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Biography
Ed Juszczak is Professor of Clinical Trials and Statistics in Medicine at Nottingham Clinical Trials Unit (NCTU) at the University of Nottingham (joined in July 2020). He has over 25 years of experience in the design, conduct, analysis, interpretation and reporting of clinical trials, specialising in the perinatal field and multi-arm trial methodology.
He graduated in Applied Statistics from Sheffield City Polytechnic in 1992, and obtained a Masters degree (MSc) in Medical Statistics from the London School of Hygiene & Tropical Medicine a year later. He then spent 5 years in the Information & Statistics Division of the NHS in Scotland developing an expertise in the design and analysis of case control and cohort studies. In 1998 he joined the Centre for Statistics in Medicine, University of Oxford, and as Senior Medical Statistician led a small dedicated team of statisticians supporting clinical research, predominantly randomised controlled trials (RCTs) and teaching medical statistics to non-statisticians.
From 2007 to 2020, Ed was Director of the Clinical Trials Unit at the University of Oxford's National Perinatal Epidemiology Unit, running a portfolio of around a dozen neonatal and maternal clinical trials. He was an Associate Professor at the University of Oxford and was conferred Chartered Scientist status (CSci) by the Science Council in 2010. Ed has also served on the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Commissioned and General Boards. He is an independent member of numerous Trial Steering and Data Monitoring Committees, chairing several.
Expertise Summary
Ed has considerable experience in the design, conduct, analysis and reporting of clinical trials, with a particular interest in multi-arm trial methodology and reporting, the use of routine data e.g., electronic patient records for conducting clinical trials, and the use of medical statistics in neonatology, paediatrics, mental health, and surgery.
Research Summary
I have over 25 years of experience in designing, conducting, analysing, interpreting, and reporting clinical trials, with expertise in perinatal research and multi-arm trial methodology. My… read more
Current Research
I have over 25 years of experience in designing, conducting, analysing, interpreting, and reporting clinical trials, with expertise in perinatal research and multi-arm trial methodology. My international reputation as a leader in perinatal clinical trials was forged at the University of Oxford, where I served as Director of the National Perinatal Epidemiology Unit Clinical Trials Unit (2010-2020). I was also a key member of the RECOVERY COVID-19 trial team, contributing to the rapid setup of the trial and the first patient recruitment in just nine days (reflected in my publications). In 2020, I joined the Nottingham Clinical Trials Unit (NCTU), where the perinatal portfolio has expanded significantly, now representing a large proportion of the unit's research.
Since my appointment at NCTU, I have demonstrated exceptional, sustained performance in three main areas: research income and publications, international impact and reputation, and leadership within and outside the University of Nottingham.
Research Income Since 2020, I have contributed to 10 successful grant awards totalling £11.3M (one as Chief Investigator and nine as Co-investigator). These grants support innovative trial designs and foster new collaborations. Notable projects include:
NIHR-funded Randomised Controlled Trials
- PROTECT (COVID-19 in care homes, as Co-investigator)
- POP-I (post-operative anaemia, as Co-investigator/CTU lead)
- DEXTA (preterm babies, as Co-investigator/CTU lead)
- OTTER (babies with reflux, as Co-investigator)
- OPTICORD (babies needing resuscitation, as Co-investigator)
Methodology
- PEARS (NIHR_RSS award) (as Co-investigator)
- NIHR Accelerator award (as Chief investigator)
- RaFT (MRC) (as Co-investigator)
Fellowships
- NIHR pre-doctoral fellowship (as Co-investigator)
- AMR fellowship (as Co-investigator)
Publications My publication record is exceptional and includes 60 papers since 2021, with 21 (35%) in the top 10% most cited worldwide, exceeding the University of Nottingham's REF expectations. I have 11,678 citations (average 195 citations/publication), a h5-index=16, FWCI=22. Eight of my publications are ranked 4* (six co-authored with University of Nottingham colleagues), double the expectation.
International Impact and Reputation I have co-authored six international clinical trial reporting guidelines, which underpin sound and transparent trial reporting. These guidelines, including extensions to CONSORT and SPIRIT for trials conducted using routinely collected data, paediatric trials and factorial trials, are highly cited and essential for publishing trials in major peer-reviewed journals. This work significantly enhances the reputation of the School of Medicine.
Past Research
Ed has nearly 200 publications including 11 in The New England Journal of Medicine, 9 in the Lancet, and 4 in JAMA. He is a author/co-author of numerous guidelines including: (i) a CONSORT extension for reporting multi-arm parallel-group randomized trials, (ii) a CONSORT extension for reporting randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE), (iii) a CONSORT extension for reporting factorial randomised controlled trials, (iv) a reporting guideline for the content of statistical analysis plans in clinical trials, and (v) determining a risk-proportionate approach to the validation of statistical programming for clinical trials.
Ed was a key member of the (University of Oxford led) RECOVERY COVID-19 trial team, playing an integral role in setting up the trial to recruit the first patients in a record 9 days from the drafting of the protocol. His role included, in March 2020 (as outgoing Director of NPEU Clinical Trials Unit, University of Oxford), combining his NPEU team with The Clinical Trial Service & Epidemiological Studies Unit (University of Oxford) providing IT systems and statistical support. He was also instrumental in the integration of pregnant women into the trial, consulting with leading UK obstetricians. As a member of the Paediatric Special Interest group, he also helped facilitate the integration of babies & children. Throughout the first 6 months of the trial (until September 2020 when he joined Nottingham Clinical Trials Unit), he led the statistical team, and contributed to trial oversight, governance and dissemination of results.