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Kate Walker

Clinical Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

Dr Kate Walker is a Clinical Assistant Professor in Obstetrics and Gynaecology at the University of Nottingham. She completed her PhD on "late pregnancy complications in women of advanced maternal age" in 2016. Part of her PhD involved the design, securing of funding and successful implementation of the 35/39 trial; a national multi-centre prospective randomised controlled trial of induction of labour versus expectant management for nulliparous women over 35 years of age published in the New England Journal of Medicine in 2016. The rationale for this trial is that women of advanced maternal age have an increased risk of antepartum stillbirth at term and that induction of labour at 39 weeks might forestall some of the risk. However women of advanced maternal age are already at high risk of obstetric intervention, the trial provided evidence for whether induction of labour has any adverse effect on mothers or babies.

Expertise Summary

Randomised controlled trials. General obstetrics. General gynaecology. Qualitative research.

Research Summary

I am performing a systematic review of clinical trial performance metrics under the guidance of Professor Lelia Duley.

I have secured a £23,000 grant from the Academy of Medical Sciences to validate the second version of the Childbirth Experience Questionnaire in the UK, the project started in October 2017 and we aim to recruit 475 women in 12 months.

I have secured a £10,000 grant from the Rosetrees Trust to do some preparatory work for a follow-up study of the babies of participants in the 35/39 labour induction trial to seven years of age.

Along with Professor Jim Thornton I am supervising an Assisted Reproductive Technology Masters student, Dr Suthaporn Sutham who is performing a systematic review of progestogen for luteal phase support in ART.

I am undertaking a master's level professional qualification in teaching (Postgraduate Certificate in Higher Education) with the University of Nottingham.

I am the independent Obstetrician member of the Trial Steering Committee for the SOLVE trial ran by the Birmingham Clinical Trials Unit: a randomised controlled trial of a synthetic osmotic cervical dilator for induction of labour in comparison to dinoprostone vaginal insert.

Past Research

Peer reviewed original research

Kate F Walker, Melina Dritsaki, George J Bugg, Marion Macpherson, Carol McCormick, Nicky Grace, Chris Wildsmith Lucy Bradshaw, Gordon C S Smith, James G Thornton. Labour induction near term for women aged 35 or over; an economic evaluation of a randomised trial. BJOG 2017: 124 (6)

Kate F Walker, George J Bugg, Marion Macpherson, Carol McCormick, Nicky Grace, Chris Wildsmith Lucy Bradshaw, Gordon C S Smith, James G Thornton. A randomized controlled trial of labor induction for women aged 35 or over. NEJM 2016; 374:813-22.

Kate F Walker, Lucy Bradshaw, George J Bugg and Jim G Thornton. Causes of antepartum stillbirth in women of advanced maternal age. European Journal of Obstetrics and Gynecology and Reproductive Biology 197 (2016) 86-90.

Kate F Walker, Gemma Malin, Philippa Wilson and Jim G Thornton. Induction of labour versus expectant management at term by subgroups of maternal age: an individual patient data meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology 197 (2016) 1-5.

Kate F Walker, Philippa Wilson, George J Bugg, Anna Dencker and Jim G Thornton. Childbirth experience questionnaire: validating its use in the United Kingdom. BMC Pregnancy and Childbirth (2015) 15:86.

Kate F Walker, Graham Stevenson and James Thornton. Still discrepancies between registration and publication of randomised controlled trials: an observational study. Journal of the Royal Society of Medicine Short Reports 2014: 5(5) 1-4.

Kate Walker, Abigail Cohen, Sophie Walker, Kirsten Allen, Darrin Baines, Jim Thornton. Dangers of the day of birth: an observational study. BJOG 2014; 121:714-718.

Kate F Walker, George J Bugg, Marion Macpherson, Carol McCormick James Thornton. Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial. BMC Pregnancy and Childbirth 2012, 12:145.

Kate F Walker, George J Bugg, Marion Macpherson, James Thornton. Induction of labour at term for women over 35 years old: a survey of the views of women and obstetricians. European Journal of Obstetrics and Gynecology and Reproductive Biology 2012 162(2):144-8

Zeina J Haoula, Kate F Walker, Martin C Powell. Levonorgestrel intra-uterine system as a treatment option for complex endometrial hyperplasia. European Journal of Obstetrics and Gynecology and Reproductive Biology 2011; 159 (1):176-179.

Kate Frances Walker, Honor Day, Jafaru Abu, David Nunns, Karin Williamson, Tim Duncan. Do surgical techniques used in groin lymphadenectomy for vulval cancer affect morbidity rates? International Journal of Gynecological Cancer 2011; 21(8):1495-1499.

K. Jayaprakasan, K.F. Walker, J.S. Clewes, I.R. Johnson & N.J. Raine-Fenning. The interobserver reliability of off-line antral follicle counts made from stored three-dimensional ultrasound data; a comparative study of different measurement techniques. Ultrasound in Obstetrics and Gynecology 2007; 29: 335-341.

Ala'Aldeen, D.A.A., Robinson, K., Wooldridge, K.G., Bland, S.J., Wells, D.B., Riordan (Walker), K.F., Taraktsoglou, M. & Todd, I. The meningococcal TspA protein is vital for normal type IV pilus biogenesis and function. Abstracts of the Thirteenth International Pathogenic Neisseria Conference. Norway 2002

Invited commentaries

Kate F Walker and James G Thornton. Induction of labour at 37 weeks for suspected fetal macrosomia may reduce birth trauma. Evidence-Based Medicine. Published online 23rd June 2017. Doi: 10.1136/ebmed-2017-110693

Kate F Walker and James G Thornton. Tocolysis and preterm labour. The Lancet (2016). Published online 1st March 2016.

Invited reviews

K.F. Walker, J Thornton Delivery at term: when, how and why. Clinics in Perinatology 2017. In press

K.F. Walker, J Thornton. Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine

Obstetrics, Gynaecology and Reproductive Medicine 2016; 26.

K.F. Walker, K. Jayaprakasan, N.J. Raine-Fenning. Ultrasound in benign gynaecology. Obstetrics, Gynaecology and Reproductive Medicine 2007; 17:2.

Case reports

Philippa Wilson, Kate F Walker, Clare Gribbin and James G Thornton. A case of aortic dissection diagnosed postnatally. European Journal of Obstetrics and Gynecology and Reproductive Biology 183 (2014) 205.

Kate F. Walker, Jaydip Dasgupta and Michael P. Cust. A neglected shelf pessary resulting in an urethrovaginal fistula. International Urogynecology Journal 2011; 22(10):1333-1334.

Letters

K Walker and J Thornton Dangers of the day of birth: an observational study (Author's comment). BJOG 2014; 121 (10), pages 1320-1321.

Book Chapters

Chapter on 'Ethics in Medicine' in Medicolegal Issues in Obstetrics and Gynaecology. In Press.

Chapter on 'Prolonged Pregnancy' in Oxford University Press Textbook of Obstetrics and Gynaecology. In Press.

StratOG (RCOG's online learning resource)

Revised and updated eLearning tutorials on Postpartum sepsis (2013) and Infectious Diseases (2013)

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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