Ken Smith

Contact

• workRoom 4038 University of Nottingham at Derby Medical School
  Royal Derby Hospital
  Uttoxeter Road
  Derby
  DE22 3DT
  UK
• work01332 724700
• fax01332 724611
• ken.smith@nottingham.ac.uk

Recent Publications

• HUGHES A, FRANCIS T, MARJORAM L, ROONEY JH, ELLISON-HUGHES G, POLLOCK R, CURTIS MJ, CAPE A, LARSEN M, PHILLIPS BE, ATHERTON PJ, SMITH K and WITARD OC, 2023. The effect of combined beta-lactoglobulin supplementation and resistance exercise training prior to limb immobilisation on muscle protein synthesis rates in healthy young adults: study protocol for a randomised controlled trial Trials. 24(1), 401
• CEGIELSKI J, BASS JJ, WILLOTT R, GORDON AL, WILKINSON DJ, SMITH K, ATHERTON PJ and PHILLIPS BE, 2023. Exploring the variability of sarcopenia prevalence in a research population using different disease definitions Aging Clin Exp Res.
• ABDULLA H, PHILLIPS B, WILKINSON D, GATES A, LIMB M, JANDOVA T, BASS J, LEWIS J, WILLIAMS J, SMITH K, IDRIS I and ATHERTON PJ, 2022. Effects of GLP-1 infusion upon whole-body glucose uptake and skeletal muscle perfusion during fed-state in older men J Clin Endocrinol Metab. dgac613
• GHARAHDAGHI N, RUDRAPPA S, BROOK MS, FARRASH W, IDRIS I, ABDUL AZIZ MH, KADI F, PAPAIONNOU K, PHILLIPS BE, SIAN T, HERROD PJ, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2022. Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans J Cachexia Sarcopenia Muscle. 13(2), 1134-1150

• View all publications

• HUGHES A, FRANCIS T, MARJORAM L, ROONEY JH, ELLISON-HUGHES G, POLLOCK R, CURTIS MJ, CAPE A, LARSEN M, PHILLIPS BE, ATHERTON PJ, SMITH K and WITARD OC, 2023. The effect of combined beta-lactoglobulin supplementation and resistance exercise training prior to limb immobilisation on muscle protein synthesis rates in healthy young adults: study protocol for a randomised controlled trial Trials. 24(1), 401
• CEGIELSKI J, BASS JJ, WILLOTT R, GORDON AL, WILKINSON DJ, SMITH K, ATHERTON PJ and PHILLIPS BE, 2023. Exploring the variability of sarcopenia prevalence in a research population using different disease definitions Aging Clin Exp Res.
• ABDULLA H, PHILLIPS B, WILKINSON D, GATES A, LIMB M, JANDOVA T, BASS J, LEWIS J, WILLIAMS J, SMITH K, IDRIS I and ATHERTON PJ, 2022. Effects of GLP-1 infusion upon whole-body glucose uptake and skeletal muscle perfusion during fed-state in older men J Clin Endocrinol Metab. dgac613
• GHARAHDAGHI N, RUDRAPPA S, BROOK MS, FARRASH W, IDRIS I, ABDUL AZIZ MH, KADI F, PAPAIONNOU K, PHILLIPS BE, SIAN T, HERROD PJ, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2022. Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans J Cachexia Sarcopenia Muscle. 13(2), 1134-1150
• BROOK MS, STOKES T, GORISSEN SHM, BASS J, MCGLORY C, CEGIELSKI J, WILKINSON DJ, PHILLIPS BE, SMITH K, PHILLIPS SM and ATHERTON PJ, 2022. Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown J Cachexia, Sarcopenia Muscle. 13(4), 2005-2016
• DAVIES RW, KOZIOR M, LYNCH AE, BASS JJ, ATHERTON PJ, SMITH K and JAKEMAN PM, 2022. The Effect of Fava Bean (Vicia faba L.) Protein Ingestion on Myofibrillar Protein Synthesis at Rest and after Resistance Exercise in Healthy, Young Men and Women: A Randomised Control Trial Nutrients. 14(18), 3688
• GUO Y, JONES EJ, INNS TB, ELY IA, STASHUK DW, WILKINSON DJ, SMITH K, PIASECKI J, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2022. Neuromuscular recruitment strategies of the vastus lateralis according to sex Acta Physiol (Oxf). 235(2), e13803
• WILKINSON DJ, BROOK MS and SMITH K, 2022. Erratum to "Principles of Stable Isotope Research - with Special Reference to Protein Metabolism" Clin Nutr Open Sci. 45, 112
• WILLIS CRG, AMES RM, DEANE CS, PHILLIPS BE, BOEREBOOM CL, ABDULLA H, BUKHARI SSI, LUND JN, WILLIAMS JP, WILKINSON DJ, SMITH K, KADI F, SZEWCZYK NJ, ATHERTON PJ and ETHERIDGE T, 2020. Network analysis of human muscle adaptation to aging and contraction Aging (Albany NY). 12, 1
• JOANISSE S, ASHCROFT S, WILKINSON DJ, POLLOCK RD, O'BRIEN KA, PHILLIPS BE, SMITH K, LAZARUS NR, HARRIDGE S, ATHERTON PJ and PHILP A, 2020. High levels of physical activity in later life are associated with enhanced markers of mitochondrial metabolism J Gerontol A Biol Sci Med Sci. glaa005
• DEANE CS, PHILLIPS BE, SMITH K, STEELE AM, LIBRETTO T, STATTON SA, ATHERTON PJ and ETHERIDGE T, 2020. Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials BMC Res Notes. 13(1), 174
• BLACKWELL JEM, DOLEMAN B, BOEREBOOM CL, MORTON A, WILLIAMS S, ATHERTON P, SMITH K, WILLIAMS JP, PHILLIPS BE and LUND JN, 2020. High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial Prostate Cancer Prostatic Dis.
• FARRASH W, BROOK M, CROSSLAND H, PHILLIPS BE, CEGIELSKI J, WILKINSON DJ, CONSTANTIN-TEODOSIU D, GREENHAFF PL, SMITH K, CLEASBY M and ATHERTON PJ, 2020. Impacts of rat hind-limb Fndc5/Irisin overexpression upon muscle and adipose tissue metabolism Am J Physiol Endocrinol Metab: 318(6):E943-E955. 318(6), E943-£955
• DAVIES RW, BASS JJ, CARSON BP, NORTON C, KOZIOR M, WILKINSON DJ, BROOK MS, ATHERTON PJ, SMITH K and JAKEMAN PM, 2020. The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men Nutrients. 12(3), 845
• MILLER BF, REID JJ, PRICE JC, LIN HL, ATHERTON PJ and SMITH K, 2020. CORP: The use of deuterated water for the measurement of protein synthesis J Appl Physiol (1985). 128(5), 1163-1176
• ABDULLA H, PHILLIPS BE, WILKINSON DJ, LIMB M, JANDOVA T, BASS JJ, RANKIN D, CEGIELSKI J, SAYA M, CROSSLAND H, WILLIAMS JP, SMITH K, IDRIS I and ATHERTON PJ, 2020. Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle Ageing Cell. e13202
• CROSSLAND, HANNAH, PIASECKI, JESSICA, MCCORMICK, DANIEL, PHILLIPS, BETHAN E., WILKINSON, DANIEL J., SMITH, KENNETH, MCPHEE, JAMIE S., PIASECKI, MATHEW and ATHERTON, PHILIP J., 2020. Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single-nucleotide polymorphisms in elite master athletes AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 319(2), R184-R194
• BASS JJ, NAKHUDA A, DEANE CS, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY DE and ATHERTON PJ, 2020. Over-expression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy Molecular Metabolism. 42, 101059
• WILKINSON DJ, RODRIGUEZ-BLANCO G, DUNN WB, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, SMITH K, GALLAGHER IJ and ATHERTON PJ, 2020. Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing Aging (Albany NY). 12(13), 12517-12533
• SAYDA MH, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, WILKINSON DJ, SMITH K and ATHERTON PJ, 2020. Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age Nutrients. 12(10), 3029
• CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Exploring mechanistic links between extracellular BCAA & muscle insulin resistance: an in vitro approach Am J Physiol Cell Physiol. 319(6), C1151-C1157
• CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Phenylbutyrate, a branched‐chain amino acid (BCAA) keto dehydrogenase activator, promotes BCAA metabolism and induces muscle catabolism in C2C12 cells Exp Physiol. 106(3), 585-592
• RAMZAN I, TAYLOR M, PHILLIPS BE, WILKINSON DJ, SMITH K, HESSION K, IDRIS I and ATHERTON PJ, 2020. A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes Nutrients. 12(1), 95
• BASS JJ, KAZI AA, DEANE CS, NAKHUDA A, ASHCROFT SP, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY ME and ATHERTON PJ, 2020. The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor (VDR) in vivo J Physiol. 599(3), 063-070
• DEANE CS, AMES RM, PHILLIPS BE, WEEDON MN, WILLIS CRG, BOEREBOOM C, ABDULLA H, BUKHARI SSI, LUND JN, WILLIAMS JP, WILKINSON DJ, SMITH K, GALLAGHER IJ, KADI F, SZEWCZYK NJ, ATHERTON PJ and ETHERIDGE T, 2019. The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging. 11(7), 2111-2126
• DAVIES RW, BASS JJ, CARSON BP, NORTON C, KOZIOR M, AMIGO-BENAVENT M, WILKINSON DJ, BROOK MS, ATHERTON PJ, SMITH K and JAKEMAN PM, 2019. Differential Stimulation of Post-Exercise Myofibrillar Protein Synthesis in Humans Following Isonitrogenous, Isocaloric Pre-Exercise Feeding. Nutrients. 11(7),
• CROSSLAND H, PEREIRA SL, SMITH K, PHILLIPS BE and ATHERTON PJ, 2019. Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation. Journal of functional foods. 56, 216-223
• GHARAHDAGHI N, RUDRAPPA S, BROOK MS, IDRIS I, CROSSLAND H, HAMROCK C, ABDUL AZIZ MH, KADI F, TARUM J, GREENHAFF PL, CONSTANTIN-TEODOSIU D, CEGIELSKI J, PHILLIPS BE, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2019. Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men J Cachexia Sarcopenia Muscle. 10(6), 1276-1294
• ABDULLA H, BASS JJ, STOKES T, GORISSEN SHM, MCGLORY C, PHILLIPS BE, PHILLIPS SM, SMITH K, IDRIS I and ATHERTON PJ, 2019. The Effect of Oral Essential Amino Acids on Incretin Hormone Production in Youth and Ageing Endocrinol Diabetes Metab. 2(4), e00085
• CROSSLAND H, SMITH K, ATHERTON PJ and WILKINSON DJ, 2018. The metabolic and molecular mechanisms of hyperammonaemia- and hyper-ethanolaemia-induced protein catabolism in skeletal muscle cells J Cell Physiol.
• PUTHUCHEARY ZA, ASTIN R, MCPHAIL MJW, SAEED S, PASHA Y, BEAR DE, CONSTANTIN D, VELLOSO C, MANNING S, CALVERT L, SINGER M, BATTERHAM RL, GOMEZ-ROMERO M, HOLMES E, STEINER MC, ATHERTON PJ, GREENHAFF PL, EDWARDS LM, SMITH K, HARRIDGE SD, HART N and MONTGOMERY HE, 2018. Metabolic phenotype of skeletal muscle in early critical illness Thorax. pii: thoraxjnl-2017-211073
• SMEUNINX B, NISHIMURA Y, MCKENDRY J, LIMB M, SMITH K, ATHERTON PJ and BREEN L, 2018. The effect of acute oral phosphatidic acid ingestion on myofibrillar protein synthesis and intracellular signaling in older males Clin Nutr. pii: S0261-5614(18)31182-8
• JACKMAN SR, BROOK MS, PULSFORD RM, COCKCROFT EJ, CAMPBELL MI, RANKIN D, ATHERTON PJ, SMITH K and BOWTELL JL, 2018. Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men Exp Gerontol. 110, 202-208
• GNIMASSOU O, FERNANDEZ-VERDEJO R, BROOK M, NASLAIN D, BALAN E, SAYDA M, CEGIELSKI J, NIELENS H, DECOTTIGNIES A, DEMOULIN JB, SMITH K, ATHERTON PJ, FRANCAUX M and DELDICQUE L, 2018. Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle FASEB J. fj201800049RR
• FRANCHI MV, RUOSS S, VALDIVIESO P, MITCHELL KW, SMITH K, ATHERTON PJ, NARICI MV and FLUCK M, 2018. Regional regulation of focal adhesion kinase after concentric and eccentric loading is related to remodelling of human skeletal muscle Acta Physiol (Oxf). 223(3), e13056
• MILLWARD DJ and SMITH K, 2018. The application of stable-isotope tracers to study human musculoskeletal protein turnover: a tale of bag filling and bag enlargement J Physiol.
• IMPEY SG, HAMMOND KM, NAUGHTON R, LANGAN-EVANS C, SHEPHERD SO, SHARPLES AP, CEGIELSKI J, SMITH K, JEROMSON S, HAMILTON DL, CLOSE GL and MORTON JP, 2018. Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability Int J Sport Nutr Exerc Metab. 14, 1-26
• BASS JJ, WILKINSON D, RANKIN D, PHILLIPS BE, SZEWCZYK NJ and SMITH K, 2017. An overview of technical considerations for Western blotting applications to physiological research. Scandinavian journal of medicine & science in sports. 27(1), 4-25
• DEANE CS, WILKINSON DJ, PHILLIPS BE, SMITH K, ETHERIDGE T and ATHERTON PJ, 2017. "Nutraceuticals" in relation to human skeletal muscle and exercise. American journal of physiology. Endocrinology and metabolism. 312(4), E282-E299
• BROOK, MATTHEW S., WILKINSON, DANIEL J., ATHERTON, PHILIP J. and SMITH, KEN, 2017. Recent developments in deuterium oxide tracer approaches to measure rates of substrate turnover: implications for protein, lipid, and nucleic acid research CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 20(5), 375-381
• ATHERTON, PHILIP J. and SMITH, KEN, 2017. Michael J. Rennie: a perspective on a scientist whose life's work helped sculpt knowledge about the regulation of the musculoskeletal system by nutrition, exercise and inactivity EXPERIMENTAL PHYSIOLOGY. 102(6), 611-613
• WILKINSON, DANIEL J., BROOK, MATTHEW S., SMITH, KENNETH and ATHERTON, PHILIP J., 2017. Stable isotope tracers and exercise physiology: past, present and future JOURNAL OF PHYSIOLOGY-LONDON. 595(9), 2873-2882
• ATHERTON, PHILIP J., KUMAR, VINOD, SELBY, ANNA L., RANKIN, DEBBIE, HILDEBRANDT, WULF, PHILLIPS, BETH E., WILLIAMS, JOHN P., HISCOCK, NATALIE and SMITH, KENNETH, 2017. Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men CLINICAL NUTRITION. 36(3), 888-895
• BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JL, PHILLIPS BE, SWECZYK NJ, KAINULAINEN H, LENSU S, KOCH LG, BRITTON SL, GREENHAFF PL, SMITH K and ATHERTON PJ, 2017. A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle. American journal of physiology. Endocrinology and metabolism. ajpendo.00157.2017 (In Press.)
• IMPEY SG, HAMMOND KM, SHEPHERD SO, SHARPLES AP, STEWART C, LIMB M, SMITH K, PHILP A, JEROMSON S, HAMILTON DL, CLOSE GL and MORTON JP, 2016. Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes. Physiological reports. 4(10),
• PHILLIPS BE, ATHERTON PJ, VARADHAN K, LIMB MC, WILLIAMS JP and SMITH K, 2016. Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men. Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme. 41(5), 548-56
• CHEE C, SHANNON CE, BURNS A, SELBY AL, WILKINSON D, SMITH K, GREENHAFF PL and STEPHENS FB, 2016. Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals. Diabetes. 65(4), 840-50
• MITCHELL WK, WILKINSON DJ, PHILLIPS BE, LUND JN and SMITH K, 2016. Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition Adv Nutr. 7(4), 828S-838S
• RUDRAPPA SS, WILKINSON D, GREENHAFF PL, SMITH K and IDRIS I, 2016. Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance—A Qualitative Review Frontiers in Physiology: Striated Muscle Physiology. 25(7), 361
• BROOK MS, WILKINSON DJ, MITCHELL MK, LUND JN, PHILLIPS BE, SZEWCYZK NJ, GREENHAFF PL, SMITH K and ATHERTON PJ, 2016. Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. JOURNAL OF PHYSIOLOGY-LONDON. 594(24), 7399–7417
• WILKINSON DJ, BROOK MS, SMITH K and ATHERTON PJ, 2016. Stable isotope tracers and exercise physiology: Past, present and future. The Journal of physiology. (In Press.)
• MITCHELL WK, PHILLIPS BE, WILKINSON DJ, WILLIAMS JP, RANKIN D, LUND JN, SMITH K and ATHERTON PJ, 2016. Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men. Clinical nutrition (Edinburgh, Scotland). (In Press.)
• ANDERSON AJ, ANDREW R, HOMER NZ, JONES GC, SMITH K, LIVINGSTONE DE, WALKER BR and STIMSON RH, 2016. Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus. The Journal of clinical endocrinology and metabolism. 101(10), 3787-3793
• BROOK, MATTHEW S., WILKINSON, DANIEL J., SMITH, KENNETH and ATHERTON, PHILIP J., 2016. The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise EUROPEAN JOURNAL OF SPORT SCIENCE. 16(6), 633-644
• PHILLIPS, BETHAN E., ATHERTON, PHILIP J., VARADHAN, KRISHNA, LIMB, MARIE C., WILLIAMS, JOHN P. and SMITH, KENNETH, 2016. Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men APPLIED PHYSIOLOGY NUTRITION AND METABOLISM. 41(5), 548-556
• BROOK, M. S., WILKINSON, D. J., PHILLIPS, B. E., PEREZ-SCHINDLER, J., PHILP, A., SMITH, K. and ATHERTON, P. J., 2016. Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise ACTA PHYSIOLOGICA. 216(1), 15-41
• ABDULLA, HAITHAM, SMITH, KENNETH, ATHERTON, PHILIP J. and IDRIS, ISKANDAR, 2016. Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis DIABETOLOGIA. 59(1), 44-55
• BELTRAN VALLS MR, WILKINSON DJ, NARICI MV, SMITH K, PHILLIPS BE, CAPOROSSI D and ATHERTON PJ, 2015. Protein Carbonylation and Heat Shock Proteins in Human Skeletal Muscle: Relationships to Age and Sarcopenia. The journals of gerontology. Series A, Biological sciences and medical sciences. 70(2), 174-81
• MALLINSON JE, MARIMUTHU K, MURTON A, SELBY A, SMITH K, CONSTANTIN-TEODOSIU D, RENNIE MJ and GREENHAFF PL, 2015. Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression. The Journal of physiology. 593(5), 1239-1257
• MITCHELL WK, PHILLIPS BE, WILLIAMS JP, RANKIN D, LUND JN, SMITH K and ATHERTON PJ, 2015. A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men. The Journal of nutrition. 145(2), 207-14
• MITCHELL WK, PHILLIPS BE, WILLIAMS JP, RANKIN D, LUND JN, WILKINSON DJ, SMITH K and ATHERTON PJ, 2015. The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. American journal of physiology. Endocrinology and metabolism. ajpendo.00112.2015 (In Press.)
• BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JN, SZEWCZYK NJ, GREENHAFF PL, SMITH K and ATHERTON PJ, 2015. Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11), 4485-96
• WILKINSON DJ, CEGIELSKI J, PHILLIPS BE, BOEREBOOM C, LUND JN, ATHERTON PJ and SMITH K, 2015. Internal comparison between deuterium oxide (D2O) and L-[ring-13C6] phenylalanine for acute measurement of muscle protein synthesis in humans. Physiological reports. 3(7),
• MURTON, ANDREW J., MARIMUTHU, KANAGARAJ, MALLINSON, JOANNE E., SELBY, ANNA L., SMITH, KENNETH, RENNIE, MICHAEL J. and GREENHAFF, PAUL L., 2015. Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function DIABETES. 64(9), 3160-3171
• FRANCHI MV, WILKINSON DJ, QUINLAN JI, MITCHELL WK, LUND JN, WILLIAMS JP, REEVES ND, SMITH K, ATHERTON PJ and NARICI MV, 2015. Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle. Physiological reports. 3(11),
• BROOK MS, WILKINSON DJ, SMITH K and ATHERTON PJ, 2015. The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise. European journal of sport science. 16(6), 633-44
• BROOK MS, WILKINSON DJ, PHILLIPS BE, PEREZ-SCHINDLER J, PHILP A, SMITH K and ATHERTON PJ, 2015. Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise. Acta physiologica (Oxford, England). 216(1), 15-41
• WILKINSON DJ, ATHERTON PJ, PHILLIPS BE, GREENHAFF PL and SMITH K, 2015. Application of deuterium oxide (D2O) to metabolic research: just D2O it? Depends just how you D2O it! American journal of physiology. Endocrinology and metabolism. 308(9), E847
• PHILLIPS BE, ATHERTON PJ, VARADHAN K, LIMB MC, WILKINSON DJ, SJØBERG KA, SMITH K and WILLIAMS JP, 2015. The effects of resistance exercise training on macro- and micro-circulatory responses to feeding and skeletal muscle protein anabolism in older men. The Journal of physiology. 593(12), 2721-34
• BUKHARI SS, PHILLIPS BE, WILKINSON DJ, LIMB MC, RANKIN D, MITCHELL WK, KOBAYASHI H, GREENHAFF PL, SMITH K and ATHERTON PJ, 2015. Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise. American journal of physiology. Endocrinology and metabolism. 308(12), E1056-65
• ABDULLA H, SMITH K, ATHERTON PJ and IDRIS I, 2015. Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis. Diabetologia. 59(1), 44-55
• WILKINSON DJ, FRANCHI MV, BROOK MS, NARICI MV, WILLIAMS JP, MITCHELL WK, SZEWCZYK NJ, GREENHAFF PL, ATHERTON PJ and SMITH K, 2014. A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein sub-fraction synthesis in humans. American journal of physiology. Endocrinology and metabolism. 306(5), E571-9
• ABDULLA H, PHILLIPS B, SMITH K, WILKINSON D, ATHERTON P and IDRIS I, 2014. Physiological Mechanisms of Action of Incretin and Insulin in Regulating Skeletal Muscle Metabolism. Current diabetes reviews. (In Press.)
• PHILLIPS BE, ATHERTON PJ, VARADHAN K, WILKINSON DJ, LIMB M, SELBY AL, RENNIE MJ, SMITH K and WILLIAMS JP, 2014. Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions. American journal of physiology. Endocrinology and metabolism. 306(2), E168-76
• MITCHELL CJ, CHURCHWARD-VENNE TA, PARISE G, BELLAMY L, BAKER SK, SMITH K, ATHERTON PJ and PHILLIPS SM, 2014. Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young men. PloS one. 9(2), e89431
• IMPEY SG, SMITH D, ROBINSON AL, OWENS DJ, BARTLETT JD, SMITH K, LIMB M, TANG J, FRASER WD, CLOSE GL and MORTON JP, 2014. Leucine-enriched protein feeding does not impair exercise-induced free fatty acid availability and lipid oxidation: beneficial implications for training in carbohydrate-restricted states. Amino acids. 47(2), 407-16
• PHILLIPS BE, SMITH K, LIPTROT S, ATHERTON PJ, VARADHAN K, RENNIE MJ, LARVIN M, LUND JN and WILLIAMS JP, 2013. Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study J Cachexia Sarcopenia Muscle. 4(1), 71-77
• PHILLIPS BE, WILLIAMS JP, GUSTAFFSON T, BOUCHARD C, RANKINEN T, KNUDSEN S, SMITH K and TIMMONS JA, 2013. Molecular Networks of Human Muscle Adaptation to Exercise and Age PloS Genetics. 9(3),
• CROSSLAND H, KAZI AA, LANG CH, TIMMONS JA, PIERRE P, WILKINSON DJ, SMITH K, SZEWCZYK NJ and ATHERTON PJ, 2013. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. American journal of physiology. Endocrinology and metabolism. 305(2), E183-93
• BREEN L, STOKES KA, CHURCHWARD-VENNE TA, MOORE DR, BAKER SK, SMITH K, ATHERTON PJ and PHILLIPS SM, 2013. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. The Journal of clinical endocrinology and metabolism. 98(6), 2604-12
• PUTHUCHEARY, Z.A., RAWAL, J., MCPHAIL, M., CONNOLLY, B., RATNAYAKE, G., CHAN, P., HOPKINSON, N.S., PADHKE, R., DEW, T., SIDHU, P.S., VELLOSO, C., SEYMOUR, J., AGLEY, C.C., SELBY, A., LIMB, M., EDWARDS, L.M., SMITH, K., ROWLERSON, A., RENNIE, M.J., MOXHAM, J., HARRIDGE, S.D.R., HART, N. and MONTGOMERY, H.E., 2013. Acute skeletal muscle wasting in critical illness JAMA: the Journal of the American Medical Association. 310(15), 1591-1600
• MITCHELL WK, PHILLIPS BE, WILLIAMS JP, RANKIN D, SMITH K, LUND JN and ATHERTON PJ, 2013. Development of a new Sonovue™ contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding. Physiological reports. 1(5), e00119
• PHILLIPS BE, SMITH K, LIPTROT S, ATHERTON PJ, VARADHAN K, RENNIE MJ, LARVIN M, LUND JN and WILLIAMS JP, 2013. Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study. Journal of cachexia, sarcopenia and muscle. 4(1), 71-7
• WILKINSON DJ, HOSSAIN T, HILL DS, PHILLIPS BE, CROSSLAND H, WILLIAMS J, LOUGHNA P, CHURCHWARD-VENNE TA, BREEN L, PHILLIPS SM, ETHERIDGE T, RATHMACHER JA, SMITH K, SZEWCZYK NJ and ATHERTON PJ, 2013. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. The Journal of physiology. 591(Pt 11), 2911-23
• WITARD OC, JACKMAN SR, BREEN L, SMITH K, SELBY A and TIPTON KD, 2013. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise. The American journal of clinical nutrition. 99(1), 86-95
• PHILLIPS BE, WILLIAMS JP, GUSTAFSSON T, BOUCHARD C, RANKINEN T, KNUDSEN S, SMITH K, TIMMONS JA and ATHERTON PJ, 2013. Molecular networks of human muscle adaptation to exercise and age. PLoS genetics. 9(3), e1003389
• PHILLIPS B., WILLIAMS J., ATHERTON P., SMITH K., HILDEBRANDT W., RANKIN D., GREENHAFF P., MACDONALD I. and RENNIE M.J., 2012. Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise Journal of Applied Physiology. 112(3), 347-353
• ATHERTON PJ and SMITH K, 2012. Role of Protein Turnover in Adaptation J Physiol. Epub ahead of print(PMID 22289911), (In Press.)
• WILLIAMS, J.P., PHILLIPS, B.E., SMITH, K., ATHERTON, P.J., RANKIN, D., SELBY, A.L., LIPTROT, S., LUND, J., LARVIN, M. and RENNIE, M.J., 2012. Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients American Journal of Clinical Nutrition. 96(5), 1064-1070
• KUMAR, V., ATHERTON, P.J., SELBY, A., RANKIN, D., WILLIAMS, J., SMITH, K., HISCOCK, N. and RENNIE, M.J., 2012. Muscle protein synthetic responses to exercise: effects of age, volume, and intensity Journals of Gerontology: A, Biological Sciences. 67(11), 1170–1177
• MILLER BF, HAMILTON KL, CUTHBERTSON DJ, SMITH K, WILLIAMS J, MITTENDORFER B, GREENHAFF P and ATHERTON P, 2012. Commentaries on viewpoint: the curious case of anabolic resistance: old wives' tales or new fables? Journal of Applied Physiology. 112(7), 1236
• ETHERIDGE, T., ATHERTON, P.J., WILKINSON, D., SELBY, A., RANKIN, D., WEBBORN, N., SMITH, K. and WATT, P.W., 2011. Effects of hypoxia on muscle protein synthesis (MPS) and anabolic signalling at rest and in response to acute resistance exercise American Journal of Physiology. Endocrinology and Metabolism. 301(4), E697-E702
• BREEN L, PHILP A, WITARD OC, JACKMAN SR, SELBY A, SMITH K, BAAR K, TIPTON KD, 2011. The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis J Physiol. 589(1), 4011-25
• ATHERTON, PHILIP J, SMITH, KEN, ETHERIDGE, TIMOTHY, RANKIN, DEBBIE and RENNIE, MICHAEL J, 2010. Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells. Amino acids. 38(5), 1533-9
• RENNIE, M J, SELBY, A, ATHERTON, P, SMITH, K, KUMAR, V, GLOVER, E L and PHILIPS, S M, 2010. Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy. Scandinavian journal of medicine & science in sports. 20(1), 5-9
• ATHERTON, P.J., ETHERIDGE, T., WATT, P.W., WILKINSON, D., SELBY, A., RANKIN, D., SMITH, K. and RENNIE, M.J., 2010. Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling American Journal of Clinical Nutrition. 92(5), 1080-1088
• WATT, KEVIN I, JASPERS, RICHARD T, ATHERTON, PHILLIP, SMITH, KEN, RENNIE, MICHAEL J, RATKEVICIUS, AIVARAS and WACKERHAGE, HENNING, 2010. SB431542 treatment promotes the hypertrophy of skeletal muscle fibers but decreases specific force. Muscle & nerve. 41(5), 624-9
• DOESSING, S., HEINEMEIER, K.M., HOLM, L., MACKEY, A.L., SCHJERLING, P., RENNIE, M., SMITH, K., REITELSEDER, S., KAPPELGAARD, A.-M., RASMUSSEN, M.H., FLYVBJERG, A. and KJAER, M., 2010. Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis Journal of Physiology. 588(2), 341-351
• WILKES, E.A., SELBY, A.L., ATHERTON, P.J., PATEL, R., RANKIN, D., SMITH, K. and RENNIE, M.J., 2009. Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia The American Journal of Clinical Nutrition. 90(5), 1343-1350
• ATHERTON, P.J., SZEWCZYK, N.J., SELBY, A., RANKIN, D., HILLIER, K., SMITH, K., RENNIE, M.J. and LOUGHNA, P.T., 2009. Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells. The Journal of Physiology. 587(14), 3719-3727
• KUMAR, V., SELBY, A., RANKIN, D., PATEL, R., ATHERTON, P., HILDEBRANDT, W., WILLIAMS, J., SMITH, K., SEYNNES, O., HISCOCK, N. and RENNIE, M.J., 2009. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men Journal of Physiology. 587(1), 211-217
• KUMAR, VINOD, ATHERTON, PHILIP, SMITH, KENNETH and RENNIE, MICHAEL J, 2009. Human muscle protein synthesis and breakdown during and after exercise. Journal of applied physiology (Bethesda, Md. : 1985). 106(6), 2026-39
• BABRAJ, JOHN ANDREE, MUSTARD, KRISTY, SUTHERLAND, CALUM, TOWLER, MHARI C, CHEN, SHAUI, SMITH, KENNETH, GREEN, KEVIN, LEESE, GRAHAM, HARDIE, DAVID GRAHAME, RENNIE, MICHAEL J and CUTHBERTSON, DANIEL JAMES, 2009. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. American journal of physiology. Endocrinology and metabolism. 296(5), E1042-8
• GREENHAFF, P.L., KARAGOUNIS, L.G., PIERCE, N,, SIMPSON, E.J., HAZELL, M., LAYFIELD, R., WACKERHAGE, H., SMITH, K., ATHERTON, P., SELBY, A. and RENNIE, M.J., 2008. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle American Journal of Physiology: Endocrinology and Metabolism. 295(3), E595-E604
• GLOVER, E.I., PHILLIPS, S.M., OATES, B.R., TANG, J.E., TARNOPOLSKY, M.A., SELBY, A., SMITH, K. and RENNIE, M.J., 2008. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion Journal of Physiology. 586(24), 6049-6061
• RENNIE, MICHAEL J, PHILLIPS, STUART and SMITH, KENNETH, 2008. Reliability of results and interpretation of measures of 3-methylhistidine in muscle interstitium as marker of muscle proteolysis. Journal of applied physiology (Bethesda, Md. : 1985). 105(4), 1380-1; author reply 1382-3
• DE BOER, M., SELBY, A., ATHERTON, P., SMITH, K., SEYNNES, O.R., MAGANARIS, C.N., MAFFULLI, N., MOVIN, T., NARICI, M.V. and RENNIE, M.J., 2007. The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. Journal of Physiology. 585(1), 241-251
• PETERSEN, A.M.W., MAGKOS, F., ATHERTON, P., SELBY, A., SMITH, K., RENNIE, M.J., PEDERSEN, B.K. and MITTENDORFER, B, 2007. Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. American Journal of Physiology: Endocrinology and Metabolism. 2007, 1-23
• RENNIE,, ATHERTON,, SELBY,, SMITH,, NARICI,, DE BOER,, PHILLIPS, and GLOVER,, 2007. Letter to the Editor on the Journal Club article by Barker and Traber. Journal of Physiology.
• SMITH, KEN and RENNIE, MICHAEL J, 2007. New approaches and recent results concerning human-tissue collagen synthesis. Current Opinion in Clinical Nutrition and Metabolic Care. 10(5), 582-90
• MILLER, BENJAMIN F, HANSEN, METTE, OLESEN, JENS L, SCHWARZ, PETER, BABRAJ, JOHN A, SMITH, KENNETH, RENNIE, MICHAEL J and KJAER, MICHAEL, 2007. Tendon collagen synthesis at rest and after exercise in women. Journal of Applied Physiology. 102(2), 541-6
• RENNIE MJ, BOHÉ J, SMITH K, WACKERHAGE H and GREENHAFF P, 2006. Branched-chain amino acids as fuels and anabolic signals in human muscle. The Journal of nutrition. 136(1 Suppl), 264S-8S
• CUTHBERTSON, D.J., BABRAJ, J., SMITH, K., WILKES, E., FEDELE, M.J., ESSER, K. and RENNIE, M, 2006. Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise. American Journal of Physiology: Endocrinology and Metabolism. 290(4), E731-E738
• MILLER, BENJAMIN F, HANSEN, METTE, OLESEN, JENS L, FLYVBJERG, ALLAN, SCHWARZ, PETER, BABRAJ, JOHN A, SMITH, KENNETH, RENNIE, MICHAEL J and KJAER, MICHAEL, 2006. No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle. American Journal of Physiology: Endocrinology and Metabolism. 290(1), E163-E168
• CHEE C, SHANNON CE, BURNS A, SELBY AL, WILKINSON D, SMITH K, GREENHAFF PL and STEPHENS FB, 2006. The relative contribution of intramyocellular lipid to whole body fat oxidation is reduced with age, but subsarcolemmal lipid accumulation and insulin resistance are only associated with overweight individuals Diabetes. pii: db151383,
• ATHERTON, P J, BABRAJ, J, SMITH, K, SINGH, J, RENNIE, M J and WACKERHAGE, H, 2005. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB Journal. 19(7), 786-788
• CUTHBERTSON, D., SMITH, K.H, BABRAJ, J., LEESE, G., WADDELL, T., ATHERTON, P., WACKERHAGE, H., TAYLOR, P.M. and RENNIE, M.J, 2005. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB Journal. 19(3), 422-424
• BABRAJ, J.A., SMITH, K., CUTHBERTSON, D.J., RICKHUSS, P., DORLING, J.S. and RENNIE, M.J, 2005. Human bone collagen synthesis is a rapid, nutritionally modulated process. Journal of Bone and Mineral Research. 20(6), 930-7
• MITTENDORFER, B., ANDERSEN, J.L., PLOMGAARD, P., SALTIN, B., BABRAJ, J.A., SMITH, K. and RENNIE, M.J, 2005. Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. Journal of Physiology. 563(1), 203-211
• BABRAJ, J.A, CUTHBERTSON, D.J.R., SMITH, K., LANGBERG, H., MILLER, B., KROGSGAARD, M.R., KJAER, M. and RENNIE, M.J, 2005. Collagen synthesis in human musculoskeletal tissues and skin. American Journal of Physiology: Endocrinology and Metabolism. 289(5), E864-E869
• MOORE, DANIEL R, PHILLIPS, STUART M, BABRAJ, JOHN A, SMITH, KENNETH and RENNIE, MICHAEL J, 2005. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. American Journal of Physiology: Endocrinology and Metabolism. 288(6), E1153-9
• LOUIS, M., POORTMANS, J. R., FRANCAUX, M., BERRE, J., BOISSEAU, N., BRASSINE, E., CUTHBERTSON, D. J. R., SMITH, K., BABRAJ, J. A. and WADDELL, T., 2003. No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise American Journal of Physiology. VOL 285(ISSU 5), E1089
• LOUIS, MAGALI, POORTMANS, JACQUES R, FRANCAUX, MARC, HULTMAN, ERIC, BERRE, JACQUES, BOISSEAU, NATHALIE, YOUNG, VERNON R, SMITH, KENNETH, MEIER-AUGENSTEIN, WOLFRAM, BABRAJ, JOHN A, WADDELL, TOM and RENNIE, MICHAEL J, 2003. Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states. American Journal of Physiology: Endocrinology and Metabolism. 284(4), E764-70
• ANDREW, R., SMITH, K., JONES, G.C. and WALKER, B.R, 2002. Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol. Journal of Clinical Endocrinology and Metabolism. 87(1), 277-285
• BABRAJ, J, CUTHBERTSON, D J, RICKHUSS, P, MEIER-AUGENSTEIN, W, SMITH, K, BOHé, J, WOLFE, R R, GIBSON, J N A, ADAMS, C and RENNIE, M J, 2002. Sequential extracts of human bone show differing collagen synthetic rates. Biochemical Society Transactions. 30(2), 61-5
• LIVINGSTONE, D E, JONES, G C, SMITH, K, JAMIESON, P M, ANDREW, R, KENYON, C J and WALKER, B R, 2000. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 141(2), 560-3