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Kate Walker

Clinical Professor In Obstetrics, Faculty of Medicine & Health Sciences

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Biography

I am currently a Clinical Professor in Obstetrics, at the University of Nottingham. I work full time and divide my time equally between research and clinical work. My research work is based in Nottingham Clinical Trials Unit (NCTU). My clinical work is based at Queen's Medical Centre, Nottingham University Hospitals Trust.

Clinically I have an interest in high risk pregnancy, labour ward management and obstetric ultrasound scanning.

My research work has focused on randomised controlled trials in obstetrics, neonatology and sexual health.

For my PhD I conducted a randomised controlled trial of induction of labour at 39 weeks versus expectant management for women over 35 years of age - the "35/39 trial", I was co-applicant on the £250K Research for Patient Benefit grant and I was the first author of the paper which was published in the NEJM in 2016.

I am the Clinical Chief Investigator for an NIHR HTA funded cluster randomised trial with economic and acceptability evaluations to determine the clinical and cost-effectiveness of testing for Group B Streptococcus in late pregnancy (GBS3). This is the first RCT of routine GBS screening in the world.

I am the Chief Investigator of an NIHR HTA funded study to determine the feasibility of a randomised trial of different techniques for managing an impacted fetal head during emergency caesarean section. This study started in February 2019 and completed in 2022.

Expertise Summary

Randomised controlled trials. General obstetrics. General gynaecology. Qualitative research. Health economics.

Teaching Summary

TRAINING TO TEACH

In 2019 I received a Postgraduate certificate in Higher Education (15 credits) following completion of an 'Individual Pathway' module. This involved completing 3 days of workshops on learning/teaching topics, and then I completed a teaching development and submitted a written report for assessment. The workshops I attended were:

  • Foundations of teaching in Higher Education
  • Contemporary issues in supervising research students
  • Assessing & giving feedback
  • Introduction to Learning Technologies
  • Internet Based Collaboration Tools

PRACTICE

I have always had a great passion for teaching and have regularly taught medical students and junior trainees through seminars, lectures and small group tutorials throughout my training. In my current post my teaching has involved:

  • Main supervisor for a BMedSci student who undertook a project involving a regional audit of laparoscopic hysterectomies in the East Midlands
  • Supervision of an UoN Assisted Reproduction Masters student
  • Supervision of a UoN PhD student, undertaking a PhD on the assessment of endometrial receptivity in response to progesterone exposure and endometrial biopsy: progesterone, endometrial gene expression, and endometrial vascularity
  • Undergraduate lecture to third year medical students on 'Antenatal Care in Healthy Singletons' in Dec 2018
  • Participation in the Medical Students interviews (Dec 2017 and 2018)
  • Delivered lectures on the Part 2 MRCOG Revision Course, University of Nottingham - Jun 2017, Nov 2017
  • Examiner for BMedSci Dissertation and Viva - Feb 2014, Feb 2018, Feb 2019
  • Supervised a second year Foundation Doctor (FY2), Dr Philippa Wilson, during a four month academic post in 2014
  • Facilitator on the Inter-professional Study Day for fourth year medical students and third year student midwives where lead a session on labour ward prioritization.

WEB-BASED LEARNING PACKAGES

StratOG (RCOG's online learning resource)

Revised and updated eLearning tutorials on Postpartum sepsis (2013) and Infectious Diseases (2013)

AWARDS

In 2019 I was nominated for a Nottingham University Hospitals NHS Trust Postgraduate Medical Education Department award for my Contribution to Undergraduate Teaching 18-19.

Research Summary

I am the Chief Investigator of an NIHR HTA funded study to determine the feasibility of a randomised trial of different techniques for managing an impacted fetal head during emergency caesarean… read more

Recent Publications

Current Research

I am the Chief Investigator of an NIHR HTA funded study to determine the feasibility of a randomised trial of different techniques for managing an impacted fetal head during emergency caesarean section. This study started in February 2019 and will take 24 months to complete.

I am the Clinical Chief Investigator of an NIHR HTA funded cluster randomised trial with economic and acceptability evaluations to determine the clinical and cost-effectiveness of testing for Group B Streptococcus in late pregnancy (GBS3). This study started in April 2019 and will take 36 months to complete.

Past Research

Peer reviewed original research

Amelia Peak, Elena Barwise, Kate F Walker. Techniques for managing an impacted fetal head at caesarean section: A systematic review. European Journal of Obstetrics and Gynecology 281 (2023) 12-22

Walker KF, Mitchell EJ, Ayers S, Jones NW, Ogollah R, Wakefield N, Dorling J, Pallotti P, Pillai A, Tempest N, Plachcinski R, Bradshaw L, Knight M & Thornton JG. Feasibility of a RCT of techniques for managing an impacted fetal head during emergency caesarean section: the MIDAS scoping study. Health Technology Assessment Volume: 27, Issue: 6, Published in March 2023

Georgina Constantinou, Susan Ayers, Eleanor J Mitchell, Kate F Walker, Jane Daniels, Sarah Moore, Anne-Marie Jones, Soo Downe Women's knowledge of and attitudes towards group B streptococcus (GBS) testing in pregnancy: a qualitative study. BMC Pregnancy and Childbirth (2023) 23:339 https://doi.org/10.1186/s12884-023-05651-0

Gabriella Romano, Susan Ayers, Georgina Gonstantinou, Eleanor J Mitchell, Rachel Plachcinski, Natalie Wakefield, Kate F Walker The acceptability and feasibility of a randomised trial exploring approaches to managing impacted fetal head during emergency caesarean section: a qualitative study. BMC Pregnancy Childbirth 23, 216 (2023). https://doi.org/10.1186/s12884-023-05444-5

Kate F. Walker, Summia Zaher, Rafael Torrejon Torres, Sita J. Saunders, Rhodri Saunders, Janesh K. Gupta Synthetic osmotic dilators (Dilapan-S) or dinoprostone vaginal inserts (Propess) for inpatient induction of labour: A UK cost-consequence model. European Journal of Obstetrics and Gynecology 278 (2022) 72-76

Laura Magee, S Tohill, K Kirkam and the WILL trial study group (including Kate F Walker (5%)) WILL (when to induce labour to limit risk in pregnancy hypertension): a multicentre randomised controlled trial - adaptations to deliver a timing-of-birth trial during the COVID-19 international pandemic. Trials 23 (2022) 884 https://doi.org/10.1186/S13063-022-06834-4

Oleia Green, Eloise M Young, Jemma Oberman, Joel Stewart, Yasmin King, Keelin O'Donoghue, Kate F Walker (30%), Jim G Thornton Recruitment of pregnant women to randomised trials of COVID 19 treatments, and pharmaceutical treatments received outside such trials: a research article. European Journal of Obstetrics & Gynecology and Reproductive Biology 275 (2022) 12-16

Sutham Suthaporn, Kanna Jayaprakasan, Jim G. Thornton, Kate F. Walker (10%), Marcos Castellanos, Sean May, Juan Hernandez-Medrano Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualization, Sean May, Juan Hernandez-Medrano https://doi.org/10.1016/j.mce.2021.111242

Nia Wyn Jones, Eleanor J Mitchell, Natalie Wakefield, Marian Knight, Jon Dorling, Jim G Thornton, Kate F Walker (50%) Impacted fetal head during second stage Caesarean birth: a prospective observational study. European Journal of Obstetrics & Gynecology and Reproductive Biology 272 (2022) 77-81

John Allotey, Shaunak Chatterjee, Tania Kew, Andrea Gaetano, Elena Stallings, Silvia Fernández-García, Magnus Yap, Jameela Sheikh, Heidi Lawson, Dyuti Coomar, Anushka Dixit, Dengyi Zhou, Rishab Balaji, Megan Littmoden, Yasmin King, Luke Debenham, Anna Clavé Llavall, Kehkashan Ansari, Guirmaan Sandu, Adeolu Banjoko, Kate Walker (10%), et al Offspring SARS-COV-2 positivity and timing of mother-to-child transmission: a living systematic review and meta-analysis. BMJ 2022;376: e067696

Eleanor J. Mitchell, Garry Meakin, Josie Anderson, Jon Dorling, Chris Gale, Rachel Haines, Charlotte Kenyan, Mark J. Johnson, William McGuire, Hema Mistry, Alan Montgomery, Sam Oddie, Reuben Ogollah, Phoebe Pallotti, Christopher Partlett, Kate F. Walker (10%) and Shalini Ojha The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age). Trials 2022 (23) 64

Managing an impacted fetal head at caesarean section: a UK survey of healthcare professionals and parents Stephanie Hanley, Kate F Walker (40%), Natalie Wakefield, Rachel Plachcinski, Phoebe Pallotti, Nicola Tempest, Arani Pillai, Jim Thornton, Nia Jones, Eleanor J. Mitchell European Journal of Obstetrics & Gynecology and Reproductive Biology 271 (2022) 88-92

Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis Steven Giesbers, Edwina Goh, Tania Kew, John Allotey, Vanessa Brizuela, Edna Kara, Heinke Kunst, Mercedes Bonet, Shakila Thangaratinam, PregCOV-19 Group (including Kate F Walker (10%), Lynne Mofenson European Journal of Obstetrics & Gynecology and Reproductive Biology 267 (2021) 120-128

COVID-19 and pregnancy: A comparison of case reports, case series and registry studies Eloise M Young, Oleia Green, Joel Stewart, Yasmin King, Keelin O'Donoghue, Kate F Walker (30%), Jim G Thornton European Journal of Obstetrics and Gynecology and Reproductive Biology 2022 (268) 135-142

Timing of umbilical cord clamping for preterm infants in low-and-middle-income countries: a survey of current practice. European Journal of Obstetrics and Gynecology and Reproductive Biology Impact factor: 1.69 Lucy Payne, Kate F Walker (10%), and Eleanor Mitchell. European Journal of Obstetrics and Gynecology and Reproductive Biology 2021 (264) Pages 15-20, https://doi.org/10.1016/j.ejogrb.2021.06.041.

Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis Juliette Servante, Gill Swallow, Jim G Thornton, Bethan Myers, Sandhya Munireddy, A. Kinga Malinowski, Maha Othman, Wentao Li, Keelin O'Donoghue, Kate F Walker (50%) BMC Pregnancy and Childbirth 2021 DOI: 10.1186/s12884-021-03568-0

The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: A qualitative study. Dr Gabriella Romano, Eleanor Mitchell, Rachel Plachcinski, Natalie Wakefield, Kate Walker (30%), Susan Ayers BMC Pregnancy Childbirth 21, 103 (2021). https://doi.org/10.1186/s12884-021-03577-z

Episiotomy and Initiation of Human Milk Feeds: A Retrospective Observational Study Juliette Servante, Janine Abramson, Kate F. Walker (10%), and Shalini Ojha Breastfeeding Medicine 2021. https://doi.org/10.1089/bfm.2020.0071

Suboptimal mid-luteal progesterone levels are associated with aberrant endometrial gene expression potentially resulting in implantation failure Sutham Suthaporn, Kanna Jayaprakasan, Jim Thornton, Kate Walker (10%), Juan Hernandez Medrano, Marcos Castellanos, Sean May, Lukasz Polanski, Nick Raine-Fenning, Walid E. Maalouf Reproductive BioMedicine Online 2021 Volume 42, Issue 3, Pages 595-608, https://doi.org/10.1016/j.rbmo.2020.10.018.

Fetal movement counting using optical fibre sensors Chalani Abeywardena, Frederique Vanheusden, Kate Walker (30%), Richard Arm, Qimei Zhange Sensors 2021, 21, 48. https://dx.doi.org/10.3390/s21010048

A novel non-antimicrobial treatment of bacterial vaginosis: an open label two-private centre study Harriett C Latham-Cork, Kate F Walker (50%), Jim G Thornton, Omar Gunnarsson, Annette Säfholm, Monika Cardell, Helena Strevens European Journal of Obstetrics and Gynecology and Reproductive Biology 2020.

Impact of late-onset group B streptococcus infection on families: An observational study Grace Raybould, Jane Plumb, Alison Stanley, Kate F. Walker (30%) European Journal of Obstetrics and Gynecology and Reproductive Biology 2020; https://doi.org/10.1016/j.ejogrb.2020.10.022

Kate F Walker, Keelin O'Donoghue, Nicky Grace, Jon Dorling, Jeannette L Comeau, Wentao Li, Jim G Thornton. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: A systematic review and critical analysis. British Journal of Obstetrics and Gynaecology 2020

Charlotte Hickson, Felicity Hoskins, Reuben Ogollah, Kate F Walker, Jim G Thornton. The risks of a range of maternal pregnancy choices, expressed as "baby micromorts" (risk of death per million births). European Journal of Obstetrics and Gynecology and Reproductive Biology 2020; https://doi.org/10.1016/j.ejogrb.2020.05.051

Rebecca Robinson, Kate F Walker, Victoria A White, George J Bugg, Kym IE Snell, Nia W Jones. The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review. European Journal of Obstetrics and Gynecology and Reproductive Biology 2020; 246: 79-85

Sutham Suthaporn, Kanna Jayaprakasan, Walid Maalouf, James G. Thornton, Kate F. Walker. The strength of evidence supporting luteal phase progestogen after assisted reproduction: a systematic review with reference to trial registration and pre-specified endpoints. European Journal of Obstetrics and Gynecology and Reproductive Biology 2020; 245: 149-161

Kate F Walker, Anna Dencker, Jim G Thornton. Childbirth Experience Questionnaire 2: Validating its Use in the United Kingdom. European Journal of Obstetrics and Gynecology and Reproductive Biology 2020; 5: 100097 http://dx.doi.org/10.1016/j.eurox.2019.100097

Victoria White, Kate F Walker and Jim G Thornton. Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting. European Journal of Obstetrics and Gynecology and Reproductive Biology 2019

Diane Whitham. Julie Turzanski, Lucy Bradshaw, Mike Clarke, Lucy Culliford, Lelia Duley, Lisa Shaw, Zoe Skea, Shaun P.Treweek, Kate F Walker, Paula R. Williamson, Alan Montgomery. Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study. Trials 2018; 19: 557

Kate F Walker; Julie Turzanski; Diane Whitham; Alan Montgomery; Lelia Duley. Monitoring performance of sites within multicentre randomised trials: A systematic review of performance metrics. Trials 2018; 19: 562.

Kate Bramham, Lucy Chappell, Kate F Walker, Lesia Kurlak, Amanda Green, Pamela Loughna, Daniele Cristovao Escouto. Postpartum Evaluation of Cardiovascular Disease Risk for Women with Pregnancies Complicated by Hypertension. Pregnancy Hypertension 2018; 13: 218-224

Kate F Walker, Melina Dritsaki, George J Bugg, Marion Macpherson, Carol McCormick, Nicky Grace, Chris Wildsmith Lucy Bradshaw, Gordon C S Smith, James G Thornton. Labour induction near term for women aged 35 or over; an economic evaluation of a randomised trial. BJOG 2017: 124 (6)

Kate F Walker, George J Bugg, Marion Macpherson, Carol McCormick, Nicky Grace, Chris Wildsmith Lucy Bradshaw, Gordon C S Smith, James G Thornton. A randomized controlled trial of labor induction for women aged 35 or over. NEJM 2016; 374:813-22.

Kate F Walker, Lucy Bradshaw, George J Bugg and Jim G Thornton. Causes of antepartum stillbirth in women of advanced maternal age. European Journal of Obstetrics and Gynecology and Reproductive Biology 197 (2016) 86-90.

Kate F Walker, Gemma Malin, Philippa Wilson and Jim G Thornton. Induction of labour versus expectant management at term by subgroups of maternal age: an individual patient data meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology 197 (2016) 1-5.

Kate F Walker, Philippa Wilson, George J Bugg, Anna Dencker and Jim G Thornton. Childbirth experience questionnaire: validating its use in the United Kingdom. BMC Pregnancy and Childbirth (2015) 15:86.

Kate F Walker, Graham Stevenson and James Thornton. Still discrepancies between registration and publication of randomised controlled trials: an observational study. Journal of the Royal Society of Medicine Short Reports 2014: 5(5) 1-4.

Kate Walker, Abigail Cohen, Sophie Walker, Kirsten Allen, Darrin Baines, Jim Thornton. Dangers of the day of birth: an observational study. BJOG 2014; 121:714-718.

Kate F Walker, George J Bugg, Marion Macpherson, Carol McCormick James Thornton. Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial. BMC Pregnancy and Childbirth 2012, 12:145.

Kate F Walker, George J Bugg, Marion Macpherson, James Thornton. Induction of labour at term for women over 35 years old: a survey of the views of women and obstetricians. European Journal of Obstetrics and Gynecology and Reproductive Biology 2012 162(2):144-8

Zeina J Haoula, Kate F Walker, Martin C Powell. Levonorgestrel intra-uterine system as a treatment option for complex endometrial hyperplasia. European Journal of Obstetrics and Gynecology and Reproductive Biology 2011; 159 (1):176-179.

Kate Frances Walker, Honor Day, Jafaru Abu, David Nunns, Karin Williamson, Tim Duncan. Do surgical techniques used in groin lymphadenectomy for vulval cancer affect morbidity rates? International Journal of Gynecological Cancer 2011; 21(8):1495-1499.

K. Jayaprakasan, K.F. Walker, J.S. Clewes, I.R. Johnson & N.J. Raine-Fenning. The interobserver reliability of off-line antral follicle counts made from stored three-dimensional ultrasound data; a comparative study of different measurement techniques. Ultrasound in Obstetrics and Gynecology 2007; 29: 335-341.

Ala'Aldeen, D.A.A., Robinson, K., Wooldridge, K.G., Bland, S.J., Wells, D.B., Riordan (Walker), K.F., Taraktsoglou, M. & Todd, I. The meningococcal TspA protein is vital for normal type IV pilus biogenesis and function. Abstracts of the Thirteenth International Pathogenic Neisseria Conference. Norway 2002

Invited commentaries

Kate F Walker and James G Thornton. Encouraging maternal reporting of altered fetal movements in pregnancy is ineffective and harmful. The Lancet. Accepted for publication 23rd July 2018

Kate F Walker and James G Thornton. Induction of labour at 37 weeks for suspected fetal macrosomia may reduce birth trauma. Evidence-Based Medicine. Published online 23rd June 2017. Doi: 10.1136/ebmed-2017-110693

Kate F Walker and James G Thornton. Tocolysis and preterm labour. The Lancet (2016). Published online 1st March 2016.

Invited reviews

Kate F. Walker, G.J. Bugg. Is it time to ban oxytocin for poor labour progress? Obstetrics, Gynaecology and Reproductive Medicine 2019.

Walker KF, Kibuka M, Thornton JG, Jones NW. Maternal position in the second stage of labour for women with epidural anaesthesia. Cochrane Database of Systematic Reviews 2018 Issue 11.

K.F. Walker, C. Gribbin, F. Siddiqui. Cultural aspects of care in obstetrics and gynaecology. Obstetrics, Gynaecology and Reproductive Medicine 2018; 28.

Churchill D, Duley L, Thornton JG, Moussa M, Ali HSM, Walker KF. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. Cochrane Database of Systematic Reviews 2018 Issue 10. Art. No.: CD003106

K.F. Walker, J Thornton. Delivery at term: when, how and why. Clinics in Perinatology 2018; 45: 2, p 199-211.

K.F. Walker, J Thornton. Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine 2016; 26.

K.F. Walker, K. Jayaprakasan, N.J. Raine-Fenning. Ultrasound in benign gynaecology. Obstetrics, Gynaecology and Reproductive Medicine 2007; 17:2.

Case reports

Philippa Wilson, Kate F Walker, Clare Gribbin and James G Thornton. A case of aortic dissection diagnosed postnatally. European Journal of Obstetrics and Gynecology and Reproductive Biology 183 (2014) 205.

Kate F. Walker, Jaydip Dasgupta and Michael P. Cust. A neglected shelf pessary resulting in an urethrovaginal fistula. International Urogynecology Journal 2011; 22(10):1333-1334.

Letters

K Walker and J Thornton Dangers of the day of birth: an observational study (Author's comment). BJOG 2014; 121 (10), pages 1320-1321.

Book Chapters

Chapter on 'Ethics in Medicine' in Medicolegal Issues in Obstetrics and Gynaecology. In Press.

Chapter on 'Prolonged Pregnancy' in Oxford University Press Textbook of Obstetrics and Gynaecology. In Press.

StratOG (RCOG's online learning resource)

Revised and updated eLearning tutorials on Postpartum sepsis (2013) and Infectious Diseases (2013)

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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