ANANE-ADJEI, AKOSUA B., FLETCHER, NICHOLAS L., CAVANAGH, ROBERT J., HOUSTON, ZACHARY H., CRAWFORD, THEODORE, PEARCE, AMANDA K., TARESCO, VINCENZO, RITCHIE, ALISON A., CLARKE, PHILLIP, GRABOWSKA, ANNA M., GELLERT, PAUL R., ASHFORD, MARIANNE B., KELLAM, BARRIE, THURECHT, KRISTOFER J. and ALEXANDER, CAMERON, 2022. Synthesis, characterisation and evaluation of hyperbranched N-(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivo BIOMATERIALS SCIENCE. TARESCO, VINCENZO, ABELHA, THAIS F., CAVANAGH, ROBERT J., VASEY, CATHERINE E., ANANE-ADJEI, AKOSUA B., PEARCE, AMANDA K., MONTEIRO, PATRICIA F., SPRIGGS, KEITH A., CLARKE, PHILIP, RITCHIE, ALISON, MARTIN, STEWART, RAHMAN, RUMAN, GRABOWSKA, ANNA M., ASHFORD, MARIANNE B. and ALEXANDER, CAMERON, 2021. Functionalized Block Co-Polymer Pro-Drug Nanoparticles with Anti-Cancer Efficacy in 3D Spheroids and in an Orthotopic Triple Negative Breast Cancer Model ADVANCED THERAPEUTICS. 4(1), 2000103 CONTE, C., MONTEIRO, PATRICIA F., GURNANI, PRATIK, STOLNIK, SNOW, UNGARO, FRANCESCA, QUAGLIA, FABIANA, CLARKE, PHILIP, GRABOWSKA, ANNA, KAVALLARIS, MARIA and ALEXANDER, CAMERON, 2021. Multi-component bioresponsive nanoparticles for synchronous delivery of Docetaxel and TUBB3 siRNA to lung cancel cells. Royal Society of Chemistry.
CONTE, CLAUDIA, MONTEIRO, PATRICIA F., GURNANI, PRATIK, STOLNIK, SNOW, UNGARO, FRANCESCA, QUAGLIA, FABIANA, CLARKE, PHILIP, GRABOWSKA, ANNA, KAVALLARIS, MARIA and ALEXANDER, CAMERON, 2021. Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells NANOSCALE. 13(26), 11414-11426 PEARCE, AMANDA K., ANANE-ADJEI, AKOSUA B., CAVANAGH, ROBERT J., MONTEIRO, PATRICIA F., BENNETT, THOMAS M., TARESCO, VINCENZO, CLARKE, PHIL A., RITCHIE, ALISON A., ALEXANDER, MORGAN R., GRABOWSKA, ANNA M. and ALEXANDER, CAMERON, 2020. Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models ADVANCED HEALTHCARE MATERIALS. MONTEIRO, PATRICIA F., GULFAM, MUHAMMAD, MONTEIRO, CINTIA J., TRAVANUT, ALESSANDRA, ABELHA, THAIS FEDATTO, PEARCE, AMANDA K., JEROME, CHRISTINE, GRABOWSKA, ANNA M., CLARKE, PHILIP A., COLLINS, HILARY M., HEERY, DAVID M., GERSHKOVICH, PAVEL and ALEXANDER, CAMERON, 2020. Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross -links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer JOURNAL OF CONTROLLED RELEASE. 323, 549-564 WADHWA, BHUMIKA, PADDAR, MASROOR, KHAN, SAMEER, MIR, SAMEER, A CLARKE, PHILIP, GRABOWSKA, ANNA M, VIJAY, DEVANAHALLI G and MALIK, FAYAZ, 2020. AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity. Oncotarget. 11(45), 4178-4194
NINGNING LI, ROYA BABAEI-JADIDI, FEDERICA LORENZI, BRADLEY SPENCER-DENE, PHILIP CLARKE, ENRIC DOMINGO, EUGENE TULCHINSKY, ROBERT G. J. VRIES, DAVID KERR, YIHANG PAN, YULONG HE, DAVID O. BATES, IAN TOMLINSON, HANS CLEVERS and ABDOLRAHMAN S. NATERI, 2019. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance: FBXW7/ZEB2 links EMT to CRC-SCs Oncogenesis. 8(3), FAIDRA ANGELEROU, MARIA GALINI, MARKUS, ROBERT, PARASKEVOPOULOU, VASILIKI, FORALOSSO, RUGERRO, CLARKE, PHILIP, ALVAREZ, CLARA V, CHENLO, MIGUEL, JOHNSON, LITTY, RUTLAND, CATRIN, ALLEN, STEPHANIE, BRASNETT, CHRISTOPHER, SEDDON, ANNELA, ZELZER, MISCHA and MARLOW, MARIA, 2019. Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of controlled release : official journal of the Controlled Release Society.
LI, NINGNING, BABAEI-JADIDI, ROYA, LORENZI, FEDERICA, SPENCER-DENE, BRADLEY, CLARKE, PHILIP, DOMINGO, ENRIC, TULCHINSKY, EUGENE, VRIES, ROBERT G. J., KERR, DAVID, PAN, YIHANG, HE, YULONG, BATES, DAVID O., TOMLINSON, IAN, CLEVERS, HANS and NATERI, ABDOLRAHMAN S., 2019. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance ONCOGENESIS. 8, MCCRORIE, PHOEBE, TARESCO, VINCENZO, XU, ZEYUAN, RITCHIE, ALISON, CLARKE, PHILIP A., MARLOW, MARIA and RAHMAN, RUMAN, 2019. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH-GRADE GLIOMAS NEURO-ONCOLOGY. 21, 275-275
ZAMBERLAN, F., TURYANSKA, L., PATANE, A., LIU, Z., WILLIAMS, H. E. L., FAY, M. W., CLARKE, P. A., IMAMURA, Y., JIN, T., BRADSHAW, T. D., THOMAS, N. R. and GRABOWSKA, A. M., 2018. Stable DHLA-PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging: Journal of Materials Chemistry B Journal of Materials Chemistry B. 6(4), 550-555 VICTORIA CAPEL, DRITON VLLASALIU, PETER WATTS, PHILIP A CLARKE, DOMINIC LUXTON, ANNA M GRABOWSKA, GIUSEPPE MANTOVANI and SNJEZANA STOLNIK, 2018. Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of SiRNA Drug Delivery. 25(1), 644-653 SAAD, NORAZALINA, ALBERIO, RAMIRO, JOHNSON, ANDREW D, EMES, RICHARD D, GILES, TOM C, CLARKE, PHILIP, GRABOWSKA, ANNA M and ALLEGRUCCI, CINZIA, 2018. Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget. 9(22), 16008-16027
CAPEL, VICTORIA, VLLASALIU, DRITON, WATTS, PETER, CLARKE, PHILIP A., LUXTON, DOMINIC, GRABOWSKA, ANNA M., MANTOVANI, GIUSEPPE and STOLNIK, SNJEZANA, 2018. Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA: Drug Delivery Drug Delivery. 25(1), 644-653 SAAD, NORAZALINA, ALBERIO, RAMIRO, JOHNSON, ANDREW D., EMES, RICHARD D., GILES, TOM C., CLARKE, PHILIP, GRABOWSKA, ANNA M. and ALLEGRUCCI, CINZIA, 2018. Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy: Oncotarget Oncotarget. 9(22), 16008-16027 ONION, D., ARGENT, R.H., REECE-SMITH, A.M., CRAZE, M.L., PINEDA, R.G., CLARKE, P.A., RATAN, H.L., PARSONS, S.L., LOBO, D.N., DUFFY, J.P., ATHERTON, J.C., MCKENZIE, A.J., KUMARI, R., KING, P., HALL, B.M. and GRABOWSKA, A.M., 2016. 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors Molecular Cancer Therapeutics. 15(4), 753-763 GRABOWSKA ANNA M, KIRCHEIS R, KUMARI R, CLARKE P, MCKENZIE A, HUGHES J, MAYNE C, DESAI A, SASSO L, WATSON S and ALEXANDER C, 2015. Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin–polyethyleneimine conjugates Biomaterials Science. Available online.. CHUA JX, VANKEMMELBEKE M, MCINTOSH RS, CLARKE PA, MOSS R, PARSONS T, SPENDLOVE I, ZAITOUN AM, MADHUSUDAN S and DURRANT LG, 2015. Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity. Clinical cancer research : an official journal of the American Association for Cancer Research. 21(13), 2963-74 SMITH SJ, RAHMAN CV, CLARKE PA, RITCHIE AA, GOULD TW, WARD JH, SHAKESHEFF KM, GRUNDY RG and RAHMAN R, 2014. Surgical delivery of drug-releasing poly(lactic-co-glycolic acid) / poly(ethylene glycol) paste with in vivo effects against glioblastoma Annals of Royal College of Surgeons England. 96, 495-501 RAHMAN CV, SMITH SJ, MORGAN PS, LANGMACK KA, CLARKE PA, RITCHIE AA, MACARTHUR DC, ROSE FR, SHAKESHEFF KM, GRUNDY RG and RUMAN RAHMAN, 2013. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PloS one. 8(10), e77435 YIN, Y., GRABOWSKA, A.M., CLARKE, P.A., WHELBAND, E., ROBINSON, K., ARGENT, R.H., TOBIAS, A., KUMARI, R., ATHERTON, J.C. and WATSON, S.A., 2010. Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7 Gut. 59(8), 1037-1045 PRIDDLE, H., GRABOWSKA, A., MORRIS, T., CLARKE, P.A., MCKENZIE, A.J., SOTTILE, V., DENNING, C., YOUNG, L. and WATSON, S., 2009. Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models Cloning and Stem Cells. 11(2), 259-267 AWAN, A. K., IFTIKHAR, S. Y., MORRIS, T. M., CLARKE, P. A., GRABOWSKA, A. M., WARAICH, N. and WATSON, S. A., 2007. Androgen receptors may act in a paracrine manner to regulate oesophageal adenocarcinoma growth. Eur J Surg Oncol. 36, 561-568 EL ZAATARI, M., TOBIAS, A., GRABOWSKA, A.M., KUMARI, R., SCOTTING, P.J., KAYE, P., ATHERTON, J., CLARKE, P.A., POWE, D.G. and WATSON, S.A., 2007. De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis British Journal of Cancer. 96(12), 1855-1861 CLARKE, P.A., DICKSON, J.H., HARRIS, J.C., GRABOWSKA, A. and WATSON, S.A., 2006. Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin-binding epidermal-like growth factor Cancer Research. 66(7), 3504-3512 SAVAGE, KAY, WALLER, H ANNE, STUBBS, MARK, KHAN, KORSA, WATSON, SUSAN A, CLARKE, PHILIP A, GRIMES, STEVE, MICHAELI, DOV, DHILLON, AMAR P and CAPLIN, MARTYN E, 2006. Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines. International journal of oncology. 29(6), 1429-35
HARRIS, J.C., CLARKE, P.A., AWAN, A., JANKOWSKI, J. and WATSON, S.A., 2004. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Research. 64(6), 1915-1919 HARRIS, J.C., GILLIAM, A.D., MCKENZIE, A.J., EVANS, S.A., GRABOWSKA, A.M., CLARKE, P.A., MCWILLIAMS, D.F. and WATSON, S.A., 2004. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas Cancer Research. 64(16), 5624-5631 WATSON, S A, MORRIS, T M, MCWILLIAMS, D F, HARRIS, J, EVANS, S, SMITH, A and CLARKE, P A, 2002. Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence. British Journal of Cancer. 87(5), 567-73 HENWOOD, M, CLARKE, P A, SMITH, A M and WATSON, S A, 2001. Expression of gastrin in developing gastric adenocarcinoma. British Journal of Surgery. 88(4), 564-8 WATSON, S A, CLARKE, P A, MORRIS, T M and CAPLIN, M E, 2000. Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. Cancer Research. 60(20), 5902-7
WATSON, S. A., MICHAELI, D., GRIMES, S., MORRIS, T. M., VARRO, A., CLARKE, P. A., SMITH, A. M., JUSTIN, T. A. and HARDCASTLE, J. D., 1999. A comparison of an anti-gastrin antibody and cytotoxic drugs in the therapy of human gastric ascites in SCID mice International Journal of Cancer. VOL 81(NUMBER 2), 248-254 WATSON SA, MICHAELI D, MORRIS TM, CLARKE P and GRIFFIN N, 1999. Antibodies raised by Gastrimmune inhibit the spontaneous metastasis of a human colorectal tumour, AP5LV European Journal of Cancer. 38(8), 1286-91 WATSON, S A, MICHAEL, D, JUSTIN, T A, GRIMES, S, MORRIS, T M, ROBINSON, G, CLARKE, P A and HARDCASTLE, J D, 1998. Pre-clinical evaluation of the Gastrimmune immunogen alone and in combination with 5-fluorouracil/leucovorin in a rat colorectal cancer model. International Journal of Cancer. 75(6), 873-7 PARSONS, S L, WATSON, S A, COLLINS, H M, GRIFFIN, N R, CLARKE, P A and STEELE, R J, 1998. Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy. British Journal of Cancer. 78(11), 1495-502
WATSON SA, CLARKE PA, SMITH AM, VARRO A, MICHAELI D and GRIMES S, 1998. Expression of CCKB/gastrin receptor isoforms in gastro-intestinal tumour cells 77(4), 572-77 ARMITAGE NC, ROONEY PS, GIFFORD KA and CLARKE PA, 1995. The effect of calcium supplements on rectal mucosal proliferation Br J Cancer. 71(1), 186-90 ROONEY PS, CLARKE PA, GIFFORD KA and HARDCASTLE JD, 1994. DNA content of rectal mucosa and rectal mucosal proliferation in individuals at high risk of colorectal cancer European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 3, 1
ROONEY PS, CLARKE PA, GIFFORD KA, ROBINSON MH and HARDCASTLE JD, 1993. Cell kinetics of the in vitro metaphase arrest technique and the clinical applications European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2(5), 387-92
ARMITAGE NC, BALLANTYNE KC, SHEFFIELD JP, CLARKE P, EVANS DF and HARDCASTLE JD, 1991. A prospective evaluation of the effect of tumor cell DNA content on recurrence in colorectal cancer Cancer. 67(10), 2599-604 ARMITAGE NC, BALLANTYNE KC, EVANS DF, CLARKE P, SHEFFIELD J and HARDCASTLE JD, 1990. The influence of tumour cell DNA content on survival in colorectal cancer: a detailed analysis Br J Cancer. 62(5), 852-6 COHEN I.J, I.J, MACKIE, S, BLEWETT, P CLARKE, R PATEL, G.H. NEILD and S.J. MACHIN, 1986. The effects of long-term cyclosporin a therapy post-renal transplantation on haemostasis 41(152), BRADSHAW TD, JUNOR M, PATANE A, CLARKE P, THOMAS NR, LI M, MANN S and L TURYANSKA, Apoferritin-encaspulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells Journal of Materials Chemistry B. 1,