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ZIERER J, JACKSON MA, KASTENMÜLLER G, MANGINO M, LONG T, TELENTI A, MOHNEY RP, SMALL KS, BELL JT, STEVES CJ, VALDES AM, SPECTOR TD and MENNI C, 2018. The fecal metabolome as a functional readout of the gut microbiome. Nature genetics. 50(6), 790-795 MATEY HERNANDEZ M, MK WILLIAMS FM, POTTER T, VALDES AM, SPECTOR T and MENNI C, 2018. Genetic and microbiome influence on lipid metabolism and dyslipidemia. Physiological genomics. (In Press.)
JIANG X, O'REILLY PF, ASCHARD H, HSU YH, RICHARDS JB, DUPUIS J, INGELSSON E, KARASIK D, PILZ S, BERRY D, KESTENBAUM B, ZHENG J, LUAN J, SOFIANOPOULOU E, STREETEN EA, ALBANES D, LUTSEY PL, YAO L, TANG W, ECONS MJ, WALLASCHOFSKI H, VÖLZKE H, ZHOU A, POWER C, MCCARTHY MI, MICHOS ED, BOERWINKLE E, WEINSTEIN SJ, FREEDMAN ND, HUANG WY, VAN SCHOOR NM, VAN DER VELDE N, GROOT LCPGM, ENNEMAN A, CUPPLES LA, BOOTH SL, VASAN RS, LIU CT, ZHOU Y, RIPATTI S, OHLSSON C, VANDENPUT L, LORENTZON M, ERIKSSON JG, SHEA MK, HOUSTON DK, KRITCHEVSKY SB, LIU Y, LOHMAN KK, FERRUCCI L, PEACOCK M, GIEGER C, BEEKMAN M, SLAGBOOM E, DEELEN J, HEEMST DV, KLEBER ME, MÄRZ W, DE BOER IH, WOOD AC, ROTTER JI, RICH SS, ROBINSON-COHEN C, DEN HEIJER M, JARVELIN MR, CAVADINO A, JOSHI PK, WILSON JF, HAYWARD C, LIND L, MICHAËLSSON K, TROMPET S, ZILLIKENS MC, UITTERLINDEN AG, RIVADENEIRA F, BROER L, ZGAGA L, CAMPBELL H, THEODORATOU E, FARRINGTON SM, TIMOFEEVA M, DUNLOP MG, VALDES AM, TIKKANEN E, LEHTIMÄKI T, LYYTIKÄINEN LP, KÄHÖNEN M, RAITAKARI OT, MIKKILÄ V, IKRAM MA, SATTAR N, JUKEMA JW, WAREHAM NJ, LANGENBERG C, FOROUHI NG, GUNDERSEN TE, KHAW KT, BUTTERWORTH AS, DANESH J, SPECTOR T, WANG TJ, HYPPÖNEN E, KRAFT P and KIEL DP, 2018. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature communications. 9(1), 260 MENNI C, ZIERER J, PALLISTER T, JACKSON MA, LONG T, MOHNEY RP, STEVES CJ, SPECTOR TD and VALDES AM, 2017. Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Scientific reports. 7(1), 11079 HOLLANDER WD, BOER CG, HART DJ, YAU MS, RAMOS YFM, METRUSTRY S, BROER L, DEELEN J, CUPPLES LA, RIVADENEIRA F, KLOPPENBURG M, PETERS M, SPECTOR TD, HOFMAN A, SLAGBOOM PE, NELISSEN RGHH, UITTERLINDEN AG, FELSON DT, VALDES AM, MEULENBELT I and VAN MEURS JJB, 2017. Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand. Annals of the rheumatic diseases. (In Press.)
MENNI C, MIGAUD M, KASTENMÜLLER G, PALLISTER T, ZIERER J, PETERS A, MOHNEY RP, SPECTOR TD, BAGNARDI V, GIEGER C, MOORE SC and VALDES AM, 2017. Metabolomic Profiling of Long-Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain. Obesity (Silver Spring, Md.). 25(9), 1618-1624 FERNANDES GS, SARMANOVA A, WARNER S, HARVEY H, AKIN-AKINYOSOYE K, RICHARDSON H, FROWD N, MARSHALL L, STOCKS J, HALL M, VALDES AM, WALSH D, ZHANG W and DOHERTY M, 2017. Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC musculoskeletal disorders. 18(1), 404 VALDES AM, RAVIPATI S, MENNI C, ABHISHEK A, METRUSTRY S, HARRIS J, NESSA A, WILLIAMS FMK, SPECTOR TD, DOHERTY M, CHAPMAN V and BARRETT DA, 2017. Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific reports. 7(1), 10748 WARNER SC, VAN MEURS JB, SCHIPHOF D, BIERMA-ZEINSTRA SM, HOFMAN A, UITTERLINDEN AG, RICHARDSON H, JENKINS W, DOHERTY M and VALDES AM, 2017. Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene. European journal of human genetics : EJHG. 25(4), 446-451 VALDES AM and GOLDRING MB, 2017. Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis. Annals of the rheumatic diseases. 76(6), 939-941 MENNI C, ZIERER J, VALDES AM and SPECTOR TD, 2017. Mixing omics: combining genetics and metabolomics to study rheumatic diseases. Nature reviews. Rheumatology. 13(3), 174-181 MENNI C, JACKSON MA, PALLISTER T, STEVES CJ, SPECTOR TD and VALDES AM, 2017. Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain. International journal of obesity (2005). 41(7), 1099-1105 PALLISTER T, JACKSON MA, MARTIN TC, GLASTONBURY CA, JENNINGS A, BEAUMONT M, MOHNEY RP, SMALL KS, MACGREGOR A, STEVES CJ, CASSIDY A, SPECTOR TD, MENNI C and VALDES AM, 2017. Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling. International journal of obesity (2005). 41(7), 1106-1113 MENNI C, METRUSTRY SJ, EHRET G, DOMINICZAK AF, CHOWIENCZYK P, SPECTOR TD, PADMANABHAN S and VALDES AM, 2017. Molecular pathways associated with blood pressure and hexadecanedioate levels. PloS one. 12(4), e0175479 WARNER SC, WALSH DA, LASLETT LL, MACIEWICZ RA, SONI A, HART DJ, ZHANG W, MUIR KR, DENNISON EM, LEAVERTON P, RAMPERSAUD E, COOPER C, SPECTOR TD, CICUTTINI FM, ARDEN NK, JONES G, DOHERTY M and VALDES AM, 2017. Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene. European journal of pain (London, England). 21(7), 1277-1284 LA-CRETTE J, JENKINS W, FERNANDES G, VALDES AM, DOHERTY M and ABHISHEK A, 2017. First validation of the gout activity score against gout impact scale in a primary care based gout cohort. Joint, bone, spine : revue du rhumatisme. (In Press.)
CHOU IJ, KUO CF, HUANG YS, GRAINGE MJ, VALDES AM, SEE LC, YU KH, LUO SF, HUANG LS, TSENG WY, ZHANG W and DOHERTY M, 2016. Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. Schizophrenia bulletin. ALTMAIER E, MENNI C, HEIER M, MEISINGER C, THORAND B, QUELL J, KOBL M, RÖMISCH-MARGL W, VALDES AM, MANGINO M, WALDENBERGER M, STRAUCH K, ILLIG T, ADAMSKI J, SPECTOR T, GIEGER C, SUHRE K and KASTENMÜLLER G, 2016. The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study. PloS one. 11(4), e0153163 MENNI C, MIGAUD M, GLASTONBURY CA, BEAUMONT M, NIKOLAOU A, SMALL KS, BROSNAN MJ, MOHNEY RP, SPECTOR TD and VALDES AM, 2016. Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health. Obesity (Silver Spring, Md.). 24(6), 1380-8 PRINS BP, ABBASI A, WONG A, VAEZ A, NOLTE I, FRANCESCHINI N, STUART PE, GUTERRIEZ ACHURY J, MISTRY V, BRADFIELD JP, VALDES AM, BRAS J, SHATUNOV A, , , , , , , , , , , , , , , LU C, HAN B, RAYCHAUDHURI S, BEVAN S, MAYES MD, TSOI LC, EVANGELOU E, NAIR RP, GRANT SF, POLYCHRONAKOS C, RADSTAKE TR, VAN HEEL DA, DUNSTAN ML, WOOD NW, AL-CHALABI A, DEHGHAN A, HAKONARSON H, MARKUS HS, ELDER JT, KNIGHT J, ARKING DE, SPECTOR TD, KOELEMAN BP, VAN DUIJN CM, MARTIN J, MORRIS AP, WEERSMA RK, WIJMENGA C, MUNROE PB, PERRY JR, POUGET JG, JAMSHIDI Y, SNIEDER H and ALIZADEH BZ, 2016. Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS medicine. 13(6), e1001976 PABINGER S, ERNST K, PULVERER W, KALLMEYER R, VALDES AM, METRUSTRY S, KATIC D, NUZZO A, KRIEGNER A, VIERLINGER K and WEINHAEUSEL A, 2016. Analysis and Visualization Tool for Targeted Amplicon Bisulfite Sequencing on Ion Torrent Sequencers. PloS one. 11(7), e0160227 CASTAÑO-BETANCOURT MC, EVANS DS, RAMOS YF, BOER CG, METRUSTRY S, LIU Y, DEN HOLLANDER W, VAN ROOIJ J, KRAUS VB, YAU MS, MITCHELL BD, MUIR K, HOFMAN A, DOHERTY M, DOHERTY S, ZHANG W, KRAAIJ R, RIVADENEIRA F, BARRETT-CONNOR E, MACIEWICZ RA, ARDEN N, NELISSEN RG, KLOPPENBURG M, JORDAN JM, NEVITT MC, SLAGBOOM EP, HART DJ, LAFEBER F, STYRKARSDOTTIR U, ZEGGINI E, EVANGELOU E, SPECTOR TD, UITTERLINDEN AG, LANE NE, MEULENBELT I, VALDES AM and VAN MEURS JB, 2016. Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis. PLoS genetics. 12(10), e1006260 WARNER SC and VALDES AM, 2016. Genetic association studies in osteoarthritis: is it fairytale? Current opinion in rheumatology. 29(1), 103-109 VALDES AM, MANON-JENSEN T, ABHISHEK A, JENKINS W, SIEBUHR AS, KARSDAL MA, DOHERTY S, ZHANG W, RICHARDSON H, DOHERTY M and BAY-JENSEN AC, 2016. Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks. Rheumatology (Oxford, England). 55(9), 1642-6 VALDES AM, WARNER SC, HARVEY HL, FERNANDES GS, DOHERTY S, JENKINS W, WHEELER M and DOHERTY M, 2015. Use of prescription analgesic medication and pain catastrophizing after total joint replacement surgery. Seminars in arthritis and rheumatism. 45(2), 150-5 KUO CF, GRAINGE MJ, VALDES AM, SEE LC, LUO SF, YU KH, ZHANG W and DOHERTY M, 2015. Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA internal medicine. 175(9), 1518-26 MENNI C, GRAHAM D, KASTENMÜLLER G, ALHARBI NH, ALSANOSI SM, MCBRIDE M, MANGINO M, TITCOMBE P, SHIN SY, PSATHA M, GEISENDORFER T, HUBER A, PETERS A, WANG-SATTLER R, XU T, BROSNAN MJ, TRIMMER J, REICHEL C, MOHNEY RP, SORANZO N, EDWARDS MH, COOPER C, CHURCH AC, SUHRE K, GIEGER C, DOMINICZAK AF, SPECTOR TD, PADMANABHAN S and VALDES AM, 2015. Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension (Dallas, Tex. : 1979). 66(2), 422-9 ABHISHEK A, VALDES AM and DOHERTY M, 2015. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Annals of the rheumatic diseases. 75(4), 784-5 TSAI PC, VAN DONGEN J, TAN Q, WILLEMSEN G, CHRISTIANSEN L, BOOMSMA DI, SPECTOR TD, VALDES AM and BELL JT, 2015. DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins. Twin research and human genetics : the official journal of the International Society for Twin Studies. 18(6), 635-46 TRAHERNE JA, JIANG W, VALDES AM, HOLLENBACH JA, JAYARAMAN J, LANE JA, JOHNSON C, TROWSDALE J and NOBLE JA, 2015. KIR haplotypes are associated with late-onset type 1 diabetes in European-American families. Genes and immunity. 17(1), 8-12 SEKULA P, GOEK ON, QUAYE L, BARRIOS C, LEVEY AS, RÖMISCH-MARGL W, MENNI C, YET I, GIEGER C, INKER LA, ADAMSKI J, GRONWALD W, ILLIG T, DETTMER K, KRUMSIEK J, OEFNER PJ, VALDES AM, MEISINGER C, CORESH J, SPECTOR TD, MOHNEY RP, SUHRE K, KASTENMÜLLER G and KÖTTGEN A, 2015. A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population. Journal of the American Society of Nephrology : JASN. 27(4), 1175-88 KUO CF, GRAINGE MJ, VALDES AM, SEE LC, LUO SF, YU KH, ZHANG W and DOHERTY M, 2015. Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families JAMA Internal Medicine. 175(9), 1518-1526 EVANS DS, CAILOTTO F, PARIMI N, VALDES AM, CASTAÑO-BETANCOURT MC, LIU Y, KAPLAN RC, BIDLINGMAIER M, VASAN RS, TEUMER A, TRANAH GJ, NEVITT MC, CUMMINGS SR, ORWOLL ES, BARRETT-CONNOR E, RENNER JB, JORDAN JM, DOHERTY M, DOHERTY SA, UITTERLINDEN AG, VAN MEURS JBJ, SPECTOR TD, LORIES RJ and LANE NE, 2015. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Annals of the rheumatic diseases. 74, 1861-7 MENNI C, MANGINO M, CECELJA M, PSATHA M, BROSNAN MJ, TRIMMER J, MOHNEY RP, CHOWIENCZYK P, PADMANABHAN S, SPECTOR TD and VALDES AM, 2015. Metabolomic study of carotid-femoral pulse-wave velocity in women. Journal of hypertension. 33(4), 791-6 FERNANDES GS and VALDES AM, 2015. Cardiovascular disease and osteoarthritis: common pathways and patient outcomes. European journal of clinical investigation. 45(4), 405-14 KUO C, GRAINGE MJ, VALDES AM, SEE L, LUO S, YU K, ZHANG W and DOHERTY M, 2015. Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: A nationwide population study. Arthritis & rheumatology (Hoboken, N.J.). 67(7), 1904-1902 MENNI C, METRUSTRY SJ, MOHNEY RP, BEEVERS S, BARRATT B, SPECTOR TD, KELLY FJ and VALDES AM, 2015. Circulating levels of antioxidant vitamins correlate with better lung function and reduced exposure to ambient pollution. American journal of respiratory and critical care medicine. 191(10), 1203-7 METRUSTRY SJ, EDWARDS MH, MEDLAND SE, HOLLOWAY JW, MONTGOMERY GW, MARTIN NG, SPECTOR TD, COOPER C and VALDES AM, 2014. Variants close to NTRK2 gene are associated with birth weight in female twins. Twin research and human genetics : the official journal of the International Society for Twin Studies. 17(4), 254-61 TZOULAKI I, EBBELS TMD, VALDES A, ELLIOTT P and IOANNIDIS JPA, 2014. Design and analysis of metabolomics studies in epidemiologic research: a primer on -omic technologies. American journal of epidemiology. 180(2), 129-39 BLUMENFELD O, WILLIAMS FMK, VALDES A, HART DJ, MALKIN I, SPECTOR TD and LIVSHITS G, 2014. Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis. Cytokine. 69(1), 94-101 RAMOS YFM, METRUSTRY S, ARDEN N, BAY-JENSEN AC, BEEKMAN M, DE CRAEN AJM, CUPPLES LA, ESKO T, EVANGELOU E, FELSON DT, HART DJ, IOANNIDIS JPA, KARSDAL M, KLOPPENBURG M, LAFEBER F, METSPALU A, PANOUTSOPOULOU K, SLAGBOOM PE, SPECTOR TD, VAN SPIL EWE, UITTERLINDEN AG, ZHU Y, ARCOGEN CONSORTIUM, TREATOA COLLABORATORS, VALDES AM, VAN MEURS JBJ and MEULENBELT I, 2014. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. Journal of medical genetics. 51(9), 596-604 BROER L, RASCHENBERGER J, DEELEN J, MANGINO M, CODD V, PIETILÄINEN KH, ALBRECHT E, AMIN N, BEEKMAN M, DE CRAEN AJM, GIEGER C, HAUN M, HENNEMAN P, HERDER C, HOVATTA I, LASER A, KEDENKO L, KOENIG W, KOLLERITS B, MOILANEN E, OOSTRA BA, PAULWEBER B, QUAYE L, RISSANEN A, RODEN M, SURAKKA I, VALDES AM, VUOLTEENAHO K, THORAND B, VAN DIJK KW, KAPRIO J, SPECTOR TD, SLAGBOOM PE, SAMANI NJ, KRONENBERG F, VAN DUIJN CM and LADWIG K, 2014. Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. European journal of epidemiology. 29(9), 629-38 MENNI C, KIDDLE SJ, MANGINO M, VIÑUELA A, PSATHA M, STEVES C, SATTLECKER M, BUIL A, NEWHOUSE S, NELSON S, WILLIAMS S, VOYLE N, SOININEN H, KLOSZEWSKA I, MECOCCI P, TSOLAKI M, VELLAS B, LOVESTONE S, SPECTOR TD, DOBSON R and VALDES AM, 2014. Circulating Proteomic Signatures of Chronological Age. The journals of gerontology. Series A, Biological sciences and medical sciences. (In Press.)
VALDES AM, MEULENBELT I, CHASSAING E, ARDEN NK, BIERMA-ZEINSTRA S, HART D, HOFMAN A, KARSDAL M, KLOPPENBURG M, KROON HM, SLAGBOOM EP, SPECTOR TD, UITTERLINDEN AG, VAN MEURS JB and BAY-JENSEN AC, 2014. Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 22(5), 683-9 STYRKARSDOTTIR U, THORLEIFSSON G, HELGADOTTIR HT, BOMER N, METRUSTRY S, BIERMA-ZEINSTRA S, STRIJBOSCH AM, EVANGELOU E, HART D, BEEKMAN M, JONASDOTTIR A, SIGURDSSON A, EIRIKSSON FF, THORSTEINSDOTTIR M, FRIGGE ML, KONG A, GUDJONSSON SA, MAGNUSSON OT, MASSON G, TREAT-OA CONSORTIUM, ARCOGEN CONSORTIUM, HOFMAN A, ARDEN NK, INGVARSSON T, LOHMANDER S, KLOPPENBURG M, RIVADENEIRA F, NELISSEN RGHH, SPECTOR T, UITTERLINDEN A, SLAGBOOM PE, THORSTEINSDOTTIR U, JONSDOTTIR I, VALDES AM, MEULENBELT I, VAN MEURS J, JONSSON H and STEFANSSON K, 2014. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nature genetics. 46(5), 498-502 RODRIGUEZ-FONTENLA C, CALAZA M, EVANGELOU E, VALDES AM, ARDEN N, BLANCO FJ, CARR A, CHAPMAN K, DELOUKAS P, DOHERTY M, ESKO T, GARCÉS ALETÁ CM, GOMEZ-REINO CARNOTA JJ, HELGADOTTIR H, HOFMAN A, JONSDOTTIR I, KERKHOF HJM, KLOPPENBURG M, MCCASKIE A, NTZANI EE, OLLIER WER, OREIRO N, PANOUTSOPOULOU K, RALSTON SH, RAMOS YF, RIANCHO JA, RIVADENEIRA F, SLAGBOOM PE, STYRKARSDOTTIR U, THORSTEINSDOTTIR U, THORLEIFSSON G, TSEZOU A, UITTERLINDEN AG, WALLIS GA, WILKINSON JM, ZHAI G, ZHU Y, ARCOGEN CONSORTIUM, FELSON DT, IOANNIDIS JPA, LOUGHLIN J, METSPALU A, MEULENBELT I, STEFANSSON K, VAN MEURS JB, ZEGGINI E, SPECTOR TD and GONZALEZ A, 2014. Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis & rheumatology (Hoboken, N.J.). 66(4), 940-9 AREF-ESHGHI E, ZHANG Y, HART D, VALDES AM, FUREY A, MARTIN G, SUN G, RAHMAN P, ARDEN N, SPECTOR TD and ZHAI G, 2014. SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study. PloS one. 9(5), e97786 SHIN S, FAUMAN EB, PETERSEN A, KRUMSIEK J, SANTOS R, HUANG J, ARNOLD M, ERTE I, FORGETTA V, YANG T, WALTER K, MENNI C, CHEN L, VASQUEZ L, VALDES AM, HYDE CL, WANG V, ZIEMEK D, ROBERTS P, XI L, GRUNDBERG E, MULTIPLE TISSUE HUMAN EXPRESSION RESOURCE (MUTHER) CONSORTIUM, WALDENBERGER M, RICHARDS JB, MOHNEY RP, MILBURN MV, JOHN SL, TRIMMER J, THEIS FJ, OVERINGTON JP, SUHRE K, BROSNAN MJ, GIEGER C, KASTENMÜLLER G, SPECTOR TD and SORANZO N, 2014. An atlas of genetic influences on human blood metabolites. Nature genetics. 46(6), 543-50 VALDES AM, ZHANG W, MUIR K, MACIEWICZ RA, DOHERTY S and DOHERTY M, 2014. Use of statins is associated with a lower prevalence of generalised osteoarthritis. Annals of the rheumatic diseases. 73(5), 943-5 EVANGELOU E, KERKHOF HJ, STYRKARSDOTTIR U, NTZANI EE, BOS SD, ESKO T, EVANS DS, METRUSTRY S, PANOUTSOPOULOU K, RAMOS YFM, THORLEIFSSON G, TSILIDIS KK, ARCOGEN CONSORTIUM, ARDEN N, ASLAM N, BELLAMY N, BIRRELL F, BLANCO FJ, CARR A, CHAPMAN K, DAY-WILLIAMS AG, DELOUKAS P, DOHERTY M, ENGSTRÖM G, HELGADOTTIR HT, HOFMAN A, INGVARSSON T, JONSSON H, KEIS A, KEURENTJES JC, KLOPPENBURG M, LIND PA, MCCASKIE A, MARTIN NG, MILANI L, MONTGOMERY GW, NELISSEN RGHH, NEVITT MC, NILSSON PM, OLLIER WE, PARIMI N, RAI A, RALSTON SH, REED MR, RIANCHO JA, RIVADENEIRA F, RODRIGUEZ-FONTENLA C, SOUTHAM L, THORSTEINSDOTTIR U, TSEZOU A, WALLIS GA, WILKINSON JM, GONZALEZ A, LANE NE, LOHMANDER LS, LOUGHLIN J, METSPALU A, UITTERLINDEN AG, JONSDOTTIR I, STEFANSSON K, SLAGBOOM PE, ZEGGINI E, MEULENBELT I, IOANNIDIS JP, SPECTOR TD, VAN MEURS JBJ and VALDES AM, 2014. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the rheumatic diseases. 73, 2130-6 HUDSON G, PANOUTSOPOULOU K, WILSON I, SOUTHAM L, RAYNER NW, ARDEN N, BIRRELL F, CARLUKE I, CARR A, CHAPMAN K, DELOUKAS P, DOHERTY M, MCCASKIE A, OLLIER WER, RALSTON SH, REED MR, SPECTOR TD, VALDES AM, WALLIS GA, WILKINSON JM, ZEGGINI E, SAMUELS DC, LOUGHLIN J and CHINNERY PF, 2013. No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Annals of the Rheumatic Diseases. 72, 136-9 MENNI C, KASTENMÜLLER G, PETERSEN AK, BELL JT, PSATHA M, TSAI P, GIEGER C, SCHULZ H, ERTE I, JOHN S, BROSNAN MJ, WILSON SG, TSAPROUNI L, LIM EM, STUCKEY B, DELOUKAS P, MOHNEY R, SUHRE K, SPECTOR TD and VALDES AM, 2013. Metabolomic markers reveal novel pathways of ageing and early development in human populations. International journal of epidemiology. (In Press.)
VALDES AM, GLASS D and SPECTOR TD, 2013. Omics technologies and the study of human ageing. Nature reviews. Genetics. (In Press.)
PANOUTSOPOULOU K, METRUSTRY S, DOHERTY SA, LASLETT LL, MACIEWICZ RA, HART DJ, ZHANG W, MUIR KR, WHEELER M, COOPER C, SPECTOR TD, CICUTTINI FM, JONES G, ARDEN NK, DOHERTY M, ZEGGINI E, VALDES AM and ARCOGEN CONSORTIUM, 2013. The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study. Annals of the rheumatic diseases. (In Press.)
MENNI C, KESER T, MANGINO M, BELL JT, ERTE I, AKMAČIĆ I, VUČKOVIĆ F, PUČIĆ BAKOVIĆ M, GORNIK O, MCCARTHY MI, ZOLDOŠ V, SPECTOR TD, LAUC G and VALDES AM, 2013. Glycosylation of immunoglobulin g: role of genetic and epigenetic influences. PloS one. 8(12), e82558 FAIRWEATHER-TAIT SJ, GUILE GR, VALDES AM, WAWER AA, HURST R, SKINNER J and MACGREGOR AJ, 2013. The contribution of diet and genotype to iron status in women: a classical twin study. PloS one. 8(12), e83047 KUO C, GRAINGE MJ, SEE L, YU K, LUO S, VALDES AM, ZHANG W and DOHERTY M, 2013. Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the rheumatic diseases. (In Press.)
EVANGELOU E, VALDES AM, CASTANO-BETANCOURT MC, DOHERTY M, DOHERTY S, ESKO T, INGVARSSON T, IOANNIDIS JPA, KLOPPENBURG M, METSPALU A, NTZANI EE, PANOUTSOPOULOU K, SLAGBOOM PE, SOUTHAM L, SPECTOR TD, STYRKARSDOTTIR U, STEFANSON K, UITTERLINDEN AG, WHEELER M, ZEGGINI E, MEULENBELT I, VAN MEURS JB and ARCOGEN CONSORTIUM, THE TREAT-OA CONSORTIUM, 2013. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Annals of the rheumatic diseases. 72(7), 1264-5 MENNI C, ZHAI G, MACGREGOR A, PREHN C, RÖMISCH-MARGL W, SUHRE K, ADAMSKI J, CASSIDY A, ILLIG T, SPECTOR TD and VALDES AM, 2013. Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics : Official journal of the Metabolomic Society. 9(2), 506-514 HEMANI G, YANG J, VINKHUYZEN A, POWELL JE, WILLEMSEN G, HOTTENGA J, ABDELLAOUI A, MANGINO M, VALDES AM, MEDLAND SE, MADDEN PA, HEATH AC, HENDERS AK, NYHOLT DR, DE GEUS EJC, MAGNUSSON PKE, INGELSSON E, MONTGOMERY GW, SPECTOR TD, BOOMSMA DI, PEDERSEN NL, MARTIN NG and VISSCHER PM, 2013. Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs. American journal of human genetics. 93(5), 865-75 KERKHOF HJM, BIERMA-ZEINSTRA SMA, ARDEN NK, METRUSTRY S, CASTANO-BETANCOURT M, HART DJ, HOFMAN A, RIVADENEIRA F, OEI EHG, SPECTOR TD, UITTERLINDEN AG, JANSSENS ACJW, VALDES AM and VAN MEURS JBJ, 2013. Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors. Annals of the rheumatic diseases. (In Press.)
NEOGI T, SONI A, DOHERTY SA, LASLETT LL, MACIEWICZ RA, HART DJ, ZHANG W, MUIR KR, WHEELER M, COOPER C, SPECTOR TD, CICUTTINI F, JONES G, NEVITT M, LIU Y, ARDEN NK, DOHERTY M and VALDES AM, 2013. Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis. Annals of the rheumatic diseases. (In Press.)
MOAYYERI A, HAMMOND CJ, VALDES AM and SPECTOR TD, 2013. Cohort Profile: TwinsUK and healthy ageing twin study. International journal of epidemiology. 42(1), 76-85 PETERS MJ, BROER L, WILLEMEN HLDM, EIRIKSDOTTIR G, HOCKING LJ, HOLLIDAY KL, HORAN MA, MEULENBELT I, NEOGI T, POPHAM M, SCHMIDT CO, SONI A, VALDES AM, AMIN N, DENNISON EM, EIJKELKAMP N, HARRIS TB, HART DJ, HOFMAN A, HUYGEN FJPM, JAMESON KA, JONES GT, LAUNER LJ, KERKHOF HJM, DE KRUIJF M, MCBETH J, KLOPPENBURG M, OLLIER WE, OOSTRA B, PAYTON A, RIVADENEIRA F, SMITH BH, SMITH AV, STOLK L, TEUMER A, THOMSON W, UITTERLINDEN AG, WANG K, VAN WINGERDEN SH, ARDEN NK, COOPER C, FELSON D, GUDNASON V, MACFARLANE GJ, PENDLETON N, SLAGBOOM PE, SPECTOR TD, VÖLZKE H, KAVELAARS A, VAN DUIJN CM, WILLIAMS FMK and VAN MEURS JBJ, 2013. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Annals of the rheumatic diseases. 72(3), 427-36 ELLIOTT KS, CHAPMAN K, DAY-WILLIAMS A, PANOUTSOPOULOU K, SOUTHAM L, LINDGREN CM, GIANT CONSORTIUM, ARDEN N, ASLAM N, BIRRELL F, CARLUKE I, CARR A, DELOUKAS P, DOHERTY M, LOUGHLIN J, MCCASKIE A, OLLIER WER, RAI A, RALSTON S, REED MR, SPECTOR TD, VALDES AM, WALLIS GA, WILKINSON M, ARCOGEN CONSORTIUM and ZEGGINI E, 2013. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Annals of the rheumatic diseases. 72(6), 935-41 HUDSON G, PANOUTSOPOULOU K, WILSON I, SOUTHAM L, RAYNER NW, ARDEN N, BIRRELL F, CARLUKE I, CARR A, CHAPMAN K, DELOUKAS P, DOHERTY M, MCCASKIE A, OLLIER WER, RALSTON SH, REED MR, SPECTOR TD, VALDES AM, WALLIS GA, WILKINSON JM, ZEGGINI E, SAMUELS DC, LOUGHLIN J, CHINNERY PF and ARCOGEN CONSORTIUM, 2013. No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Annals of the rheumatic diseases. 72(1), 136-9 ERLICH HA, VALDES AM, MCDEVITT S, SIMEN BB, BLAKE LA, MCGOWAN KR, TODD JA, RICH SS and NOBLE J, 2013. Next Generation Sequencing Reveals the Association of DRB3*02:02 with Type I Diabetes. Diabetes. (In Press.)
CODD, V., NELSON, C.P., ALBRECHT, E., MANGINO, M., DEELEN, J., BUXTON, J.L., HOTTENGA, J.J., FISCHER, K., ESKO, T., SURAKKA, I., BROER, L., NYHOLT, D.R., MATEO LEACH, I., SALO, P., HÄGG, S., MATTHEWS, M.K., PALMEN, J., NORATA, G.D., O'REILLY, P.F., SALEHEEN, D., AMIN, N., BALMFORTH, A.J., BEEKMAN, M., DE BOER, R.A., BÖHRINGER, S., BRAUND, P.S., BURTON, P.R., CRAEN, A.J.M., DENNIFF, M., DONG, Y., DOUROUDIS, K., DUBININA, E., ERIKSSON, J.G., GARLASCHELLI, K., GUO, D., HARTIKAINEN, A.L., HENDERS, A.K., HOUWING-DUISTERMAAT, J.J., KANANEN, L., KARSSEN, L.C., KETTUNEN, J., KLOPP, N., LAGOU, V., VAN LEEUWEN, E.M., MADDEN, P.A., MÄGI, R., MAGNUSSON, P.K.E., MÄNNISTÖ, S., MCCARTHY, M.I., MEDLAND, S.E., MIHAILOV, E., MONTGOMERY, G.W., OOSTRA, B.A., PALOTIE, A., PETERS, A., POLLARD, H., POUTA, A., PROKOPENKO, I., RIPATTI, S., SALOMAA, V., SUCHIMAN, H.E.D., VALDES, A.M., VERWEIJ, N., VIÑUELA, A., WANG, X., WICHMANN, H.E., WIDEN, E., WILLEMSEN, G., WRIGHT, M.J., XIA, K., XIAO, X., VAN VELDHUISEN, D.J., CATAPANO, A.L., TOBIN, M.D., HALL, A.S., BLAKEMORE, A.I.F., VAN GILST, W.H., ZHU, H., ERDMANN, J., REILLY, M.P., KATHIRESAN, S., SCHUNKERT, H., TALMUD, P.J., PEDERSEN, N.L., PEROLA, M., OUWEHAND, W., KAPRIO, J., MARTIN, N.G., VAN DUIJN, C.M., HOVATTA, I., GIEGER, C., METSPALU, A., BOOMSMA, D.I., JARVELIN, M., SLAGBOOM, P.E., THOMPSON, J.R., SPECTOR, T.D., VAN DER HARST, P. and SAMANI, N.J., 2013. Identification of seven loci affecting mean telomere length and their association with disease Nature Genetics. 45(4), 422-427 VALDES AM, VARNEY MD, ERLICH HA and NOBLE JA, 2013. Receiver Operating Characteristic Analysis of HLA, CTLA4, and Insulin Genotypes for Type 1 Diabetes. Diabetes Care. epub ahead of print,
EVANGELOU, E, VALDES, AM, CASTANO-BETANCOURT, MC, DOHERTY, M, DOHERTY, S, ESKO, T, INGVARSSON, T, IOANNIDIS, JP, KLOPPENBURG, M, METSPALU, A, NTZANI, EE, PANOUTSOPOULOU, K, SLAGBOOM, PE, SOUTHAM, L, SPECTOR, TD, STYRKARSDOTTIR, U, STEFANSON, K, UITTERLINDEN, AG, WHEELER, M, ZEGGINI, E, MEULENBELT, I, VAN MEURS, JB, ARCOGEN CONSORTIUM and TREAT-OA CONSORTIUM, 2013. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Annals of the Rheumatic Diseases: Ann Rheum Dis. 72, 1264-5 ERLICH, HA, VALDES, AM and NOBLE, JA, 2013. Prediction of type 1 diabetes. Diabetes. 62(4), 1020-1 MENNI, C, ZHAI, G, MACGREGOR, A, PREHN, C, ROMISCH-MARGL, W, SUHRE, K, ADAMSKI, J, CASSIDY, A, ILLIG, T, SPECTOR, TD and VALDES, AM, 2013. Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics. 9(2), 506-14 VALDES AM, DOHERTY SA, MUIR KR, WHEELER M, MACIEWICZ RA, ZHANG W and DOHERTY M, 2013. The genetic contribution to severe post-traumatic osteoarthritis. Annals of the rheumatic diseases. 72, 1687-90 CHAPMAN K and VALDES AM, 2012. Genetic factors in OA pathogenesis. Bone. 51(2), 258-64 KERKHOF HJM, EVANGELOU E, MEULENBELT I, VAN MEURS JBJ, ZEGGINI E and VALDES AM, 2012. Reply to "Human genetic studies on osteoarthritis from clinicians' viewpoints". Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 20(3), 250-1; author reply 252 ENGLAND A, VALDES AM, SLATER-JEFFERIES JL, GILL R, HOWELL WM, CALDER PC and GRIMBLE RF, 2012. Variants in the genes encoding TNF-α, IL-10, and GSTP1 influence the effect of α-tocopherol on inflammatory cell responses in healthy men. The American journal of clinical nutrition. 95(6), 1461-7 MANGINO M, HWANG S, SPECTOR TD, HUNT SC, KIMURA M, FITZPATRICK AL, CHRISTIANSEN L, PETERSEN I, ELBERS CC, HARRIS T, CHEN W, SRINIVASAN SR, KARK JD, BENETOS A, EL SHAMIEH S, VISVIKIS-SIEST S, CHRISTENSEN K, BERENSON GS, VALDES AM, VIÑUELA A, GARCIA M, ARNETT DK, BROECKEL U, PROVINCE MA, PANKOW JS, KAMMERER C, LIU Y, NALLS M, TISHKOFF S, THOMAS F, ZIV E, PSATY BM, BIS JC, ROTTER JI, TAYLOR KD, SMITH E, SCHORK NJ, LEVY D and AVIV A, 2012. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Human molecular genetics. 21(24), 5385-94 ZEGGINI, E., PANOUTSOPOULOU, K., SOUTHAM, L., RAYNER, N.W., DAY-WILLIAMS, A.G., LOPES, M.C., BORASKA, V., ESKO, T., EVANGELOU, E., HOFMAN, A., HOUWING-DUISTERMAAT, J.J., INGVARSSON, T., JONSDOTTIR, I., JONSSON, H., KERKHOF, H.J.M., KLOPPENBURG, M., BOS, S.D., MANGINO, M., METRUSTRY, S., SLAGBOOM, P.E., THORLEIFSSON, G., RAINE, E.V.A., RATNAYAKE, M., RICKETTS, M., BEAZLEY, C., BLACKBURN, H., BUMPSTEAD, S., ELLIOTT, K.S., HUNT, S.E., POTTER, S.C., SHIN, S.Y., YADAV, V.K., ZHAI, G., SHERBURN, K., DIXON, K., ARDEN, E., ASLAM, N., BATTLEY, P.K., CARLUKE, I., DOHERTY, S., GORDON, A., JOSEPH, J., KEEN, R., KOLLER, N.C., MITCHELL, S., O'NEILL, F., PALING, E., REED, M.R., RIVADENEIRA, F., SWIFT, D., WALKER, K., WATKINS, B., WHEELER, M., BIRRELL, F., IOANNIDIS, J.P.A., MEULENBELT, I., METSPALU, A., RAI, A., SALTER, D., STEFANSSON, K., STYRKARSDOTTIR, U., UITTERLINDEN, A.G., VAN MEURS, J.B.J., CHAPMAN, K., DELOUKAS, P., OLLIER, W.E.R., WALLIS, G.A., ARDEN, N., CARR, A., DOHERTY, M., MCCASKIE, A., WILKINSON, J.M., RALSTON, S.H., VALDES, A.M., SPECTOR, T.D. and LOUGHLIN, J., 2012. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study Lancet. 380(9844), 815-823 CASTAÑO BETANCOURT, M.C., CAILOTTO, F., KERKHOF, H.J., CORNELIS, F.M., DOHERTY, S.A., HART, D.J., HOFMAN, A., LUYTEN, F.P., MACIEWICZ, R.A., MANGINO, M., METRUSTRY, S., MUIR, K., PETERS, M.J., RIVADENEIRA, F. and WHEELER, M., 2012. Genome wide association and functional studiess identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis Proceedings of the National Academy of Sciences of the United States of America. 109(21), 8218-8223 VALDES AM, DOHERTY S, MUIR KR, ZHANG W, MACIEWICZ RA, WHEELER M, ARDEN N, COOPER C and DOHERTY M, 2012. Genetic contribution to radiographic severity in osteoarthritis of the knee. Annals of the rheumatic diseases. 71(9), 1537-40 MALFAIT A, SEYMOUR AB, GAO F, TORTORELLA MD, LE GRAVERAND-GASTINEAU MH, WOOD LS, DOHERTY M, DOHERTY S, ZHANG W, ARDEN NK, VAUGHN FL, LEAVERTON PE, SPECTOR TD, HART DJ, MACIEWICZ RA, MUIR KR, DAS R, SORGE RE, SOTOCINAL SG, SCHORSCHER-PETCU A, VALDES AM and MOGIL JS, 2012. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Annals of the rheumatic diseases. 71(6), 1042-8 NOBLE JA, JOHNSON J, LANE JA and VALDES AM, 2011. Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue antigens. 78(5), 348-51 KERKHOF HJM, MEULENBELT I, AKUNE T, ARDEN NK, AROMAA A, BIERMA-ZEINSTRA SMA, CARR A, COOPER C, DAI J, DOHERTY M, DOHERTY SA, FELSON D, GONZALEZ A, GORDON A, HARILAINEN A, HART DJ, HAUKSSON VB, HELIOVAARA M, HOFMAN A, IKEGAWA S, INGVARSSON T, JIANG Q, JONSSON H, JONSDOTTIR I, KAWAGUCHI H, KLOPPENBURG M, KUJALA UM, LANE NE, LEINO-ARJAS P, LOHMANDER LS, LUYTEN FP, MALIZOS KN, NAKAJIMA M, NEVITT MC, POLS HAP, RIVADENEIRA F, SHI D, SLAGBOOM E, SPECTOR TD, STEFANSSON K, SUDO A, TAMM A, TAMM AE, TSEZOU A, UCHIDA A, UITTERLINDEN AG, WILKINSON JM, YOSHIMURA N, VALDES AM and VAN MEURS JBJ, 2011. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 19(3), 254-64 VALDES AM, 2011. Involvement of the CLEC3B gene in osteoarthritis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 19(2), 249 VALDES AM and SPECTOR TD, 2011. Genetic epidemiology of hip and knee osteoarthritis. Nature reviews. Rheumatology. 7(1), 23-32 PANOUTSOPOULOU K, SOUTHAM L, ELLIOTT KS, WRAYNER N, ZHAI G, BEAZLEY C, THORLEIFSSON G, ARDEN NK, CARR A, CHAPMAN K, DELOUKAS P, DOHERTY M, MCCASKIE A, OLLIER WER, RALSTON SH, SPECTOR TD, VALDES AM, WALLIS GA, WILKINSON JM, ARDEN E, BATTLEY K, BLACKBURN H, BLANCO FJ, BUMPSTEAD S, CUPPLES LA, DAY-WILLIAMS AG, DIXON K, DOHERTY SA, ESKO T, EVANGELOU E, FELSON D, GOMEZ-REINO JJ, GONZALEZ A, GORDON A, GWILLIAM R, HALLDORSSON BV, HAUKSSON VB, HOFMAN A, HUNT SE, IOANNIDIS JPA, INGVARSSON T, JONSDOTTIR I, JONSSON H, KEEN R, KERKHOF HJM, KLOPPENBURG MG, KOLLER N, LAKENBERG N, LANE NE, LEE AT, METSPALU A, MEULENBELT I, NEVITT MC, O'NEILL F, PARIMI N, POTTER SC, REGO-PEREZ I, RIANCHO JA, SHERBURN K, SLAGBOOM PE, STEFANSSON K, STYRKARSDOTTIR U, SUMILLERA M, SWIFT D, THORSTEINSDOTTIR U, TSEZOU A, UITTERLINDEN AG, VAN MEURS JBJ, WATKINS B, WHEELER M, MITCHELL S, ZHU Y, ZMUDA JM, ARCOGEN CONSORTIUM, ZEGGINI E and LOUGHLIN J, 2011. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Annals of the rheumatic diseases. 70(5), 864-7 SOUTHAM L, PANOUTSOPOULOU K, RAYNER NW, CHAPMAN K, DURRANT C, FERREIRA T, ARDEN N, CARR A, DELOUKAS P, DOHERTY M, LOUGHLIN J, MCCASKIE A, OLLIER WER, RALSTON S, SPECTOR TD, VALDES AM, WALLIS GA, WILKINSON JM, ARCOGEN CONSORTIUM, MARCHINI J and ZEGGINI E, 2011. The effect of genome-wide association scan quality control on imputation outcome for common variants. European journal of human genetics : EJHG. 19(5), 610-4 WILLIAMS FMK, POPHAM M, HART DJ, DE SCHEPPER E, BIERMA-ZEINSTRA S, HOFMAN A, UITTERLINDEN AG, ARDEN NK, COOPER C, SPECTOR TD, VALDES AM and VAN MEURS J, 2011. GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women. Arthritis and rheumatism. 63(3), 708-12 NOBLE JA and VALDES AM, 2011. Genetics of the HLA region in the prediction of type 1 diabetes. Current diabetes reports. 11(6), 533-42 VALDES AM, STYRKARSDOTTIR U, DOHERTY M, MORRIS DL, MANGINO M, TAMM A, DOHERTY SA, KISAND K, KERNA I, TAMM A, WHEELER M, MACIEWICZ RA, ZHANG W, MUIR KR, DENNISON EM, HART DJ, METRUSTRY S, JONSDOTTIR I, JONSSON GF, JONSSON H, INGVARSSON T, COOPER C, VYSE TJ, SPECTOR TD, STEFANSSON K and ARDEN NK, 2011. Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations. PloS one. 6(8), e23371 DAY-WILLIAMS AG, SOUTHAM L, PANOUTSOPOULOU K, RAYNER NW, ESKO T, ESTRADA K, HELGADOTTIR HT, HOFMAN A, INGVARSSON T, JONSSON H, KEIS A, KERKHOF HJM, THORLEIFSSON G, ARDEN NK, CARR A, CHAPMAN K, DELOUKAS P, LOUGHLIN J, MCCASKIE A, OLLIER WER, RALSTON SH, SPECTOR TD, WALLIS GA, WILKINSON JM, ASLAM N, BIRELL F, CARLUKE I, JOSEPH J, RAI A, REED M, WALKER K, ARCOGEN CONSORTIUM, DOHERTY SA, JONSDOTTIR I, MACIEWICZ RA, MUIR KR, METSPALU A, RIVADENEIRA F, STEFANSSON K, STYRKARSDOTTIR U, UITTERLINDEN AG, VAN MEURS JBJ, ZHANG W, VALDES AM, DOHERTY M and ZEGGINI E, 2011. A variant in MCF2L is associated with osteoarthritis. American journal of human genetics. 89(3), 446-50 VALDES, A.M., DE WILDE, G., DOHERTY, S.A., LORIES, R.J., VAUGHN, F.L., LASLETT, L.L., MACIEWICZ, R.A., SONI, A., HART, D.J., ZHANG, W., MUIR, K.R., DENNISON, E.M., WHEELER, M., LEAVERTON, P., COOPER, C., SPECTOR, T.D., CICUTTINI, F.M., CHAPMAN, V., JONES, G., ARDEN, N.K. and DOHERTY, M., 2011. The IIe585Val TRPV1 variant is involved in risk of painful knee osteoarthritis Annals of the Rheumatic Diseases. 70(9), 1556-1561 VALDES AM, ARDEN NK, VAUGHN FL, DOHERTY SA, LEAVERTON PE, ZHANG W, MUIR KR, RAMPERSAUD E, DENNISON EM, EDWARDS MH, JAMESON KA, JAVAID MK, SPECTOR TD, COOPER C, MACIEWICZ RA and DOHERTY M, 2011. Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. Arthritis care & research. 63(3), 440-4 EVANGELOU E, VALDES AM, KERKHOF HJM, STYRKARSDOTTIR U, ZHU Y, MEULENBELT I, LORIES RJ, KARASSA FB, TYLZANOWSKI P, BOS SD, ARCOGEN CONSORTIUM, AKUNE T, ARDEN NK, CARR A, CHAPMAN K, CUPPLES LA, DAI J, DELOUKAS P, DOHERTY M, DOHERTY S, ENGSTROM G, GONZALEZ A, HALLDORSSON BV, HAMMOND CL, HART DJ, HELGADOTTIR H, HOFMAN A, IKEGAWA S, INGVARSSON T, JIANG Q, JONSSON H, KAPRIO J, KAWAGUCHI H, KISAND K, KLOPPENBURG M, KUJALA UM, LOHMANDER LS, LOUGHLIN J, LUYTEN FP, MABUCHI A, MCCASKIE A, NAKAJIMA M, NILSSON PM, NISHIDA N, OLLIER WER, PANOUTSOPOULOU K, VAN DE PUTTE T, RALSTON SH, RIVADENEIRA F, SAARELA J, SCHULTE-MERKER S, SHI D, SLAGBOOM PE, SUDO A, TAMM A, TAMM A, THORLEIFSSON G, THORSTEINSDOTTIR U, TSEZOU A, WALLIS GA, WILKINSON JM, YOSHIMURA N, ZEGGINI E, ZHAI G, ZHANG F, JONSDOTTIR I, UITTERLINDEN AG, FELSON DT, VAN MEURS JB, STEFANSSON K, IOANNIDIS JPA, SPECTOR TD and TRANSLATION RESEARCH IN EUROPE APPLIED TECHNOLOGIES FOR OSTEOARTHRITIS (TREATOA), 2011. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the rheumatic diseases. 70(2), 349-55 KERKHOF HJM, DOHERTY M, ARDEN NK, ABRAMSON SB, ATTUR M, BOS SD, COOPER C, DENNISON EM, DOHERTY SA, EVANGELOU E, HART DJ, HOFMAN A, JAVAID K, KERNA I, KISAND K, KLOPPENBURG M, KRASNOKUTSKY S, MACIEWICZ RA, MEULENBELT I, MUIR KR, RIVADENEIRA F, SAMUELS J, SEZGIN M, SLAGBOOM E, SMITH AJP, SPECTOR TD, TAMM A, TAMM A, UITTERLINDEN AG, WHEELER M, ZHAI G, ZHANG W, VAN MEURS JBJ and VALDES AM, 2011. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 19(3), 265-71 KERKHOF, H.J.M., MEULENBELT, I., AKUNE, T., ARDEN, N., AROMAA, A., BIERMA-ZEINSTRA, S., CARR, A., COOPER, C., DAI, J. and DOHERTY, M. ET AL, 2011. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium Osteoarthritis and Cartilage. 19, 254-64 VALDES, A.M., EVANGELOU, E., KERKHOF, H.J.M., TAMM, A., DOHERTY, S.A., KISAND, K., TAMM, A., KERNA, I., UITTERLINDEN, A., HOFMAN, A., RIVADENEIRA, F., COOPER, C., DENNISON, E.M., ZHANG, W. and MUIR, K.R., 2011. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance Annals of the Rheumatic Diseases. 70(5), 873-875 SOUTHAM, L., PANOUTSOPOULOU, K., RAYNER, N.W., CHAPMAN, K., DURRANT, C., FERREIRA, T., ARDEN, N., CARR, A., DELOUKAS, P. and DOHERTY, M. ET AL, 2011. The effect of genome-wide association scan quality control on imputation outcome for common variants. European Journal of Human Genetics. 610-14 VARNEY MD, VALDES AM, CARLSON JA, NOBLE JA, TAIT BD, BONELLA P, LAVANT E, FEAR AL, LOUEY A, MOONSAMY P, MYCHALECKYJ JC, ERLICH H and TYPE 1 DIABETES GENETICS CONSORTIUM, 2010. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes. 59(8), 2055-62 VALDES AM, DEARY IJ, GARDNER J, KIMURA M, LU X, SPECTOR TD, AVIV A and CHERKAS LF, 2010. Leukocyte telomere length is associated with cognitive performance in healthy women. Neurobiology of aging. 31(6), 986-92 VALDES AM and SPECTOR TD, 2010. The genetic epidemiology of osteoarthritis. Current opinion in rheumatology. 22(2), 139-43 VALDES AM and SPECTOR TD, 2010. The clinical relevance of genetic susceptibility to osteoarthritis. Best practice & research. Clinical rheumatology. 24(1), 3-14 CODD V, MANGINO M, VAN DER HARST P, BRAUND PS, KAISER M, BEVERIDGE AJ, RAFELT S, MOORE J, NELSON C, SORANZO N, ZHAI G, VALDES AM, BLACKBURN H, MATEO LEACH I, DE BOER RA, KIMURA M, AVIV A, WELLCOME TRUST CASE CONTROL CONSORTIUM, GOODALL AH, OUWEHAND W, VAN VELDHUISEN DJ, VAN GILST WH, NAVIS G, BURTON PR, TOBIN MD, HALL AS, THOMPSON JR, SPECTOR T and SAMANI NJ, 2010. Common variants near TERC are associated with mean telomere length. Nature genetics. 42(3), 197-9 RAKYAN VK, DOWN TA, MASLAU S, ANDREW T, YANG T, BEYAN H, WHITTAKER P, MCCANN OT, FINER S, VALDES AM, LESLIE RD, DELOUKAS P and SPECTOR TD, 2010. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome research. 20(4), 434-9 THORGEIRSSON TE, GUDBJARTSSON DF, SURAKKA I, VINK JM, AMIN N, GELLER F, SULEM P, RAFNAR T, ESKO T, WALTER S, GIEGER C, RAWAL R, MANGINO M, PROKOPENKO I, MÄGI R, KESKITALO K, GUDJONSDOTTIR IH, GRETARSDOTTIR S, STEFANSSON H, THOMPSON JR, AULCHENKO YS, NELIS M, ABEN KK, DEN HEIJER M, DIRKSEN A, ASHRAF H, SORANZO N, VALDES AM, STEVES C, UITTERLINDEN AG, HOFMAN A, TÖNJES A, KOVACS P, HOTTENGA JJ, WILLEMSEN G, VOGELZANGS N, DÖRING A, DAHMEN N, NITZ B, PERGADIA ML, SAEZ B, DE DIEGO V, LEZCANO V, GARCIA-PRATS MD, RIPATTI S, PEROLA M, KETTUNEN J, HARTIKAINEN A, POUTA A, LAITINEN J, ISOHANNI M, HUEI-YI S, ALLEN M, KRESTYANINOVA M, HALL AS, JONES GT, VAN RIJ AM, MUELLER T, DIEPLINGER B, HALTMAYER M, JONSSON S, MATTHIASSON SE, OSKARSSON H, TYRFINGSSON T, KIEMENEY LA, MAYORDOMO JI, LINDHOLT JS, PEDERSEN JH, FRANKLIN WA, WOLF H, MONTGOMERY GW, HEATH AC, MARTIN NG, MADDEN PAF, GIEGLING I, RUJESCU D, JÄRVELIN M, SALOMAA V, STUMVOLL M, SPECTOR TD, WICHMANN H, METSPALU A, SAMANI NJ, PENNINX BW, OOSTRA BA, BOOMSMA DI, TIEMEIER H, VAN DUIJN CM, KAPRIO J, GULCHER JR, ENGAGE CONSORTIUM, MCCARTHY MI, PELTONEN L, THORSTEINSDOTTIR U and STEFANSSON K, 2010. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature genetics. 42(5), 448-53 VALDES AM, SPECTOR TD, TAMM A, KISAND K, DOHERTY SA, DENNISON EM, MANGINO M, TAMM A, KERNA I, HART DJ, WHEELER M, COOPER C, LORIES RJ, ARDEN NK and DOHERTY M, 2010. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis and rheumatism. 62(8), 2347-52 NOBLE JA, VALDES AM, VARNEY MD, CARLSON JA, MOONSAMY P, FEAR AL, LANE JA, LAVANT E, RAPPNER R, LOUEY A, CONCANNON P, MYCHALECKYJ JC, ERLICH HA and TYPE 1 DIABETES GENETICS CONSORTIUM, 2010. HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes. 59(11), 2972-9 NJAJOU OT, BLACKBURN EH, PAWLIKOWSKA L, MANGINO M, DAMCOTT CM, KWOK P, SPECTOR TD, NEWMAN AB, HARRIS TB, CUMMINGS SR, CAWTHON RM, SHULDINER AR, VALDES AM and HSUEH W, 2010. A common variant in the telomerase RNA component is associated with short telomere length. PloS one. 5(9), e13048 KERKHOF HJM, MEULENBELT I, CARR A, GONZALEZ A, HART D, HOFMAN A, KLOPPENBURG M, LANE NE, LOUGHLIN J, NEVITT MC, POLS HAP, RIVADENEIRA F, SLAGBOOM EP, SPECTOR TD, STOLK L, TSEZOU A, UITTERLINDEN AG, VALDES AM and VAN MEURS JBJ, 2010. Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis. BMC medical genetics. 11, 164 KERKHOF HJM, LORIES RJ, MEULENBELT I, JONSDOTTIR I, VALDES AM, ARP P, INGVARSSON T, JHAMAI M, JONSSON H, STOLK L, THORLEIFSSON G, ZHAI G, ZHANG F, ZHU Y, VAN DER BREGGEN R, CARR A, DOHERTY M, DOHERTY S, FELSON DT, GONZALEZ A, HALLDORSSON BV, HART DJ, HAUKSSON VB, HOFMAN A, IOANNIDIS JPA, KLOPPENBURG M, LANE NE, LOUGHLIN J, LUYTEN FP, NEVITT MC, PARIMI N, POLS HAP, RIVADENEIRA F, SLAGBOOM EP, STYRKÁRSDÓTTIR U, TSEZOU A, VAN DE PUTTE T, ZMUDA J, SPECTOR TD, STEFANSSON K, UITTERLINDEN AG and VAN MEURS JBJ, 2010. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis and rheumatism. 62(2), 499-510 VALDES AM, ARDEN NK, TAMM A, KISAND K, DOHERTY S, POLA E, COOPER C, TAMM A, MUIR KR, KERNA I, HART D, O'NEIL F, ZHANG W, SPECTOR TD, MACIEWICZ RA and DOHERTY M, 2010. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 18(5), 699-704 VALDES AM, MCWILLIAMS D, ARDEN NK, DOHERTY SA, WHEELER M, MUIR KR, ZHANG W, COOPER C, MACIEWICZ RA and DOHERTY M, 2010. Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis and rheumatism. 62(9), 2688-95 VALDES, A.M., SPECTOR, T.D., TAMM, A., DENNISON, E.M., KISAND, K., DOHERTY, S., KERNA, I., HART, D., WHEELER, M., COOPER, C., LORIES, R.J., ARDEN, N.K. and DOHERTY, M., 2010. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis and Rheumatism. 62, 2347-52 RODRIGUEZ-LOPEZ J, POMBO-SUAREZ M, LOUGHLIN J, TSEZOU A, BLANCO FJ, MEULENBELT I, SLAGBOOM PE, VALDES AM, SPECTOR TD, GOMEZ-REINO JJ and GONZALEZ A, 2009. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 17(3), 321-7 VALDES AM and SPECTOR TD, 2009. The contribution of genes to osteoarthritis. The Medical clinics of North America. 93(1), 45-66, x VALDES AM, THOMSON G and TYPE 1 DIABETES GENETICS CONSORTIUM, 2009. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes, obesity & metabolism. 11 Suppl 1, 46-52 MANGINO M, RICHARDS JB, SORANZO N, ZHAI G, AVIV A, VALDES AM, SAMANI NJ, DELOUKAS P and SPECTOR TD, 2009. A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. Journal of medical genetics. 46(7), 451-4 ERLICH HA, LOHMAN K, MACK SJ, VALDES AM, JULIER C, MIREL D, NOBLE JA, MORAHAN GE, RICH SS and TYPE I DIABETES GENETICS CONSORTIUM, 2009. Association analysis of SNPs in the IL4R locus with type I diabetes. Genes and immunity. 10 Suppl 1, S33-41 ERLICH HA, VALDES AM, JULIER C, MIREL D, NOBLE JA and TYPE I DIABETES GENETICS CONSORTIUM, 2009. Evidence for association of the TCF7 locus with type I diabetes. Genes and immunity. 10 Suppl 1, S54-9 EVANGELOU E, CHAPMAN K, MEULENBELT I, KARASSA FB, LOUGHLIN J, CARR A, DOHERTY M, DOHERTY S, GÓMEZ-REINO JJ, GONZALEZ A, HALLDORSSON BV, HAUKSSON VB, HOFMAN A, HART DJ, IKEGAWA S, INGVARSSON T, JIANG Q, JONSDOTTIR I, JONSSON H, KERKHOF HJM, KLOPPENBURG M, LANE NE, LI J, LORIES RJ, VAN MEURS JBJ, NÄKKI A, NEVITT MC, RODRIGUEZ-LOPEZ J, SHI D, SLAGBOOM PE, STEFANSSON K, TSEZOU A, WALLIS GA, WATSON CM, SPECTOR TD, UITTERLINDEN AG, VALDES AM and IOANNIDIS JPA, 2009. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis and rheumatism. 60(6), 1710-21 ZHAI G, VAN MEURS JBJ, LIVSHITS G, MEULENBELT I, VALDES AM, SORANZO N, HART D, ZHANG F, KATO BS, RICHARDS JB, WILLIAMS FMK, INOUYE M, KLOPPENBURG M, DELOUKAS P, SLAGBOOM E, UITTERLINDEN A and SPECTOR TD, 2009. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. Journal of medical genetics. 46(9), 614-6 VALDES AM, LORIES RJ, VAN MEURS JB, KERKHOF H, DOHERTY S, HOFMAN A, HART DJ, ZHANG F, LUYTEN FP, UITTERLINDEN AG, DOHERTY M and SPECTOR TD, 2009. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis and rheumatism. 60(7), 2046-54 VALDES, A.M., LORIES, R.J., VAN MEURS, J.B., KERHOFF, J.M., DOHERTY, S., HOFMAN, A., HART, D.J., ZHANG, F., LUYTEN, F., UITTERLINDEN, A., DOHERTY, M. and SPECTOR, T.D., 2009. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis and Rheumatism. 60, 2046-54 VALDES, A.M., SPECTOR, T.D., DOHERTY, S., WHEELER, M., HART, D.J. and DOHERTY, M., 2009. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations Annals of the Rheumatic Diseases. 68(12), 1916-1920 ZHAI G, HART DJ, VALDES AM, KATO BS, RICHARDS JB, HAKIM A and SPECTOR TD, 2008. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 19(8), 1211-7 THOMSON G, BARCELLOS LF and VALDES AM, 2008. Searching for additional disease loci in a genomic region. Advances in genetics. 60, 253-92 VALDES, A.M., LOUGHLIN, J., TIMMS, K.M., VAN MEURS, J.J.B., SOUTHAM, L., WILSON, S.G., DOHERTY, S., LORIES, R.J., LUYTEN, F.P., GUTIN, A., ABKEVICH, V., GE, D., HOFMAN, A., UITTERLINDEN, A.G., HART, D.J., ZHANG, F., ZHAI, G., EGLI, R.J., DOHERTY, M., LANCHBURY, J. and SPECTOR, T.D., 2008. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis American Journal of Human Genetics. 82(6), 1231-1240 RICHARDS, J.B., RIVADENEIRA, F., INOUYE, M., PASTINEN, T.M., SORANZO, N., WILSON, S.G., ANDREW, T., FALCHI, M., GWILLIAM, R., AHMADI, K.R., VALDES, A.M., ARP, P., WHITTAKER, P., VERLAAN, D.J., JHAMAI, M., KUMANDURI, V., MOORHOUSE, M., VAN MEURS JB, HOFMAN, A., POLS, H.A.P., HART, D., ZHAI, G., KATO, B.S., MULLIN, B.H., ZHANG, F., DELOUKAS, P., UITTERLINDEN, A.G. and SPECTOR, T.D., 2008. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet. 371(9623), 1505-1512 VALDES AM and SPECTOR TD, 2008. The contribution of genes to osteoarthritis. Rheumatic diseases clinics of North America. 34(3), 581-603 RICHARDS JB, VALDES AM, GARDNER JP, KATO BS, SIVA A, KIMURA M, LU X, BROWN MJ, AVIV A and SPECTOR TD, 2008. Homocysteine levels and leukocyte telomere length. Atherosclerosis. 200(2), 271-7 KERKHOF JM, UITTERLINDEN AG, VALDES AM, HART DJ, RIVADENEIRA F, JHAMAI M, HOFMAN A, POLS HAP, BIERMA-ZEINSTRA SMA, SPECTOR TD and VAN MEURS JB, 2008. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 16(10), 1141-9 VALDES AM, DOHERTY M and SPECTOR TD, 2008. The additive effect of individual genes in predicting risk of knee osteoarthritis. Annals of the rheumatic diseases. 67(1), 124-7 ZHAI G, VALDES AM, CHERKAS L, CLEMENT G, STRACHAN D and SPECTOR TD, 2007. The interaction of genes and smoking on forced expiratory volume: a classic twin study. Chest. 132(6), 1772-7 THOMSON G, VALDES AM, NOBLE JA, KOCKUM I, GROTE MN, NAJMAN J, ERLICH HA, CUCCA F, PUGLIESE A, STEENKISTE A, DORMAN JS, CAILLAT-ZUCMAN S, HERMANN R, ILONEN J, LAMBERT AP, BINGLEY PJ, GILLESPIE KM, LERNMARK A, SANJEEVI CB, RØNNINGEN KS, UNDLIEN DE, THORSBY E, PETRONE A, BUZZETTI R, KOELEMAN BPC, ROEP BO, SARUHAN-DIRESKENELI G, UYAR FA, GÜNOZ H, GORODEZKY C, ALAEZ C, BOEHM BO, MLYNARSKI W, IKEGAMI H, BERRINO M, FASANO ME, DAMETTO E, ISRAEL S, BRAUTBAR C, SANTIAGO-CORTES A, FRAZER DE LLADO T, SHE J, BUGAWAN TL, ROTTER JI, RAFFEL L, ZEIDLER A, LEYVA-COBIAN F, HAWKINS BR, CHAN SH, CASTANO L, POCIOT F and NERUP J, 2007. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue antigens. 70(2), 110-27 STEENKISTE A, VALDES AM, FEOLO M, HOFFMAN D, CONCANNON P, NOBLE J, SCHOCH G, HANSEN J, HELMBERG W, DORMAN JS, THOMSON G, PUGLIESE A and 13TH IHWS 1 DIABETES COMPONENT PARTICIPATING INVESTIGATORS, 2007. 14th International HLA and Immunogenetics Workshop: report on the HLA component of type 1 diabetes. Tissue antigens. 69 Suppl 1, 214-25 RING HZ, VALDES AM, NISHITA DM, PRASAD S, JACOB P, TYNDALE RF, SWAN GE and BENOWITZ NL, 2007. Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism. Pharmacogenetics and genomics. 17(12), 1007-15 ANDREW T, AVIV A, FALCHI M, SURDULESCU GL, GARDNER JP, LU X, KIMURA M, KATO BS, VALDES AM and SPECTOR TD, 2006. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. American journal of human genetics. 78(3), 480-6 AVIV A, VALDES AM and SPECTOR TD, 2006. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. International journal of epidemiology. 35(6), 1424-9 CHERKAS LF, AVIV A, VALDES AM, HUNKIN JL, GARDNER JP, SURDULESCU GL, KIMURA M and SPECTOR TD, 2006. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging cell. 5(5), 361-5 VALDES AM, VAN OENE M, HART DJ, SURDULESCU GL, LOUGHLIN J, DOHERTY M and SPECTOR TD, 2006. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis and rheumatism. 54(2), 533-9 VALDES AM, ANDREW T, GARDNER JP, KIMURA M, OELSNER E, CHERKAS LF, AVIV A and SPECTOR TD, 1. Obesity, cigarette smoking, and telomere length in women. Lancet. 366(9486), 662-4 NOBLE JA, MARTIN A, VALDES AM, LANE JA, GALGANI A, PETRONE A, LORINI R, POZZILLI P, BUZZETTI R and ERLICH HA, 1. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. Human immunology. 69(4-5), 291-300