Associate Professor in Medical Statistics, Faculty of Medicine & Health Sciences
Dr Matthew Grainge achieved his BSc in Statistics at Reading University and his MSc in Medical Statistics at the University of Leicester, before going on to complete his PhD on the topic of cervical screening and human papillomavirus at the University of Nottingham.
Medical statistics, clinical trials methodology, systematic reviews, use of primary care databases
- Critical Thinking Skills in Epidemiology and Public Health - BMedSci Year 3 students
- Data Organisation and Management in Epidemiology: a practical course using Stata - MSc in Applied Epidemiology
- BMedSci Honour's year homebase co-ordinator for Epidemiology and Public Health
- Faculty of Medicine and Health Sciences Honour's Year Group- Member
Dr Grainge has developed a successful research programme in the areas of database and cancer epidemiology, as well as contributing to the success of the gastrointestinal research group in the… read more
COLEMAN, T., COOPER, S., THORNTON, J.G., GRAINGE, M.J., WATTS, K., BRITTON, J. and LEWIS, S., 2012. A randomized trial of nicotine-replacement therapy patches in pregnancy New England Journal of Medicine. 366(9), 808-818
COLE, B.F., LOGAN, R.F., HALABI, S., BENAMOUZIG, R., SANDLER, R.S., GRAINGE, M.J., CHAUSSADE, S. and BARON, J.A., 2009. Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials Journal of the National Cancer Institute. 101(4), 256-266
- Statistical Editor - Cochrane Skin Group
- Fellow - Royal Statistical Society
- Panel member for Research for Patient Benefit (East Midlands Regional Advisory Committee)
Dr Grainge has developed a successful research programme in the areas of database and cancer epidemiology, as well as contributing to the success of the gastrointestinal research group in the division. His main research interests are:
- Prevention of venous thromboembolism (VTE) through identification of the within-person periods of greatest risk in specified patient groups, for example cancer patients and pregnant women.
- Use of general practice databases to carry out research in gastroenterology, cancer, and other areas of clinical epidemiology.
- Cancer epidemiology and prognosis, especially relating to colorectal and breast cancer.
- Adoption of novel methodological techniques in the design and analysis of data from observational studies and clinical trials.
ABHISHEK A, DOHERTY M, KUO CF, MALLEN CD, ZHANG W and GRAINGE MJ, 2017. Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study. Rheumatology (Oxford). 56(5), 736-744 MADDISON P, GOZZARD P, GRAINGE MJ and LANG B, 2017. Long-term survival in paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology.
JESSOP S, WHITELAW DA, GRAINGE MJ and JAYASEKERA P, 2017. Drugs for discoid lupus erythematosus. The Cochrane database of systematic reviews. 5, CD002954 KUO, C.-F.A B, GRAINGE, M.J.C, MALLEN, C.D, ZHANG, W.A and DOHERTY, M.A, 2016. Impact of gout on the risk of atrial fibrillation Rheumatology (United Kingdom). 55(4), 721-728 KUO, C.-F.A B, GRAINGE, M.J.C, MALLEN, C.D, ZHANG, W.A E and DOHERTY, M.A, 2016. Comorbidities in patients with gout prior to and following diagnosis: Case-control study Annals of the Rheumatic Diseases. 75(1), 210-217 WALKER, A.J., WEST, J., CARD, T.R., CROOKS, C., KIRWAN, C.C., GRAINGE, M.J., 2016. When are breast cancer patients at highest risk of venous thromboembolism? a cohort study using english health care data Blood. 127(7), 849-857 REES, FRANCES, DOHERTY, MICHAEL, GRAINGE, MATTHEW, DAVENPORT, GRAHAM, LANYON, PETER and ZHANG, WEIYA, 2016. The incidence and prevalence of systemic lupus erythematosus in the UK, 1999-2012 ANNALS OF THE RHEUMATIC DISEASES. 75(1), 136-141
PEARCE, FIONA A., SHAUNAK, REENA, LANYON, PETER C., MAHR, ALFRED, GRAINGE, MATTHEW J., WATTS, RICHARD A. and HUBBARD, RICHARD B., 2016. INCIDENCE OF ANCA-ASSOCIATED VASCULITIS IN A UK MIXED ETHNICITY POPULATION RHEUMATOLOGY. 55, 37-38
REES, FRANCES, DOHERTY, MICHAEL, GRAINGE, MATTHEW J., LANYON, PETER, DAVENPORT, GRAHAM and ZHANG, WEIYA, 2016. Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 RHEUMATOLOGY. 55(5), 854-860
REES, FRANCES, DOHERTY, MICHAEL, GRAINGE, MATTHEW, LANYON, PETER, DAVENPORT, GRAHAM and ZHANG, WEIYA, 2016. Burden of Comorbidity in Systemic Lupus Erythematosus in the UK, 1999-2012. Arthritis care & research. 68(6), 819-27
SCHMITT J, DECKERT S, ALAM M, APFELBACHER C, BARBARIC J, BAUER A, CHALMERS J, CHOSIDOW O, DELAMERE F, DONEY E, ELEFTHERIADOU V, GRAINGE M, JOHANNSEN L, KOTTNER J, LE CLEACH L, MAYER A, PINART M, PRESCOTT L, PRINSEN CA, RATIB S, SCHLAGER JG, SHARMA M, THOMAS KS, WEBERSCHOCK T, WELLER K, WERNER RN, WILD T, WILKES SR and WILLIAMS HC, 2016. Report from the kick-off meeting of the Cochrane Skin Group Core Outcome Set Initiative (CSG-COUSIN). The British journal of dermatology. 174(2), 287-95 WALKER AJ, BALDWIN DR, CARD TR, POWELL HA, HUBBARD RB and GRAINGE MJ, 2016. Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data. British journal of cancer. 115(1), 115-21 SULTAN, ALYSHAH ABDUL, WEST, JOE, GRAINGE, MATTHEW J, RILEY, RICHARD D, TATA, LAILA J, STEPHANSSON, OLOF, FLEMING, KATE M, NELSON-PIERCY, CATHERINE and LUDVIGSSON, JONAS F, 2016. Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study: BMJ BMJ. 355, RATIB S, WALKER AJ, CARD TR and GRAINGE MJ, 2016. Risk of venous thromboembolism in hospitalised cancer patients in England-a cohort study. Journal of hematology & oncology. 9(1), 60 CHOU IJ, KUO CF, HUANG YS, GRAINGE MJ, VALDES AM, SEE LC, YU KH, LUO SF, HUANG LS, TSENG WY, ZHANG W and DOHERTY M, 2016. Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. Schizophrenia bulletin.
KUO C, GRAINGE MJ, MALLEN C, ZHANG W and DOHERTY M, 2015. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Annals of the rheumatic diseases. 74(4), 661-667 KUO C, GRAINGE MJ, VALDES AM, SEE L, LUO S, YU K, ZHANG W and DOHERTY M, 2015. Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: A nationwide population study. Arthritis & rheumatology (Hoboken, N.J.). 67(7), 1904-1902 KUO C, GRAINGE MJ, ZHANG W and DOHERTY M, 2015. Global epidemiology of gout: prevalence, incidence and risk factors. Nature reviews. Rheumatology. 11(11), 649-662 KUO C, GRAINGE MJ, SEE L, YU K, LUO S, ZHANG W and DOHERTY M, 2015. Epidemiology and management of gout in Taiwan: a nationwide population study. Arthritis research & therapy. 17, 13 ABDUL SULTAN A, WEST J, STEPHANSSON O, GRAINGE MJ, TATA LJ, FLEMING KM, HUMES D and LUDVIGSSON JF, 2015. Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study. BMJ open. 5(11), e008864 COOPER S, LEWIS S, THORNTON JG, MARLOW N, WATTS K, BRITTON J, GRAINGE MJ, TAGGAR J, ESSEX H, PARROTT S, DICKINSON A, WHITEMORE R, COLEMAN T and , 2014. The SNAP trial: a randomised placebo-controlled trial of nicotine replacement therapy in pregnancy--clinical effectiveness and safety until 2 years after delivery, with economic evaluation. Health technology assessment (Winchester, England). 18(54), 1-128 PRASAD, V., BROGAN, E., MULVANEY, C., GRAINGE, M., STANTON, W. and SAYAL, K., 2013. How effective are drug treatments for children with ADHD at improving on-task behaviour and academic achievement in the school classroom? A systematic review and meta-analysis. European Child and Adolescent Psychiatry. 22(4), 203-216 SULTAN, A.A., TATA, L.J., WEST, J., FIASCHI, L., FLEMING, K.M., NELSON-PIERCY, C. and GRAINGE, M.J., 2013. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom Blood. 121(19), 3953-3961 SULTAN, A.A., WEST, J., TATA, L.J., FLEMING, K.M., NELSON-PIERCY, C. and GRAINGE, M.J., 2013. Risk of first venous thromboembolism in pregnant women in hospital: a population based cohort study from England BMJ. n/a(n/a), n/a VAZ LR, LEONARDI-BEE J, AVEYARD P, COOPER S, GRAINGE M, COLEMAN T and ON BEHALF OF THE SNAP TRIAL TEAM, 2013. Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 16(4), 381-389 WALKER AJ, GRAINGE MJ, CARD TR, WEST J, RANTA S and LUDVIGSSON JF, 2013. Venous thromboembolism in children with cancer - A population-based cohort study. Thrombosis research. 133(3), 340-4 KUO C, GRAINGE MJ, SEE L, YU K, LUO S, VALDES AM, ZHANG W and DOHERTY M, 2013. Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the rheumatic diseases.
GRAINGE MJ, WEST J, SOLAYMANI-DODARAN M, CARD TR and LOGAN RFA, 2012. The Long-Term Risk Of Malignancy Following A Diagnosis Of Coeliac Disease Or Dermatitis Herpetiformis: A Cohort Study. Alimentary Pharmacology & Therapeutics. 35(6), 730-739 COLEMAN, T., COOPER, S., THORNTON, J.G., GRAINGE, M.J., WATTS, K., BRITTON, J. and LEWIS, S., 2012. A randomized trial of nicotine-replacement therapy patches in pregnancy New England Journal of Medicine. 366(9), 808-818 WALKER AJ, CARD TR, WEST J, CROOKS C and GRAINGE MJ, 2012. Incidence of venous thromboembolism in patients with cancer - a cohort study using linked united kingdom databases. European journal of cancer (oxford, england : 1990). 49(6), 1404-1413 WALKER AJ, GRAINGE M, BATES TE and CARD TR, 2012. Survival of glioma and colorectal cancer patients using tricyclic antidepressants post-diagnosis. Cancer causes & control : ccc. 23(12), 1959-64 SULTAN, A.A., WEST, J., TATA, L.J., FLEMING, K.M., NELSON-PIERCY, C. and GRAINGE, M.J., 2011. Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study British Journal of Haematology. 156(3), 366-373 MAHMOUD, S.M.A., PAISH, E.C., POWE, D.G., MACMILLAN, R.D., GRAINGE, M.J., LEE, A.H.S., ELLIS, I.O. and GREEN, A.R., 2011. Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 29(15), 1949-1955 FIGUEIREDO JC, MOTT LA, GIOVANNUCCI E, WU K, COLE B, GRAINGE MJ, LOGAN RF and BARON JA, 2011. Folic Acid And Prevention Of Colorectal Adenomas: A Combined Analysis Of Randomized Clinical Trials. International Journal Of Cancer. Journal International Du Cancer. 129(1), 192-203 KWOK, TC, RAKHA, EA, LEE, AH, GRAINGE, M, GREEN, AR, ELLIS, IO and POWE, DG, 2010. Histological grading of breast cancer on needle core biopsy: the role of immunohistochemical assessment of proliferation Histopathology. 57(2), 212-9 VASS, C.D., SAHOTA, O., DRUMMOND, A., KENDRICK, D., GLADMAN, J., SACH, T., AVIS, M. and GRAINGE, M., 2009. REFINE (Reducing Falls in In-patient Elderly): a randomised controlled trial Trials. 10, 83 ELSHEIKH, S.E., GREEN, A.R., RAKHA, E.A., POWE, D.G., AHMED, R.A., COLLINS, H.M., SORIA, D., GARIBALDI, J.M., PAISH, C.E., AMMAR, A.A., GRAINGE, M.J., BALL, G.R., ABDELGHANY, M.K., MARTINEZ-POMARES, L., HEERY, D.M. and ELLIS, I.O., 2009. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome Cancer Research. 69(9), 3802-3809 GRAINGE, MJ, SHAHAB, L, HAMMOND, D, O'CONNOR, RJ and MCNEILL, A, 2009. First cigarette on waking and time of day as predictors of puffing behaviour in UK adult smokers. Drug Alcohol Depend. 101, 191-195 COLE, B.F., LOGAN, R.F., HALABI, S., BENAMOUZIG, R., SANDLER, R.S., GRAINGE, M.J., CHAUSSADE, S. and BARON, J.A., 2009. Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials Journal of the National Cancer Institute. 101(4), 256-266 RAKHA, EMAD A, EL-SAYED, MAYSA E, POWE, DESMOND G, GREEN, ANDREW R, HABASHY, HANY, GRAINGE, MATTHEW J, ROBERTSON, JOHN F R, BLAMEY, ROGER, GEE, JULIA, NICHOLSON, ROBERT I, LEE, ANDREW H S and ELLIS, IAN, 2008. Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes. European Journal of Cancer. 44(1), 73-83 FOULKES,, GRAINGE,, RAKHA,, GREEN, and ELLIS,, 2008. Tumor size is an unreliable predictor of prognosis in basal-like breast cancers and does not correlate closely with lymph node status. Breast Cancer Research and Treatment. 117(1), 199-204 HUBNER, RICHARD A, MUIR, KENNETH R, LIU, JO-FEN, LOGAN, RICHARD F A, GRAINGE, MATTHEW J, HOULSTON, RICHARD S and ,, 2008. Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. Clinical Cancer Research. 14(8), 2303-9 GRAINGE,, WEST,, SOLAYMANI-DODARAN,, AITHAL, and CARD,, 2008. The antecedents of biliary cancer: a primary care case-control study in the United Kingdom. British journal of cancer. 100(1), 178-80 LOGAN, R.F.A., GRAINGE, M.J., SHEPHERD, V.C., ARMITAGE, N.C., MUIR, K.R. and ,, 2008. Aspirin and folic acid for the prevention of recurrent colorectal adenomas Gastroenterology. 134(1), 29-38 RAKHA, E.A., EL-SAYED, M.E., LEE, A.H.S., ELSTON, C.W., GRAINGE, M.J., HODI, Z., BLAMEY, R.W. and ELLIS, I.O., 2008. Prognostic significance of Nottingham histologic grade in invasive breast carcinoma Journal of Clinical Oncology. 26(19), 3153-3158 HUBNER, RICHARD A, MUIR, KENNETH R, LIU, JO-FEN, LOGAN, RICHARD F A, GRAINGE, MATTHEW J, HOULSTON, RICHARD S and ,, 2008. Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence. International journal of cancer. Journal international du cancer. 123(3), 586-93 DATTA, SAYAN, FOSS, ALEXANDER J E, GRAINGE, MATTHEW J, GREGSON, RICHARD M, ZAMAN, ANWAR, MASUD, TAHIR, OSBORN, FRAN and HARWOOD, ROWAN H, 2008. The importance of acuity, stereopsis, and contrast sensitivity for health-related quality of life in elderly women with cataracts. Investigative Ophthalmology and Visual Science. 49(1), 1-6 BROWN, K.S., KEOGH, M.J., TAGIURI, N., GRAINGE, M.J., PRESANIS, J.S., RYDER, S.D., IRVING, W.L., BALL, J.K., SIM, R.B. and HICKLING, T.P., 2007. Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex. Clinical and Experimental Immunology. 147(1), 90-98 ELSHEIKH,, GREEN,, ALESKANDARANY,, GRAINGE,, PAISH,, LAMBROS,, REIS-FILHO, and ELLIS,, 2007. CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome. Breast Cancer Research and Treatment. ELBAUOMY ELSHEIKH,, GREEN,, LAMBROS,, TURNER,, GRAINGE,, POWE,, ELLIS, and REIS-FILHO,, 2007. FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis. Breast Cancer Research. 9(2), R23 HUBNER, RICHARD A, MUIR, KENNETH R, LIU, JO-FEN, LOGAN, RICHARD F A, GRAINGE, MATTHEW J, HOULSTON, RICHARD S and ,, 2007. Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. International Journal of Cancer. 121(9), 2001-4 ROBINSON, T., MOSHA, F., GRAINGE, M. and MADELEY, R., 2006. Indicators of mortality in African adults with malaria Transactions of the Royal Society of Tropical Medicine and Hygiene. 100(8), 719-724 HUBNER, R.A., MUIR, K.R., LIU, J-F., SELLICK, G.S., LOGAN, R.F.A., GRAINGE, M. ARMITAGE, N., CHAU, I. and HOULSTON, R.S., 2006. Folate metabolism polymorphisms influence risk of colorectal adenoma recurrence Cancer Epidemiology, Biomarkers & Prevention. 15(9), 1607-1613 HUBNER, RICHARD A, MUIR, KENNETH R, LIU, JO-FEN, LOGAN, RICHARD F A, GRAINGE, MATTHEW, ARMITAGE, NICHOLAS, SHEPHERD, VIC, POPAT, SANJAY and HOULSTON, RICHARD S, 2006. Genetic Variants of UGT1A6 Influence Risk of Colorectal Adenoma Recurrence. Clinical Cancer Research. 12(21), 6585-9
GRAINGE, M.J, SETH, R, GUO, L, NEAL, K.R, COUPLAND, C, VRYENHOEF, P, JOHNSON, J and JENKINS, D, 2005. Cervical human papillomavirus screening among older women Emerging Infectious Diseases. 11(11), 1680-1685
GRAINGE, M. ., SETH, R., COUPLAND, C., GUO, L., RITTMAN, T., VRYENHOEF, P., JOHNSON, J., JENKINS, D. and NEAL, K. R., 2005. Human papillomavirus infection in women who develop high-grade cervical intraepithelial neoplasia or cervical cancer: a case-control study in the UK British Journal of Cancer. 92(9), 1794-1799 MUIR, K R, CHILVERS, C E D, HARRISS, C, COULSON, L, GRAINGE, M, DARBYSHIRE, P, GEARY, C, HOWS, J, MARSH, J, RUTHERFORD, T, TAYLOR, M and GORDON-SMITH, E C, 2003. The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation. British Journal of Haematology. 123(5), 906-14 GRAINGE, M.J., COUPLAND, C.A., CLIFFE, S.J., CHILVERS, C.E. and HOSKING, D.J., 2001. Reproductive, menstrual and menopausal factors: which are associated with bone mineral density in early postmenopausal women? Osteoporosis International. 12(9), 777-787 LUND, J.N., SCHOLEFIELD, J.H., GRAINGE, M.J., SMITH, S.J., MANGHAM, C., ARMITAGE, N.C., ROBINSON, M.H. and LOGAN, R.F., 2001. Risks, costs, and compliance limit colorectal adenoma surveillance: lessons from a randomised trial. Gut. 49(1), 91-6
O'NEILL, C., BLACK, D., JENNINGS, S., GRAINGE, M., ALLABY, M., HOSKINS, D. and HIPPISLEY-COX, J., 2001. The prevention of osteoporotic fracture in women in a primary care setting, 2001: Trent Institute for Health Services Research, University of Leicester, Nottingham and Sheffield Nottingham: University of Nottingham.
COUPLAND, C A, GRAINGE, M J, CLIFFE, S J, HOSKING, D J and CHILVERS, C E, 2000. Occupational activity and bone mineral density in postmenopausal women in England. Osteoporosis International. 11(4), 310-5
GRAINGE, M J, COUPLAND, C A, CLIFFE, S J, CHILVERS, C E and HOSKING, D J, 1998. Cigarette smoking, alcohol and caffeine consumption, and bone mineral density in postmenopausal women. The Nottingham EPIC Study Group. Osteoporosis International. 8(4), 355-63