Dr Claire Seedhouse is an Associate Professor within the Division of Cancer and Stem Cells, in the School of Medicine, at the University of Nottingham
Claire studied for a BSc (Hons) at Bath University which included two industrial placements (1995). She did her PhD at the Paterson Institute for Cancer Research, Manchester where she developed an interest in DNA damage and repair (1999). After completing several post-doctoral research positions and a fellowship at the University of Nottingham she was appointed as the Skillington Haematology Lecturer in 2009. She has published more than 40 papers (h index 24) and receives external, and local, peer-reviewed funding for her research.
Course Director MSc Oncology
Theme lead for MSc in Clinical Sciences (Blood Sciences)
Claire's research focuses on mechanisms of drug action and resistance in haematological malignancies, including acute myeloid leukaemia (AML), multiple myeloma and lymphoma.
Current research projects include:
- Targeting Bcl2 family members in AML and myeloma
- NPM as a therapeutic target in AML
- Targeting dormant cells in leukaemia
- Response of AML and myeloma cells to novel therapeutic drugs
Research is funded by peer-reviewed grants from national and local charities and industrial support. The group is comprised of laboratory scientists and has strong links with clinicians and clinical scientists and has a solid publication track record in high-quality peer-reviewed journals with a number of highly cited (>100 citations) papers.
SEEDHOUSE, C.H, HUNTER, H.M., LLOYD-LEWIS, B., MASSIP, A-M., PALLIS, M., CARTER, G.I., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2006. DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412 Leukemia. 20(12), 2130-2136 SEEDHOUSE, C., GRUNDY, M., SHANG, S., RONAN, J., PIMBLETT, H., RUSSELL, N. and PALLIS, M., 2009. Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine Clinical Cancer Research. 15(23), 7291-7298 SEEDHOUSE,, GRUNDY,, WHITE,, LI,, FISHER,, YAKUNINA,, MOORMAN,, HOY,, RUSSELL,, BURNETT, and PALLIS,, 2007. Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials. Clinical Cancer Research. 13(23), 7059-7066
JAWAD, M., SEEDHOUSE, C., MONY, U., GRUNDY, M., RUSSELL, N.H. and PALLIS, M., 2010. Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia Leukemia. 24(1), 74-80