Barrie Kellam

Contact

• workRoom C08 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 9513026
• fax0115 9513412
• barrie.kellam@nottingham.ac.uk

Biography

I am a Pharmacist and gained my PhD from the School of Pharmacy at the University of Nottingham under the supervision of Prof Barrie Bycroft. After an eighteen month postdoctoral position at the School of Pharmacy, London under the mentorship of Prof Istvan Toth I was appointed to a lectureship at Nottingham in 1997. I was promoted to Associate Professor in 2006 and full Professor in 2013.

I was the co-founder and Director of Medicinal Chemistry of a successful spin-out from the University of Nottingham, CellAura Technologies Ltd between 2006-2014.

I was a member of the General Pharmaceutical Council's (GPhC) Accreditation & Recognition Panel between 2012-2021 and I am currently chair of the Royal Pharmaceutical Society's (RPS) Science and Research Committee, helping provide strategic leadership, advocacy and expert advice around pharmaceutical sciences and pharmacy research in the UK and internationally.

Teaching (Undergraduate)

MPharm:

PHAR1002 (Essential Skills for Pharmacy)

PHAR1003 (Dyspepsia)

PHAR2005 (Pain)

PHAR4012 (Advanced Drug Discovery)

MSci: Pharmaceutical Sciences

PHAR1020 (Synthesis of Simple Drugs)

Teaching (Postgraduate)

MSc in Drug Discovery & Pharmaceutical Sciences

PHAR4006 (Fundamentals of Drug Discovery)

PHAR4008 (Drug Discovery and Development I)

Research Summary

My academic research is focussed around small molecule synthetic medicinal chemistry, especially pertaining to G Protein Coupled Receptors (GPCRs), making significant scientific and commercial… read more

Selected Publications

• DISNEY AJ, KELLAM B and DEKKER LV, 2016. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications. ChemMedChem. 11(9), 972-9
• STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77
• SCHEMBRI, LUKE S., STODDART, LEIGH A., BRIDDON, STEPHEN J., KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM* and SCAMMELLS, PETER J.*, 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the mu-Opioid Receptor JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9754-9767
• SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328

• View all publications

Current Research

My academic research is focussed around small molecule synthetic medicinal chemistry, especially pertaining to G Protein Coupled Receptors (GPCRs), making significant scientific and commercial contributions in this area. Developing an international reputation in fluorescent small molecule ligand synthesis through a highly productive collaborative programme with Prof Steve Hill in applying fluorescent-based technologies to characterise and interrogate ligand-receptor interactions for a number of class A GPCRs in living cells; leading to development of novel high-throughput fluorescence-based assays for identification of new medicinal agents.

This also allowed single-cell pharmacological measurements to be undertaken in primary cells, with publications in PNAS, FASEB, Chemistry & Biology and J Med Chem highlighting our successes. Patents generated from this work formed background IP to leverage equity-based investment to spin out CellAura Technologies Ltd. In 2006.

I have led the medicinal chemistry component in drug discovery programmes, e.g. a £2.8M funded Seeding Drug Discovery programme from the Wellcome Trust. Over a 2-year period we synthesised over 1500 novel compounds as part of a focussed lead optimisation programme for future treatment of patients with concomitant cardiovascular and respiratory disease. From a highly selective β1-adrenoceptor partial agonist 'hit', structure optimisation generated a suite of high affinity pure antagonists, with improved selectivity over other β-adrenoceptor subtypes. We generated three drug candidate series, all displaying good oral bioavailability, pronounced β1mediated reduction of heart rate with no β2-mediated side-effects. These compounds possessed excellent disposition properties without adverse toxicology.

All of the studies above have necessitated a joined-up approach using in silico and traditional synthetic medicinal chemistry methods to help reach fruition and have provided a highly varied environment to help train over 40 PhD students and postdoctoral researchers.

In my academic career, I have published over 80 scientific papers and patents, supervised 36 PhD students and mentored 10 postdoctoral fellows; many of whom are now in senior positions within the pharmaceutical industry or academia.

Memberships of Committees and Professional Bodies

• Fellow of the Royal Pharmaceutical Society of Great Britain
• Member of the Royal Society of Chemistry
• Chair of the Royal Pharmaceutical Society's Science and Research Committee

• COMEO, ELEONORA, TRINH, PHUC, NGUYEN, ANH T., NOWELL, CAMERON J., KINDON, NICHOLAS D., SOAVE, MARK, STODDART, LEIGH A., WHITE, JONATHAN M., HILL, STEPHEN J., KELLAM, BARRIE, HALLS, MICHELLE L., MAY, LAUREN T. and SCAMMELLS, PETER J., 2021. Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A(1) Receptor in Living Cells JOURNAL OF MEDICINAL CHEMISTRY. 64(10), 6670-6695
• SOUKARIEH, FADI, MASHABI, ALAA, RICHARDSON, WILLIAM, OTON, EDUARD VICO, ROMERO, MANUEL, ROBERSTON, SHAUN N., GROSSMAN, SCOTT, SOU, TOMAS, LIU, RUILING, HALLIDAY, NIGEL, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C., BERGSTROM, CHRISTEL A. S., KELLAM, BARRIE, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, STOCKS, MICHAEL J. and CAMARA, MIGUEL, 2021. Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa ACS INFECTIOUS DISEASES. 7(9), 2666-2685
• SOUKARIEH, FADI, MASHABI, ALAA, RICHARDSON, WILLIAM, OTON, EDUARD VICO, ROMERO, MANUEL, ROBERSTON, SHAUN N., GROSSMAN, SCOTT, SOU, TOMAS, LIU, RUILING, HALLIDAY, NIGEL, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C., BERGSTROM, CHRISTEL A. S., KELLAM, BARRIE, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, STOCKS, MICHAEL J. and CÁMARA, MIGUEL, 2021. Design and Evaluation of New Quinazolin-4(3H)‑one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa ACS Infectious Diseases. 7(9), 2666-2685
• DAMASKINAKI, FOTEINI-NAFSIKA, MORAN, LUIS A., GARCIA, ANGEL, KELLAM, BARRIE and WATSON, STEVE P., 2021. Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2 Platelets. 32(6), 744-752
• STODDART, LEIGH A., KILPATRICK, LAURA E., CORRIDEN, ROSS, KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2021. Efficient G protein coupling is not required for agonist‐mediated internalization and membrane reorganization of the adenosine A3 receptor The FASEB Journal. 35(4), e21211
• COMEO, ELEONORA, TRINH, PHUC, NGUYEN, ANH T, NOWELL, CAMERON J, KINDON, NICHOLAS D, SOAVE, MARK, STODDART, LEIGH A, WHITE, JONATHAN M, HILL, STEPHEN J, KELLAM, BARRIE, HALLS, MICHELLE L, MAY, LAUREN T and SCAMMELLS, PETER J, 2021. Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A 1 Receptor in Living Cells Journal of Medicinal Chemistry. 64(10), 6670-6695
• GOULDING, JOËLLE, MISTRY, SARAH J., SOAVE, MARK, WOOLARD, JEANETTE, BRIDDON, STEPHEN J., WHITE, CARL W., KELLAM, BARRIE and HILL, STEPHEN J., 2021. Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels Pharmacology Research & Perspectives. 9(3), e00779
• GILLIS A, GONDIN AB, KLIEWER A, SANCHEZ J, LIM HD, ALAMEIN C, MANANDHAR P, SANTIAGO M, FRITZWANKER S, SCHMIEDEL F, KATTE TA, REEKIE T, GRIMSEY NL, KASSIOU M, KELLAM B, KRASEL C, HALLS ML, CONNOR M, LANE JR, SCHULZ S, CHRISTIE MJ and CANALS M, 2020. Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling. 13(625),
• COMEO, ELEONORA, KINDON, NICHOLAS D., SOAVE, MARK, STODDART, LEIGH A., KILPATRICK, LAURA E., SCAMMELLS, PETER J., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A(2A) Receptor JOURNAL OF MEDICINAL CHEMISTRY. 63(5), 2656-2672
• STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells COMMUNICATIONS BIOLOGY. 3(1),
• BAKER, JILLIAN G, FROMONT, CHRISTOPHE, BRUDER, MARJORIE, THOMPSON, KEVIN S J, KELLAM, BARRIE, HILL, STEPHEN J, GARDINER, SHEILA M and FISCHER, PETER M, 2020. Using Esterase Selectivity to Determine the In Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers ACS Pharmacology & Translational Science.
• MATOS, THIAGO KELVIN BRITO, BATISTA, PEDRO HENRIQUE JATAI, ROCHO, FERNANDA DOS REIS, VITA, DANIELA DE, PEARCE, NICHOLAS, KELLAM, BARRIE, MONTANARI, CARLOS ALBERTO and LEITÃO, ANDREI, 2020. Synthesis and Matched Molecular Pair Analysis of Covalent Reversible Inhibitors of the Cysteine Protease CPB Bioorganic & Medicinal Chemistry Letters. 30(18), 127439
• STEPHENSON, ZOE A, HARVEY, ROBERT F, PRYDE, KENNETH R, MISTRY, SARAH, HARDY, RACHEL E, SERRELI, RICCARDO, CHUNG, INJAE, ALLEN, TIMOTHY EH, STONELEY, MARK, MACFARLANE, MARION, FISCHER, PETER M, HIRST, JUDY, KELLAM, BARRIE and WILLIS, ANNE E, 2020. Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I. eLife. 9, e55845
• SOAVE, MARK, HEUKERS, RAIMOND, KELLAM, BARRIE, WOOLARD, JEANETTE, SMIT, MARTINE J, BRIDDON, STEPHEN J and HILL, STEPHEN J, 2020. Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies Cell Chemical Biology.
• STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells Communications Biology. 3(1), 722
• GILLIS, ALEXANDER, GONDIN, ARISBEL B, KLIEWER, ANDREA, SANCHEZ, JULIE, LIM, HERMAN D, ALAMEIN, CLAUDIA, MANANDHAR, PREETI, SANTIAGO, MARINA, FRITZWANKER, SEBASTIAN, SCHMIDEL, FRANK, KATTE, TIMOTHY A, REEKIE, TRISTAN, GRIMSEY, NATASHA L, KASSIOU, MICHAEL, KELLAM, BARRIE, KRASEL, CORNELIUS, HALLS, MICHELLE L, CONNOR, MARK, LANE, J ROBERT, SCHULZ, STEFAN, CHRISTIE, MACDONALD J and CANALS, MERITXELL, 2020. Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling. 13(625), eaaz3140
• COMEO, ELEONORA, KINDON, NICHOLAS D, SOAVE, MARK, STODDART, LEIGH A, KILPATRICK, LAURA E, SCAMMELLS, PETER J, HILL, STEPHEN J and KELLAM, BARRIE, 2020. Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor. Journal of medicinal chemistry.
• TIM J. FYFE, BARRIE KELLAM, DAVID A. SYKES, BEN CAPUANO, PETER J. SCAMMELLS, J. ROBERT LANE, STEVEN J. CHARLTON and SHAILESH N. MISTRY, 2019. Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor Journal of Medicinal Chemistry. 62(21), 9488-9520
• FYFE, TIM J., ZARZYCKA, BARBARA, LIM, HERMAN D., KELLAM, BARRIE, MISTRY, SHAILESH N., KATRICH, VSEVOLOD, SCAMMELLS, PETER J., LANE, J. ROBERT and CAPUANO, BEN, 2019. A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D-2 Receptor JOURNAL OF MEDICINAL CHEMISTRY. 62(1), 174-206
• FYFE, TIM J., KELLAM, BARRIE, SYKES, DAVID A., CAPUANO, BEN, SCAMMELLS, PETER J., LANE, J. ROBERT, CHARLTON, STEVEN J. and MISTRY, SHAILESH N., 2019. Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D-2 Receptor JOURNAL OF MEDICINAL CHEMISTRY. 62(21), 9488-9520
• ADLERE, ILZE, CASPAR, BIRGIT, ARIMONT, MARTA, DEKKERS, SEBASTIAN, VISSER, KIRSTEN, STUIJT, JEFFREY, DE GRAAF, CHRIS, STOCKS, MICHAEL, KELLAM, BARRIE, BRIDDON, STEPHEN, WIJTMANS, MAIKEL, DE ESCH, IWAN, HILL, STEPHEN and LEURS, ROB, 2019. Modulators of CXCR4 and CXCR7/ACKR3 Function MOLECULAR PHARMACOLOGY. 96(6), 737-752
• ARRUDA MA, STODDART LA, GHERBI K, BRIDDON SJ, KELLAM B and HILL SJ, 2018. A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells. Frontiers in pharmacology. 8, 908
• STODDART LA, VERNALL AJ, BOUZO-LORENZO M, BOSMA R, KOOISTRA AJ, DE GRAAF C, VISCHER HF, LEURS R, BRIDDON SJ, KELLAM B and HILL SJ, 2018. Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells. Scientific reports. 8(1), 1572
• LAM R, GONDIN AB, CANALS M, KELLAM B, BRIDDON SJ, GRAHAM B and SCAMMELLS PJ, 2018. Fluorescently Labeled Morphine Derivatives for Bioimaging Studies. Journal of medicinal chemistry. (In Press.)
• EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2017. GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure & Dynamics. 35(12), 2604-2619
• BAKER JG, GARDINER SM, WOOLARD J, FROMONT C, JADHAV GP, MISTRY SN, THOMPSON KS, KELLAM B, HILL SJ and FISCHER PM, 2017. Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal. 31(7), 3150-3166
• SCHWEHM C, KELLAM B, GARCES AE, HILL SJ, KINDON ND, BRADSHAW TD, LI J, MACDONALD SJ, ROWEDDER JE, STODDART LA and STOCKS MJ, 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors. Journal of medicinal chemistry. 60(4), 1534-1554
• DISNEY AJ, KELLAM B and DEKKER LV, 2016. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications. ChemMedChem. 11(9), 972-9
• SKILLING, K. J., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2016. Developing a self-healing supramolecular nucleoside hydrogel SOFT MATTER. 12(43), 8950-8957
• CONROY, SEAN, KINDON, NICHOLAS, KELLAM, BARRIE and STOCKS, MICHAEL J., 2016. Drug-like Antagonists of P2Y Receptors-From Lead Identification to Drug Development JOURNAL OF MEDICINAL CHEMISTRY. 59(22), 9981-10005
• STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77
• SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328
• STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F. G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery BIOORGANIC & MEDICINAL CHEMISTRY. 23(21), 6891-6899
• SCHEMBRI, LUKE S., STODDART, LEIGH A., BRIDDON, STEPHEN J., KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM* and SCAMMELLS, PETER J.*, 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the mu-Opioid Receptor JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9754-9767
• SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J, 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.: Acs Medicinal Chemistry Letters Acs Medicinal Chemistry Letters. 6(3), 324-328
• STONE, ERICA L, CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B, MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F G, LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D, 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.: Bioorganic & medicinal chemistry Bioorganic & medicinal chemistry. 23(21), 6891-6899
• STODDART, LEIGH A, VERNALL, ANDREA J., BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2015. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.: Neuropharmacology Neuropharmacology. 98, 68-77
• SCHEMBRI, LUKE S, STODDART, LEIGH A, BRIDDON, STEPHEN J, KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM and SCAMMELLS, PETER J, 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.: Journal of Medicinal Chemistry Journal of Medicinal Chemistry. 58(24), 9754-9767
• VERNALL, ANDREA J., HILL, STEPHEN J. and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1073-1084
• STODDART, LEIGH A., KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization BRITISH JOURNAL OF PHARMACOLOGY. 171(16), 3827-3844
• HILL, STEPHEN J., MAY, LAUREN T., KELLAM, BARRIE and WOOLARD, JEANETTE, 2014. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1102-1113
• CORRIDEN R, KILPATRICK LE, KELLAM B, BRIDDON SJ and HILL SJ, 2014. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB journal. 28, 4211-4222
• SKILLING, K. J., NDUNGU, A., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives JOURNAL OF MATERIALS CHEMISTRY B. 2(47), 8412-8417
• SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J., KELLAM, BARRIE and STOCKS, MICHAEL J., 2014. Preparation and structural analysis of (±)- cis -ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)- trans -ethyl 2-oxooctahydro-1 H -pyrrolo[3,2- c ]pyridine-5-carboxylate: Acta Crystallographica Section C Structural Chemistry Acta Crystallographica Section C Structural Chemistry. 70, 1161-1168
• SKILLING, K J, NDUNGU, A, KELLAM, BARRIE, ASHFORD, M, BRADSHAW, T D and MARLOW, M, 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives: J. Mater. Chem. B J. Mater. Chem. B. 2(47), 8412-8417
• HILL, STEPHEN J, MAY, LAUREN T, KELLAM, BARRIE and WOOLARD, JEANETTE, 2014. Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization: British journal of pharmacology British journal of pharmacology. 171(5), 1102-1113
• VERNALL, ANDREA J., HILL, STEPHEN J and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs: British journal of pharmacology British journal of pharmacology. 171(5), 1073-1084
• SKILLING, KATHRYN J, CITOSSI, FRANCESCA, BRADSHAW, TRACEY D, ASHFORD, MARIANNE, KELLAM, BARRIE and MARLOW, MARIA, 2014. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications.: Soft Matter Soft Matter. 10(2), 237-256
• STODDART, LEIGH A, KELLAM, BARRIE, BRIDDON, STEPHEN J and HILL, STEPHEN J, 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.: British journal of pharmacology British journal of pharmacology. 171(16), 3827-3844
• SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J, KELLAM, BARRIE and STOCKS, MICHAEL J, 2014. Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate.: Acta crystallographica. Section C, Structural chemistry Acta crystallographica. Section C, Structural chemistry. 70(Pt 12), 1161-1168
• CORRIDEN, R., SELF, T., AKONG-MOORE, K., NIZET, V., KELLAM, B., BRIDDON, S.J. and HILL, S.J., 2013. Adenosine-A₃ receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes EMBO Reports. 14(8), 726-732
• MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Synthesis and in vitro and in vivo characterization of highly β₁-selective β-adrenoceptor partial agonists Journal of Medicinal Chemistry. 56(10), 3852-3865
• VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & biomolecular chemistry. 11(34), 5673-82
• K. J. SKILLING, F. CITOSSI, T. D. BRADSHAW, M. ASHFORD, B. KELLAM and M. MARLOW, 2013. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications SOFT MATTER. 10(2), 237-256
• DICKENS MP, ROXBURGH P, HOCK A, MEZNA M, KELLAM B, VOUSDEN KH and FISCHER PM, 2013. 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorganic & medicinal chemistry. 21(22), 6868-77
• VERNALL, A.J., STODDART, L.A., BRIDDON, S.J., HILL, S.J. and KELLAM, B., 2012. Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-α]quinoxalin-1-one scaffold Journal of Medicinal Chemistry. 55(4), 1771-1782
• DALE CL, HILL SJ and KELLAM B, 2012. New potent, short-linker BODIPY-630/650 labelled fluorescent adenosine MedChemComm. 3, 333-338
• STODDART, L.A., VERNALL, A.J., DENMAN, J.L., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2012. Fragment screening at adenosine-A₃ receptors in living cells using a fluorescence-based binding assay Chemistry & Biology. 19(9), 1105-1115
• BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2011. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods in Molecular Biology. 746, 211-36
• DEY, S., KELLAM, B., ALEXANDER, M.R., ALEXANDER, C. and ROSE, F.R.A.J., 2011. Enzyme-passage free culture of mouse embryonic stem cells on thermo-responsive polymer surfaces Journal of Materials Chemistry. 21(19), 6883-6890
• BAKER, J.G., ADAMS, L.A., SALCHOW, K., MISTRY, S.N., MIDDLETON, R.J., HILL, S.J. and KELLAM, B., 2011. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors Journal of Medicinal Chemistry. 54(19), 6874-6887
• JADHAV GP, CHHABRA SR, TELFORD G, HOOI DS, RIGHETTI K, WILLIAMS P, KELLAM B, PRITCHARD DI and FISCHER PM, 2011. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. Journal of Medicinal Chemistry. 54(9), 3348-3359
• BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A₁ receptor ligands British Journal of Pharmacology. 159(4), 772-786
• CORDEAUX, Y., BRIDDON, S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2008. Agonist-occupied A₃ adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells FASEB Journal. 22(3), 850-860
• MIDDLETON,R, BRIDDON,S.J., CORDEAUX,Y., YATES,A.S., DALE,C.L., GEORGE,M., BAKER,J.G., HILL,S.J. and KELLAM,B., 2007. New Fluorescent Adenosine A(1)-Receptor Agonists That Allow Quantification of Ligand-Receptor Interactions in Microdomains of Single Living Cells. Journal of Medicinal Chemistry. 50(4), 782-793
• CORDEAUX, Y., BRIDDON,S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2007. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.The FASEB Journal FASEB. Available at: <http://www.fasebj.org/papbyrecent.dtl>
• DE BANK, P.A., HOU,Q., WARNER, R.M., WOOD, I.V., ALI, B.E., MACNEIL, S., KENDALL, D.A., KELLAM, B.K., SHAKESHEFF, K.M. and BUTTERY, L.D.K., 2007. Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking Biotechnology and Bioengineering. 97(6), 1617-1625
• YATES, A.S., DOUGHTY, S.W., KENDALL, D.A. and KELLAM, B., 2005. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB₂ receptor Bioorganic & Medicinal Chemistry Letters. 15(16), 3758-3762
• ABUKHADER, M., HEAP, J., DE MATTEIS, C., KELLAM, B., DOUGHTY, S.W., MINTON, N. and PAOLI, M., 2005. Binding of the anticancer prodrug CB1954 to the activating enzyme NQ02 revealed by the crystal structure of their complex Journal of Medicinal Chemistry. 48(24), 7714-7719
• DE BANK, P. A., KELLAM, B., KENDALL, D. A. and SHAKESHEFF, K. M., 2005. Altered cellular response to adsorbed matrix protein by chemoselective ligation of small molecules JOURNAL OF MATERIALS CHEMISTRY. VOL 15, 2047-2055
• KELLAM,B., WARD,PA.., RAHIM,A.S.A. and CHHABRA,S.R., 2005. N^α-Dmc protected amino acid aglycones: versatile hydrogenolysis stable acceptors for O-glycosylation Tetrahedron Letters. 46(10), 1703-1706
• SEDMAN, V.L., ALLEN, S., CHAN, W.C., KELLAM, B. and TENDLER S.J.B., 2005. Functionalizing human amylin (20-29) fibrils FEBS Journal. 272, 517-518
• ALI, BE, DE BANK, PA, KELLAM, B and SHAKESHEFF, KM, 2005. Controlled cell aggregation via cell-surface engineering International Journal of Experimental Pathology. 86(3), A21-A22
• BRIDDON, S.J., MIDDLETON, R.J., CORDEAUX, Y., FLAVIN, F.M., WEINSTEIN, J.A., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells Proceedings of the National Academy of Sciences of the United States of America. 101(13), 4673-4678
• BRIDDON, S.J., MIDDLETON, R.J., YATES, A.S., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level Faraday Discussions. 126, 197-207
• SLEEMAN, MARK C, SMITH, PAUL, KELLAM, BARRIE, CHHABRA, SIRI RAM, BYCROFT, BARRIE W and SCHOFIELD, CHRISTOPHER J, 2004. Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). ChemBioChem. 5(6), 879-82
• QUIRK, R.A., KELLAM, B., BHANDARI, R.N., DAVIES, M.C., TENDLER, S.J.B. and SHAKESHEFF, K.M., 2003. Cell-type-specific adhesion onto polymer surfaces from mixed cell populations. Biotechnology and Bioengineering. 81(5), 625-628
• DE BANK, P.A., KELLAM, B., KENDALL, D.A. and SHAKESHEFF, K.M., 2003. Surface engineering of living myoblasts via selective periodate oxidation Biotechnology and Bioengineering. 81(7), 800-808
• KELLAM, BARRIE, DE BANK, PAUL A and SHAKESHEFF, KEVIN M, 2003. Chemical modification of mammalian cell surfaces. Chemical Society Reviews. 32(6), 327-37
• BYCROFT, B.W., CHHABRA, S.R., KELLAM, B. and SMITH, P., 2003. Convenient syntheses of (3S, 5S)-carbapenam-3-carboxylates and their biosynthetic relevance Tetrahedron Letters. 44(5), 973-976
• CHHABRA, SIRI RAM, RAHIM, AISYAH S ABDUL and KELLAM, BARRIE, 2003. Recent progress in the design of selectin inhibitors. Mini Reviews in Medicinal Chemistry. 3(7), 679-87
• SHAKESHEFF, K.M., SILVA, M., HOWDLE, S.M., SALEM, A.K., ROSE, F.R., WHITAKER, M.J., WOOD, I., DE BANK, P., KENDALL, D.A. and KELLAM, B., 2002. Delivering protein and cell therapeutics for tissue regeneration In: International Symposium on Recent Advances in Drug Delivery Systems.
• SMITH, P., CHHABRA, S.R., KELLAM, B. and BYCROFT, B.W., 2002. Synthetic and biotransformations studies on trans-(3S, 5S)-1-carbapenam-3-carboxylic acid In: Third International Meeting. 33
• CHHABRA, S. R., PAREKH, H., KHAN, A. N., BYCROFT, B. W. and KELLAM, B., 2001. A Dde-based carboxy linker for solid-phase synthesis Tetrahedron Letters. VOL 42(PART 11), 2189-2192
• PAREKH, H., CHHABRA, S.R., BYCROFT, B.W. and KELLAM, B., 2001. Synthesis, evaluation and solid-phase applications of a Dde-based carboxy linker In: American Peptide Symposium. 145
• WARD, P., CHHABRA, S.R. and KELLAM, B., 2001. Nsuper^α-Dmc protected amino acids: Hydrogenolysis and acid stable acceptors for α-glycosyl-1-O-amino acid synthesis In: American Peptide Symposium. P204
• CHAN, W.C., BYCROFT, B.W. and KELLAM, B., 1998. Solid phase strategies: applications of 2-acetyl-4-nitroindane-1,3-dione as a selective protecting group for primary Tetrahedron. 54, 6817-6832
• CHHABRA, S.R., BYCROFT, B.W., KELLAM, B. and CHAN, W.C., 1997. Transient affinity tags based on the Dde protection/deprotection strategy: synthesis and application of 2-biotinyl- and 2-hexanoyldimedone Tetrahedron Letters. 38, 5391-5394
• KELLAM, B., BYCROFT, B. W. and CHHABRA, S. R., 1997. Solid phase applications of Dde and the analogue Nde: synthesis of trypanothione disulphide Tetrahedron Letters. VOL 38(NUMBER 27), 4849-4852
• DROUILLAT, B., KELLAM, B., DEKANY, G., STARR, M. S. and TOTH, I., 1997. Solid Phase Synthesis of C-Terminal Carbohydrate Modified Enkephalins Bioorganic and Medicinal Chemistry Letters. VOL 7(NUMBER 17), 2247-2250
• KELLAM, B., CHAN, W.C., CHHABRA, S.R. and BYCROFT, B.W., 1997. Transient affinity tags based on the Dde protection/deprotection strategy: Synthesis and application of 2-biotinyl- and 2-hexanoyldimedone Tetrahedron Letters. 38(30), 5391-5394