Folu Paul-Odeniran

Contact

• workRoom A12 BioDiscovery Institute 1
  University Park
  Nottingham
  NG7 2RD
  UK
• work01158468009
• Folu.Paul-Odeniran@nottingham.ac.uk

Biography

Folu does research in Computational Pharmaceutical Chemistry. She evaluates the potency of small molecule inhibitors in the treatment of neglected tropical parasitic diseases (NTPDs). She had her bachelor's and master's degrees in Biochemistry from the University of Ibadan and thereafter proceeded to the University of KwaZulu Natal in South Africa where she had master's and PhD degrees in Pharmaceutical Chemistry. She is presently a Royal Society Newton International Fellow at the School of Pharmacy, University of Nottingham, hosted by Professor Charles Anthony Laughton. Folu pushes for her research findings to be translated into real-time solutions for the sufferers and those at risk of NTPDs.

Research Summary

Computational and experimental evaluation of statin and statin-like compounds in the treatment of schistosomiasis

Recent Publications

• OKUNLOLA, FELIX O, AKAWA, OLUWOLE B, SUBAIR, TEMITAYO, I, KF OMOLABI (PAUL-ODENIRAN) and SOLIMAN, MAHMOUD E. S., 2022. Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach Cell Biochemistry and Biophysics. 80(1), 1-10
• KF OMOLABI (PAUL-ODENIRAN), ODENIRAN PAUL O, ADEMOLA ISAIAH O and HEZEKIEL KUMALO, 2022. Mango in all her majesty”—the potential of mangiferin and its analogues in the inhibition of Eimeria tenella hexokinase—a computational approach Journal of Biomolecular Structures and Dynamics.
• KF OMOLABI (PAUL-ODENIRAN), ODENIRAN PAUL O and SOLIMAN, MAHMOUD E. S., 2022. A meta-analysis of Cryptosporidium species in humans from southern Africa (2000–2020) Journal of Parasitic Diseases. 46, 304-316
• AKAWA, OLUWOLE B, SUBAIR, TEMITAYO, I, KF OMOLABI (PAUL-ODENIRAN), OKUNLOLA, FELIX O and SOLIMAN, MAHMOUD E. S., 2021. Mechanistic insights into the selective dual BET and PLK1 inhibitory activity of a novel benzamide compound in castration-resistant prostate cancer Chemistry and Biodiversity. 18(12), e2100519

• View all publications

Past Research

Atomic and molecular scalar methods in identifying anticryptosporidials.

Meta-analysis of the prevalence of neglected tropical diseases

Future Research

• Computer-aided design of drugs against neglected tropical parasitic diseases.
• Unravelling the molecular mechanism of drug action as it pertains neglected tropical parasitic diseases.
• Natural products potential and their pharmacokinetics in the treatment of neglected tropical parasitic diseases.
• Detection and characterization of druggable targets in neglected tropical disease-causing parasites.

• OKUNLOLA, FELIX O, AKAWA, OLUWOLE B, SUBAIR, TEMITAYO, I, KF OMOLABI (PAUL-ODENIRAN) and SOLIMAN, MAHMOUD E. S., 2022. Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach Cell Biochemistry and Biophysics. 80(1), 1-10
• KF OMOLABI (PAUL-ODENIRAN), ODENIRAN PAUL O, ADEMOLA ISAIAH O and HEZEKIEL KUMALO, 2022. Mango in all her majesty”—the potential of mangiferin and its analogues in the inhibition of Eimeria tenella hexokinase—a computational approach Journal of Biomolecular Structures and Dynamics.
• KF OMOLABI (PAUL-ODENIRAN), ODENIRAN PAUL O and SOLIMAN, MAHMOUD E. S., 2022. A meta-analysis of Cryptosporidium species in humans from southern Africa (2000–2020) Journal of Parasitic Diseases. 46, 304-316
• AKAWA, OLUWOLE B, SUBAIR, TEMITAYO, I, KF OMOLABI (PAUL-ODENIRAN), OKUNLOLA, FELIX O and SOLIMAN, MAHMOUD E. S., 2021. Mechanistic insights into the selective dual BET and PLK1 inhibitory activity of a novel benzamide compound in castration-resistant prostate cancer Chemistry and Biodiversity. 18(12), e2100519
• OLOTU FISAYO A, KF OMOLABI (PAUL-ODENIRAN) and SOLIMAN, MAHMOUD E. S., 2021. Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex Cell Biochemistry and Biophysics. 79(2), 175-187
• KF OMOLABI (PAUL-ODENIRAN), AGONI CLEMENT, OLOTU FISAYO A and SOLIMAN, MAHMOUD E. S., 2021. Finding the needle in the haystack'- will natural products fit for purpose in the treatment of cryptosporidiosis? - A theoretical perspective Molecular Simulations. 47(8), 636-649
• KF OMOLABI (PAUL-ODENIRAN), IWUCHUKWU EMMANUEL A, ODENIRAN PAUL O and SOLIMAN, MAHMOUD E. S., 2021. Could chroman-4-one derivative be a better inhibitor of PTR1? - Reason for the identified disparity in its inhibitory potency in Trypanosoma brucei and Leishmania major Computational Biology and Chemistry. 90, 107412
• KF OMOLABI (PAUL-ODENIRAN), AGONI CLEMENT, OLOTU FISAYO A and SOLIMAN, MAHMOUD E. S., 2021. A probable means to an end: exploring P131 pharmacophoric scaffold to identify potential inhibitors of Cryptosporidium parvum inosine monophosphate dehydrogenase Journal of Molecular Modeling. 27(2),
• KF OMOLABI (PAUL-ODENIRAN), ODENIRAN PAUL O, OLOTU FISAYO A and SOLIMAN, MAHMOUD E. S., 2021. A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds? Chemistry and Biodiversity. 18(2),
• KF OMOLABI (PAUL-ODENIRAN), AGONI CLEMENT, OLOTU FISAYO A and SOLIMAN, MAHMOUD E. S., 2021. Molecular Basis of P131 Cryptosporidial-IMPDH Selectivity-A Structural, Dynamical and Mechanistic Stance Cell Biochemistry and Biophysics. 79(1), 11-24
• ODENIRAN PAUL O, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2021. Economic impact assessment of small ruminant fasciolosis in Nigeria using pooled prevalence obtained from literature and field epidemiological data Veterinary Parasitology- Regional Studies and Report. 24, 100548
• ODENIRAN PAUL O, ONIFADE AKINDELE A, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2021. Financial losses estimation of African animal trypanosomosis in Nigeria: field reality-based model Tropical Animal Health and Production. 53(1), 159
• SOREMEKUN OPEYEMI, KF OMOLABI (PAUL-ODENIRAN), ADEWUMI ADENIYI T and SOLIMAN, MAHMOUD E. S., 2021. Exploring the effect of ritonavir and TMC-310911 on SARS-CoV-2 and SARS-CoV main proteases: potential from a molecular perspective Future Science Open Access. 7(1), FSO640
• ODENIRAN PAUL O, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2020. Risk factors associated with seropositivity for Toxoplasma gondii in population-based studies among immunocompromised patients (pregnant women, HIV patients and children) in West African countries, Cameroon and Gabon: a meta-analysis Acta Tropica. 209, 105544
• ODENIRAN PAUL O, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2020. Economic model of bovine fasciolosis in Nigeria: an update Tropical Animal Health and Production. 52(6), 3359-3363
• ODENIRAN PAUL O, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2020. Epidemiological dynamics and associated risk factors of S. haematobium in humans and its snail vectors in Nigeria: a meta-analysis (1983-2018) Pathogens and Global Health. 114(2), 76-90
• ODENIRAN PAUL O, KF OMOLABI (PAUL-ODENIRAN) and ADEMOLA ISAIAH O, 2020. A meta-analysis of Toxoplasma gondii seroprevalence, genotypes and risk factors among food animals in West African countries from public health perspectives Preventive Veterinary Medicine. 176, 104925
• OLOTU FISAYO A, KF OMOLABI (PAUL-ODENIRAN) and SOLIMAN, MAHMOUD E. S., 2020. Leaving no stone unturned: Allosteric targeting of SARS-CoV-2 spike protein at putative druggable sites disrupts human angiotensin-converting enzyme interactions at the receptor binding domain Informatics in Medicine Unlocked. 21, 100451
• SOREMEKUN OPEYEMI, KF OMOLABI (PAUL-ODENIRAN) and SOLIMAN, MAHMOUD E. S., 2020. Identification and classification of differentially expressed genes reveal potential molecular signature associated with SARS-CoV-2 infection in lung adenocarcinomal cells Informatics in Medicine Unlocked. 20, 100384