Contact

• workQueen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158231214
• fax01158231409
• Aloysious.Aravinthan@nottingham.ac.uk

Biography

Dr. Aravinthan is an Associate Professor in Hepatology at the University of Nottingham and an Honorary Consultant Hepatologist at the Nottingham University Hospitals NHS Trust. He completed his postgraduate training in Hepatology at Cambridge University Hospitals NHS Trust, UK and Toronto General Hospital/University of Toronto, Canada. His doctoral thesis, awarded by the University of Cambridge, focused on the role of hepatocyte senescence in the progression of chronic liver disease. He was awarded the prestigious Sheila Sherlock Research Award by the British Association for the Study of the Liver in 2014 and the Sheila Sherlock Travelling Fellowship by the Royal College of Physicians in 2015. His research continues to focus on the prognostic and therapeutic role of cellular senescence in liver disease.

Research Summary

Identification of novel liver/serum markers of hepatocyte senescence for the prognostication of liver disease. Investigation of the systemic impact of hepatocyte senescence in liver… read more

Selected Publications

• ARAVINTHAN AD, BRUNI SG, DOYLE AC, THEIN HH, GOLDARACENA N, ISSACHAR A, LILLY LB, SELZNER N, BHAT M, SREEHARSHA B, SELZNER M, GHANEKAR A, CATTRAL MS, MCGILVRAY ID, GREIG PD, RENNER EL, GRANT DR and SAPISOCHIN G, 2017. Liver Transplantation is a Preferable Alternative to Palliative Therapy for Selected Patients with Advanced Hepatocellular Carcinoma. Annals of surgical oncology. 24(7), 1843-1851
• ARAVINTHAN AD and ALEXANDER GJ, 2016. Senescence in chronic liver disease: Is the future in aging? Journal of hepatology. 65(4), 825-834
• ARAVINTHAN AD, DOYLE AC, ISSACHAR A, DIB M, PERETZ D, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, GRANT DR, SELZNER N, LILLY LB and RENNER EL, 2016. First-degree living-related donor liver transplantation in autoimmune liver diseases. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(12), 3512-3521
• ARAVINTHAN AD and ALEXANDER GJ, 2015. Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure. Journal of hepatology. 63(2), 532-533

• View all publications

Current Research

• Identification of novel liver/serum markers of hepatocyte senescence for the prognostication of liver disease.
• Investigation of the systemic impact of hepatocyte senescence in liver disease.
• Identification of newer therapeutic strategies for patients with liver injury, including the prevention of hepatocyte senescence, elimination of senescent hepatocytes, and inhibition of the senescent secretome.

• SUBHANI, MOHSAN, SHETH, ABHISHEK, AHMED, JAMAL, WIJAYASIRI, PRAMUDI, GARDEZI, SYED A., ENKI, DOYO, MORLING, JOANNE R., AITHAL, GURUPRASAD P., RYDER, STEPHEN D. and ARAVINTHAN, ALOYSIOUS D., 2022. Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis THROMBOSIS RESEARCH. 215, 19-29
• PRAMUDI WIJAYASIRI, STUART ASTBURY, PHILIP KAYE, FIONA OAKLEY, GRAEME J ALEXANDER, TIMOTHY J KENDALL and ALOYSIOUS D ARAVINTHAN, 2022. Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression CELLS. 11(14), 2221
• TSIEN, CYNTHIA, TAN, HUEY, SHARMA, SOWMYA, PALANIYAPPAN, NAAVENTHAN, WIJAYASIRI, PRAMUDI, LEUNG, KRISTEL, HAYRE, JATINDER, MOWLEM, ELIZABETH, KANG, RACHEL, EDDOWES, PETER J, WILKES, EMILIE, VENKATACHALAPATHY, SURESH V, GUHA, INDRA N, ANTONOVA, LILIA, CHEUNG, ANGELA C, GRIFFITHS, WILLIAM JH, BUTLER, ANDREW J, RYDER, STEPHEN D, JAMES, MARTIN W, AITHAL, GURUPRASAD P and ARAVINTHAN, ALOYSIOUS D, 2021. Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine (London, England). 21(1), e32-e38
• VENKATACHALAPATHY, SURESH VASAN, JAMES, MARTIN W, HUGGETT, MATTHEW, PARANANDI, BHARAT, PEREIRA, STEPHEN P, JOHNSON, GAVIN, ARAVINTHAN, ALOYSIOUS D and AITHAL, GURUPRASAD P, 2021. Utility of palliative EUS-guided biliary drainage using lumen-apposing metal stents: a prospective multicenter feasibility study (with video). Gastrointestinal endoscopy.
• PRAMUDI WIJAYASIRI, JATINDER HAYRE, EDWARD S. NICHOLSON, PHILIP KAYE, EMILIE A. WILKES, JONATHAN EVANS, GURUPRASAD P. AITHAL, GABRIELA JONES and FIONA PEARCE, 2021. Estimating the clinical prevalence of Wilson's disease in the UK JHEP Reports. 3(5), 100329
• CHOW CW, HAIDER SA, RAGUNATH K, AITHAL GP, ORTIZ-FERNANDEZ-SORDO J, ORTIZ-FERNANDEZ-SORDO J, ARAVINTHAN AD and VENKATACHALAPATHY SV, 2020. Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle World Journal of Gastrointestinal Endoscopy. 12(9), 266-275
• DOYLE A, GORGEN A, MUADDI H, ARAVINTHAN AD, ISSACHAR A, MIRONOV O, ZHANG W, KACHURA J, BEECROFT R, CLEARY SP, GHANEKAR A, GREIG PD, MCGILVRAY ID, SELZNER M, CATTRAL MS, GRANT DR, LILLY LB, SELZNER N, RENNER EL, SHERMAN M and SAPISOCHIN G, 2019. Outcomes of Radiofrequency Ablation as First-Line Therapy for Hepatocellular Carcinoma less than 3 cm in Potentially Transplantable Patients. Journal of hepatology. 70(5), 866-873
• ARAVINTHAN AD, FATEEN W, DOYLE AC, VENKATACHALAPATHY SV, ISSACHAR A, GALVIN Z, SAPISOCHIN G, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GRANT DR, SELZNER N, LILLY LB, RENNER EL and BHAT M, 2019. The impact of preexisting and posttransplant diabetes mellitus on outcomes following liver transplantation. Transplantation. 103(12), 2523-2530
• GOLDARACENA, NICOLAS, JUNG, JUDY, ARAVINTHAN, ALOYSIOUS D., ABBEY, SUSAN E., KRAUSE, SANDRA, PRITLOVE, CHERYL, LYNCH, JOANNA, WRIGHT, LINDA, SELZNER, NAZIA, STUNGURIS, JENNIFER, GREIG, PAUL, GHANEKAR, ANAND, MCGILVRAY, IAN, SAPISOCHIN, GONZALO, NG, VICKY LEE, LEVY, GARY, CATTRAL, MARK and GRANT, DAVID, 2019. Donor outcomes in anonymous live liver donation JOURNAL OF HEPATOLOGY. 71(5), 951-959
• ARAVINTHAN AD and ALEXANDER GJ, 2018. Telomere, telomerase and liver disease. Liver international : official journal of the International Association for the Study of the Liver. 38(1), 33-34
• ARAVINTHAN AD, BRUNI SG, DOYLE AC, THEIN HH, GOLDARACENA N, ISSACHAR A, LILLY LB, SELZNER N, BHAT M, SREEHARSHA B, SELZNER M, GHANEKAR A, CATTRAL MS, MCGILVRAY ID, GREIG PD, RENNER EL, GRANT DR and SAPISOCHIN G, 2017. Liver Transplantation is a Preferable Alternative to Palliative Therapy for Selected Patients with Advanced Hepatocellular Carcinoma. Annals of surgical oncology. 24(7), 1843-1851
• ARAVINTHAN AD, BARBAS AS, DOYLE AC, TAZARI M, SAPISOCHIN G, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, BHAT M, SELZNER N, GRANT DR, LILLY LB and RENNER EL, 2017. Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study. Transplant international : official journal of the European Society for Organ Transplantation. 30(11), 1140-1149
• BARBAS AS, GOLDARACENA N, DIB MJ, AL-ADRA DP, ARAVINTHAN AD, LILLY LB, RENNER EL, SELZNER N, BHAT M, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SAPISOCHIN G, SELZNER M, GREIG PD and GRANT DR, 2017. Early Intervention With Live Donor Liver Transplantation Reduces Resource Utilization in NASH: The Toronto Experience. Transplantation direct. 3(6), e158
• ARAVINTHAN AD and ALEXANDER GJ, 2016. Senescence in chronic liver disease: Is the future in aging? Journal of hepatology. 65(4), 825-834
• ARAVINTHAN AD, DOYLE AC, ISSACHAR A, DIB M, PERETZ D, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, GRANT DR, SELZNER N, LILLY LB and RENNER EL, 2016. First-degree living-related donor liver transplantation in autoimmune liver diseases. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(12), 3512-3521
• TACHTATZIS PM, MARSHALL A, ARAVINTHAN A, VERMA S, PENRHYN-LOWE S, MELA M, SCARPINI C, DAVIES SE, COLEMAN N and ALEXANDER GJ, 2015. Correction: Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis. PloS one. 10(7), e0134315
• TACHTATZIS PM, MARSHALL A, ARVINTHAN A, VERMA S, PENRHYN-LOWE S, MELA M, SCARPINI C, DAVIES SE, COLEMAN N and ALEXANDER GJ, 2015. Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis. PloS one. 10(5), e0127511
• ARAVINTHAN AD and ALEXANDER GJ, 2015. Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure. Journal of hepatology. 63(2), 532-533
• ARAVINTHAN A, 2015. Cellular senescence: a hitchhiker's guide. Human cell. 28(2), 51-64
• WOODWARD JM, GKRANIA-KLOTSAS E, CORDERO-NG AY, ARAVINTHAN A, BANDOH BN, LIU H, DAVIES S, ZHANG H, STEVENSON P, CURRAN MD and KUMARARATNE D, 2015. The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency. The American journal of gastroenterology. 110(2), 320-327
• ARAVINTHAN A, CHALLIS B, SHANNON N, HOARE M, HEANEY J and ALEXANDER GJ, 2014. Selective insulin resistance in hepatocyte senescence. Experimental cell research. 331(1), 38-45
• ARAVINTHAN A, SHANNON N, HEANEY J, HOARE M, MARSHALL A and ALEXANDER GJ, 2014. The senescent hepatocyte gene signature in chronic liver disease. Experimental gerontology. 60, 37-45
• ARAVINTHAN A, MELLS G, ALLISON M, LEATHART J, KOTRONEN A, YKI-JARVINEN H, DALY AK, DAY CP, ANSTEE QM and ALEXANDER G, 2014. Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease. Cell cycle (Georgetown, Tex.). 13(9), 1489-1494
• ARAVINTHAN A, PIETROSI G, HOARE M, JUPP J, MARSHALL A, VERRILL C, DAVIES S, BATEMAN A, SHERON N, ALLISON M and ALEXANDER GJ, 2013. Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease. PloS one. 8(9), e72904
• ARAVINTHAN A, GELSON W, LIMBU A, BRAIS R and RICHARDSON P, 2013. Hepatic sarcoidosis complicating treatment-naive viral hepatitis. World journal of hepatology. 4(12), 402-405
• ARAVINTHAN A, SCARPINI C, TACHTATZIS P, VERMA S, PENRHYN-LOWE S, HARVEY R, DAVIES SE, ALLISON M, COLEMAN N and ALEXANDER G, 2012. Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease. Journal of hepatology. 58(3), 549-56
• POTTER VA and ARAVINTHAN A, 2012. Identifying patients at risk of severe Clostridium difficile-associated disease. British journal of hospital medicine (London, England : 2005). 73(5), 265-270
• ARAVINTHAN A, VERMA S, COLEMAN N, DAVIES S, ALLISON M and ALEXANDER G, 2012. Vacuolation in hepatocyte nuclei is a marker of senescence. Journal of clinical pathology. 65(6), 557-560
• ARAVINTHAN A, NIKOLIC M, OUYANG X and LEE YM, 2012. The hidden cause of dysphagia--epiphrenic diverticulum and esophageal motility disorders. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. 26(2), 68-69
• ARAVINTHAN A, AL-NAEEB Y, ABUBACKER Z and RICHARDSON P, 2009. A gastrointestinal cause for heart failure. Gut. 58(8), 1103, 1128
• ARAVINTHAN A, AL-NAEEB Y and RICHARDSON P, 2009. Relative adrenal insufficiency in a patient with liver disease. European journal of gastroenterology & hepatology. 21(4), 471-473
• ARAVINTHAN A, SEN S and MARCUS N, 2009. Transfusion-related acute lung injury: a rare and life-threatening complication of a common procedure. Clinical medicine (London, England). 9(1), 87-89
• KEJARIWAL D, ARAVINTHAN A, BROMLEY D and MIAO Y, 2008. Buried bumper syndrome: cut and leave it alone! Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 23(3), 322-324