Andrew graduated from Nottingham in 2003 with a BMBS and entered clinical practice. He commenced the paediatric postgraduate training scheme in 2005. In 2009, he commenced a PhD in child health, and was awarded a NIHR Doctoral Research Fellowship in 2010, where he studied biomarkers of toxicity in children and adults with cystic fibrosis. Post PhD, after a further period of clinical practice he returned to research and holds a NIHR Academic Clinical Lecturer post in Child Health. He subsequently completed specialist training, and held a locum consultant post in Paediatric Respiratory, Critical Care and Transport Medicine, before his current post at the University of Nottingham as a Clinical Associate Professor in Paediatric Respiratory Medicine.
Andrew's expertise is in MRI in young children - his studies include whole day MRI protocols for children aged 6 and over with cystic fibrosis, and using an upright MRI scanner for lung imaging in children as young as 3 years. He also undertakes studies of novel lung function tests in young children and infants. All of these studies are designed to address the need for better tests of lung health in young children, infants and babies.
Andrew is interested in improving the health of children with rare diseases, in particular Ataxia-Telangiectasia and Cystic Fibrosis. He sits on the Research Advisory Committee for ActionforA-T
Andrew has an interest in understanding how clinical trials influence research practice, and how the medical literature influences medical practice. Andrew is interested in applying machine learning to clinical problems.
Andrew teaches in the Masters of Public Health (https://www.nottingham.ac.uk/pgstudy/course/taught/public-health-mph), on the Data Organisation and Management in Epidemiology module. This taught… read more
Andrew is currently working on identifying pulmonary endpoints for clinical trials, with the goal of improving the pulmonary health of children. During childhood the lungs develop and grow, and the… read more
PRAYLE AP, COX T, SMITH SJ, RYCROFT-MALONE J, THOMAS KS, HUGHES DA and SMYTH AR, 2017. Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review. Thorax.
SAFAVI, S., PRAYLE, A.P., HALL, I.P. and PARMAR, J., 2017. Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients Cochrane Database of Systematic Reviews. 2017(9), STEWART E, PRAYLE AP, TOOKE A, PASALODOS S, SURI M, BUSH A and BHATT JM, 2016. Growth and nutrition in children with ataxia telangiectasia. Archives of disease in childhood. 101(12), 1137-1141
HURLEY MN, , PRAYLE AP and FLUME P, 2015. Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis. Paediatric respiratory reviews. 16(4), 246-8
Andrew is currently working on identifying pulmonary endpoints for clinical trials, with the goal of improving the pulmonary health of children. During childhood the lungs develop and grow, and the single biggest predictor of your lifespan as an adult is your lung function. Therefore, it is important to optimize the health of the lungs in childhood. In recent years, it has become clear that our current tools for assessing lung health, particularly in young children, are either too invasive for clinical research, or to insensitive to subtle changes in lung function. Andrew is therefore running a number of projects to investigate the application of pulmonary MRI and other novel methods of lung ehalth testing in children as endpoints in clinical trials.