I am a Pharmacist and gained my PhD from the School of Pharmacy at the University of Nottingham under the supervision of Prof Barrie Bycroft. After an eighteen month postdoctoral position at the School of Pharmacy, London under the mentorship of Prof Istvan Toth I was appointed to a lectureship at Nottingham in 1997. I was promoted to Associate Professor in 2006.
I am the co-founder and Director of Medicinal Chemistry of a successful spin-out from the University of Nottingham, CellAura Technologies Ltd (www.cellaura.com).
Recognition of my work in the area of medicinal and biological chemistry has recently resulted in my election to the EPSRC Peer Review College.
Pharmaceutical & Biological Chemistry 1
Pharmaceutical & Biological Chemistry 2
Laboratories in Pharmaceutical Sciences
Medicinal Chemistry and Drug Design
My research career is focused on the synthesis of novel molecular entities and their application to a wide arena of biological and pharmacological problems. My background in solid-and solution-phase… read more
STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77 SCHEMBRI, LUKE S., STODDART, LEIGH A., BRIDDON, STEPHEN J., KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM and SCAMMELLS, PETER J., 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the mu-Opioid Receptor JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9754-9767
SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328
My research career is focused on the synthesis of novel molecular entities and their application to a wide arena of biological and pharmacological problems. My background in solid-and solution-phase small molecule, peptide and carbohydrate chemistry enabled me to bring a new array of skills to the Medicinal Chemistry group at Nottingham.
Of my two current major areas of research, the first centers on employing synthetic and biochemical methodologies to re-engineer the surface of living cells and exploit their novel chemical phenotype in applications such as tissue engineering. I am involved in a cross School collaboration with Prof Kevin Shakesheff (Pharmacy) and Prof Dave Kendall (Biomedical Sciences) which has resulted in the ability to generate artificial cell aggregates using mild oxidation chemistry, carbohydrate biochemistry and native chemical ligation techniques. As principal investigator, the award of one of only thirteen highly competitive EPSRC 'Adventure Fund' grants has recently enabled us to develop new and powerful cellular and protein ligation chemistries and the first publication from this was a recent 'hot paper' in the Journal of Materials Chemistry.
My second major area of research focuses upon the synthesis of fluorescently labelled bioactive small molecules and their application to biospectroscopy and molecular pharmacology. As co-applicant on major JIF and Wellcome Trust funded projects, and in collaboration with Professor Steve Hill (Institute of Cell Signalling, Nottingham) we have established a unique UK based pharmacochemistry imaging facility and demonstrated, for the first time, the ability to measure and quantify small molecule-receptor interactions in real-time at both the single cell and single molecule level; exemplified in our recent PNAS and J Med Chem papers.
In my academic career, I have published over 30 scientific papers and patents, supervised 15 PhD students and mentored 5 postdoctoral fellows; many of whom are now in senior positions within the pharmaceutical industry or academia.
Memberships of Committees and Professional Bodies
- Member of the Royal Pharmaceutical Society of Great Britain
- Member of the Royal Society of Chemistry
- Member of the Royal Society of Chemistry Carbohydrate Group
- Member of the Editorial Board of Current Drug Delivery.
- Member, EPSRC Peer Review College