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Paloma Ordonez Moran

Assistant Professor in Stem Cell Biology & Cancer Sciences, Faculty of Medicine & Health Sciences

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Biography

Dr. Ordóñez-Morán received her PhD at the University of Madrid and did a postdoctoral research in the laboratory of Prof. Joerg Huelsken at the Swiss Institute for Experimental Cancer Research, École Polytechnique Federale de Lausanne, Switzerland. She joined the University of Nottingham as an Assistant Professor and project leader in July 2019.

Expertise Summary

Stem Cells

Oncology/Cancer

Cell fate

Cell plasticity

Tissue Renewal

Intestinal epithelial biology

Research Summary

Aberrant activation of some pathways can create hierarchically organized tumour tissues where a subpopulation of self-renewing cancer stem cells sustain the long-term clonal maintenance of the… read more

Selected Publications

Projects

Guest Editor in Cancers journal

Special Issue "Stemness and Differentiation in Cancer" (https://www.mdpi.com/journal/cancers/special_issues/Stemness_Differentiation)

The purpose of this Special Issue is to define differentiation processes in tumoral cells which affect phenotypic heterogeneity and stemness in cancer, including a) molecular signatures and mechanisms regulating stemness and differentiation; b) drug resistance and tumour heterogeneity; c) in vivo and in vitro 3D models for studying stemness and differentiation; d) stem cell differentiation and its application to cancer therapy. This Special Issue welcomes both reviews as well as original research articles. The deadline for submissions is 30 November 2020.

Applications for a PhD position are invited all year round to study stem cell plasticity in cancer.

Candidates interested in joining our lab to work can contact Dr Ordonez-Moran by sending an e-mail to paloma.ordonezmoran@nottingham.ac.uk

There are a number of international studentships available to international applicants: http://www.nottingham.ac.uk/InternationalOffice/prospective-students/scholarships/index.aspx.

Current Research

Aberrant activation of some pathways can create hierarchically organized tumour tissues where a subpopulation of self-renewing cancer stem cells sustain the long-term clonal maintenance of the neoplasm. These cells have proven to be resistant to conventional therapy and to be responsible for tumour relapse. My objective is to target these cells based on their stem-like properties and thereby identify efficient approaches for cancer therapies to improve patient survival. To this end, I use mouse models, clinical association analyses, high-throughput approaches, next-generation sequencing, single cell technologies, patient-derived material and 3D organoids.

Future Research

The practical goals of my research are to understand how cell plasticity is related to drug resistance and how combination of cancer therapies can overcome resistance. My results will help to increase patient's response to treatment with target-directed drugs.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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