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Cornelia de Moor

Associate Professor in RNA Biology, Faculty of Science

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Biography

Cornelia de Moor is an RNA biologist with a long term interest in the untranslated regions (UTRs) and poly(A) tails of mRNAs and their effects on protein synthesis and mRNA degradation.

As a postgraduate student she studied the translational control of insulin like growth factor by its alternative 5' UTRs in human tissues. During my postdoctoral research, she investigated the role of translational control in Xenopus oocyte maturation and made significant contributions to the elucidation the translational repression of cyclin B1 and its activation by cytoplasmic polyadenylation. Her work was instrumental in formulating the first molecular model for translational control by a 3' untranslated region, the maskin model.

In 2000, she started her own laboratory as a lecturer in the School of Biomedical Sciences at the University of Nottingham, transferring to the School of Pharmacy in 2005. In 2013, she was promoted to associate professor. Most of her current work is on the role of mRNA polyadenylation in gene expression and the therapeutic potential of the polyadenylation inhibitor cordycepin, which is isolated from the caterpillar fungus Cordyceps militaris.

Her laboratory uses mathematical modelling, standard molecular biology techniques, as well as a number of novel techniques developed in our laboratory, such as methods for measuring poly(A) tail size, mathematical modeling of mRNA decay and thiouridine labelling. In collaboration with others, she is studying the role of mRNA polyadenylation and the effect of cordycepin on the growth of breast cancer cells and on osteoarthritis pain. Her research is funded by grants fromthe BBSRC and Arthritis Research UK, as well as a donation from Geo-rope.

Expertise Summary

Teaching Summary

B31ESP Introductory Molecular Biology, Genetics and Metabolism (8 lectures). B31GIL Gut Microbiology (4 lectures) B31GIL Case studies Personal Tutor of 16 Pharmacy students

Research Project supervisor for 3 pharmacy students (3rd year)

Research Summary

The research in my laboratory focuses on post-transcriptional gene regulation of mRNA and protein expression, especially by sequences downstream of the stop codon of the protein coding region. This… read more

Selected Publications

Pharmacy School Building, East Drive, University Park, Nottingham, NG7 2RD

Current Research

The research in my laboratory focuses on post-transcriptional gene regulation of mRNA and protein expression, especially by sequences downstream of the stop codon of the protein coding region. This type of gene regulation is much more common than previously thought, and includes modulation of mRNA stability, translational control, mRNA localisation and changes in nuclear polyadenylation. The regulation is generally mediated by RNA binding proteins, microRNAs and/or polyadenylation and deadenylation. We study these processes in cell lines during cell adhesion and proliferation, during the inflammatory response and in human embryonic stem cells. Our work has potential applications in the treatment of inflammatory diseases, cancer and regenerative medicine.

Our funding currently comes from the BBSRC and Arthritis Research UK.

Memberships of Committees and Professional Bodies

  • Member of the RNA Society
  • Member of the Biochemical Society
  • Member of the editorial advisory board of The Biochemical Journal

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

For all enquiries please visit:
www.nottingham.ac.uk/enquiry