Academic Pathology
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Emad Rakha

Professor and Consultant Pathologist, Faculty of Medicine & Health Sciences

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Biography

I am a Professor of Breast Pathology and Honorary Consultant Pathologist, at the University of Nottingham (UoN) and Nottingham University Hospitals NHS Trust, Nottingham, UK.

My main clinical disciplines are Breast Pathology. I am medically qualified and gained master (MSc pathology) and MD in Pathology (by examination) , PhD in molecular pathology (Breast cancer) from UoN and obtained the Fellowship of the Royal College of Pathologists by examination. I am a leading member of the multi-disciplinary Nottingham Breast Research Group at the University of Nottingham. As part of my clinical commitment, I work as a co-chair of the UK National Breast Pathology Interpretive Quality Assurance Scheme (EQA) and a co-lead of the Trust core-facility Biorepository (Nottingham Health Science Biobank). I am a member of the National Institute of Cancer Research (NICR) Breast Clinical Studies Group (CSG) and its Breast Translational Subgroup, The national Coordinating Committee of Breast Pathology (BIG18), the Pathological Society of Great Britain and Ireland Management Committee, International Society of Breast Pathology, and international Breast pathology Group. I served as a member of Breast Cancer Campaign Scientific Advisory Board and I am a member of the Breast Cancer Now Tissue Access Committee.,

I organise the National Nottingham breast Pathology Masterclass which is an annual course run in Nottingham, UK, Italy and Egypt (http://nottinghambreastpathologymasterclass.com/). I run the national and international referral service of breast pathology consultation cases in Nottingham with Professor Ian Ellis

During the past 10 years I have been co-author on more than 250 peer-reviewed publications (87 first author publications and 35 senior authors) in addition to 28 articles submitted or in preparation and more than 200 abstract submissions to national and international conferences and meetings. I am is an author for 25 book chapters in breast disease including the WHO blue book and Flecther diagnostic histopathology of tumors new editions and I am acting as a reviewer to 20 indexed and high profile international journals and editor to three journals. I am supervising and co-supervising a number of Postgraduate and undergraduate students at UoN. We have an extensive network of national and international research collaborators.

PROFESSIONAL SOCIETY MEMBERSHIP AND REGISTRATION

Fellow of the Royal College of Pathologists 2008-present

Medical Protection Society 2008-present

Pathological Society of Great Britain and Ireland 2007-present

British Division of the International Academy of Pathology 2009-present

Nottingham Research Biorepository Access Committee 2010-Present

Breast Cancer Campaign Scientific Advisory Board 2011-2015

UK National Co-ordinating Committee For Breast Pathology (BIG 18)). 2013-Present

NICR Breast CSG Translational Subgroup 2013-Present

International Society of Breast Pathology 2015-present

Pathological Society of Great Britain and Ireland management Committee 2005-present

Breast Cancer Now, Tissue Bank Access Committee 2016-Present

National Cancer Research Institute, Breast Clinical Studies Group (CSG): 2017- Present

AWARDS AND HONOURS

1.Higher Education Funding Council of England (HEFCE) Senior Lecturer Award 2010.

2.National Bronze Clinical Excellence Award 2017

3.Invited to contribute to the 4th edition of WHO Classification of Tumours of the Breast. 2012 and the WHO consensus meeting on Neuroendocrine Tumours, Lyon 2017

4.Invited to chairing The Oral Presentations Session of the Breast Category, USCAP meeting and Pathological Society of Great Britain & Ireland.

5.One of the JCO Tope Cited 50 Authors in by Thomson Reuters

6.One of the top 20 research articles published by PLoS in 2010

7.One of the highest cited article in Breast Cancer Research 2012

8.Fourth (4) of the top twenty most Highly Cited Papers published in the International Journal of Cancer (as of Dec. 2008).

9.Two of my articles were discussed by Reuters Health New York in their editorials.

10.Highest ranked abstract, Pathological Society of GB 195th Scientific Meeting 2009 and 202nd meeting 2012.

11.Highest ranked abstract, 5th European Breast Cancer conference, Nice, France, 2006Nominated for RCPath's Gold and Specialty Medial Awards 2009.

12.Highest ranked abstract, Pathological Society of GB & Ireland and Dutch Pathological Society, Amsterdam, 2004.

13.Excellence in Reviewing Award from the Journal of American Medical Association (JAMA), 2008.

14.Best Poster prize, Pathological Society of GB & Ireland, London, 2005.

Research Summary

1) Use of tissue array technology to allow immunophenotypic characterisation of protein expression of a large series of approximately 4000 breast cancer cases from the Nottingham Breast Cancer… read more

Selected Publications

Current Research

1) Use of tissue array technology to allow immunophenotypic characterisation of protein expression of a large series of approximately 4000 breast cancer cases from the Nottingham Breast Cancer series. This provides a baseline data set of known and important proteins expressed in breast cancer, the frequency of their expression and their associations. The hypothesis being that breast cancer exhibits a number of distinct phenotypes which are related to different differentiation pathways from stem cell to normal adult cell types and which are influential on tumour behaviour.

2) Mechanisms of hormone response and resistance in breast cancer

3) Special types of breast cancer including Papillary carcinoma and metaplastic carcinoma and adenomyoepithelioma.

4) Assessment of the role of different DNA repair pathways in cancer

5) Molecular characterisation and outcome prediction of DCIS

6) Mechanisms underlying lymphovascular invasion in breast cancer

7) Molecular classification, molecular prediction assays in breast cancer

8) Using digital Pathology and Novel Imaging technique in breast cancer diagnosis and prognosis

Future Research

1-DNA damage repair profiling in breast cancer with in vitro modeling

2-Breast cancer with weak oestrogen receptor expression and its biological significance

3-Predictors of breast cancer growth rate in vivo and their biological and medicolegal value

4-Impact of biological features local recurrences on the behaviour and outcome of breast cancer and relating these to primary tumours characteristics

4-Low grade breast neoplasia family

5-Phenotypic and clinical characterization of metaplastic breast carcinoma

6-General aspects of breast cancer biology, pathology, molecular genetics, morphology, diagnosis, classification and behaviour

7- Molecular pathology and triple negative breast cancer and therapeutic implications

8-Using Raman Spectroscopy technology to identify cancer cells in breast specimen excision margins and sentinel lymph nodes intraoperatively

9-Deciphering molecular mechanisms underlying lymphovascular invasion in breast cancer

Group resources include expertise in

Image analysis Immunocytochemistry

Tissue Microarrays Laser microdissection

Tissue culture PCR and RT-qPCR

Raman Spectroscopy. Gene expression array and NGS

Histology / Morphological assessment of tissue

Current PhD students

1- Sultan Sonbul

2- Nouf ALSUBHI

3- Mansour Alsaleem

4- Islam Miligy

5- Rokaya El Ansari

6- Abdulbaqi A Hamid

7- Michael Shawky Toss

8- Lutfi Alfarsi

9- Sami Saeed

10-Muslin Alabdullah

Staff

Dr Andrew Green PhD

Dr Mohamed Aleskandarany PhD

Mr Chris Nolan

Miss Maria Diez Rodriguez

Dr Chitra Joseph PhD

Dr Sasagu Kurozumi, PhD

We are welcoming new PhD students

Academic Pathology

The University of Nottingham
School of Medicine, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0)115 969 1169
email:ian.ellis@nottingham.ac.uk