Dr Claire Seedhouse is an Associate Professor within the Division of Cancer and Stem Cells, in the School of Medicine, at the University of Nottingham
Claire studied for a BSc (Hons) at Bath University which included two industrial placements (1995). She did her PhD at the Paterson Institute for Cancer Research, Manchester where she developed an interest in DNA damage and repair (1999). After completing several post-doctoral research positions and a fellowship at the University of Nottingham she was appointed as the Skillington Haematology Lecturer in 2009. She has published more than 40 papers (h index 24) and receives external, and local, peer-reviewed funding for her research.
Course Director MSc Oncology
Lecturer - MSc Oncology, BMed Sciences, BSc/MSci Cancer Sciences
Claire's research focuses on mechanisms of drug action and resistance in haematological malignancies, including acute myeloid leukaemia (AML), multiple myeloma and lymphoma.
Current research projects include:
- Targeting Bcl2 family members in AML and myeloma
- NPM as a therapeutic target in AML
- Targeting dormant cells in leukaemia
- Response of AML and myeloma cells to novel therapeutic drugs
Research is funded by peer-reviewed grants from national and local charities and industrial support. The group is comprised of laboratory scientists and has strong links with clinicians and clinical scientists and has a solid publication track record in high-quality peer-reviewed journals with a number of highly cited (>100 citations) papers.
BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia SCIENTIFIC REPORTS. 10(1), BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia. British journal of haematology.
GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun BMC CANCER. 20(1),