Contact

• workRoom B03 Applied Health Research Building
  University Park
  Nottingham
  NG7 2RD
  UK
• Caroline.Rick@nottingham.ac.uk

Biography

Following a degree, PhD and post-doctoral lab-based research, I had a career change and started working in Clinical Trials management in 2005 (to present day). My research is mainly in Clinical Trials in Neurology, Elderly Care, complex Interventions and some work in Test Evaluation Trials. I am also the Nottingham Clinical Trials Unit (NCTU) lead for Patient and Public involvement and Engagement (PPIE) in Clinical Trials

I moved to the University of Nottingham to an Associate Professor in Clinical Trials in 2019.

Expertise Summary

I have been involved in the design, day to day management, analysis and dissemination of trials for over 18 years. I have worked on Trials in a wide range of neurological and non-neurological conditions and am particularly interested in complex intervention trials involving Allied Health Professions. I have also been involved in Test Evaluation Trials and trials of Medical and surgical interventions,

I sit on the UK CRC Task and Finish group for PPIE and the University of Nottingham, School of Medicine PPIE group lead PPIE at NCTU.

Research Summary

I am currently working on Clinical Trials including:

1. Methotrexate Oral Or SubcutanEous for RA (The MOOSE study)

Source: NIHR HTA

Chief Investigator: Prof A. Abhishek

2. Randomised controlled trial of a new relief inhaler in mild asthma (The Relief Trial)

Source NIHR HTA

Chief Investigator: Prof T. Harrison

3. Follow-up and structured monitoring for adults offered a NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial

Source: NIHR HTA

Chief Investigator: Prof K. Munro

4. Prophylactic therapy in Care Homes Trial: PROTECT-CH.

Source: NIHR

Chief Investigator: Prof P. Bath

5. The COACH trial. A randomised controlled trial of cochlear implantation versus hearing aids in adults with severe hearing loss

Source: Cochlear Inc

Chief Investigator: Prof P. Kitterick & Doug Hartley

6. Tranexamic acid for hyper acute spontaneous intracerebral haemorrhage TICH-3

Source: NIHR HTA

Chief Investigator: Prof N. Sprigg

7. In vivo serial neuromelanin MRI to assess depigmentation rates in the substantia nigra of early Parkinson's disease

Source: Weston Brain Institute (From Feb 2020)

Chief Investigator: Prof D Auer

8. Developing an Artificial Intelligence augmented diagnostic imaging strategy for patients with occult scaphoid fractures of the wrist (AI-MRI)

Source: University of Nottingham

A. Karantana, various

9. PD MED: A large randomised assessment of the relative cost-effectiveness of different classes of drugs for Parkinson's disease (Extension)

Source: NIHR HTA

Gray R, various

Recent Publications

• SACKLEY CM, SMITH CH, RICK CE, BRADY MC, IVES N, PATEL S, WOOLLEY R, DOWLING F, PATEL R, ROBERTS H, JOWETT S, WHEATLEY K, KELLY D, SANDS G, CLARKE CE and , 2018. Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and feasibility studies. 4, 30
• HERD CP, TOMLINSON CL, RICK C, SCOTTON WJ, EDWARDS J, IVES N, CLARKE CE and SINCLAIR A, 2018. Botulinum toxins for the prevention of migraine in adults. The Cochrane database of systematic reviews. 6, CD011616
• OTTRIDGE R, MOLLAN SP, BOTFIELD H, FREW E, IVES NJ, MATTHEWS T, MITCHELL J, RICK C, SINGHAL R, WOOLLEY R and SINCLAIR AJ, 2017. Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol. BMJ open. 7(9), e017426
• MARKEY KA, OTTRIDGE R, MITCHELL JL, RICK C, WOOLLEY R, IVES N, NIGHTINGALE P and SINCLAIR AJ, 2017. Assessing the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. JMIR research protocols. 6(9), e181

• View all publications

Past Research

Selected references:

1. Leighton P, Sprange K, Robinson K, Rick C. Establishing Covid-19 Research in UK Care Homes - Infrastructure Challenges for Trial Design: Paul Leighton. Eur J Public Health. 2022 Oct; 32(Suppl 3): ckac129.751.
2. Gordon AL, Rick C, Juszczak E, Montgomery A, Howard R, Guthrie B, Lim WS, Shenkin S, Leighton P, Bath PM, the PROTECT-CH triallists. The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age Ageing. 2022
3. Gray R; Patel S; Ives N; Rick C; Woolley R; Muzerengi S; Gray A; Jenkinson C; McIntosh E; Wheatley K; Williams A; Clarke C.E.; for the PD MED Collaborative Group (2021) Long-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa TherapyThe PD MED Randomized Clinical Trial JAMA Neurol.
4. Scobie S, Jowett S , Lambe T, Patel S, Woolley R, Ives N, Rick C, Smith C, Brady MC, Clarke C and Sackley C. (2021) Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: preliminary cost‑consequence analysis of the PD COMM pilot randomised controlled trial. Pilot Feasibility Stud (2021) 7:154
5. Susan P. Mollan, James L. Mitchell, Ryan S. Ottridge, Magda Aguiar, Andreas Yiangou, Zerin Alimajstorovic, David M. Cartwright, Olivia Grech, Gareth G. Lavery, Connar S. J. Westgate, Vivek Vijay, William Scotton, Ben R. Wakerley, Tim D. Matthews, Alec Ansons, Simon J. Hickman, James Benzimra, Caroline Rick, Rishi Singhal, Abd A. Tahrani, Kristian Brock, Emma Frew, Alexandra J. Sinclair. Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial. JAMA Neurol. 2021 Jun; 78(6): 678-686.
6. McIntosh E, Kent S, Gray A, Clarke CE, A, Jenkinson C, Ives N, Patel S, Rick C, Wheatley K, Gray R, PD MED Collaborative Group (2021) Cost-Effectiveness of Dopamine Agonists and Monoamine Oxidase B Inhibitors in Early Parkinson's Disease. Mov Dis http://doi.org/10.1002/mds.28623
7. Rick C*, Mallett S*, Brown J, Ottridge R, Palmer A, Parker V, Priest L, and Deeks JJ. (2020) Test evaluation trials present different challenges for trial managers compared to Intervention trials. Trials 21, 987 * joint first author https://doi.org/10.1186/s13063-020-04861-7
8. Sackley C*; Rick C*; Au P; Brady M; Beaton G; Burton C; Caulfield M; Dickson S; Dowling F; Hughes M; Ives N; Jowett S; Masterson-Algar P; Nicoll A; Patel S; Smith CH; Woolley R; Clarke CE (2020) A Multi-Centre Randomised Controlled Trial to Compare the Clinical and Cost Effectiveness of Lee Silverman Voice Treatment Versus Standard NHS Speech and Language Therapy Versus Control in Parkinson's Disease: a Study Protocol for a Randomised Controlled Trial. 27th May 2020, Trials 21: 436 * joint first author DOI: 10.1186/s13063-020-04354-7
9. Markey, K, Mitchell, J, Botfield, H, Ottridge, RS, Matthews, T, Krishnan, A, Woolley, R, Westgate, C, Yiangou, A, Alimajstorovic, Z, Shah, P, Rick, C, Ives, N, Taylor, AE, Gilligan, LC, Jenkinson, C, Arlt, W, Scotton, W, Fairclough, R, Singhal, R, Stewart, PM, Tomlinson, JW, Lavery, GG, Mollan, SP, Sinclair, AJ. 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Idiopathic Intracranial Hypertension: A Double-Blind Randomized Controlled Trial. Brain Communications, (2020). doi.org/10.1093/braincomms/fcz050
10. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A: Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine 2019 BMJ Open Vol 9 (7):e027953 DOI: 10.1136/bmjopen-2018-027953
11. Smith CH, Patel S, Woolley RL, Brady MC, Rick CE, Halfpenny R, Rontiris A, Knox-Smith L, Dowling F, Clarke CE, Au P, Ives N, Wheatley K, Sackley CM. Rating the intelligibility of dysarthic speech amongst people with Parkinson's Disease: a comparison of trained and untrained listeners. Clin Linguist Phon. 2019 Apr 29:1-8.
12. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A Botulinumtoxins for the prevention of migraine in adults (Review) Cochrane Database of Systematic Reviews 2018, Issue 6. Art. No: CD011616.
13. Sackley CM, Smith CH, Rick C, Brady MC, Patel S, Woolley R, Dowling F, Patel R, Roberts R, Jowett S, Wheatley K, Kelly D, Sands G, Clarke CE and on behalf of the PD COMM Pilot Collaborative Group Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies (2018) 4:30
14. Markey, K; Ottridge, R; Mitchell, J; Rick, C; Woolley, R; Ives, N; Nightingale, P; Sinclair, A. Assessing the Efficacy and Safety of an 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. JMIR Research Protocols, 2017, 6(9) 181.
15. Ottridge, R; Mollan, SP; Botfield, H; Frew, E; Ives, NJ; Matthews, T; Mitchell, J; Rick, C; Singhal, R; Woolley, R; Sinclair, AJ. Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol. BMJ Open, 2017, 7(9)
16. Masterson-Algar, P; Burton, CR; Brady, MC; Nicoll, A; Clarke, CE; Rick, C; Hughes, M; Au, P; Smith, CH; Sackley, CM. The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson's disease. 2017, Trials, 18
17. S. Muzerengi, C. Rick, I. Begaj, N. Ives, F. Evison, R.L. Woolley, C.E. Clarke. Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK. Public Health, 2017, 147, 4-9
18. Sundar, S; Rick, C; Dowling, F; Au, P; Snell, K; Rai, N; Champaneria, R; Stobart, H; Neal, R; Davenport, C; Mallett, S; Sutton, A; Kehoe, S; Timmerman, D; Bourne, T; Van Calster, B; Gentry-Maharaj, A; Menon, U; Deeks, J on behalf of the ROCkeTS Study Grp . Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer. BMJ Open 2016, 6 (8).
19. Mathers, J; Rick, C; Jenkinson, C; Garside, R; Pall, H; Mitchell, R; Bayliss, S; Jones, LL. Patients' experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis. BMJ OPEN (2016) Volume: 6 (6) e011525
20. McIntosh, Emma; Gray, Alastair; Daniels, Jane; et al. Group Author(s): PD SURG Collaborators Grp Cost-utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial MOVEMENT DISORDERS 2016, 31 (8)1173-1182
21. Clarke CE, Patel S, Ives N, Rick C, Dowling F, Woolley R, Wheatley K, Walker M, Sackley C. Physiotherapy and Occupational therapy versus no therapy in mild to moderate Parkinson's disease. A randomised controlled trial. JAMA Neurology. 2016;73(3):291-299
22. Muzerengi, S; Herd, C; Rick, C; Clarke, CE. A systematic review of interventions to reduce hospitalisation in Parkinson's disease. PARKINSONISM & RELATED DISORDERS 2016, 24, 3-7
23. Stow R, Ives N, Smith C, Rick C, and Rushton A. A cluster randomised feasibility trial evaluating nutritional interventions in the treatment of malnutrition in care home adult residents. Trials (2015) 16:433 1 - 21

• SACKLEY CM, SMITH CH, RICK CE, BRADY MC, IVES N, PATEL S, WOOLLEY R, DOWLING F, PATEL R, ROBERTS H, JOWETT S, WHEATLEY K, KELLY D, SANDS G, CLARKE CE and , 2018. Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and feasibility studies. 4, 30
• HERD CP, TOMLINSON CL, RICK C, SCOTTON WJ, EDWARDS J, IVES N, CLARKE CE and SINCLAIR A, 2018. Botulinum toxins for the prevention of migraine in adults. The Cochrane database of systematic reviews. 6, CD011616
• OTTRIDGE R, MOLLAN SP, BOTFIELD H, FREW E, IVES NJ, MATTHEWS T, MITCHELL J, RICK C, SINGHAL R, WOOLLEY R and SINCLAIR AJ, 2017. Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol. BMJ open. 7(9), e017426
• MARKEY KA, OTTRIDGE R, MITCHELL JL, RICK C, WOOLLEY R, IVES N, NIGHTINGALE P and SINCLAIR AJ, 2017. Assessing the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. JMIR research protocols. 6(9), e181
• MASTERSON-ALGAR P, BURTON CR, BRADY MC, NICOLL A, CLARKE CE, RICK C, HUGHES M, AU P, SMITH CH and SACKLEY CM, 2017. The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson's disease. Trials. 18(1), 397
• MUZERENGI S, RICK C, BEGAJ I, IVES N, EVISON F, WOOLLEY RL and CLARKE CE, 2017. Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK. Public health. 146, 4-9
• CLARKE CE, PATEL S, IVES N, RICK CE, WOOLLEY R, WHEATLEY K, WALKER MF, ZHU S, KANDIYALI R, YAO G and SACKLEY CM, 2016. Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB). Health technology assessment (Winchester, England). 20(63), 1-96
• CLARKE CE, PATEL S, IVES N, RICK CE, DOWLING F, WOOLLEY R, WHEATLEY K, WALKER MF, SACKLEY CM and , 2016. Physiotherapy and Occupational Therapy vs No Therapy in Mild to Moderate Parkinson Disease: A Randomized Clinical Trial. JAMA neurology. 73(3), 291-9
• MCINTOSH, E., GRAY, A., DANIELS, J., GILL, S., IVES, N., JENKINSON, C., MITCHELL, R., PALL, H., PATEL, S., QUINN, N., RICK, C., WHEATLEY, K. and WILLIAMS, A., 2016. Cost-utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial: Mov Disord Mov Disord. 31(8), 1173-82
• SUNDAR S, RICK C, DOWLING F, AU P, SNELL K, RAI N, CHAMPANERIA R, STOBART H, NEAL R, DAVENPORT C, MALLETT S, SUTTON A, KEHOE S, TIMMERMAN D, BOURNE T, VAN CALSTER B, GENTRY-MAHARAJ A, MENON U, DEEKS J and , 2016. Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer. BMJ open. 6(8), e010333
• MATHERS J, RICK C, JENKINSON C, GARSIDE R, PALL H, MITCHELL R, BAYLISS S and JONES LL, 2016. Patients' experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis. BMJ open. 6(6), e011525
• MUZERENGI S, HERD C, RICK C and CLARKE CE, 2016. A systematic review of interventions to reduce hospitalisation in Parkinson's disease. Parkinsonism & related disorders. 24, 3-7
• STOW R, IVES N, SMITH C, RICK C and RUSHTON A, 2015. A cluster randomised feasibility trial evaluating nutritional interventions in the treatment of malnutrition in care home adult residents. Trials. 16, 433
• JENKINSON C, CLARKE C, GRAY R, HEWITSON P, IVES N, MORLEY D, RICK C, WHEATLEY K and WILLIAMS A, 2015. Comparing results from long and short form versions of the Parkinson's disease questionnaire in a longitudinal study. Parkinsonism & related disorders. 21(11), 1312-6
• STOW R, RUSHTON A, IVES N, SMITH C and RICK C, 2015. A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol. Pilot and feasibility studies. 1, 3
• , GRAY R, IVES N, RICK C, PATEL S, GRAY A, JENKINSON C, MCINTOSH E, WHEATLEY K, WILLIAMS A and CLARKE CE, 2014. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet (London, England). 384(9949), 1196-205
• XIN Y, CLARKE CE, MUZERENGI S, RICK CE, GRAY A, GRAY R, WHEATLEY K, IVES N and MCINTOSH E, 2014. Treatment Reasons, Resource use and Costs of Hospitalisations in People with Parkinson's: Results from a Large Rct. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 17(7), A809
• CLARKE CE, PATEL S, IVES N, RICK C, WHEATLEY K and GRAY R, 2011. Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops? Movement disorders : official journal of the Movement Disorder Society. 26(7), 1187-93
• TOMLINSON CL, STOWE R, PATEL S, RICK C, GRAY R and CLARKE CE, 2010. Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 25(15), 2649-53
• WILLIAMS A, GILL S, VARMA T, JENKINSON C, QUINN N, MITCHELL R, SCOTT R, IVES N, RICK C, DANIELS J, PATEL S, WHEATLEY K and , 2010. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. The Lancet. Neurology. 9(6), 581-91