Dr Selby studied medicine at the University of Nottingham, graduating in 1998. After undertaking post-graduate training in the East Midlands, during which time he completed a Doctor of Medicine (DM) under the supervision of Chris McIntyre, he was appointed a full-time NHS consultant nephrologist at the Royal Derby Hospital in 2009. He maintained an active involvement in research, and in 2015 was appointed Associate Professor of Nephrology at the University of Nottingham, based in the Division of Medical Sciences and Graduate Entry Medicine at the Royal Derby Hospital Postgraduate Medical School.
Acute Kidney Injury, haemodynamic and cardiovascular consequences of dialysis, Renal imaging
I deliver teaching at both undergraduate and postgraduate levels, including the Graduate Entry Medicine pre-clinical course. I have led a number of innovative educational programmes for acute kidney… read more
I am a clinical researcher with interests in acute kidney injury (AKI) and the haemodynamic and cardiovascular consequences of dialysis. My specific interests are:
Long term outcomes of AKI
I am principle investigator for the AKI Risk in Derby (ARID) study, an investigator-instigated study adopted onto the NIHR portfolio, which will examine the long-term outcomes of AKI in 1084 participants with the aim of developing tools (clinical and biomarker based) that will stratify patients into low and high risk of adverse outcomes (ISRCTN25405995).
Improving AKI care delivery
I led the development of the first e-alert system for AKI that has become a useful tool to allow epidemiological study of AKI (now rolled out nationally via an NHS England Patient Safety Alert) and have delivered service improvement programmes in both primary and secondary care (alongside data collection to evidence efficacy). This has led to Tackling AKI, a multi-centre study funded by the Health Foundation that will test the scalability and effectiveness of a complex AKI intervention in networks of hospitals in Yorkshire and Surrey.
Dialysis for AKI
I am principle investigator for an on-going study examining dialysis-related cardiac injury during acute dialysis; this observational study will determine whether dialysis-based interventions may be feasible to improve outcomes in this high risk patient group.
Novel MRI techniques in renal disease
Our research group is working collaboratively with a team from the Sir Peter Mansfield Magnetic Resonance Centre (School of Physics and Astronomy), and we have recently completed a study in which dynamic MR images of the heart have been obtained during haemodialysis. We now seek to use this model of intradialytic MRI to study the acute effects of dialysis on the heart, brain and kidney concurrently. An MRC-CiC grant has funded a study of the first clinical application of a new MRI protocol of renal imaging that will incorporate a number of measures to quantify renal perfusion, blood flow and oxygenation as well as precise measurements of kidney structure including assessment of fibrosis. Future collaborative work includes development and clinical application of 23Na MRI for kidney diseases and the acute effects of dialysis on skeletal muscle.
Peritoneal dialysis and heart failure
I am the local principle investigator for the British Heart Foundation funded multi-centre PD-HF study that will test the effectiveness of peritoneal dialysis to treat heart failure.
HORNE, K. L., SHARDLOW, A., TAAL, M. W. and SELBY, N. M., 2015. Long Term Outcomes after Acute Kidney Injury: Lessons from the ARID Study: Nephron Nephron. 131(2), 102-6 REDFERN, A., MAHMOUD, H., MCCULLOCH, T., SHARDLOW, A., HALL, M., BYRNE, C. and SELBY, N. M., 2015. Renal arcuate vein microthrombi-associated AKI: Clin J Am Soc Nephrol Clin J Am Soc Nephrol. 10(2), 180-6
SELBY, N. M., HILL, R., FLUCK, R. J. and N. H. S. ENGLAND 'THINK KIDNEYS'' AKI PROGRAMME, 2015. Standardizing the Early Identification of Acute Kidney Injury: The NHS England National Patient Safety Alert: Nephron Nephron. 131(2), 113-7