Contact

• workRopewalk House
  113 The Ropewalk
  Nottingham
  NG1 5DU
  UK
• Ruth.Spriggs@nottingham.ac.uk

Biography

I joined the University of Nottingham as a Research Fellow in Hearing Sciences in 2021 to carry out bioinformatics-based research in the auditory field.

During my research career I have gained experience in many different fields of bioinformatics including protein structure comparison, protein sequence analysis, translational profiling arrays, next generation sequencing, database design, and RNA sequence analysis.

Recent Publications

• GRAHAM, CHARLOTTE, STEFANATOS, RHODA, YEK, ANGELINE E. H., SPRIGGS, RUTH, V, LOH, SAMANTHA H. Y., URIBE, ALEJANDRO HUERTA, ZHANG, TONG, MARTINS, L. MIGUEL, MADDOCKS, OLIVER D. K., SCIALO, FILIPPO and SANZ, ALBERTO, 2022. Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies GEROSCIENCE. 44(4), 1961-1974
• GROSSO, STEFANO, MARINI, ALBERTO, GYURASZOVA, KATARINA, VOORDE, JOHAN VANDE, SFAKIANOS, ARISTEIDIS, GARLAND, GAVIN D., TENOR, ANGELA RUBIO, MORDUE, RYAN, CHERNOVA, TANYA, MORONE, NOBU, SERENO, MARCO, SMITH, CLAIRE P., OFFICER, LEAH, FARAHMAND, POOYEH, ROONEY, CLAIRE, SUMPTON, DAVID, DAS, MADHUMITA, TEODOSIO, ANA, FICKEN, CATHERINE, MARTIN, MARIA GUERRA, SPRIGGS, RUTH V., SUN, XIAO-MING, BUSHELL, MARTIN, SANSOM, OWEN J., MURPHY, DANIEL, MACFARLANE, MARION, LE QUESNE, JOHN P. C. and WILLIS, ANNE E., 2021. The pathogenesis of mesothelioma is driven by a dysregulated translatome NATURE COMMUNICATIONS. 12(1),
• SCIALO, FILIPPO, SRIRAM, ASHWIN, STEFANATOS, RHODA, SPRIGGS, RUTH, V, LOH, SAMANTHA H. Y., MARTINS, L. MIGUEL and SANZ, ALBERTO, 2020. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster REDOX BIOLOGY. 32,
• SOLEILHAVOUP, CLEMENT, TRAVAGLIO, MARCO, PATRICK, KIERAN, GARCAO, PEDRO, BOOBALAN, ELANGOVAN, ADOLFS, YOURI, SPRIGGS, RUTH V., MOLES-GARCIA, EMMA, DHIRAJ, DALBIR, OOSTERVEEN, TONY, FERRI, SARAH L., ABEL, TED, BRODKIN, EDWARD S., PASTERKAMP, R. JEROEN, BROOKS, BRIAN P. and PANMAN, LIA, 2020. Nolz1 expression is required in dopaminergic axon guidance and striatal innervation NATURE COMMUNICATIONS. 11(1),

• View all publications

• GRAHAM, CHARLOTTE, STEFANATOS, RHODA, YEK, ANGELINE E. H., SPRIGGS, RUTH, V, LOH, SAMANTHA H. Y., URIBE, ALEJANDRO HUERTA, ZHANG, TONG, MARTINS, L. MIGUEL, MADDOCKS, OLIVER D. K., SCIALO, FILIPPO and SANZ, ALBERTO, 2022. Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies GEROSCIENCE. 44(4), 1961-1974
• GROSSO, STEFANO, MARINI, ALBERTO, GYURASZOVA, KATARINA, VOORDE, JOHAN VANDE, SFAKIANOS, ARISTEIDIS, GARLAND, GAVIN D., TENOR, ANGELA RUBIO, MORDUE, RYAN, CHERNOVA, TANYA, MORONE, NOBU, SERENO, MARCO, SMITH, CLAIRE P., OFFICER, LEAH, FARAHMAND, POOYEH, ROONEY, CLAIRE, SUMPTON, DAVID, DAS, MADHUMITA, TEODOSIO, ANA, FICKEN, CATHERINE, MARTIN, MARIA GUERRA, SPRIGGS, RUTH V., SUN, XIAO-MING, BUSHELL, MARTIN, SANSOM, OWEN J., MURPHY, DANIEL, MACFARLANE, MARION, LE QUESNE, JOHN P. C. and WILLIS, ANNE E., 2021. The pathogenesis of mesothelioma is driven by a dysregulated translatome NATURE COMMUNICATIONS. 12(1),
• SCIALO, FILIPPO, SRIRAM, ASHWIN, STEFANATOS, RHODA, SPRIGGS, RUTH, V, LOH, SAMANTHA H. Y., MARTINS, L. MIGUEL and SANZ, ALBERTO, 2020. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster REDOX BIOLOGY. 32,
• SOLEILHAVOUP, CLEMENT, TRAVAGLIO, MARCO, PATRICK, KIERAN, GARCAO, PEDRO, BOOBALAN, ELANGOVAN, ADOLFS, YOURI, SPRIGGS, RUTH V., MOLES-GARCIA, EMMA, DHIRAJ, DALBIR, OOSTERVEEN, TONY, FERRI, SARAH L., ABEL, TED, BRODKIN, EDWARD S., PASTERKAMP, R. JEROEN, BROOKS, BRIAN P. and PANMAN, LIA, 2020. Nolz1 expression is required in dopaminergic axon guidance and striatal innervation NATURE COMMUNICATIONS. 11(1),
• MOORE, DAVID ALLAN, SERENO, MARCO, DAS, MADHUMITA, ACEVEDO, JUVENAL DARIO BAENA, SINNADURAI, SAMANTHA, SMITH, CLAIRE, MCSWEENEY, ABI, SU, XIAOYU, OFFICER, LEAH, JONES, CAROLYN, DUDEK, KATE, GUTTERY, DAVID, TANIERE, PHILLIPE, SPRIGGS, RUTH V. and LE QUESNE, JOHN, 2019. In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction MODERN PATHOLOGY. 32(8), 1095-1105
• LEZINA, LARISSA, SPRIGGS, RUTH, V, BECK, DANIEL, JONES, CAROLYN, DUDEK, KATE M., BZURA, ALEKSANDRA, JONES, GEORGE D. D., PACKHAM, GRAHAM, WILLIS, ANNE E. and WAGNER, SIMON D., 2018. CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM BLOOD ADVANCES. 2(15), 1869-1881
• SBARRATO, THOMAS, SPRIGGS, RUTH V., WILSON, LINDSAY, JONES, CAROLYN, DUDEK, KATE, BASTIDE, AMANDINE, PICHON, XAVIER, POYRY, TUIJA and WILLIS, ANNE E., 2017. An improved analysis methodology for translational profiling by microarray RNA. 23(11), 1601-1613
• BASTIDE, AMANDINE, PERETTI, DIEGO, KNIGHT, JOHN R. P., GROSSO, STEFANO, SPRIGGS, RUTH V., PICHON, XAVIER, SBARRATO, THOMAS, ROOBOL, ANNE, ROOBOL, JO, VITO, DAVIDE, BUSHELL, MARTIN, VON DER HAAR, TOBIAS, SMALES, C. MARK, MALLUCCIL, GIOVANNA R. and WILLIS, ANNE E., 2017. RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3 CURRENT BIOLOGY. 27(5), 638-650
• SBARRATO, T., HORVILLEUR, E., POYRY, T., HILL, K., CHAPLIN, L. C., SPRIGGS, R. V., STONELEY, M., WILSON, L., JAYNE, S., VULLIAMY, T., BECK, D., DOKAL, I., DYER, M. J. S., YEOMANS, A. M., PACKHAM, G., BUSHELL, M., WAGNER, S. D. and WILLIS, A. E., 2016. A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment CELL DEATH & DISEASE. 7,
• KHONG, ANTHONY, BONDEROFF, JENNIFER M., SPRIGGS, RUTH V., TAMMPERE, ERIK, KERR, CRAIG H., JACKSON, THOMAS J., WILLIS, ANNE E. and JAN, ERIC, 2016. Temporal Regulation of Distinct Internal Ribosome Entry Sites of the Dicistroviridae Cricket Paralysis Virus VIRUSES-BASEL. 8(1),
• SPRIGGS, RUTH V and WILLIS, ANNE E, 2014. TRANS PROF DB: A new resource for sharing translational profiles. Translation (Austin, Tex.). 2(2), e965615
• JACKSON, THOMAS J., SPRIGGS, RUTH V., BURGOYNE, NICHOLAS J., JONES, CAROLYN and WILLIS, ANNE E., 2014. Evaluating bias-reducing protocols for RNA sequencing library preparation BMC GENOMICS. 15,
• HORVILLEUR, E., SBARRATO, T., HILL, K., SPRIGGS, R. V., SCREEN, M., GOODREM, P. J., SAWICKA, K., CHAPLIN, L. C., TOURIOL, C., PACKHAM, G., POTTER, K. N., DIRNHOFER, S., TZANKOV, A., DYER, M. J. S., BUSHELL, M., MACFARLANE, M. and WILLIS, A. E., 2014. A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma LEUKEMIA. 28(5), 1092-1102
• SANCHEZ-RIPOLL, YOLANDA, BONE, HEATHER K., OWEN, TOM, GUEDES, ANA M. V., ABRANCHES, ELSA, KUMPFMUELLER, BENJAMIN, SPRIGGS, RUTH V., HENRIQUE, DOMINGOS and WELHAM, MELANIE J., 2013. Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal PLOS ONE. 8(4),
• MEIJER, H. A., KONG, Y. W., LU, W. T., WILCZYNSKA, A., SPRIGGS, R. V., ROBINSON, S. W., GODFREY, J. D., WILLIS, A. E. and BUSHELL, M., 2013. Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation SCIENCE. 340(6128), 82-85
• MURAKAMI, YOICHI, SPRIGGS, RUTH V., NAKAMURA, HARUKI and JONES, SUSAN, 2010. PiRaNhA: a server for the computational prediction of RNA-binding residues in protein sequences NUCLEIC ACIDS RESEARCH. 38, W412-W416
• SPRIGGS, RUTH V. and JONES, SUSAN, 2009. RNA-binding residues in sequence space: Conservation and interaction patterns COMPUTATIONAL BIOLOGY AND CHEMISTRY. 33(5), 397-403
• SPRIGGS, R. V., MURAKAMI, Y., NAKAMURA, H. and JONES, S., 2009. Protein function annotation from sequence: prediction of residues interacting with RNA BIOINFORMATICS. 25(12), 1492-1497
• GEORGE, RA, SPRIGGS, RV, BARTLETT, GJ, GUTTERIDGE, A, MACARTHUR, MW, PORTER, CT, AL-LAZIKANI, B, THORNTON, JM and SWINDELLS, MB, 2005. Effective function annotation through catalytic residue conservation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 102(35), 12299-12304
• MITCHELL, SA, SPRIGGS, KA, BUSHELL, M, EVANS, JR, STONELEY, M, LE QUESNE, JPC, SPRIGGS, RV and WILLIS, AE, 2005. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry GENES & DEVELOPMENT. 19(13), 1556-1571
• FREILICH, S, SPRIGGS, RV, GEORGE, RA, AL-LAZIKANI, B, SWINDELLS, M and THORNTON, JM, 2005. The complement of enzymatic sets in different species JOURNAL OF MOLECULAR BIOLOGY. 349(4), 745-763
• NOBELI, I, SPRIGGS, RV, GEORGE, RA and THORNTON, JM, 2005. A ligand-centric analysis of the diversity and evolution of protein-ligand relationships in E-coli JOURNAL OF MOLECULAR BIOLOGY. 347(2), 415-436
• ARTYMIUK, PJ, SPRIGGS, RV and WILLETT, P, 2005. Graph theoretic methods for the analysis of structural relationships in biological macromolecules JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY. 56(5), 518-528
• GEORGE, RICHARD A., SPRIGGS, RUTH V., THORNTON, JANET M., AL-LAZIKANI, BISSAN and SWINDELLS, MARK B., 2004. SCOPEC: a database of protein catalytic domains BIOINFORMATICS. 20, 130-136
• SPRIGGS, RV, ARTYMIUK, PJ and WILLETT, P, 2003. Searching for patterns of amino acids in 3D protein structures JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES. 43(2), 412-421