leukaemia cells to genotoxic therapies. Work is now focused upon the differences in the responses to drugs between the distinct subgroups of AML, inclduing those subgroups with FLT3 and/or NPM mutations.

Current research projects include:

- Differences in DNA repair capacities between AML subgroups

- Differences in Bcl2 family members between AML subgroups

- DNA damage and response of AML cells to novel therapeutic drugs, including telomere-targeting agents

- DNA repair in dormant leukaemia cells

- The contribution of single nucleotide polymorphisms to AML pathogenesis and drug resistance

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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