I am a postdoctoral researcher currently working on a number of projects within the MRC funded Nottingham Molecular Pathology Node and NIHR Nottingham Digestive Diseases BRU. These projects focus on markers of non-alcoholic fatty liver disease progression (with Prof Guruprasad Aithal and Dr Jane Grove), and chronic hepatitis B infection (with Prof Will Irving and Dr Alexander Tarr).
My broader research interests are liver and GI inflammation, intestinal permeability, pregnancy and the GI tract, and interactions between diet, pregnancy and the microbiota.
Current projects include:
- Serum and tissue markers of apoptosis in NAFLD and ALD
- Circulating microRNAs and bacterial translocation in liver disease
- Links between diet, genetics and NAFLD risk, particularly in South Asians
- Effects of genetic variation of hepatitis B virus on infection & diagnosis
- Single-molecule sequencing of hepatitis B virus
My PhD from the Division of Child Health, Obstetrics and Gynaecology at the University of Nottingham covered maternal gastrointestinal and liver adaptation to pregnancy, and the effect of maternal diet on this adaptation, as well as the effect of maternal diet on GI development in the offspring. I also spent 2 years as a Visiting Graduate Student in the Division of Human Nutrition at the University of Alberta, Canada studying the effect of high intakes of fructose during pregnancy.
I previously worked in the Molecular Gastroenterology group at the University of Sheffield, studying the role of fibre, butyrate and histone deacetylase inhibition in colorectal cancer progression.
GROVE, J. I., THIAGARAJAN, P., ASTBURY, S., HARRIS, R., DELAHOOKE, T., CARD, T. R., GUHA, I. N. and AITHAL, G. P., 2017. Prevalence of combined PNPLA3 and GCKR variant genotype is increased in patients with risk factors for alcoholic or non-alcoholic liver disease who have clinically significant serum procollagen III levels Journal of Hepatology. 66(1), S587 LINEKER, CHRISTOPHER, KERR, PAUL M., NGUYEN, PATRICIA, BLOOR, IAN, ASTBURY, STUART, PATEL, NIKHIL, BUDGE, HELEN, HEMMINGS, DENISE G., PLANE, FRANCES, SYMONDS, MICHAEL E. and BELL, RHONDA C., 2015. High fructose consumption in pregnancy alters the perinatal environment without increasing metabolic disease in the offspring Reproduction, Fertility and Development.
ASTBURY, STUART, MOSTYN, ALISON, SYMONDS, MICHAEL E and BELL, RHONDA C, 2015. Nutrient availability, the microbiome, and intestinal transport during pregnancy Applied Physiology, Nutrition, and Metabolism. 40(11), 1100-1106