Ian Ellis

Contact

• workDept Histopathology, City Hospital Campus, Nottingham University Hospitals, Hucknall Rd
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 969 1169 56875
• fax0115 9627768
• ian.ellis@nottingham.ac.uk

Research Summary

The Nottingham/Tenovus Breast Cancer Research Group at Nottingham City Hospital has a longstanding research interest and international track record in classification of breast cancer diagnosis of… read more

Selected Publications

• ROSS-INNES CS, STARK R, TESCHENDORFF AE, HOLMES KA, ALI HR, DUNNING MJ, BROWN GD, GOJIS O, ELLIS IO, GREEN AR, ALI S, CHIN S, PALMIERI C, CALDAS C and CARROLL JS, 2012. Differential Oestrogen Receptor Binding Is Associated With Clinical Outcome In Breast Cancer. Nature. 481(7381), 389-93
• MOHAMMED, RABAB AA, MARTIN, STEWART G, MAHMMOD, ALI M, MACMILLAN, R DOUGLAS, GREEN, ANDREW R, PAISH, EMMA C and ELLIS, IAN O, 2011. Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up. The Journal of pathology. 223(3), 358-65
• GIAMAS, G, FILIPOVIC, A, JACOB, J, MESSIER, W, ZHANG, H, YANG, DY, ZHANG, W, SHIFA, BA, PHOTIOU, A, TRALAU-STEWART, C, CASTELLANO, L, GREEN, AR, COOMBES, RC, ELLIS, IO, ALI, S, LENZ, HJ and STEBBING, J, 2011. Kinome Screening For Regulators Of The Estrogen Receptor Identifies Lmtk3 As A New Therapeutic Target In Breast Cancer Nature Medicine. 17(6), 715-U105
• CUZICK, J, SESTAK, I, PINDER, SE, ELLIS, IO, FORSYTH, S, BUNDRED, NJ, FORBES, JF, BISHOP, H, FENTIMAN, IS and GEORGE, WD, 2011. Effect Of Tamoxifen And Radiotherapy In Women With Locally Excised Ductal Carcinoma In Situ: Long-Term Results From The Uk/Anz Dcis Trial Lancet Oncology. 12(1), 21-29

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Current Research

The Nottingham/Tenovus Breast Cancer Research Group at Nottingham City Hospital has a longstanding research interest and international track record in classification of breast cancer diagnosis of breast disease, evaluation of prognostic factors in breast cancer and understanding of the mechanisms governing hormone response in breast cancer. We have developed a histological grading system, which has become the international gold standard for histological classification (WHO, UICC, EU and UK). The Nottingham Prognostic Index, also developed by the group, is regarded as the most effective system for clinical decision support in routine clinical management. These systems are largely based on morphological assessment of tumour tissue sections and are subject to problems of interobserver variation. As a consequence our group have examined a wide range of potential objective prognostic markers and have over the last 5 years been exploring the hypothesis that a novel classification of breast cancer based on phenotypic and molecular genetic characteristics will provide a more robust system for classification and therapeutic decision-making. This hypothesis has been confirmed in principle with recognition of novel classes of breast cancer defined through their protein expression characteristics. Further studies are in place to identify and examine the influence of novel proteins identified in this context.

Current studies include:

1) Use of tissue array technology to allow immunophenotypic characterisation of protein expression of a large series of approximately 2000 breast cancer cases from the Nottingham Tenovus Breast Cancer series. This will provide a baseline data set of known and important proteins expressed in breast cancer, the frequency of their expression and their associations. The hypothesis being that breast cancer exhibits a number of distinct phenotypes which are related to different differentiation pathways from stem cell to normal adult cell types and which are influential on tumour behaviour.

2) Molecular genetic analysis of specific lesions with a pure histological morphology using array comparative genomic hybridisation (CGH), CISH and immunocytochemical protein expression analysis.

3) A proteomic and molecular approach to characterisation of breast tumours

4) Mechanisms of hormone response and resistance in breast cancer

5) Examination of expression of each member of the Type 1 growth factor family in a large series of breast cancer cases examining the clinical effect of co expression of receptors and ligands.

Group resources include expertise in

Histology / Morphological assessment of tissue

Image analysis

Immunocytochemistry

Laser microdissection

Future Research

Aspects of breast cancer biology, pathology, molecular genetics, morphology, diagnosis, classification and behaviour

• ZHAO X, MIRZA S, ALSHAREEDA A, ZHANG Y, GURUMURTHY CB, BELE A, KIM JH, MOHIBI S, GOSWAMI M, LELE SM, WEST W, QIU F, ELLIS IO, RAKHA EA, GREEN AR, BAND H and BAND V, 2012. Overexpression Of A Novel Cell Cycle Regulator Ecdysoneless In Breast Cancer: A Marker Of Poor Prognosis In Her2/Neu-Overexpressing Breast Cancer Patients. Breast Cancer Research And Treatment. (In Press.)
• ALESKANDARANY MA, GREEN AR, BENHASOUNA AA, BARROS FF, NEAL KR, REIS-FILHO JS, ELLIS IO and RAKHA EA, 2012. Prognostic Value Of Proliferation Assay In The Luminal, Her2 Positive And Triple Negative Biological Classes Of Breast Cancer. Breast Cancer Research : Bcr. 14(1), R3 (In Press.)
• ROSS-INNES CS, STARK R, TESCHENDORFF AE, HOLMES KA, ALI HR, DUNNING MJ, BROWN GD, GOJIS O, ELLIS IO, GREEN AR, ALI S, CHIN S, PALMIERI C, CALDAS C and CARROLL JS, 2012. Differential Oestrogen Receptor Binding Is Associated With Clinical Outcome In Breast Cancer. Nature. 481(7381), 389-93
• GARIBALDI JM, ZHOU S, WANG X, JOHN RI and ELLIS IO, 2012. Incorporation Of Expert Variability Into Breast Cancer Treatment Recommendation In Designing Clinical Protocol Guided Fuzzy Rule System Models. Journal Of Biomedical Informatics. (In Press.)
• MAHMOUD SMA, LEE AHS, PAISH EC, MACMILLAN RD, ELLIS IO and GREEN AR, 2012. Tumour-Infiltrating Macrophages And Clinical Outcome In Breast Cancer. Journal Of Clinical Pathology. 65(2), 159-63
• LEE AHS, KEY HP, BELL JA, HODI Z and ELLIS IO, 2012. Concordance Of Her2 Status Assessed On Needle Core Biopsy And Surgical Specimens Of Invasive Carcinoma Of The Breast. Histopathology. (In Press.)
• ZHAO, X., MIRZA, S., ALSHAREEDA, A., ZHANG, Y., GURUMURTHY, C. B., BELE, A., KIM, J. H., MOHIBI, S., GOSWAMI, M., LELE, S. M., WEST, W., QIU, F., ELLIS, I. O., RAKHA, E. A., GREEN, A. R., BAND, H. and BAND, V., 2012. Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients: Breast Cancer Res Treat Breast Cancer Res Treat.
• ROSS-INNES, C. S., STARK, R., TESCHENDORFF, A. E., HOLMES, K. A., ALI, H. R., DUNNING, M. J., BROWN, G. D., GOJIS, O., ELLIS, I. O., GREEN, A. R., ALI, S., CHIN, S. F., PALMIERI, C., CALDAS, C. and CARROLL, J. S., 2012. Differential oestrogen receptor binding is associated with clinical outcome in breast cancer: Nature Nature. 481(7381), 389-93
• NATRAJAN, R., MACKAY, A., LAMBROS, M. B., WEIGELT, B., WILKERSON, P. M., MANIE, E., GRIGORIADIS, A., A'HERN, R., VAN DER GROEP, P., KOZAREWA, I., POPOVA, T., MARIANI, O., TURALJIC, S., FURNEY, S. J., MARAIS, R., RODRUIGUES, D. N., FLORA, A. C., WAI, P., PAWAR, V., MCDADE, S., CARROLL, J., STOPPA-LYONNET, D., GREEN, A. R., ELLIS, I. O., SWANTON, C., VAN DIEST, P., DELATTRE, O., LORD, C. J., FOULKES, W. D., VINCENT-SALOMON, A., ASHWORTH, A., HENRI STERN, M. and REIS-FILHO, J. S., 2012. A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers: J Pathol J Pathol.
• MAHMOUD, S. M., LEE, A. H., PAISH, E. C., MACMILLAN, R. D., ELLIS, I. O. and GREEN, A. R., 2012. Tumour-infiltrating macrophages and clinical outcome in breast cancer: J Clin Pathol J Clin Pathol. 65(2), 159-63
• LEE, A. H., RAKHA, E. A., HODI, Z. and ELLIS, I. O., 2012. Re-audit of revised method for assessing the mitotic component of histological grade in needle core biopsies of invasive carcinoma of the breast: Histopathology Histopathology.
• LEE, A. H., KEY, H. P., BELL, J. A., HODI, Z. and ELLIS, I. O., 2012. Concordance of HER2 status assessed on needle core biopsy and surgical specimens of invasive carcinoma of the breast: Histopathology Histopathology.
• JOHNSTON, S. J., KENNY, F. S., SYED, B. M., ROBERTSON, J. F., PINDER, S. E., WINTERBOTTOM, L., ELLIS, I. O., BLAMEY, R. W. and CHEUNG, K. L., 2012. A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up: Ann Oncol Ann Oncol.
• GARIBALDI, J. M., ZHOU, S. M., WANG, X. Y., JOHN, R. I. and ELLIS, I. O., 2012. Incorporation of expert variability into breast cancer treatment recommendation in designing clinical protocol guided fuzzy rule system models: J Biomed Inform J Biomed Inform.
• ALESKANDARANY, M. A., GREEN, A. R., BENHASOUNA, A. A., BARROS, F. F., NEAL, K. R., REIS-FILHO, J. S., ELLIS, I. O. and RAKHA, E. A., 2012. Prognostic value of proliferation assay in the luminal, HER2 positive and triple negative biological classes of breast cancer: Breast Cancer Res Breast Cancer Res. 14(1), R3
• C CURTIS, S SHAH, SF CHIN, G TURASHVILI, O RUEDA, M DUNNING, D SPEED, A LYNCH, S SAMARAJIWA, Y YUAN, S GRAF, G HA, G HAFFARI, A BASHASHATI, R RUSSELL, S MCKINNEY, A LANGEROD, AR GREEN, E PROVENZANO, G WISHART, S PINDER, P WATSON, F MARKOWETZ, L MURPHY, I ELLIS, A PURUSHOTHAM, AL BORRESEN-DAL, J BRENTON, S TAVARE, C CALDAS and S APARACIO, 2012. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. (In Press.)
• MOHAMMED, RABAB AA, MARTIN, STEWART G, MAHMMOD, ALI M, MACMILLAN, R DOUGLAS, GREEN, ANDREW R, PAISH, EMMA C and ELLIS, IAN O, 2011. Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up. The Journal of pathology. 223(3), 358-65
• FILIPOVIĆ, ALEKSANDRA, GRONAU, JULIAN HENDRIK, GREEN, ANDREW R, WANG, JAYSON, VALLATH, SABARI, SHAO, DONGMIN, RASUL, SABEENA, ELLIS, IAN O, YAGÜE, ERNESTO, STURGE, JUSTIN and COOMBES, R CHARLES, 2011. Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast cancer research and treatment. 125(1), 43-53
• AHMED MAH, ALESKANDARANY MA, RAKHA EA, MOUSTAFA RZA, BENHASOUNA A, NOLAN C, GREEN AR, ILYAS M and ELLIS IO, 2011. A Cd44(-)/Cd24 (+) Phenotype Is A Poor Prognostic Marker In Early Invasive Breast Cancer. Breast Cancer Research And Treatment. (In Press.)
• AGBOOLA AJ, PAISH EC, RAKHA EA, POWE DG, MACMILLAN RD, ELLIS IO and GREEN AR, 2011. Epcam Expression Is An Indicator Of Recurrence In Basal-Like Breast Cancer. Breast Cancer Research And Treatment. (In Press.)
• CUZICK J, DOWSETT M, PINEDA S, WALE C, SALTER J, QUINN E, ZABAGLO L, MALLON E, GREEN AR, ELLIS IO, HOWELL A, BUZDAR AU and FORBES JF, 2011. Prognostic Value Of A Combined Estrogen Receptor, Progesterone Receptor, Ki-67, And Human Epidermal Growth Factor Receptor 2 Immunohistochemical Score And Comparison With The Genomic Health Recurrence Score In Early Breast Cancer. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology. 29(32), 4273-8
• BERAL V, ALEXANDER M, DUFFY S, ELLIS IO, GIVEN-WILSON R, HOLMBERG L, MOSS SM, RAMIREZ A, REED MWR, RUBIN C, WHELEHAN P, WILSON R and YOUNG KC, 2011. The Number Of Women Who Would Need To Be Screened Regularly By Mammography To Prevent One Death From Breast Cancer. Journal Of Medical Screening. 18(4), 210-2
• RAKHA EA, MARTIN S, LEE AHS, MORGAN D, PHAROAH PDP, HODI Z, MACMILLAN D and ELLIS IO, 2011. The Prognostic Significance Of Lymphovascular Invasion In Invasive Breast Carcinoma. Cancer. (In Press.)
• LEE AHS, KEY HP, BELL JA, HODI Z and ELLIS IO, 2011. Breast Carcinomas With Borderline (2+) Her2 Immunohistochemistry: Percentage Of Cells With Complete Membrane Staining For Her2 And The Frequency Of Her2 Amplification. Journal Of Clinical Pathology. 64(6), 490-2
• RAKHA EA, HO BC, NAIK V, SEN S, HAMILTON LJ, HODI Z, ELLIS IO and LEE AHS, 2011. Outcome Of Breast Lesions Diagnosed As Lesion Of Uncertain Malignant Potential (B3) Or Suspicious Of Malignancy (B4) On Needle Core Biopsy, Including Detailed Review Of Epithelial Atypia. Histopathology. 58(4), 626-32
• HOLLAND DG, BURLEIGH A, GIT A, GOLDGRABEN MA, PEREZ-MANCERA PA, CHIN S, HURTADO A, BRUNA A, ALI HR, GREENWOOD W, DUNNING MJ, SAMARAJIWA S, MENON S, RUEDA OM, LYNCH AG, MCKINNEY S, ELLIS IO, EAVES CJ, CARROLL JS, CURTIS C, APARICIO S and CALDAS C, 2011. Znf703 Is A Common Luminal B Breast Cancer Oncogene That Differentially Regulates Luminal And Basal Progenitors In Human Mammary Epithelium. Embo Molecular Medicine. 3(3), 167-80
• ALI AMG, DAWSON S, BLOWS FM, PROVENZANO E, ELLIS IO, BAGLIETTO L, HUNTSMAN D, CALDAS C and PHAROAH PD, 2011. Comparison Of Methods For Handling Missing Data On Immunohistochemical Markers In Survival Analysis Of Breast Cancer. British Journal Of Cancer. 104(4), 693-9
• CUZICK, J, DOWSETT, M, PINEDA, S, WALE, C, SALTER, J, QUINN, E, ZABAGLO, L, MALLON, E, GREEN, AR, ELLIS, IO, HOWELL, A, BUZDAR, AU and FORBES, JF, 2011. Prognostic Value Of A Combined Estrogen Receptor, Progesterone Receptor, Ki-67, And Human Epidermal Growth Factor Receptor 2 Immunohistochemical Score And Comparison With The Genomic Health Recurrence Score In Early Breast Cancer Journal Of Clinical Oncology. 29(32), 4273-4278
• GIAMAS, G, FILIPOVIC, A, JACOB, J, MESSIER, W, ZHANG, H, YANG, DY, ZHANG, W, SHIFA, BA, PHOTIOU, A, TRALAU-STEWART, C, CASTELLANO, L, GREEN, AR, COOMBES, RC, ELLIS, IO, ALI, S, LENZ, HJ and STEBBING, J, 2011. Kinome Screening For Regulators Of The Estrogen Receptor Identifies Lmtk3 As A New Therapeutic Target In Breast Cancer Nature Medicine. 17(6), 715-U105
• CUZICK, J, SESTAK, I, PINDER, SE, ELLIS, IO, FORSYTH, S, BUNDRED, NJ, FORBES, JF, BISHOP, H, FENTIMAN, IS and GEORGE, WD, 2011. Effect Of Tamoxifen And Radiotherapy In Women With Locally Excised Ductal Carcinoma In Situ: Long-Term Results From The Uk/Anz Dcis Trial Lancet Oncology. 12(1), 21-29
• MOHAMMED, RAA, MARTIN, SG, MAHMMOD, AM, MACMILLAN, RD, GREEN, AR, PAISH, EC and ELLIS, IO, 2011. Objective Assessment Of Lymphatic And Blood Vascular Invasion In Lymph Node-Negative Breast Carcinoma: Findings From A Large Case Series With Long-Term Follow-Up Journal Of Pathology. 223(3), 358-365
• WOOLSTON, C. M., STORR, S. J., ELLIS, I. O., MORGAN, D. A. and MARTIN, S. G., 2011. Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer: Radiother Oncol Radiother Oncol. 100(2), 308-13
• WOOLSTON, C. M., AL-ATTAR, A., STORR, S. J., ELLIS, I. O., MORGAN, D. A. and MARTIN, S. G., 2011. Redox protein expression predicts radiotherapeutic response in early-stage invasive breast cancer patients: Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys. 79(5), 1532-40
• VAN DEURZEN, C. H., LEE, A. H., GILL, M. S., MENKE-PLUIJMERS, M. B., JAGER, A., ELLIS, I. O. and RAKHA, E. A., 2011. Metaplastic breast carcinoma: tumour histogenesis or dedifferentiation?: J Pathol J Pathol. 224(4), 434-7
• TANG, S. W., PARKER, H., WINTERBOTTOM, L., HASSELL, K., ELLIS, I. O., MORGAN, D. A. and CHEUNG, K. L., 2011. Early primary breast cancer in the elderly - pattern of presentation and treatment: Surg Oncol Surg Oncol. 20(1), 7-12
• SYED, B. M., JOHNSTON, S. J., WONG, D. W., GREEN, A. R., WINTERBOTTOM, L., KENNEDY, H., SIMPSON, N., MORGAN, D. A., ELLIS, I. O. and CHEUNG, K. L., 2011. Long-term (37 years) clinical outcome of older women with early operable primary breast cancer managed in a dedicated clinic: Ann Oncol Ann Oncol.
• SYED, B. M., AL-KHYATT, W., JOHNSTON, S. J., WONG, D. W., WINTERBOTTOM, L., KENNEDY, H., GREEN, A. R., MORGAN, D. A., ELLIS, I. O. and CHEUNG, K. L., 2011. Long-term clinical outcome of oestrogen receptor-positive operable primary breast cancer in older women: a large series from a single centre: Br J Cancer Br J Cancer. 104(9), 1393-400
• STORR, S. J., WOOLSTON, C. M., BARROS, F. F., GREEN, A. R., SHEHATA, M., CHAN, S. Y., ELLIS, I. O. and MARTIN, S. G., 2011. Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy: Int J Cancer Int J Cancer. 129(7), 1773-80
• STORR, S. J., SAFUAN, S., MITRA, A., ELLIOTT, F., WALKER, C., VASKO, M. J., HO, B., COOK, M., MOHAMMED, R. A., PATEL, P. M., ELLIS, I. O., NEWTON-BISHOP, J. A. and MARTIN, S. G., 2011. Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma: Mod Pathol Mod Pathol.
• STORR, S. J., MOHAMMED, R. A., WOOLSTON, C. M., GREEN, A. R., PARR, T., SPITERI, I., CALDAS, C., BALL, G. R., ELLIS, I. O. and MARTIN, S. G., 2011. Calpastatin is associated with lymphovascular invasion in breast cancer: Breast Breast. 20(5), 413-8
• STEBBING, J., FILIPOVIC, A., ELLIS, I. O., GREEN, A. R., D'SILVA, T. R., LENZ, H. J., COOMBES, R. C., WANG, T., LEE, S. C. and GIAMAS, G., 2011. LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome: Breast Cancer Res Treat Breast Cancer Res Treat.
• RICHARDSON, J., SHAABAN, A. M., KAMAL, M., ALISARY, R., WALKER, C., ELLIS, I. O., SPEIRS, V., GREEN, A. R. and BELL, S. M., 2011. Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation: Breast Cancer Res Treat Breast Cancer Res Treat. 127(3), 639-48
• RAKHA, E. A., MARTIN, S., LEE, A. H., MORGAN, D., PHAROAH, P. D., HODI, Z., MACMILLAN, D. and ELLIS, I. O., 2011. The prognostic significance of lymphovascular invasion in invasive breast carcinoma: Cancer Cancer.
• RAKHA, E. A., LEE, A. H., JENKINS, J. A., MURPHY, A. E., HAMILTON, L. J. and ELLIS, I. O., 2011. Characterization and outcome of breast needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening: Int J Cancer Int J Cancer. 129(6), 1417-24
• RAKHA, E. A., HO, B. C., NAIK, V., SEN, S., HAMILTON, L. J., HODI, Z., ELLIS, I. O. and LEE, A. H., 2011. Outcome of breast lesions diagnosed as lesion of uncertain malignant potential (B3) or suspicious of malignancy (B4) on needle core biopsy, including detailed review of epithelial atypia: Histopathology Histopathology. 58(4), 626-32
• RAKHA, E. A., GANDHI, N., CLIMENT, F., VAN DEURZEN, C. H., HAIDER, S. A., DUNK, L., LEE, A. H., MACMILLAN, D. and ELLIS, I. O., 2011. Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis: Am J Surg Pathol Am J Surg Pathol. 35(8), 1093-103
• RAKHA, E. A. and ELLIS, I. O., 2011. Modern classification of breast cancer: should we stick with morphology or convert to molecular profile characteristics: Adv Anat Pathol Adv Anat Pathol. 18(4), 255-67
• POWE, D. G., VOSS, M. J., HABASHY, H. O., ZANKER, K. S., GREEN, A. R., ELLIS, I. O. and ENTSCHLADEN, F., 2011. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study: Breast Cancer Res Treat Breast Cancer Res Treat. 130(2), 457-63
• O'SHEA, A. M., RAKHA, E. A., HODI, Z., ELLIS, I. O. and LEE, A. H., 2011. Histological grade of invasive carcinoma of the breast assessed on needle core biopsy - modifications to mitotic count assessment to improve agreement with surgical specimens: Histopathology Histopathology. 59(3), 543-8
• MVERE, M. Z., JAMES, J. J., CORNFORD, E. J., TENNANT, S. L., EVANS, A. J., ELLIS, I. O. and CHAN, S. Y., 2011. Frequency and patterns of metastatic disease in locally advanced inflammatory and non-inflammatory breast cancer: Clin Oncol (R Coll Radiol) Clin Oncol (R Coll Radiol). 23(9), 608-12
• MOHAMMED, R. A., MARTIN, S. G., MAHMMOD, A. M., MACMILLAN, R. D., GREEN, A. R., PAISH, E. C. and ELLIS, I. O., 2011. Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up: J Pathol J Pathol. 223(3), 358-65
• MOHAMMED, R. A., ELLIS, I. O., MAHMMOD, A. M., HAWKES, E. C., GREEN, A. R., RAKHA, E. A. and MARTIN, S. G., 2011. Lymphatic and blood vessels in basal and triple-negative breast cancers: characteristics and prognostic significance: Mod Pathol Mod Pathol. 24(6), 774-85
• MAHMOUD, S. M., PAISH, E. C., POWE, D. G., MACMILLAN, R. D., LEE, A. H., ELLIS, I. O. and GREEN, A. R., 2011. An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat. 127(1), 99-108
• MAHMOUD, S. M., PAISH, E. C., POWE, D. G., MACMILLAN, R. D., GRAINGE, M. J., LEE, A. H., ELLIS, I. O. and GREEN, A. R., 2011. Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer: J Clin Oncol J Clin Oncol. 29(15), 1949-55
• MAHMOUD, S. M., LEE, A. H., PAISH, E. C., MACMILLAN, R. D., ELLIS, I. O. and GREEN, A. R., 2011. The prognostic significance of B lymphocytes in invasive carcinoma of the breast: Breast Cancer Res Treat Breast Cancer Res Treat.
• LEE, A. H., KEY, H. P., BELL, J. A., HODI, Z. and ELLIS, I. O., 2011. Breast carcinomas with borderline (2+) HER2 immunohistochemistry: percentage of cells with complete membrane staining for HER2 and the frequency of HER2 amplification: J Clin Pathol J Clin Pathol. 64(6), 490-2
• KNOWLDEN, J. M., GEE, J. M., BARROW, D., ROBERTSON, J. F., ELLIS, I. O., NICHOLSON, R. I. and HUTCHESON, I. R., 2011. erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines: Breast Cancer Res Breast Cancer Res. 13(5), R93
• KHOSHNAW, S. M., POWE, D. G., ELLIS, I. O. and GREEN, A. R., 2011. Detection and quantification of microRNAs in laser-microdissected formalin-fixed paraffin-embedded breast cancer tissues: Methods Mol Biol Methods Mol Biol. 755, 119-42
• HOLLAND, D. G., BURLEIGH, A., GIT, A., GOLDGRABEN, M. A., PEREZ-MANCERA, P. A., CHIN, S. F., HURTADO, A., BRUNA, A., ALI, H. R., GREENWOOD, W., DUNNING, M. J., SAMARAJIWA, S., MENON, S., RUEDA, O. M., LYNCH, A. G., MCKINNEY, S., ELLIS, I. O., EAVES, C. J., CARROLL, J. S., CURTIS, C., APARICIO, S. and CALDAS, C., 2011. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium: EMBO Mol Med EMBO Mol Med. 3(3), 167-80
• HABASHY, H. O., RAKHA, E. A., ALESKANDARANY, M., AHMED, M. A., GREEN, A. R., ELLIS, I. O. and POWE, D. G., 2011. FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat. 129(1), 11-21
• HABASHY, H. O., POWE, D. G., GLAAB, E., BALL, G., SPITERI, I., KRASNOGOR, N., GARIBALDI, J. M., RAKHA, E. A., GREEN, A. R., CALDAS, C. and ELLIS, I. O., 2011. RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype: Breast Cancer Res Treat Breast Cancer Res Treat. 128(2), 315-26
• HABASHY, H. O., POWE, D. G., ABDEL-FATAH, T. M., GEE, J. M., NICHOLSON, R. I., GREEN, A. R., RAKHA, E. A. and ELLIS, I. O., 2011. A review of the biological and clinical characteristics of luminal-like oestrogen receptor-positive breast cancer: Histopathology Histopathology.
• GIAMAS, G., FILIPOVIC, A., JACOB, J., MESSIER, W., ZHANG, H., YANG, D., ZHANG, W., SHIFA, B. A., PHOTIOU, A., TRALAU-STEWART, C., CASTELLANO, L., GREEN, A. R., COOMBES, R. C., ELLIS, I. O., ALI, S., LENZ, H. J. and STEBBING, J., 2011. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer: Nat Med Nat Med. 17(6), 715-9
• FILIPOVIC, A., GRONAU, J. H., GREEN, A. R., WANG, J., VALLATH, S., SHAO, D., RASUL, S., ELLIS, I. O., YAGUE, E., STURGE, J. and COOMBES, R. C., 2011. Biological and clinical implications of nicastrin expression in invasive breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat. 125(1), 43-53
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• AMMAR, A., MOHAMMED, R. A., SALMI, M., PEPPER, M., PAISH, E. C., ELLIS, I. O. and MARTIN, S. G., 2011. Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis: Anal Cell Pathol (Amst) Anal Cell Pathol (Amst). 34(1-2), 67-78
• ALI, A. M., DAWSON, S. J., BLOWS, F. M., PROVENZANO, E., ELLIS, I. O., BAGLIETTO, L., HUNTSMAN, D., CALDAS, C. and PHAROAH, P. D., 2011. Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer: Br J Cancer Br J Cancer. 104(4), 693-9
• ALESKANDARANY, M. A., RAKHA, E. A., MACMILLAN, R. D., POWE, D. G., ELLIS, I. O. and GREEN, A. R., 2011. MIB1/Ki-67 labelling index can classify grade 2 breast cancer into two clinically distinct subgroups: Breast Cancer Res Treat Breast Cancer Res Treat. 127(3), 591-9
• ALESKANDARANY, M. A., RAKHA, E. A., AHMED, M. A., POWE, D. G., ELLIS, I. O. and GREEN, A. R., 2011. Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat. 127(2), 407-16
• ALBASRI, A., ALESKANDARANY, M., BENHASOUNA, A., POWE, D. G., ELLIS, I. O., ILYAS, M. and GREEN, A. R., 2011. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis: Breast Cancer Res Treat Breast Cancer Res Treat. 126(1), 47-54
• AHMED, M. A., ALESKANDARANY, M. A., RAKHA, E. A., MOUSTAFA, R. Z., BENHASOUNA, A., NOLAN, C., GREEN, A. R., ILYAS, M. and ELLIS, I. O., 2011. A CD44(-)/CD24 (+) phenotype is a poor prognostic marker in early invasive breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat.
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• STORR, SARAH J, WOOLSTON, CAROLINE M, BARROS, FABRICIO F T, GREEN, ANDREW R, SHEHATA, MOHAMED, CHAN, STEPHEN Y, ELLIS, IAN O and MARTIN, STEWART G, 2010. Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. International journal of cancer. Journal international du cancer. 129(7), 1773-1780
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• HABASHY, HANY ONSY, POWE, DESMOND G, GLAAB, ENRICO, BALL, GRAHAM, SPITERI, INMACULADA, KRASNOGOR, NATALIO, GARIBALDI, JONATHAN M, RAKHA, EMAD A, GREEN, ANDREW R, CALDAS, C and ELLIS, IAN O, 2010. RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype. Breast cancer research and treatment.
• HABASHY, HANY ONSY, POWE, DESMOND G, STAKA, CINDY M, RAKHA, EMAD A, BALL, GRAHAM, GREEN, ANDREW R, ALESKANDARANY, MOHAMMED, PAISH, E CLAIRE, DOUGLAS MACMILLAN, R, NICHOLSON, ROBERT I, ELLIS, IAN O and GE, 2010. Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen. Breast cancer research and treatment. 119(2), 283-93
• CUZICK, JACK, SESTAK, IVANA, PINDER, SARAH E, ELLIS, IAN O, FORSYTH, SHARON, BUNDRED, NIGEL J, FORBES, JOHN F, BISHOP, HUGH, FENTIMAN, IAN S and GEORGE, WILLIAM D, 2010. Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. The lancet oncology.
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• RAKHA, EMAD A, LEE, ANDREW H S, EVANS, ANDREW J, MENON, SINDHU, ASSAD, NANCY Y, HODI, ZSOLT, MACMILLAN, DOUGLAS, BLAMEY, ROGER W and ELLIS, IAN O, 2010. Tubular carcinoma of the breast: further evidence to support its excellent prognosis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28(1), 99-104
• RAKHA, EMAD A, LEE, ANDREW HS, JENKINS, JACQUIE A, MURPHY, ALISON E, HAMILTON, LISA J and ELLIS, IAN O, 2010. Characterisation and outcome of breast needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening. International journal of cancer. Journal international du cancer.
• MAHMOUD, SAHAR M A, PAISH, EMMA C, POWE, DESMOND G, MACMILLAN, R DOUGLAS, LEE, ANDREW H S, ELLIS, IAN O and GREEN, ANDREW R, 2010. An evaluation of the clinical significance of FOXP3(+) infiltrating cells in human breast cancer. Breast cancer research and treatment.
• POWE DG, VOSS MJ, ZÄNKER KS, HABASHY HO, GREEN AR, ELLIS IO and ENTSCHLADEN F, 2010. Beta-Blocker Drug Therapy Reduces Secondary Cancer Formation In Breast Cancer And Improves Cancer Specific Survival. Oncotarget. 1(7), 628-38
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• SORIA, D., GARIBALDI, J. M., AMBROGI, F., GREEN, A. R., POWE, D., RAKHA, E., MACMILLAN, R. D., BLAMEY, R. W., BALL, G., LISBOA, P. J., ETCHELLS, T. A., BORACCHI, P., BIGANZOLI, E. and ELLIS, I. O., 2010. A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients: Comput Biol Med Comput Biol Med. 40(3), 318-30
• RAKHA, E. A., REIS-FILHO, J. S. and ELLIS, I. O., 2010. Combinatorial biomarker expression in breast cancer: Breast Cancer Res Treat Breast Cancer Res Treat. 120(2), 293-308
• RAKHA, E. A., REIS-FILHO, J. S., BAEHNER, F., DABBS, D. J., DECKER, T., EUSEBI, V., FOX, S. B., ICHIHARA, S., JACQUEMIER, J., LAKHANI, S. R., PALACIOS, J., RICHARDSON, A. L., SCHNITT, S. J., SCHMITT, F. C., TAN, P. H., TSE, G. M., BADVE, S. and ELLIS, I. O., 2010. Breast cancer prognostic classification in the molecular era: the role of histological grade: Breast Cancer Res Breast Cancer Res. 12(4), 207
• RAKHA, E. A., PATEL, A., POWE, D. G., BENHASOUNA, A., GREEN, A. R., LAMBROS, M. B., REIS-FILHO, J. S. and ELLIS, I. O., 2010. Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast: Am J Surg Pathol Am J Surg Pathol. 34(10), 1472-9
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• RAKHA, E. A., LEE, A. H., EVANS, A. J., MENON, S., ASSAD, N. Y., HODI, Z., MACMILLAN, D., BLAMEY, R. W. and ELLIS, I. O., 2010. Tubular carcinoma of the breast: further evidence to support its excellent prognosis: J Clin Oncol J Clin Oncol. 28(1), 99-104
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• PROVENZANO, E., BARTER, S. J., WRIGHT, P. A., FOROUHI, P., ALLIBONE, R. and ELLIS, I. O., 2010. Erdheim-chester disease presenting as bilateral clinically malignant breast masses: Am J Surg Pathol Am J Surg Pathol. 34(4), 584-8
• POWE, D. G., VOSS, M. J., ZANKER, K. S., HABASHY, H. O., GREEN, A. R., ELLIS, I. O. and ENTSCHLADEN, F., 2010. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival: Oncotarget Oncotarget. 1(7), 628-38
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• LANCASHIRE, L. J., POWE, D. G., REIS-FILHO, J. S., RAKHA, E., LEMETRE, C., WEIGELT, B., ABDEL-FATAH, T. M., GREEN, A. R., MUKTA, R., BLAMEY, R., PAISH, E. C., REES, R. C., ELLIS, I. O. and BALL, G. R., 2010. A validated gene expression profile for detecting clinical outcome in breast cancer using artificial neural networks: Breast Cancer Res Treat Breast Cancer Res Treat. 120(1), 83-93
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• GARCIA-CABALLERO, T., GRABAU, D., GREEN, A. R., GREGORY, J., SCHAD, A., KOHLWES, E., ELLIS, I. O., WATTS, S. and MOLLERUP, J., 2010. Determination of HER2 amplification in primary breast cancer using dual-colour chromogenic in situ hybridization is comparable to fluorescence in situ hybridization: a European multicentre study involving 168 specimens: Histopathology Histopathology. 56(4), 472-80
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• POWE DG, AKHTAR G, HABASHY HO, ABDEL-FATAH T, RAKHA EA, GREEN AR and ELLIS IO, 2009. Investigating Ap-2 And Yy1 Protein Expression As A Cause Of High Her2 Gene Transcription In Breast Cancers With Discordant Her2 Gene Amplification. Breast Cancer Research : Bcr. 11(6), R90
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• PICKARD MR, GREEN AR, ELLIS IO, CALDAS C, HEDGE VL, MOURTADA-MAARABOUNI M and WILLIAMS GT, 2009. Dysregulated Expression Of Fau And Melk Is Associated With Poor Prognosis In Breast Cancer. Breast Cancer Research : Bcr. 11(4), R60
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• POROCK, D., CHEUNG, K. L., MORGAN, D. A., WINTERBOTTOM, L., RICHARDSON, H. and ELLIS, I. O., 2009. Care of the older woman with primary breast cancer: a sign of the times?: Eur J Cancer Care (Engl) Eur J Cancer Care (Engl). 18(6), 527-9
• PICKARD, M. R., GREEN, A. R., ELLIS, I. O., CALDAS, C., HEDGE, V. L., MOURTADA-MAARABOUNI, M. and WILLIAMS, G. T., 2009. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer: Breast Cancer Res Breast Cancer Res. 11(4), R60
• PARADISO, A., ELLIS, I. O., ZITO, F. A., MARUBINI, E., PIZZAMIGLIO, S. and VERDERIO, P., 2009. Short- and long-term effects of a training session on pathologists' performance: the INQAT experience for histological grading in breast cancer: J Clin Pathol J Clin Pathol. 62(3), 279-81
• PAISH, E. C., GREEN, A. R., RAKHA, E. A., MACMILLAN, R. D., MADDISON, J. R. and ELLIS, I. O., 2009. Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth: J Clin Pathol J Clin Pathol. 62(7), 617-23
• OKUNADE, G., GREEN, A. R., YING, M., AGRAWAL, A., PAISH, E. C., ALESKANDRANY, M., WINTERBOTTOM, L., HASSELL, K., MORGAN, D. A., ELLIS, I. O. and CHEUNG, K. L., 2009. Biological profile of oestrogen receptor positive primary breast cancers in the elderly and response to primary endocrine therapy: Crit Rev Oncol Hematol Crit Rev Oncol Hematol. 72(1), 76-82
• MOHAMMED, R. A., ELLIS, I. O., LEE, A. H. and MARTIN, S. G., 2009. Vascular invasion in breast cancer; an overview of recent prognostic developments and molecular pathophysiological mechanisms: Histopathology Histopathology. 55(1), 1-9
• MOHAMMED, R. A., ELLIS, I. O., ELSHEIKH, S., PAISH, E. C. and MARTIN, S. G., 2009. Lymphatic and angiogenic characteristics in breast cancer: morphometric analysis and prognostic implications: Breast Cancer Res Treat Breast Cancer Res Treat. 113(2), 261-73
• KHOSHNAW, S. M., GREEN, A. R., POWE, D. G. and ELLIS, I. O., 2009. MicroRNA involvement in the pathogenesis and management of breast cancer: J Clin Pathol J Clin Pathol. 62(5), 422-8
• HAMILTON, L. J., EVANS, A. J., CORNFORD, E. J., RAKHA, E. A., ELLIS, I. O. and FOULKES, W. D., 2009. Will MRI screening deliver the expected survival advantage in BRCA 1 carriers?: Clin Radiol Clin Radiol. 64(11), 1045-7
• GREEN, A. R., YOUNG, P., KRIVINSKAS, S., RAKHA, E. A., CLAIRE PAISH, E., POWE, D. G. and ELLIS, I. O., 2009. The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR: Histopathology Histopathology. 54(4), 419-27
• GREEN, A. R., KRIVINSKAS, S., YOUNG, P., RAKHA, E. A., PAISH, E. C., POWE, D. G. and ELLIS, I. O., 2009. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast: Breast Cancer Res Treat Breast Cancer Res Treat. 113(1), 59-66
• GEE, J. M., ELORANTA, J. J., IBBITT, J. C., ROBERTSON, J. F., ELLIS, I. O., WILLIAMS, T., NICHOLSON, R. I. and HURST, H. C., 2009. Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival: J Pathol J Pathol. 217(1), 32-41
• FOULKES, W. D., GRAINGE, M. J., RAKHA, E. A., GREEN, A. R. and ELLIS, I. O., 2009. Tumor size is an unreliable predictor of prognosis in basal-like breast cancers and does not correlate closely with lymph node status: Breast Cancer Res Treat Breast Cancer Res Treat. 117(1), 199-204
• ELSHEIKH, S. E., GREEN, A. R., RAKHA, E. A., POWE, D. G., AHMED, R. A., COLLINS, H. M., SORIA, D., GARIBALDI, J. M., PAISH, C. E., AMMAR, A. A., GRAINGE, M. J., BALL, G. R., ABDELGHANY, M. K., MARTINEZ-POMARES, L., HEERY, D. M. and ELLIS, I. O., 2009. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome: Cancer Res Cancer Res. 69(9), 3802-9
• DOYLE, S., EVANS, A. J., RAKHA, E. A., GREEN, A. R. and ELLIS, I. O., 2009. Influence of E-cadherin expression on the mammographic appearance of invasive nonlobular breast carcinoma detected at screening: Radiology Radiology. 253(1), 51-5
• CHUA, Y. L., ITO, Y., POLE, J. C., NEWMAN, S., CHIN, S. F., STEIN, R. C., ELLIS, I. O., CALDAS, C., O'HARE, M. J., MURRELL, A. and EDWARDS, P. A., 2009. The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene: Oncogene Oncogene. 28(46), 4041-52
• AU-YONG, I. T., EVANS, A. J., TANEJA, S., RAKHA, E. A., GREEN, A. R., PAISH, C. and ELLIS, I. O., 2009. Sonographic correlations with the new molecular classification of invasive breast cancer: Eur Radiol Eur Radiol. 19(10), 2342-8
• ELLIS, P, BARRETT-LEE, P, JOHNSON, L, CAMERON, D, WARDLEY, A, O'REILLY, S, VERRILL, M, SMITH, I, YARNOLD, J, COLEMAN, R, EARL, H, CANNEY, P, TWELVES, C, POOLE, C, BLOOMFIELD, D, HOPWOOD, P, JOHNSTON, S, DOWSETT, M, BARTLETT, JMS, ELLIS, I, PECKITT, C, HALL, E and BLISS, JM, 2009. Sequential Docetaxel As Adjuvant Chemotherapy For Early Breast Cancer (Tact): An Open-Label, Phase Iii, Randomised Controlled Trial Lancet. 373(9676), 1681-1692
• RAKHA, EMAD A, EL-SAYED, MAYSA E, POWE, DESMOND G, GREEN, ANDREW R, HABASHY, HANY, GRAINGE, MATTHEW J, ROBERTSON, JOHN F R, BLAMEY, ROGER, GEE, JULIA, NICHOLSON, ROBERT I, LEE, ANDREW H S and ELLIS, IAN, 2008. Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes. European Journal of Cancer. 44(1), 73-83
• GREEN,, KRIVINSKAS,, YOUNG,, RAKHA,, PAISH,, POWE, and ELLIS,, 2008. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast. Breast Cancer Research and Treatment.
• RAKHA, EMAD A, EL-SHEIKH, SOMAIA E, KANDIL, MONA A, EL-SAYED, MAYSA E, GREEN, ANDREW R and ELLIS, IAN O, 2008. Expression of BRCA1 protein in breast cancer and its prognostic significance. Human pathology. 39(6), 857-65
• RAKHA,, EL-SAYED,, REIS-FILHO, and ELLIS,, 2008. Patho-biological aspects of basal-like breast cancer. Breast Cancer Research and Treatment.
• EL-SAYED ME, RAKHA EA, REED J, LEE AHS, EVANS AJ and ELLIS IO, 2008. Predictive Value Of Needle Core Biopsy Diagnoses Of Lesions Of Uncertain Malignant Potential (B3) In Abnormalities Detected By Mammographic Screening. Histopathology. 53(6), 650-7
• TENNANT SL, EVANS A, HAMILTON LJ, JAMES J, LEE AHS, HODI Z, ELLIS IO, RAKHA EA and WILSON ARM, 2008. Vacuum-Assisted Excision Of Breast Lesions Of Uncertain Malignant Potential (B3) - An Alternative To Surgery In Selected Cases. Breast (Edinburgh, Scotland). 17(6), 546-9
• RAKHA EA, EL-SAYED ME, REIS-FILHO JS and ELLIS IO, 2008. Expression Profiling Technology: Its Contribution To Our Understanding Of Breast Cancer. Histopathology. 52(1), 67-81
• FANSHAWE TR, LYNCH AG, ELLIS IO, GREEN AR and HANKA R, 2008. Assessing Agreement Between Multiple Raters With Missing Rating Information, Applied To Breast Cancer Tumour Grading. Plos One. 3(8), e2925
• ZHU, X., MULCAHY, L. A., MOHAMMED, R. A., LEE, A. H., FRANKS, H. A., KILPATRICK, L., YILMAZER, A., PAISH, E. C., ELLIS, I. O., PATEL, P. M. and JACKSON, A. M., 2008. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines: Breast Cancer Res Breast Cancer Res. 10(6), R95
• WEBSTER, L. R., LEE, S. F., RINGLAND, C., MOREY, A. L., HANBY, A. M., MORGAN, G., BYTH, K., MOTE, P. A., PROVAN, P. J., ELLIS, I. O., GREEN, A. R., LAMOURY, G., RAVDIN, P., CLARKE, C. L., WARD, R. L., BALLEINE, R. L. and HAWKINS, N. J., 2008. Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification: Clin Cancer Res Clin Cancer Res. 14(20), 6625-33
• WALKER, R. A., BARTLETT, J. M., DOWSETT, M., ELLIS, I. O., HANBY, A. M., JASANI, B., MILLER, K. and PINDER, S. E., 2008. HER2 testing in the UK: further update to recommendations: J Clin Pathol J Clin Pathol. 61(7), 818-24
• TENNANT, S. L., EVANS, A., HAMILTON, L. J., JAMES, J., LEE, A. H., HODI, Z., ELLIS, I. O., RAKHA, E. A. and WILSON, A. R., 2008. Vacuum-assisted excision of breast lesions of uncertain malignant potential (B3) - an alternative to surgery in selected cases: Breast Breast. 17(6), 546-9
• TANEJA, S., EVANS, A. J., RAKHA, E. A., GREEN, A. R., BALL, G. and ELLIS, I. O., 2008. The mammographic correlations of a new immunohistochemical classification of invasive breast cancer: Clin Radiol Clin Radiol. 63(11), 1228-35
• SPENDLOVE, I., AL-ATTAR, A., WATHERSTONE, O., WEBB, T. M., ELLIS, I. O., LONGMORE, G. D. and SHARP, T. V., 2008. Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival: Int J Cancer Int J Cancer. 123(10), 2247-53
• SPEIRS, V., GREEN, A. R., HUGHES, T. A., ELLIS, I. O., SAUNDERS, P. T. and SHAABAN, A. M., 2008. Clinical importance of estrogen receptor beta isoforms in breast cancer: J Clin Oncol J Clin Oncol. 26(35), 5825; author reply 5825-6
• SHAABAN, A. M., GREEN, A. R., KARTHIK, S., ALIZADEH, Y., HUGHES, T. A., HARKINS, L., ELLIS, I. O., ROBERTSON, J. F., PAISH, E. C., SAUNDERS, P. T., GROOME, N. P. and SPEIRS, V., 2008. Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients: Clin Cancer Res Clin Cancer Res. 14(16), 5228-35
• REIS-FILHO, J. S., NATRAJAN, R., VATCHEVA, R., LAMBROS, M. B., MARCHIO, C., MAHLER-ARAUJO, B., PAISH, C., HODI, Z., EUSEBI, V. and ELLIS, I. O., 2008. Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probes: Histopathology Histopathology. 52(7), 840-6
• RAMPAUL, R. S., DALE, O. T., MITCHELL, M., BLAMEY, R. W., MACMILLAN, R. D., ROBERTSON, J. F. and ELLIS, I. O., 2008. Incidence of intramammary nodes in completion mastectomy specimens after axillary node sampling: implications for breast conserving surgery: Breast Breast. 17(2), 195-8
• RAKHA, E. A., REIS-FILHO, J. S. and ELLIS, I. O., 2008. Basal-like breast cancer: a critical review: J Clin Oncol J Clin Oncol. 26(15), 2568-81
• RAKHA, E. A., REIS-FILHO, J. S. and ELLIS, I. O., 2008. Impact of basal-like breast carcinoma determination for a more specific therapy: Pathobiology Pathobiology. 75(2), 95-103
• RAKHA, E. A., EL-SHEIKH, S. E., KANDIL, M. A., EL-SAYED, M. E., GREEN, A. R. and ELLIS, I. O., 2008. Expression of BRCA1 protein in breast cancer and its prognostic significance: Hum Pathol Hum Pathol. 39(6), 857-65
• RAKHA, E. A., EL-SAYED, M. E., REIS-FILHO, J. S. and ELLIS, I. O., 2008. Expression profiling technology: its contribution to our understanding of breast cancer: Histopathology Histopathology. 52(1), 67-81
• RAKHA, E. A., EL-SAYED, M. E., POWE, D. G., GREEN, A. R., HABASHY, H., GRAINGE, M. J., ROBERTSON, J. F., BLAMEY, R., GEE, J., NICHOLSON, R. I., LEE, A. H. and ELLIS, I. O., 2008. Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes: Eur J Cancer Eur J Cancer. 44(1), 73-83
• RAKHA, E. A., EL-SAYED, M. E., MENON, S., GREEN, A. R., LEE, A. H. and ELLIS, I. O., 2008. Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast: Breast Cancer Res Treat Breast Cancer Res Treat. 111(1), 121-7
• RAKHA, E. A., EL-SAYED, M. E., LEE, A. H., ELSTON, C. W., GRAINGE, M. J., HODI, Z., BLAMEY, R. W. and ELLIS, I. O., 2008. Prognostic significance of Nottingham histologic grade in invasive breast carcinoma: J Clin Oncol J Clin Oncol. 26(19), 3153-8
• RAKHA, E. A., ELLIS, I. O. and REIS-FILHO, J. S., 2008. Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas): Mod Pathol Mod Pathol. 21(8), 1060-1; author reply 1061-2
• MENON, S., PORTER, G. J., EVANS, A. J., ELLIS, I. O., ELSTON, C. W., HODI, Z. and LEE, A. H., 2008. The significance of lobular neoplasia on needle core biopsy of the breast: Virchows Arch Virchows Arch. 452(5), 473-9
• LUCK, A. A., EVANS, A. J., JAMES, J. J., RAKHA, E. A., PAISH, E. C., GREEN, A. R. and ELLIS, I. O., 2008. Breast carcinoma with basal phenotype: mammographic findings: AJR Am J Roentgenol AJR Am J Roentgenol. 191(2), 346-51
• LUCK, A. A., EVANS, A. J., GREEN, A. R., RAKHA, E. A., PAISH, C. and ELLIS, I. O., 2008. The influence of basal phenotype on the metastatic pattern of breast cancer: Clin Oncol (R Coll Radiol) Clin Oncol (R Coll Radiol). 20(1), 40-5
• LEE, A. H., HODI, Z. and ELLIS, I. O., 2008. False-negative assessment of oestrogen receptor on needle core biopsy of invasive carcinoma of the breast: J Clin Pathol J Clin Pathol. 61(2), 239-40
• LEE, A. H. and ELLIS, I. O., 2008. The Nottingham prognostic index for invasive carcinoma of the breast: Pathol Oncol Res Pathol Oncol Res. 14(2), 113-5
• HABASHY, H. O., POWE, D. G., RAKHA, E. A., BALL, G., PAISH, C., GEE, J., NICHOLSON, R. I. and ELLIS, I. O., 2008. Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance: Eur J Cancer Eur J Cancer. 44(11), 1541-51
• GREEN, A. R., BURNEY, C., GRANGER, C. J., PAISH, E. C., EL-SHEIKH, S., RAKHA, E. A., POWE, D. G., MACMILLAN, R. D., ELLIS, I. O. and STYLIANOU, E., 2008. The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome: Breast Cancer Res Treat Breast Cancer Res Treat. 110(3), 427-37
• FANSHAWE, T. R., LYNCH, A. G., ELLIS, I. O., GREEN, A. R. and HANKA, R., 2008. Assessing agreement between multiple raters with missing rating information, applied to breast cancer tumour grading: PLoS One PLoS One. 3(8), e2925
• ELSHEIKH, S. E., GREEN, A. R., RAKHA, E. A., SAMAKA, R. M., AMMAR, A. A., POWE, D., REIS-FILHO, J. S. and ELLIS, I. O., 2008. Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype: Br J Cancer Br J Cancer. 99(2), 327-34
• ELSHEIKH, S., GREEN, A. R., ALESKANDARANY, M. A., GRAINGE, M., PAISH, C. E., LAMBROS, M. B., REIS-FILHO, J. S. and ELLIS, I. O., 2008. CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome: Breast Cancer Res Treat Breast Cancer Res Treat. 109(2), 325-35
• EL-SAYED, M. E., RAKHA, E. A., REED, J., LEE, A. H., EVANS, A. J. and ELLIS, I. O., 2008. Audit of performance of needle core biopsy diagnoses of screen detected breast lesions: Eur J Cancer Eur J Cancer. 44(17), 2580-6
• EL-SAYED, M. E., RAKHA, E. A., REED, J., LEE, A. H., EVANS, A. J. and ELLIS, I. O., 2008. Predictive value of needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening: Histopathology Histopathology. 53(6), 650-7
• COOKE, S. L., POLE, J. C., CHIN, S. F., ELLIS, I. O., CALDAS, C. and EDWARDS, P. A., 2008. High-resolution array CGH clarifies events occurring on 8p in carcinogenesis: BMC Cancer BMC Cancer. 8, 288
• CHEUNG, K. L., WONG, A. W., PARKER, H., LI, V. W., WINTERBOTTOM, L., MORGAN, D. A. and ELLIS, I. O., 2008. Pathological features of primary breast cancer in the elderly based on needle core biopsies--a large series from a single centre: Crit Rev Oncol Hematol Crit Rev Oncol Hematol. 67(3), 263-7
• ABDULKADER, M., ELLIS, I. O., SCHOLEFIELD, J. H. and KAYE, P. V., 2008. Extramammary Paget's possibly arising from a non-invasive rectal adenoma: Histopathology Histopathology. 53(2), 228-31
• ABDEL-FATAH, T. M., POWE, D. G., HODI, Z., REIS-FILHO, J. S., LEE, A. H. and ELLIS, I. O., 2008. Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family: Am J Surg Pathol Am J Surg Pathol. 32(4), 513-23
• DOWSETT M, ALLRED C, KNOX J, QUINN E, SALTER J, WALE C, CUZICK J, HOUGHTON J, WILLIAMS N, MALLON E, BISHOP H, ELLIS I, LARSIMONT D, SASANO H, CARDER P, CUSSAC AL, KNOX F, SPEIRS V, FORBES J and BUZDAR A, 2008. Relationship Between Quantitative Estrogen And Progesterone Receptor Expression And Human Epidermal Growth Factor Receptor 2 (Her-2) Status With Recurrence In The Arimidex, Tamoxifen, Alone Or In Combination Trial. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology. 26(7), 1059-65