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Jim Thornton

Professor of Obstetrics and Gynaecology, Faculty of Medicine & Health Sciences

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Biography

Qualified Leeds university 1977. Worked in Chogoria mission hospital in Kenya for four years 1979-1983. Subsequently research fellow, and registrar Leeds and Bradford. Lecturer in OBGYN University Hospital of Wales 1989-1991. Consultant St James University Hospital Leeds 1991-1992. Reader/Hon consultant Leeds General Infirmary 1992-2002. Editor-in-Chief Eur J Obs, Gyn & Reprod Med 2001-2002, Editor-in-Chief Br J Obs & Gyn 2003-2005, Director Nottingham Clinical Trials Unit 2009-2011, chief investigator of the Growth Restriction Intervention Trial (Lancet 2004). Conservative party parliamentary candidate Nottingham East 2005.

Currently deputy director of the Nottingham Clinical Trials Unit. Lead for the Trent Pregnancy and Childbirth Specialty Group. Head of Service Obstet, Gynaecol and Neonatal NUH NHS Trust. An Editor of the European Journal of Obstetrics and Gynaecology.

Expertise Summary

Randomised controlled trials. General obstetrics. General gynaecology.

Research Summary

Randomised controlled trials in pregnancy and gynaecology. Chief investigator for the Growth Restriction Intervention Trial (GRIT). Chief investigator for the Pregnancy Intervention Trial in… read more

Recent Publications

Current Research

Randomised controlled trials in pregnancy and gynaecology. Chief investigator for the Growth Restriction Intervention Trial (GRIT). Chief investigator for the Pregnancy Intervention Trial in Cholestasis (PITCH) trial. Co-chief investigator for the Smoking and Nicotine and Pregnancy (SNAP) trial. Chief investigator for 35-39 trial. UK Chief investigator for the Control of Hypertension in pregnancy Study (CHIPS), Twin Birth Study (TBS). Deputy director of the Nottingham Clinical Trials Unit

Past Research

The following are the main publications of trials I've been involved with:

DeBoer CN, Thornton JG. Prophylactic short course rectal metronidazole for Cesarean section: a double-blind controlled trial of simple low cost regimen. Int J Obstet Gynecol (1989) 28: 103-7.

Cartmill RSV, Thornton JG. Obstetric decision making; the effect of varying the presentation of partogram information.Lancet (1992) 339: 1520-1522.

Lilford RJ, Kelly M, Baines A, Cameron S, Cave M, Guthrie K, Thornton JG. Improved medical care through the use of protocols: a randomised trial based on the first antenatal visit. Br Med J 1992 305: 1181-4.

Breart G, Mlika-Cabane N, Thornton JG, Trakas D, Alexander S, Mandrauzzato P, Sederberg-Olsen J, Herruzo-Nalda A. (1992) European trials on artificial rupture of membranes and professional support during labour. Trial B Results of the continuous professional support. J Perinat Med 20:37.

UK Amniotomy Group (director JGT). (1994) A multicentre randomised trial comparing routine versus delayed amniotomy in spontaneous first labour at term. CCT Online 1994 Apr 1;3 (Doc No 122) A shortened version of this paper appeared in Br J Obstet Gynaecol 101: 307-9.

Thornton JG, Hewison J, Lilford RJ, Vail A. (1995) A Randomised Trial of Three Methods of Giving Information about Prenatal Testing. Br Med J 311: 1127-30..

Doweswell Thornton JG, Hewison J, Lilford RJ.(1996) Should there be a randomised trial of home birth? Br Med J 312: 753-4. (This paper was followed by a full length debate among six other experts)

Vause S, Congdon HM, Thornton JG (1998) Immediate and delayed pushing in the second stage of labour for nulliparous women with epidural analgesia: a randomised controlled trial. Br J Obstet Gynaecol 105: 186-188.

HE Keane, HE, Thornton JG (1998) A trial of cetrimide/chlorhexidine or tapwater for perineal cleaning. Br J Midwifery 6: 34-37.

Thomlinson J, Thornton JG (1998) A randomised trial of prophylactic antibiotics for the repair of vesico vaginal fistula Br J Obstet Gynaecol 105: 397-399..

Ross-McGill H, Hewison J, Hirst J, Dowswell T, Holt A, Brunskill P, Thornton JG. (2000) Antenatal home blood pressure monitoring; a pilot trial. Br J Obstet Gynaecol 107: 217-221.

The GRIT Study Group director JGT (2003) A randomised trial of timed delivery for the compromised preterm fetus: short term outcomes and Bayesian interpretation. BJOG 110: 27-32. (Cited in OBGYN Survey (2003) 58: 449-450)

Onwude JL, Thornton JG, Morley S, Lilleyman J, Currie I, Lilford RJ. (2004) A randomised trial of photographic reinforcement during postoperative counselling after diagnostic laparoscopy for pelvic pain. Eur J Obstet Gynecol Reprod Biol.112: 89-94.

Bekker HL, Hewison J, Thornton JG (2004) Applying decision analysis to facilitate informed decision making about prenatal diagnosis for Down's syndrome: a randomised controlled trial. Prenatal Diagnosis 24: 265-75.

The GRIT Study Group (director JGT) (2004) Infant wellbeing at 2 years of age in the Growth Restriction Intervention trial (GRIT): a multicentred randomised controlled trial. Lancet 364:513-519.

Wong SSM, Thornton JG, Gbolade B, Bekker HL. (2006) A randomised controlled trial of a decision aid leaflet to facilitate women's choice between pregnancy termination methods. BJOG: An International Journal of Obstetrics & Gynaecology Jun;113(6):688-94.

Logghe HL, Mason GC, Thornton JG, Stringer MD. A randomized controlled trial of elective preterm delivery of fetuses with gastroschisis. J Pediatr Surg. 2005 Nov;40(11):1726-31.

HEWISON, J, NIXON, J, FOUNTAIN, J, HAWKINS, K, JONES, C R, MASON, G, MORLEY, S and THORNTON, J G, 2007. A randomised trial of two methods of issuing prenatal test results: the ARIA (Amniocentesis Results: Investigation of Anxiety) trial. BJOG, 114(4), 462-8.

Hinshaw K, Simpson S, Cummings S, Hildreth A, Thornton JG (2008) A randomised controlled trial of early versus delayed oxytocin augmentation to treat primary dysfunctional labour in nulliparous women. BJOG 115: 1289-1296.

Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S, Calder A, Mires G, Danielian P, Sturgiss S, MacLennan G, Tydeman G, Thornton S, Martin B, Thornton JG, Neilson JP, Norrie J. Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 2009 373: 2034-40

Walker D-M, Marlow N, Upstone, L, Gross, H. Hornbuckle J, Vail A, Wolke D, Thornton JG on behalf of the GRIT Study Group (2011) The Growth Restriction Intervention Trial (GRIT): Long-term outcomes in a randomised trial of timing of delivery in fetal growth restriction. Am J Obstet Gynecol 204(1):34 1-9.

Boers K, Bijlenga D, Vijgen S, van der Post J, Bekedam D, Kwee A, van der Salm P, van Pampus M, Spaanderman M, de Boer K, Bremer H, Duvekot J, Hasaart T, Delemarre F, Bloemenkamp K, van Meir C, Willekes C, Wijnen E, Rijken M, le Cessie S, Roumen F, Thornton JG, van Lith J, Mol BW, Scherjon S (2011) Induction versus expectant monitoring for intrauterine growth restriction at term (the DIGITAT trial). Br Med J 342: 35

Coleman T, Cooper S, Thornton JG, Grainge MJ, Watts K, John Britton J, Lewis S for the SNAP Trial Team (2012) A randomized trial of nicotine replacement therapy patches in pregnancy. New Engl J Med. 366:808-818

Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG on behalf of the PITCH Study Consortium. (2012) Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semi-factorial randomised clinical trial. BMJ 2012; 344 doi: 10.1136/bmj.e3799 (Published 13 June 2012)

Magee LA, von Dadelszen P, Rey E, Ross S, Asztalos E, Murphy KE, Menzies JM, Sanchez J, Singer J, Gafni A, Gruslin A, Helewa M, Hutton E, Lee SK, Logan AG, Ganzevoort JW, Welch R, Thornton JG, Moutquin JM, and the CHIPS Study Group. (2015) The Control of Hypertension In Pregnancy Study (CHIPS) randomized controlled trial. New Engl J Med 372: 407-17. DOI: 10.1056/NEJMoa1404595

Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Alger CS, Thornton JG, Crowther C, on behalf of the PPROMT Collaboration. (2105).The Preterm Pre-labour Rupture of the Membranes close to Term (PPROMT) randomized trial; immediate delivery increases neonatal morbidity. Lancet. 2016; 387: 444-52

Walker KW, Bugg GJ, Macpherson MBM, Carol McCormick C, Grace N, Wildsmith C, Bradshaw L, Smith GCS, Thornton JG on behalf of the 35/39 trial group New Engl J Med. 2016 Online first 3 march 2016

I've also done some systematic reviews

Bugg GJ, Siddique F, Thornton JG (2011) Oxytocin versus no treatment or delayed treatment for slow progress in the first stage of spontaneous labour' The Cochrane Library June module Issue 7, 2011 (published 6 July 2011).

Gurung V, Middleton P, Milan SJ, Hague W, Thornton JG. (2013) Interventions for treating cholestasis in pregnancy. Cochrane Database Syst Rev. 2013 Jun 24;6:CD000493. doi: 10.1002/14651858.CD000493.pub2. Review.

Churchill D, Duley L, Thornton JG, Jones L. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD003106. DOI: 10.1002/14651858.CD003106.pub2.

Future Research

Planning trials on obstetric cholestasis, varying the timing of cord clamping, smoking cessation interventions in pregnancy, and pruritus vulvae.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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